380,336 results match your criteria: "Pennsylvania; University of Pennsylvania Perelman School of Medicine[Affiliation]"
Plants (Basel)
December 2024
Programa de Pós-Graduação em Ecologia e Conservação de Recursos Naturais, Instituto de Biologia, Universidade Federal de Uberlândia, Uberlândia 38408-100, MG, Brazil.
Plants express many types of defenses in response to herbivory damage. These defenses can be displayed as a sequence or they can overlap, increasing efficiency in protection. However, leaf defense shifts during leaf development, including extrafloral nectaries (EFNs), are neglected in natural tropical systems.
View Article and Find Full Text PDFAnimals (Basel)
January 2025
Havemeyer Equine Behavior Laboratory, Section of Reproduction and Behavior, Department of Clinical Studies, University of Pennsylvania School of Veterinary Medicine, New Bolton Center, Kennett Square, PA 19348, USA.
Gastric ulcer disease and other potentially painful gastric conditions are among the most common afflictions adversely affecting the welfare of domestic equids. A large percentage of affected animals may not display the classic signs of gastric disease, such as unexplained weight loss, poor hair coat, and inappetence until the disease becomes severe. As a clinical service within our equine referral hospital, we routinely evaluate 24-h video recorded samples of horses to assist clinicians in identifying subtle discomfort and potential sources or to scan for infrequent neurologic or cardiac-related behavioral events.
View Article and Find Full Text PDFTrials
January 2025
Palliative and Advanced Illness Research (PAIR) Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Background: A key challenge for many critical care clinical trials is that some patients will die before their outcome is fully measured. This is referred to as "truncation due to death" and must be accounted for in both the treatment effect definition (i.e.
View Article and Find Full Text PDFBMC Public Health
January 2025
Department of Exercise Science & Sports Medicine, University of Witwatersrand, Johannesburg, Gauteng, South Africa.
Background: Emerging work highlights the potential of community health workers (CHWs) to promote physical activity (PA) as a part of their role in preventing and managing non-communicable diseases. However, little is known about CHW preferences and desires towards receiving PA training.
Methods: Community health promoters (CHPs), a type of CHWs in South Africa, from seven health districts in Johannesburg participated in a day-long in-service training on PA and healthy eating.
J Cyst Fibros
January 2025
Division of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Background: Food insecurity (FI) is more prevalent in people with cystic fibrosis (PwCF) than the reported national prevalence, but there are limited data on the relationship between FI and health outcomes in PwCF. The objective of this study was to analyze the relationship between FI in PwCF and pulmonary and nutritional status.
Methods: We leveraged an electronic cross-sectional survey that ascertained FI status and gave participants the option to link their survey data to their records in the Cystic Fibrosis Foundation Patient Registry (CFFPR).
BMJ Mil Health
January 2025
Neuromuscular Research Laboratory/Warrior Human Performance Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Theoretically, the serial measurement of biomarkers to monitor physiological responses to military training could be used to mitigate musculoskeletal injury risk and better understand the recovery status of personnel. To date, the cost and scalability of these initiatives have impeded their uptake by defence organisations. However, advances in technology are increasing the accessibility of a range of health and performance biomarkers.
View Article and Find Full Text PDFFertil Steril
January 2025
Department of Obstetrics & Gynecology, University of Pennsylvania, Philadelphia, PA, USA.
J Vasc Interv Radiol
January 2025
Department of Radiology, Memorial Sloan Kettering Cancer Center.
Purpose: To understand the state of IR practice and education worldwide and identify factors impacting access to IR services.
Methods And Materials: A Society of Interventional Radiology (SIR) approved anonymous survey was created to gather demographics, regional IR practice and education characteristics, and challenges impacting local IR development. The survey was distributed to members of global IR societies and shared on social media from 6/2022 to 9/2023.
Lancet Rheumatol
January 2025
US Department of Veterans Affairs (VA) Nebraska-Western Iowa Health Care System, Omaha, NE, USA; University of Nebraska Medical Center, Omaha, NE, USA.
Background: Uncertainty exists regarding patient outcomes when using TNF inhibitors versus other biological and targeted synthetic disease-modifying antirheumatic drugs (DMARDs) in rheumatoid arthritis-associated interstitial lung disease (ILD). We compared survival and respiratory hospitalisation outcomes following initiation of TNF-inhibitor or non-TNF inhibitor biological or targeted synthetic DMARDs for treatment of rheumatoid arthritis-associated ILD.
Methods: We did a retrospective, active-comparator, new-user, observational cohort study with propensity score matching following the target trial emulation framework using US Department of Veterans Affairs (VA) electronic and administrative health records.
EBioMedicine
January 2025
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Heart and Vascular Institute, UPMC, Pittsburgh, PA, USA.
Background: Preclinical data have shown that low levels of metabolites with anti-inflammatory properties may impact metabolic disease processes. However, the association between mid-life levels of such metabolites and long-term ASCVD risk is not known.
Methods: We characterised the plasma metabolomic profile (1228 metabolites) of 1852 participants (58.
J Surg Res
January 2025
Division of Trauma, Acute, and Critical Care Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina. Electronic address:
Introduction: Malnutrition among older adults continues to be a prevalent health concern. While literature has highlighted an increased risk of malnutrition mortality for adults older than 65 y, the age threshold at which malnutrition effects survival and mortality remains unexplored.
Methods: Annual crude and age-adjusted malnutrition-related mortality data from 2009 to 2018 was extracted from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database.
Vet Immunol Immunopathol
December 2024
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, United States; Pennsylvania Equine Toxicology & Research Laboratory, West Chester, PA 19382, United States. Electronic address:
Interleukin 1 beta (IL-1β) and IL-1 receptor antagonist (IL-1RA) are both upregulated following traumatic injury. As IL-1RA blocks inflammatory signaling by IL-1β, overexpression of IL-1β relative to IL-1RA may drive inflammatory diseases. As such, determination of the relationship between IL-1β to IL-1RA expression levels in horses may provide insight into disease states or serve as a therapeutic readout of response to medical interventions.
View Article and Find Full Text PDFSurg Endosc
January 2025
Department of Surgery, University of Pennsylvania, 800 Walnut St 20th Floor, Philadelphia, PA, 19107, USA.
Introduction: Despite remarkable progress, gender inequality in medicine remains a significant issue. This disparity extends beyond clinical practices and educational programs; it is also evident in the recognition and awards received by surgeons. Underrepresentation of women in Surgical Society awards is a multi-layered issue that needs a holistic approach since these awards are used to hire, promote, and advance surgeons.
View Article and Find Full Text PDFNat Struct Mol Biol
January 2025
Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.
The epigenetic cofactor ENL (eleven-nineteen-leukemia) and the acetyltransferase MOZ (monocytic leukemia zinc finger) have vital roles in transcriptional regulation and are implicated in aggressive forms of leukemia. Here, we describe the mechanistic basis for the intertwined association of ENL and MOZ. Genomic analysis shows that ENL and MOZ co-occupy active promoters and that MOZ recruits ENL to its gene targets.
View Article and Find Full Text PDFNat Commun
January 2025
Department of Physics, Emory University, Atlanta, GA, USA.
Iceberg calving is a major contributor to Greenland's ice mass loss. Ice mélange, tightly packed sea ice and icebergs, has been hypothesized to buttress the calving fronts. However, quantifying the mélange buttressing force from field observations remains a challenge.
View Article and Find Full Text PDFJ Geriatr Oncol
January 2025
Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA; Penn Center for Cancer Care Innovation, Abramson Cancer Center, Penn Medicine, Philadelphia, PA, USA.
Genes Dev
January 2025
Department of Biochemistry, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801, USA;
Hepatocyte polyploidy and maturity are critical to acquiring specialized liver functions. Multiple intracellular and extracellular factors influence ploidy, but how they cooperate temporally to steer liver polyploidization and maturation or how post-transcriptional mechanisms integrate into these paradigms is unknown. Here, we identified an important regulatory hierarchy in which postnatal activation of epithelial splicing regulatory protein 2 (ESRP2) stimulates processing of liver-specific microRNA () to facilitate polyploidization, maturation, and functional competence of hepatocytes.
View Article and Find Full Text PDFJ Thorac Oncol
January 2025
Department of Clinical Oncology, Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Food Chem Toxicol
January 2025
Member Expert Panel for Fragrance Safety, The Journal of Dermatological Science (JDS), , Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, Japan.
Food Chem Toxicol
January 2025
Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ 07430, USA.
J Am Acad Dermatol
January 2025
Department of Dermatology, Center for Global Health, and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania and Florida Center for Dermatology, St Augustine, Florida. Electronic address:
Bioresour Technol
January 2025
Department of Agricultural and Biological Engineering, University of Illinois at Urbana-Champaign, 1304 W. Pennsylvania Avenue, Urbana, IL 61801, USA; DOE Center for Advanced Bioenergy and Bioproducts Innovation (CABBI), University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. Electronic address:
Bioenergy crops have been known for their ability to produce biofuels and bioproducts. In this study, the product portfolio of recently developed transgenic sugarcane (oilcane) bagasse has been redefined for recovering natural pigments (anthocyanins), sugars, and vegetative lipids.The total anthocyanin content in oilcane bagasse has been estimated as 92.
View Article and Find Full Text PDFJ Surg Res
January 2025
Division of Pediatric Surgery, Yale New Haven Children's Hospital, New Haven, Connecticut. Electronic address:
Introduction: Laparoscopic inguinal hernia repair (IHR) is being performed more frequently in children, but few studies have evaluated surgical practice patterns in infants. In this study, we surveyed pediatric surgeons within a regional consortium to assess current preferences for IHR strategy in infants. We hypothesized that early-career pediatric surgeons would prefer laparoscopic IHR over open IHR in this patient population.
View Article and Find Full Text PDFAm J Emerg Med
January 2025
Department of Emergency Medicine, Yale University School of Medicine, New Haven, CT, USA; Center for Outcomes Research and Evaluation, Yale University, New Haven, CT, USA.
Background: This study aimed to examine how physician performance metrics are affected by the speed of other attendings (co-attendings) concurrently staffing the ED.
Methods: A retrospective study was conducted using patient data from two EDs between January-2018 and February-2020. Machine learning was used to predict patient length of stay (LOS) conditional on being assigned a physician of average speed, using patient- and departmental-level variables.
Proc Natl Acad Sci U S A
January 2025
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104.
Dorsal closure is a process that occurs during embryogenesis of . During dorsal closure, the amnioserosa (AS), a one-cell thick epithelial tissue that fills the dorsal opening, shrinks as the lateral epidermis sheets converge and eventually merge. During this process, both shape index and aspect ratio of amnioserosa cells increase markedly.
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