Robust thumb flexor tendon repairs with a six-strand M-Tang method, pulley venting, and early active motion.

Unlabelled: We present the outcomes of flexor pollicis longus tendon repairs in 34 thumbs using a six-strand M-Tang repair with venting of one or two pulleys according to site of tendon laceration. The A2 pulley was vented in all three thumbs with zone 1 injury. In 31 thumbs with zone 2 injuries, the oblique pulley was vented partially or entirely.

TCN, an AKT inhibitor, exhibits potent antitumor activity and enhances radiosensitivity in hypoxic esophageal squamous cell carcinoma and .

The aim of the present study was to investigate the radiosensitization effect of triciribine (TCN) on human esophageal squamous cell carcinoma (ESCC) in normoxia or hypoxia and its mechanism. The cytotoxicity and radiosensitization mechanism of TCN were investigated by Cell Counting Kit 8, clonogenic assay, flow cytometry, western blotting (WB) and immunofluorescence staining of phospho-histone H2A.X, Ser139 (γ-H2AX) in ESCC , while the protein expression levels of AKT, phosphorylated (p)-AKT, hypoxia-inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) were evaluated by WB .

Outcomes of the six-strand M-Tang repair for zone 2 primary flexor tendon repair in 54 fingers.

Unlabelled: We repaired complete divisions of flexor tendons in zone 2 in 54 fingers using a six-strand core M-Tang repair method. Partial active digital motion started with early passive digital motion carried out first in the first 3-4 weeks after surgery and full range of active motion in later weeks. The patients were followed for 4-27 months.

Impact of bilateral subcostal rooftop incision combined double lifting retractor on recent surgical outcomes of obese patients with advanced gastric cancer.

Objective: To investigate the impact of bilateral subcostal rooftop incision under bilateral costal margins combined double lifting retractors on the recent surgical outcome of obese patients with advanced gastric cancer.

Patients And Methods: We retrospectively analyzed the clinical data of 138 obese patients with gastric cancer under radical gastrectomy. The patients were divided into two groups, the MI group (n=68) and RI group (n=70).

The antidepressant-like effect of alarin is related to TrkB-mTOR signaling and synaptic plasticity.

Alarin is a newly derived neuropeptide from a splice variant of the galanin-like peptide gene. We previously showed that alarin has an antidepressant-like effect by increasing the activity of the extracellular signal-regulated kinase (ERK) and protein kinase B (AKT) pathways, mediated by the tropomyosin-related kinase B receptor in the unpredictable chronic mild stress (UCMS) mouse model. Administration of rapamycin, a mammalian target of rapamycin (mTOR) inhibitor, prevents the rapid antidepressant-like effect induced by ketamine in animal models, indicating a vital role of mTOR in depression pathophysiology.

Effects of astragalosides from Radix Astragali on high glucose-induced proliferation and extracellular matrix accumulation in glomerular mesangial cells.

Diabetic nephropathy (DN) exhibits a deteriorating course that may lead to end-stage renal failure. Astragalosides have been clinically tested for the treatment of DN, but the mechanism is unclear at present. In this study, the effects of astragalosides were investigated on high glucose-induced proliferation and expression of transforming growth factor-β1 (TGF-β1), connective tissue growth factor (CTGF), type IV collagen (colIV) and fibronectin (FN) in glomerular mesangial cells (MCs).

Intrathecal L-arginine reduces the antinociception of sevoflurane in formalin-induced pain in rats.

The purpose of this study was to investigate the contribution of spinal nitric oxide (NO) to the antinociceptive effects of emulsified sevoflurane in rats. Formalin tests were used to assess the nociceptive response. Immunohistochemistry was performed to determine the effects of emulsified sevoflurane on formalin-induced changes of Fos-like immunoreactive (Fos-LI)-positive neurons in the spinal cord.

The association between BMP4 gene polymorphism and its serum level with the incidence of LVH in hypertensive patients.

Background: Bone morphogenic proteins 4 (BMP4) is associated with cardiac remodeling under different conditions. However, the role of BMP4 and its gene polymorphism in the incidence of left ventricular hypertrophy (LVH) in hypertensive patients remains unknown.

Methods: A total of 1265 patients diagnosed with essential hypertension (EH) were recruited.

Effect of CETP polymorphism on atorvastatin lipid-regulating effect and clinical prognosis of patients with coronary heart disease.

Background: The aim of this study was to investigate the influence of genetic polymorphism of cholesteryl ester transfer protein (CETP) gene polymorphism -629C/A on the therapeutic effect of atorvastatin and clinical outcome in Han Chinese patients with coronary heart disease (CHD).

Material And Methods: From October 2011 to December 2012, 348 patients with angiographically confirmed CHD were recruited. CETP gene polymorphism was determined by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) method.

[Correlation between Chlamydia pneumoniae infection and chronic obstructive pulmonary disease].

Objective: To investigate the correlation between Chlamydia pneumonia (Cpn) infection and chronic obstructive pulmonary disease (COPD).

Methods: 82 patients with acute exacerbation COPD (AE-COPD) or stabilized COPD patients at outpatient visits, in the People's Hospital of Jiangyin city from Aug. 2010 to May 2012, together with 46 cases having stationary phase COPD and 38 healthy volunteers as control group, were involved in this study.

[Supracricoid partial laryngectomy for the therapeutic outcomes of laryngeal cancer].

Objective: To evaluate the therapeutic effect of supracricoid partial laryngectomy(SCPL).

Method: A retrospective analysis of the clinical data of 24 patients undergoing laryngeal carcinoma (including 5 senile patients). In those patients, 14 were glottic cancer, 9 were supraglottic cancer,and 1 were transglottic cancer.

A novel biosynthetic hybrid scaffold seeded with olfactory ensheathing cells for treatment of spinal cord injuries.

Background: Implantation of tissue-engineered scaffolds is one of the most promising therapeutic strategies for inducing nerve regenerations following spinal cord injuries. In this paper, we report a novel bioengineered hybrid scaffold comprised of three major extracellular matrix (ECM) proteins.

Methods: ECM-scaffolds (ECM-S) were prepared by gelling fibrinogen, fibronectin and laminin using fresh rat plasma.

[The experimental research about relationship between neuropeptides and mast cell in allergic rhinitis].

Objective: To explore the relationship between neuropeptides and mast cell in the initiation and development of allergic rhinitis.

Method: Thirty healthy rats were randomly divided into three groups. The rat model of allergic rhinitis was established by using ovalbumin intraperitoneal immunization and nasal antigen challenge.

[Compression of the deep branch of ulnar nerve at the wrist].

Objective: To investigate the compression factor and clinical manifestation of the compression of deep branch of the ulnar nerve at the wrist.

Methods: Anatomic study was done on both sides of 10 cadavers, the deep branch of ulnar nerve, the Guyon's canal and the flexor digiti minimi brevis pedis were observed. Then from Jan.