Glenoid labral repair in Major League Baseball pitchers.

Little is known about outcomes of glenoid labral repair in Major League Baseball (MLB) pitchers. We hypothesized that following repair, pitching performance would not be significantly different from an uninjured cohort. Fifty-one pitchers were identified who pitched in at least one MLB game prior to undergoing isolated glenoid labral repair.

Druggable targets and targeted drugs: enhancing the development of new therapeutics.

The advent of functional genomics, proteomics, chemi-informatics, and other systems-based scientific approaches have raised expectations of novel targets for drug discovery and design. Similarly, advances in materials sciences and biomolecular chemistries raised the prospects of highly targeted therapeutics that maximize efficacy while minimizing systemic toxicity. In spite of these advances, the gross measure of approvable drug output is declining, with only 17 new chemical entities approved by the FDA in 2007.

Molecular dynamics simulations of supported phospholipid/alkanethiol bilayers on a gold(111) surface.

Molecular dynamics simulations have been used to investigate the structure of hybrid bilayers (HB) formed by dipalmitoylphosphatidylcholine (DPPC) lipid monolayers adsorbed on a hydrophobic alkanethiol self-assembled monolayer (SAM). The HB system was studied at 20 degrees C and 60 degrees C, and the results were compared with recent neutron reflectivity measurements (Meuse, C. W.