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Glucose transporter polymorphisms are associated with clear-cell renal carcinoma.
Cancer Genet Cytogenet
December 2005
Molecular Medicine Research Group, Peninsula Medical School, Institute of Biomedical Sciences, Peninsula Medical School Headquarters, Derriford, Plymouth PL6 8BU, United Kingdom.
Clear-cell renal cell carcinoma (CCRCC) is identified by abundant glycogen-rich cytoplasm, due to the aberrant influx and storage of glucose. The objective was to investigate the frequency of polymorphisms of the facilitative glucose transporter (GLUT1). GLUT1 is a downstream target of Hypoxia-inducible factor (HIF-1alpha), a mediator of hypoxia-controlled angiogenesis.
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