2 results match your criteria: "People's Republic of China. Electronic address: liang.li@zs-hospital.sh.cn.[Affiliation]"
Unveiling major histocompatibility complex-mediated pan-cancer immune features by integrated single-cell and bulk RNA sequencing.
Cancer Lett
August 2024
Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China. Electronic address:
Article Synopsis
- Immune checkpoint inhibitors (ICIs) are important in cancer treatment, but challenges like low response rates and differences in patient responses still need to be addressed.
- This study explores the major histocompatibility complex (MHC) as a key factor influencing ICI effectiveness by analyzing various types of RNA sequencing data from a large number of cells across multiple cancer types.
- The findings suggest that the MHC transcriptional feature (MHC.sig) can serve as a universal marker for anti-tumor immunity and may help identify new therapeutic targets, improving predictions for ICI responsiveness and guiding treatment strategies.
Coiled-coil domain-containing 154 promotes colorectal cancer proliferation and metastasis via interacting with minichromosome maintenance complex component 2.
Cancer Lett
December 2023
Department of Medical Oncology, Zhongshan Hospital Fudan University, NO. 180, Fenglin Road, Xuhui District, Shanghai, 200032, People's Republic of China; Cancer Center, Zhongshan Hospital Fudan University, NO. 180, Fenglin Road, Xuhui District, Shanghai, 200032, People's Republic of China; Evidence-Based Medicine Center, Zhongshan Hospital Fudan University, NO. 180, Fenglin Road, Xuhui District, Shanghai 200032, People's Republic of China. Electronic address:
Coiled-Coil Domain-Containing (CCDC) is a large class of structural proteins containing left-handed supercoiled structure. The clinical value and the functional implication of CCDC in colorectal cancer (CRC) remain unknown. Based on the genetic, transcriptional, and clinical data from The Cancer Genome Atlas, five of thirty-six CCDC proteins were differentially expressed in the CRC and associated with the survival of patients with CRC.
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