Facile synthesis of CoTe-FeC for efficient overall water-splitting in an alkaline medium.

The large amounts of attention directed towards the commercialization of renewable energy systems have motivated extensive research to develop non-precious-metal-based catalysts for promoting the electrochemical production of H and O from water. Here, we report promising technology, , electrochemical water splitting for OER and HER. This work used a simple hydrothermal method to synthesize a novel CoTe-FeC nanocomposite directly on a stainless-steel substrate.

Shen Zhi Ling oral liquid improve neuroinflammation against Alzheimer's disease via the PI3K/Akt pathway.

The etiology and pathogenesis of Alzheimer's disease (AD) are complex, and currently, no comprehensive treatment measures exist. In this study, we initially utilized ultra-high-performance liquid chromatography with quadrupole orbitrap mass spectrometry (UHPLC-QE-MS) to profile the bioactive constituents of SZLOL present in the bloodstream. Subsequent Y-maze experimental data demonstrated that SZLOL could ameliorate short-term memory deficits in APP/PS1 mice.

Digestive tract reconstruction after laparoscopic proximal gastrectomy: Double tract reconstruction or double flap technique?

Aim: The reconstruction methods after proximal gastrectomy (PG) are varied but not standardized. This study was performed to evaluate the short-term clinical outcomes between double tract reconstruction (DTR) and double flap technique (DFT).

Methods: We retrospectively reviewed and collected data of patients who underwent DTR and DFT after laparoscopic proximal gastrectomy (LPG), respectively, between January 2020 and March 2023.

Mutation in and a Variant Linked to a Severe Sporadic Infant Dilated Cardiomyopathy Case.

Structural or electrophysiologic cardiac anomalies may compromise cardiac function, leading to sudden cardiac death (SCD). Genetic screening of families with severe cardiomyopathies underlines the role of genetic variations in cardiac-specific genes. The present study details the clinical and genetic characterization of a malignant dilated cardiomyopathy (DCM) case in a 1-year-old Mexican child who presented a severe left ventricular dilation and dysfunction that led to SCD.

Single-cell RNA sequencing reveals the changes of the pulmonary immune environment in rat after L. treatment.

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A novel strategy based on the dielectric barrier discharge plasma for rapid elimination of the carryover associated with μPESI-MS/MS system.

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A holistic visualization for quality of Chinese materia medica: Structural and metabolic visualization by magnetic resonance imaging.

The quality of Chinese materia medica (CMM) is a challenging and focused topic in the modernization of traditional Chinese medicine (TCM). A profound comprehension of the morphology, structure, active constituents, and dynamic changes during the whole process of CMM growth is essential, which needs highly precise contemporary techniques for in-depth elucidation. Magnetic resonance imaging (MRI) is a cutting-edge tool integrating the benefits of both nuclear magnetic resonance (NMR) spectroscopy and imaging technology.

Investigation of oligomeric proanthocyanidins extracted from Rhodiolae Crenulatae Radix et Rhizomes using deep eutectic solvents and identified via data-dependent acquisition mass-spectroscopy.

In this study, 34 deep eutectic solvents (DESs) were successfully prepared for the extraction of proanthocyanidin from Rhodiolae Crenulatae Radix et Rhizomes. The extraction process was optimized using single factor exploration and Box-Behnken design-response surface analysis. The extraction rate was significantly improved when the molar ratio of choline chloride to 1,3-propanediol was 1:3.

Green analytical chemistry metrics for evaluating the greenness of analytical procedures.

Green analytical chemistry (GAC) focuses on mitigating the adverse effects of analytical activities on human safety, human health, and environment. In addition to the 12 principles of GAC, proper GAC tools should be developed and employed to assess the greenness of different analytical assays. The 15 widely used GAC metrics, i.

Nano Acacetin Mitigates Intestinal Mucosal Injury in Sepsis Rats by Protecting Mitochondrial Function and Regulating TRX1 to Inhibit the NLRP3 Pyroptosis Pathway.

Background: Acacetin (AC) is a flavonoid compound with antiperoxidant, anti-inflammatory, and antiplasmodial activity. However, the solubility of AC is poor and nano acacetin (Nano AC) was synthesized. The intestinal mucosal barrier is impaired in sepsis rats, and the protective effects and mechanism of AC and Nano AC on the intestinal mucosal barrier are unclear.

Recent Advancements of Nanomedicine in Breast Cancer Surgery.

Breast cancer surgery plays a pivotal role in the multidisciplinary approaches. Surgical techniques and objectives are gradually shifting from tumor complete resection towards prolonging survival, improving cosmetic outcomes, and restoring the social and psychological well-being of patients. However, surgical treatment still faces challenges such as inadequate sensitivity in sentinel lymph node localization, the need to improve intraoperative tumor boundary localization imaging, postoperative scar healing, and the risk of recurrence, necessitating other adjunct measures for improvement.

Corrigendum: Characterization of expression in mouse cochlear hair cells.

[This corrects the article DOI: 10.3389/fgene.2021.

A perspective on field-effect in energy and environmental catalysis.

The development of catalytic technologies for sustainable energy conversion is a critical step toward addressing fossil fuel depletion and associated environmental challenges. High-efficiency catalysts are fundamental to advancing these technologies. Recently, field-effect facilitated catalytic processes have emerged as a promising approach in energy and environmental applications, including water splitting, CO reduction, nitrogen reduction, organic electrosynthesis, and biomass recycling.

Probing the synergistic effects of amino compounds in mitigating oxidation in 2D TiCT MXene nanosheets in aqueous environments.

The shelf life of 2D MXenes in functional devices and colloidal dispersions is compromised due to oxidation in the aqueous system. Herein, a systematic investigation was carried out to explore the potential of various amino compounds as antioxidants for TiCT MXenes. A range of basic, acidic, and neutral amino acids were examined for their effectiveness, where certain antioxidants failed to protect MXenes from oxidation, while others accelerated their decomposition.

Aerobic oxidation of alkylarenes and polystyrene waste to benzoic acids a copper-based catalyst.

The chemical recycling of polystyrene (PS) waste to value-added aromatic compounds is an attractive but formidable challenge due to the inertness of the C-C bonds in the polymer backbone. Here we develop a light-driven, copper-catalyzed protocol to achieve aerobic oxidation of various alkylarenes or real-life PS waste to benzoic acid and oxidized styrene oligomers. The resulting oligomers can be further transformed under heating conditions, thus achieving benzoic acid in up to 65% total yield through an integrated one-pot two-step procedure.

Redefining the roles of alkali activators for porous carbon.

Alkali activation is a common method to prepare commercial porous carbon. In a mixed alkali activation system, the role of each individual alkali has generally been assumed to be the same as in a single alkali activation system, and the low corrosiveness of weak alkalis has mainly been emphasized. However, the intrinsic roles of the individual alkalis should be understood in detail and redefined to illuminate the activation pathways from the perspective of internal chemical reactions rather than corrosiveness.

Highly efficient heteronuclear polarization transfer using dipolar-echo edited R-symmetry sequences in solid-state NMR.

In solid-state NMR, dipolar-based heteronuclear polarization transfer has been extensively used for sensitivity enhancement and multidimensional correlations, but its efficiency often suffers from undesired spin interactions and hardware limitations. Herein, we propose a novel dipolar-echo edited R-symmetry (DEER) sequence, which is further incorporated into the INEPT-type scheme, dubbed DEER-INEPT, for achieving highly efficient heteronuclear polarization transfer. Numerical simulations and NMR experiments demonstrate that DEER-INEPT offers significantly improved robustness, enabling efficient polarization transfer under a wide range of MAS conditions, from slow to ultrafast rates, outperforming existing methods.

Rational design of a series of non-centrosymmetric antiperovskite and double antiperovskite borate fluorides.

Non-centrosymmetric (NCS) compounds can exhibit many symmetry-dependent functional properties, yet their rational structure design remains a great challenge. Herein, a strategy to introduce F-centered octahedra to construct a perovskite-type framework filled by π-conjugated [BO] dimers is proposed to obtain NCS compounds. The first examples of antiperovskite or double antiperovskite borate fluorides, [(M/Ba)Ca]F[BO] (M = K, Rb) and [CsBaCa]F[BO], have been successfully designed and synthesized.

Ruthenium-catalyzed three-component tandem remote C-H functionalization of naphthalenes: modular and concise synthesis of multifunctional naphthalenes.

The prevalence of naphthalene compounds in biologically active natural products, organic ligands and approved drugs has motivated investigators to develop efficient strategies for their selective synthesis. C-H functionalization of naphthalene has been frequently deployed, but mainly involves two-component reactions, while multiple-component C-H functionalization for the synthesis of naphthalene compounds has thus far proven elusive. Herein, we disclose a versatile three-component protocol for the modular synthesis of multifunctional naphthalenes from readily available simple naphthalenes, olefins and alkyl bromides P(iii)-assisted ruthenium-catalyzed remote C-H functionalization.

Molecular engineering of supramolecular polymer adhesive with confined water and a single crown ether.

Here, we report a water-induced supramolecular polymer adhesive formed from confined water and an intrinsically amphiphilic macrocyclic self-assembly in a nanophase-separated structure. The selenium-containing crown ether macrocycle, featuring a strong hydrophilic hydrogen-bond receptor (selenoxide) and a synergistic hydrophobic selenium-substituted crown core, confines water within a segregated, interdigitated architecture. While water molecules typically freeze around 0 °C, the confined water in this supramolecular polymer remains in a liquid-like state down to -80 °C.

Serum Hsa_circ_0023919 is a Predictive Biomarker of Chemoresistance in CRC Treatment.

Background: The diversity of available chemotherapeutic modalities for colorectal cancer (CRC) entails the implementation of personalized therapeutic regimens to optimize patient outcomes. Currently, the clinical use of biological markers for treatment selection is inadequate to achieve individualization. Circulatory RNAs (circRNAs), which function as plasma biomarkers, play a critical role in regulating biological processes in different types of cancer.

Identification and Validation of Epithelial Cell Centre Regulatory Transcription Factors in the Gastric Cancer Microenvironment.

Purpose: To identify the epithelial cell centre regulatory transcription factors in the gastric cancer (GC) microenvironment and provide a new strategy for the diagnosis and treatment of GC.

Methods: The GC single-cell dataset was downloaded from the Gene Expression Omnibus (GEO) database. The regulatory mechanisms of transcription factors in both pan-cancer and GC microenvironments were analysed using the Cancer Genome Atlas (TGCA) database.

Clinical Effect of Treatment with Metformin for Type 2 Diabetes on Non-Small Cell Lung Cancer Patients Undergoing Immunotherapy: A Retrospective Study.

Purpose: To further identify the clinical impact of metformin on the prognosis of non-small cell lung cancer (NSCLC) with type 2 diabetes who received immunotherapy.

Methods: Stage IV NSCLC patients with type 2 diabetes receiving the immunotherapy from 2017 to 2021 were retrospectively enrolled and divided into the metformin group or non-metformin group according to the treatment strategy for type 2 diabetes (metformin vs other hypoglycemic medicines). The overall response rate (ORR) was primary endpoint, and overall survival (OS), progression-free survival (PFS) and disease control rate (DCR) were secondary endpoints.

Association Between High-Density Lipoprotein Cholesterol and Length of Hospital Stay in Acute Pancreatitis: A Retrospective Cohort Study.

Background: Acute pancreatitis (AP) is a complex inflammatory disorder with varying degrees of severity, impacting patient recovery and healthcare resource utilization. The length of hospital stay (LOS) is a pivotal indicator of recovery, and identifying factors influencing LOS can offer insights into AP management. High-density lipoprotein cholesterol (HDL-C), known for its cardioprotective properties, has been posited to influence AP outcomes; however, its relationship with LOS remains unclear.

Predictive Value of Kidney Failure Risk Equation and Neutrophil Gelatinase-Associated Lipocalin for Chronic Kidney Disease Progression in Chinese Population - A Retrospective Study.

Objective: To analyze the independent associations of the Kidney Failure Risk Equation (KFRE) and neutrophil gelatinase-associated lipocalin (NGAL) with end-stage renal disease (ESRD) among patients with chronic kidney disease (CKD) stages 3-5 in China and evaluate their predictive values for ESRD.

Patients And Methods: A total of 716 patients with CKD stages 3-5 at the time of the initial renal medicine referral were retrospectively enrolled, and the study outcome was the observed incidence of ESRD at 2 years after the initial referral. Baseline characteristics were collected, and relevant laboratory indexes, including neutrophil gelatinase-associated lipocalin (NGAL), were detected.