Controlled release of bFGF loaded into electrospun core-shell fibrous membranes for use in guided tissue regeneration.

In this study, basic fibroblast growth factor (bFGF) was loaded into a poly(lactic-co-glycolic acid) (PLGA)/wool keratin composite membrane by emulsion electrospinning to prepare a composite membrane with a core-shell structure for guided tissue regeneration (GTR). The physicochemical properties, drug release performance in vitro and cytotoxicity of the composite membrane were evaluated to select the optimum concentration of bFGF. The fibers in the six groups of composite membranes were uniform in thickness, had a smooth surface, and did not exhibit a string bead structure.