1 results match your criteria: "Pennsylvania. Electronic address: nicole.simone@jeffersonhospital.org.[Affiliation]"
microRNA alterations driving acute and late stages of radiation-induced fibrosis in a murine skin model.
Int J Radiat Oncol Biol Phys
September 2014
Department of Radiation Oncology, Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University Hospital, Philadelphia, Pennsylvania. Electronic address:
Purpose: Although ionizing radiation is critical in treating cancer, radiation-induced fibrosis (RIF) can have a devastating impact on patients' quality of life. The molecular changes leading to radiation-induced fibrosis must be elucidated so that novel treatments can be designed.
Methods And Materials: To determine whether microRNAs (miRs) could be responsible for RIF, the fibrotic process was induced in the right hind legs of 9-week old CH3 mice by a single-fraction dose of irradiation to 35 Gy, and the left leg served as an unirradiated control.