246 results match your criteria: "Penn State Health Children's Hospital.[Affiliation]"
Eur J Hum Genet
December 2024
Department of Human Genetics, Inselspital Bern, University of Bern, Bern, Switzerland.
While mostly de novo truncating variants in SCAF4 were recently identified in 18 individuals with variable neurodevelopmental phenotypes, knowledge on the molecular and clinical spectrum is still limited. We assembled data on 50 novel individuals with SCAF4 variants ascertained via GeneMatcher and personal communication. With detailed evaluation of clinical data, in silico predictions and structural modeling, we further characterized the molecular and clinical spectrum of the autosomal dominant SCAF4-associated neurodevelopmental disorder.
View Article and Find Full Text PDFBackground: Most patients with idiopathic generalized epilepsy have good seizure control on antiseizure medications. Although idiopathic generalized epilepsy subtypes such as juvenile absence epilepsy and juvenile myoclonic epilepsy have a high risk of relapse, childhood absence epilepsy may have seizure remission. After 2 years of seizure freedom in childhood absence epilepsy, typically antiseizure medications are discontinued, but follow-up protocols are unclear.
View Article and Find Full Text PDFPediatr Crit Care Med
November 2024
Department of Pediatrics, Yale School of Medicine, New Haven, CT.
J Surg Case Rep
November 2024
Division of Pediatric Surgery, Penn State Health Children's Hospital, 600 University Dr, Hershey, PA 17033, United States.
Pediatrics
November 2024
Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Penn State Health Children's Hospital, Hershey, Pennsylvania.
World J Pediatr Congenit Heart Surg
October 2024
Penn State Hershey Pediatric Cardiovascular Research Center, Department of Pediatrics, Penn State College of Medicine, Penn State Health Children's Hospital, Hershey, PA, USA.
Telemed J E Health
September 2024
Division of Adolescent Medicine, Department of Pediatrics, Penn State Health Children's Hospital, Hershey, Pennsylvania, USA.
This is a retrospective chart review examining factors, which may contribute to timing of receipt of prescription for testosterone or estrogen-based interventions for transgender adolescents and young adults who do not receive such a prescription at their first medical appointment. A total of 176 patient records were available; of this a minority received a prescription for hormone therapy at first medical appointment. Of the remaining 108 unique individuals, 49 received a prescription at a subsequent medical.
View Article and Find Full Text PDFJ Clin Med
August 2024
Department of Pediatrics, Penn State Health Children's Hospital, Hershey, PA 17033, USA.
: Traumatic brain injury (TBI) is a leading cause of death and disability in children. Currently, no biological test can predict outcomes in pediatric TBI, complicating medical management. This study sought to identify brain-related micro-ribosomal nucleic acids (miRNAs) in saliva associated with moderate-to-severe TBI in children, offering a potential non-invasive, prognostic tool.
View Article and Find Full Text PDFPediatr Res
September 2024
Department of Pediatrics, Penn State Health Children's Hospital, Hershey, PA, USA.
Background: PDA and ASD are common intracardiac shunts noted in prematurely born infants. While there is evidence of persistent PDA and ASD associated with a higher risk for developing bronchopulmonary dysplasia (ICS-BPD) and pulmonary hypertension (ICS-BPD-PH), the underlying pathogenesis is poorly understood and hence challenging to identify at-risk infants. Our study goal was to evaluate transcriptomic expression and associated pathways in tracheal aspirates (TAs) of low-birth-weight infants with hemodynamically significant cardiac shunt (ICS) that develop bronchopulmonary dysplasia (ICS-BPD) and pulmonary hypertension (ICS-BPD-PH).
View Article and Find Full Text PDFChildren (Basel)
July 2024
Department of Pediatrics, West Virginia University School of Medicine, Morgantown, WV 26506, USA.
Background/objectives: The COVID-19 pandemic period from 2020 to 2022 had a significant impact on maternal infant health with mothers impacted more than their infants. We questioned whether there have been any lingering effects from the pandemic.
Methods: We examined intermediate and long-term pandemic effects on maternal and neonatal outcomes before, during, and after the COVID-19 pandemic period.
Support Care Cancer
August 2024
Penn State College of Medicine, Hershey, PA, USA.
Womens Health (Lond)
July 2024
Division of Gynecology, Department of Surgery, Boston Children's Hospital, Boston, MA, USA.
J Perinatol
September 2024
Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Penn State Health Children's Hospital, Hershey, PA, USA.
Respir Care
October 2024
Drs Wisecup, Stephens, and Amatya and Mss Donnelly and Erkinger are affiliated with Division of Newborn Medicine, Department of Pediatrics, Penn State Health Children's Hospital, Hershey, Pennsylvania.
Background: CPAP benefits preterm infants with respiratory distress, including reduced bronchopulmonary dysplasia (BPD) incidence, surfactant use, and extubation failure. Successful CPAP weaning also promotes oral feeding. However, there is no consensus on the optimal weaning of CPAP in neonates.
View Article and Find Full Text PDFJ Perinatol
October 2024
Division of Neonatal-Perinatal Medicine, Penn State Health Children's Hospital, Hershey, PA, USA.
Cureus
June 2024
Pediatrics, Penn State Health Children's Hospital, Hershey, USA.
PLoS One
July 2024
Pediatrics, Division of Pediatric Critical Care Medicine, Penn State Health Children's Hospital, Hershey, Pennsylvania, United States of America.
Hyponatremia, though common in women with preeclampsia, has not been well studied. Our primary objectives are to assess the clinical characteristics and emergency therapy applied to subjects diagnosed with preeclampsia. We hypothesize that hyponatremia present in preeclamptic patients with severe features is associated with greater use of emergency hypertensives, antenatal steroids, and cesarean delivery.
View Article and Find Full Text PDFJ Clin Med
June 2024
Department of Pediatrics, Penn State Health Children's Hospital, Hershey, PA 17033, USA.
Advances in perinatal intensive care have significantly enhanced the survival rates of extremely low gestation-al-age neonates but with continued high rates of bronchopulmonary dysplasia (BPD). Nevertheless, as the survival of these infants improves, there is a growing awareness of associated abnormalities in pulmonary vascular development and hemodynamics within the pulmonary circulation. Premature infants, now born as early as 22 weeks, face heightened risks of adverse development in both pulmonary arterial and venous systems.
View Article and Find Full Text PDFTransplant Cell Ther
August 2024
Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota; Division of Pulmonary Medicine, Masonic Children's Hospital, Minneapolis, Minnesota.
Hematopoietic stem cell transplantation (HSCT) is undertaken in children with the aim of curing a range of malignant and nonmalignant conditions. Unfortunately, pulmonary complications, especially bronchiolitis obliterans syndrome (BOS), are significant sources of morbidity and mortality post-HSCT. Currently, criteria developed by a National Institutes of Health (NIH) working group are used to diagnose BOS in children post-HSCT.
View Article and Find Full Text PDFAcad Pediatr
October 2024
Sidney Kimmel Medical College (JF Rohde, C Dorrian, and NK Goyal), Thomas Jefferson University, Philadelphia, Pa; Value-Based Service Organization (NK Goyal, JF Rohde and C Dorrian), Nemours Children's Health, Philadelphia, Pa.
Objective: Intrauterine opioid exposure (IOE) has increased over the last 2 decades and is associated with additional needs after birth. To date, no clinical guidelines address the primary care of children with IOE. We aimed to characterize clinician-reported screening and referral practices, barriers to effective primary care for children with IOE, and clinician- and practice-level characteristics associated with perceived barriers.
View Article and Find Full Text PDFLeuk Res
August 2024
Blood and Marrow Transplant Program, Division of Hematology and Oncology, Penn State Cancer Institute, Hershey, PA, USA.
Primary graft failure (PGF) and multi-lineage cytopenia (MLC) increase the risk of nonrelapse mortality in allogeneic hematopoietic cell transplants (HCT). We evaluated the impact of post-transplant cyclophosphamide (PTCy) and splenomegaly on PGF and MLC for hematological malignancies. This study included patients with PTCy (N=84) and conventional graft-vs.
View Article and Find Full Text PDFMed Clin North Am
July 2024
Case Western Reserve School of Medicine, Cleveland Clinic Department of Family Medicine, 551 East Washington Street, Chagrin Falls, OH 44023, USA. Electronic address:
This chapter presents an overview of eosinophilic esophagitis (EoE) for the Primary Care Practitioner (PCP). The focus is on helping PCPs keep it in their differential diagnosis by discussing the spectrum of clinical presentations, how to screen for EoE in at-risk populations and subsequently manage the patient with this condition. The authors review epidemiology, risk factors and associated conditions, pathology, clinical presentation, diagnosis, and management options.
View Article and Find Full Text PDFJ Emerg Med
August 2024
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia.
Background: Children aged 0-4 years have the highest rate of emergency department (ED) visits for traumatic brain injury (TBI); falls are the leading cause. Infants younger than 2 years are more likely to sustain a fractured skull after a fall.
Objective: This study examined caregiver actions and products associated with ED visits for fall-related fractured skulls in infants aged 0-4 months.
J Innov Card Rhythm Manag
May 2024
Division of Pediatric Cardiology, Penn State Health Children's Hospital, Hershey, PA, USA.
We report the case of a 7-year-old boy who presented with post-viral myositis, rhabdomyolysis, and hepatitis, who was later readmitted due to a seizure-like activity and ultimately found to have episodes of recalcitrant polymorphic ventricular tachycardia secondary to simultaneous QT prolongation and severe hypothyroidism. Temporary transvenous atrial pacing was successful at controlling the ventricular arrhythmias in the intensive care unit. With levothyroxine therapy and cessation of QT-prolonging medications, the corrected QT (QTc) normalized.
View Article and Find Full Text PDFJ Pediatr Surg
October 2024
Mary Bridge Children's, Tacoma, WA, USA. Electronic address:
The American Pediatric Surgical Association (APSA) Practice Committee endorsed by the Board of Governors presents a Position Statement on the role of locum tenens in the practice of pediatric surgery. The Practice Committee also presents a set of guidelines for locum tenens practice. These recommendations highlight safe practice and quality care that protects the patient as well as the pediatric surgeon by offering best practice standards, defining optimal resources and establishing parameters by which hospitals and locum tenens agencies should abide.
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