884 results match your criteria: "Pemphigus Erythematosus"
Anti-vitamin D antibodies.
Autoimmun Rev
December 2024
Reichman University, Herzelia, Israel; Zabludowicz Center for Autoimmune Diseases (Founder), Sheba Medical Center, Tel-Hashomer, Israel.
Background: Low vitamin D levels are commonly observed in autoimmune diseases, suggesting a potential role in disease pathogenesis. The presence of anti-vitamin D antibodies may contribute to these deficiencies and influence autoimmune processes.
Objective: To review and analyze studies investigating the occurrence of anti-vitamin D antibodies in autoimmune diseases.
Article Synopsis
- The study focuses on pemphigus, a rare but serious skin blistering disease linked to multiple genetic factors and an increased risk of other autoimmune disorders.
- Researchers analyzed data from 126 million patients, finding 18,000 cases of pemphigus, to explore the relationship between pemphigus and 74 different autoimmune diseases.
- Results indicated strong associations between pemphigus and several conditions, including pemphigoid diseases, discoid lupus erythematosus, lichen planus, and undifferentiated connective tissue disease, highlighting the importance of understanding these links across different ethnic groups.
Mechanisms of autophagy and their implications in dermatological disorders.
Front Immunol
November 2024
School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Deyang Hospital Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Deyang, China.
Autophagy is a highly conserved cellular self-digestive process that underlies the maintenance of cellular homeostasis. Autophagy is classified into three types: macrophage, chaperone-mediated autophagy (CMA) and microphagy, which maintain cellular homeostasis through different mechanisms. Altered autophagy regulation affects the progression of various skin diseases, including psoriasis (PA), systemic lupus erythematosus (SLE), vitiligo, atopic dermatitis (AD), alopecia areata (AA) and systemic sclerosis (SSc).
View Article and Find Full Text PDFContemporary and prospective use of azathioprine (AZA) in viral, rheumatic, and dermatological disorders: a review of pharmacogenomic and nanotechnology applications.
Naunyn Schmiedebergs Arch Pharmacol
November 2024
Department of Pharmacy Practice, Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research Pimpri, Pune, Maharashtra, India.
Article Synopsis
- Azathioprine (AZA), commonly used for autoimmune disorders and organ transplants, shows potential for modern applications in viral, rheumatic, and skin diseases.
- Advances in pharmacogenomics and nanotechnology may enhance AZA's effectiveness while reducing side effects, particularly by utilizing the active metabolites 6-mercaptopurine and 6-thioguanine.
- The study suggests that personalized medicine approaches, including genetic testing and innovative drug delivery systems, can improve treatment outcomes for conditions like systemic lupus erythematosus and psoriasis.
Application of novel CAR technologies to improve treatment of autoimmune disease.
Front Immunol
October 2024
Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.
Chimeric antigen receptor (CAR) T cell therapy has become an important treatment for hematological cancers, and its success has spurred research into CAR T cell therapies for other diseases, including solid tumor cancers and autoimmune diseases. Notably, the development of CAR-based treatments for autoimmune diseases has shown great progress recently. Clinical trials for anti-CD19 and anti-BCMA CAR T cells in treating severe B cell-mediated autoimmune diseases, like systemic lupus erythematosus (SLE), have shown lasting remission thus far.
View Article and Find Full Text PDFOral lichen planus-like lesions in skin of color: a review.
Int J Dermatol
November 2024
Department of Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Article Synopsis
- Lichenoid lesions in dermatology are characterized by a violaceous color due to basal cell damage and inflammation beneath the epithelium.
- These lesions are primarily associated with lichen planus but can appear in various other disorders, which complicates diagnosis.
- Accurate diagnosis is crucial for treatment, and dermatologists use clinical features, patient history, and additional tests like histopathology to differentiate these conditions from mimickers.
Current Knowledge on Nail Involvement in Autoimmune Bullous Disorders.
Skin Appendage Disord
October 2024
Dermatology Departement, Saint Pierre and Brugmann University Hospitals, Université Libre de Bruxelles, Brussels, Belgium.
Article Synopsis
- Nail involvement in autoimmune bullous disorders presents diverse symptoms, often differing from skin manifestations, such as paronychia, onychomadesis, and onycholysis without blisters.
- Various autoimmune conditions like pemphigus vulgaris and bullous pemphigoid can cause nail changes, and the presence of Langerhans cells in the nails is noteworthy due to its unique immunological aspects.
- Diagnosing these nail issues typically requires histopathological and immunofluorescence tests, and researchers stress the need for more studies to improve treatment strategies for affected individuals.
The causal effects of inflammatory and autoimmune skin diseases on thyroid diseases: evidence from Mendelian randomization study.
Front Endocrinol (Lausanne)
September 2024
Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China.
Article Synopsis
- The study used two-sample Mendelian randomization (MR) to investigate the links between inflammatory or autoimmune skin diseases and thyroid diseases.
- Genetic data was analyzed from a large sample of participants with various skin conditions and thyroid disorders to assess risks.
- Key findings indicated that atopic dermatitis (AD), systemic lupus erythematosus (SLE), and seborrheic dermatitis (SD) significantly increase the risk of hypothyroidism, while bullous pemphigoid (BP) lowers that risk; no causal effects were found for hyperthyroidism.
Targeting Bruton's tyrosine kinase (BTK) as a signaling pathway in immune-mediated diseases: from molecular mechanisms to leading treatments.
Adv Rheumatol
August 2024
Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- BTK, or Bruton's tyrosine kinase, is crucial for transmitting signals in cells, especially B and T immune cells, affecting their growth and survival.
- Various BTK inhibitors are being researched for treating immune disorders and blood cancers, with ongoing clinical trials exploring their effectiveness.
- The article reviews how these inhibitors work, discusses recent findings in autoimmune and inflammatory diseases, and addresses potential side effects and patient risks associated with their use.
The potential of Bruton's tyrosine kinase (BTK) inhibitors in the pharmacotherapeutic management of immune and dermatological disease.
Expert Opin Pharmacother
August 2024
Department of Dermatology, St. George Hospital, Sydney, NSW, Australia.
Article Synopsis
- The article reviews the role of Bruton's tyrosine kinase (BTK) inhibitors in treating skin conditions driven by the immune system, highlighting gaps in existing treatments.
- It covers how BTK inhibitors work, their use in conditions like pemphigus and atopic dermatitis, and discusses their advantages and challenges compared to current therapies.
- Experts believe BTK inhibitors could significantly improve treatment options in dermatology due to their targeted effects, oral administration, and better safety profiles, with ongoing research aimed at filling existing treatment gaps.
Late-Term Outcomes of Surgical Treatment of Infective Endocarditis.
Surg Infect (Larchmt)
November 2024
Department of Cardiovascular Surgery, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
Article Synopsis
- * A total of 20 patients (12 male, 8 female) were analyzed, revealing common risk factors like prosthetic valves and chronic conditions such as renal failure; laboratory findings showed high levels of anemia and inflammation preoperatively.
- * Key challenges identified included comorbid conditions, neurological complications, and impaired heart function post-surgery, which significantly impacted patient survival and quality of life, making IE management quite complex.
A Case Report on Senear-Usher Syndrome.
Cureus
November 2023
Dermatology, Venereology, and Leprosy, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Article Synopsis
- * A 21-year-old woman presented with multiple thick plaques on seborrheic areas like her face, chest, and elbows, leading to a diagnosis based on her clinical signs and positive lab tests for specific antibodies.
- * The patient was treated with immunosuppressive therapy, and the details of her treatment course are documented in a case report.
Oral Lesions of Immune-Mediated and Autoimmune Diseases: A 12-year Experience at a Single Brazilian Referral Center.
Head Neck Pathol
June 2024
Department of Oral Diagnosis and Pathology, School of Dentistry, Universidade Federal do Rio de Janeiro, Cidade Universitária, R. Rodolpho Paulo Rocco, n. 325, 1st floor, Rio de Janeiro, RJ, Brazil.
Article Synopsis
- A study in Brazil examined the occurrence and characteristics of oral lesions linked to immune-mediated and autoimmune diseases in patients over a twelve-year period.
- Out of 3,790 lesions diagnosed, 160 (4.2%) were related to such diseases, mainly affecting middle-aged women, with oral lichen planus, mucous membrane pemphigoid, and pemphigus vulgaris being the most common types.
- The research highlighted that these lesions often cause pain and require a comprehensive, multidisciplinary approach for management and treatment, with varying times for disease stabilization depending on the condition.
Seborrheic Pemphigus: A Misunderstood Variant of Pemphigus Foliaceus.
Cureus
April 2024
Dermatología, Instituto Dermatológico de Jalisco, Zapopan, MEX.
Article Synopsis
- Seborrheic pemphigus (SP) is a localized and superficial skin condition often confused with seborrheic dermatitis (SD) and pemphigus erythematosus (PE), highlighting the challenges in accurate diagnosis due to similar symptoms.
- A case study of a 38-year-old woman illustrates the importance of thorough clinical and histopathological analysis to correctly identify SP after an initial misdiagnosis of SD.
- The study emphasizes the effectiveness of topical treatments for SP, contrasting with the systemic therapies typically needed for PE, and calls for more research to enhance management strategies and clarify terminology in dermatological practice.
New Onset and Exacerbation of Autoimmune Bullous Dermatosis Following COVID-19 Vaccination: A Systematic Review.
Vaccines (Basel)
April 2024
Department of Dermatology, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan 33305, Taiwan.
Article Synopsis
- Autoimmune bullous dermatosis (AIBD) cases have been observed in patients after receiving COVID-19 vaccinations, prompting a systematic review of their characteristics and outcomes.
- The review analyzed 98 studies involving 229 new-onset AIBD cases (mostly bullous pemphigoid) and 216 flare cases (predominantly pemphigus), with mRNA vaccines being a common link.
- Most AIBD cases emerged within 1 to 123 days after vaccination, with many patients experiencing favorable outcomes, highlighting the need for healthcare professionals to monitor post-vaccination effects carefully.
Article Synopsis
- Rituximab, commonly used to treat pemphigus vulgaris, may trigger psoriasis in some patients, especially those with a prior history of psoriasis.
- Medical professionals should be aware of the potential skin-related side effects of rituximab to better identify and manage these complications.
- The text highlights a case study of a 48-year-old patient who developed psoriatic lesions after receiving rituximab treatment, emphasizing the need for caution in prescribing this medication.
From neglect to spotlight: the underappreciated role of B cells in cutaneous inflammatory diseases.
Front Immunol
March 2024
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Article Synopsis
- - The skin is the body's largest organ and has complex functions that involve both systemic and local immune responses, with B cells previously thought to be absent but now recognized as important players in skin health. - Recent studies show that B cells significantly affect immunity in inflammatory skin conditions like Pemphigus Vulgaris, Systemic Lupus Erythematosus, and Atopic Dermatitis, highlighting their crucial role in managing skin disorders. - The text also discusses how current treatments for skin diseases may negatively impact B cells, suggesting the need for new therapeutic strategies that consider the intricate relationship between B cells and skin immunity.
Superficial and Bullous Neutrophilic Dermatoses: Sneddon-Wilkinson, IgA Pemphigus, and Bullous Lupus.
Dermatol Clin
April 2024
Department of Dermatology, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:
Article Synopsis
- Sneddon-Wilkinson disease (SWD), IgA pemphigus, and bullous systemic lupus erythematosus (BSLE) are skin conditions characterized by neutrophilic inflammation, which is a type of immune response.
- SWD and IgA pemphigus both feature flaccid pustules and involve the epidermis, but they may represent variations of the same disease, with IgA pemphigus confirmed by specific immunofluorescence results.
- In contrast, BSLE is marked by tense bullae and a different immune response, exhibiting linear IgG deposits at the junction between the dermis and epidermis.
Immune-mediated oral mucosal pathology: a comprehensive review and update for clinicians - part II.
Ital J Dermatol Venerol
February 2024
Faculty of Dentistry, Al-Ahliyya Amman University, Amman, Jordan.
Article Synopsis
- * Common issues include pain, taste disturbance, and dysphagia, negatively impacting patients' quality of life and leading to potential delays in correct diagnosis and treatment.
- * This review serves as an evidence-based reference for clinicians, covering key conditions, their clinical features, diagnostic methods, and treatment options, divided into two parts focusing on different disorders.
Breg-Mediated Immunoregulation in the Skin.
Int J Mol Sci
January 2024
Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Article Synopsis
- * Bregs have been shown to be significant in skin immunity, impacting various conditions like diabetes, psoriasis, and lupus by helping to maintain tissue homeostasis in the wound environment.
- * The review highlights mechanisms Bregs use for wound healing, including promoting blood vessel formation and suppressing harmful immune cells, and suggests potential clinical uses for Bregs, such as in adoptive Breg therapy.
Dental implants for patients with oral mucosal diseases: A narrative review and clinical guidance.
Dent Med Probl
December 2023
Department of Oral Diagnostic Sciences, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.
Article Synopsis
- Oral mucosal diseases are various conditions affecting the mouth, including recurrent aphthous stomatitis, oral lichen planus, pemphigus vulgaris, mucous membrane pemphigoid, and systemic lupus erythematosus, which can cause painful symptoms like ulcers and erosions.
- Treatment typically involves corticosteroids to manage acute symptoms and ongoing therapy to maintain stability, while dental implants may be needed for tooth replacement in these patients.
- Due to the rising incidence of immune-related conditions, dentists need to be knowledgeable about the challenges and best practices for safely placing dental implants in patients with oral mucosal diseases.
The realistic positioning of UVA1 phototherapy after 25 years of clinical experience and the availability of new biologics and small molecules: a retrospective clinical study.
Front Med (Lausanne)
November 2023
Department of Dermatology, University of Brescia, Brescia, Italy.
Article Synopsis
- Ultraviolet (UVA) A1 phototherapy has been an effective treatment for various skin conditions since the 1990s, yet its application remains limited to a few dermatology centers even after 30 years.
- A study at a single center reviewed 740 patients treated from 1998 to 2022, assessing treatment outcomes and side effects, revealing significant improvements in several conditions, including morphea and skin sarcoidosis.
- Despite showing good efficacy, the usage of UVA1 phototherapy has decreased over the years due to multiple factors, including possible changes in clinical practices and alternatives available.
Cutaneous Lupus Erythematosus: Review and Considerations for Older Populations.
Drugs Aging
January 2024
Department of Dermatology, Penn State College of Medicine, Hershey, PA, USA.
Though more common earlier in life, increasing attention is being focused on the development of cutaneous lupus erythematosus (CLE) in patients with advancing age. Studies show that CLE is more common in older populations than previously thought, and all CLE subtypes are possible in this group. Just like patients in the third or fourth decade of life, CLE may appear alongside or independent of systemic lupus erythematosus.
View Article and Find Full Text PDFA Recalcitrant Case of Senear-Usher Syndrome Treated With Rituximab.
Cureus
October 2023
Internal Medicine, University of Central Florida College of Medicine, Orlando, USA.
Article Synopsis
- * Biopsy results indicated acantholysis, leading to a diagnosis of pemphigus erythematosus, supported by lab tests showing elevated anti-desmoglein 1 and positive antinuclear antibodies.
- * After failing to respond adequately to maximum doses of mycophenolate mofetil and systemic corticosteroids, the patient was treated with rituximab, resulting in significant improvement and complete resolution of skin lesions within three months.
Immune-mediated oral mucosal pathology: a comprehensive review and update for clinicians. Part I.
Ital J Dermatol Venerol
October 2023
Department of Clinics and Preventive Dentistry, Federal University of Pernambuco, Recife, Brazil.
Article Synopsis
- The oral mucosa can be affected by various immune-mediated conditions that cause inflammation and pain, impacting patients' oral health and quality of life.
- Many of these conditions have overlapping symptoms, leading to potential delays in accurate diagnosis and appropriate treatment.
- This review serves as a comprehensive resource for clinicians, detailing the oral manifestations, clinical features, and recent research on immune-mediated mucocutaneous conditions, focusing on specific disorders over two parts.