140 results match your criteria: "Pemphigus Drug-Induced"
Putative pemphigus-like reaction to oral fluralaner in a dog.
Vet Dermatol
August 2024
Hospital Clínic Veterinari UAB, Barcelona, Spain.
Article Synopsis
- - A 9-month-old mixed-breed dog developed widespread pustular skin lesions and showed signs of lethargy and increased body temperature a week after receiving oral fluralaner treatment.
- - Skin evaluations confirmed the condition as pustular acantholytic dermatitis, indicating an immune response likely triggered by the medication.
- - After a 4-month course of immunosuppressive therapy, the dog's skin lesions healed completely and did not return once the medication was stopped.
Article Synopsis
- * A case study reveals that a lung cancer patient initially diagnosed with herpes simplex was actually suffering from DIP, as confirmed by detailed laboratory tests including histology and immunofluorescence.
- * The findings suggest that positive herpesvirus IgG antibodies are not definitive indicators of herpesvirus infection, highlighting the need for thorough histological evaluations in patients presenting with unexplained skin blisters.
The emerging concern of oral pemphigus vulgaris arising post-COVID-19 infection: A case series.
J Oral Maxillofac Pathol
September 2023
Dentistry and Oral Health Department, La Trobe University, Rural Health School, Australia.
Article Synopsis
- COVID-19 can lead to various health issues, notably an uncontrolled immune response that may trigger autoimmune diseases like pemphigus vulgaris (PV) in some patients.
- A case study documented four individuals, aged 33 to 57, who developed PV after recovering from COVID-19, without prior drug allergen exposure.
- Clinicians are urged to monitor for autoimmune reactions in post-COVID patients, and further research is needed to understand the connection between SARS-CoV-2 and autoimmune diseases.
Cutaneous Lupus Erythematosus: Review and Considerations for Older Populations.
Drugs Aging
January 2024
Department of Dermatology, Penn State College of Medicine, Hershey, PA, USA.
Though more common earlier in life, increasing attention is being focused on the development of cutaneous lupus erythematosus (CLE) in patients with advancing age. Studies show that CLE is more common in older populations than previously thought, and all CLE subtypes are possible in this group. Just like patients in the third or fourth decade of life, CLE may appear alongside or independent of systemic lupus erythematosus.
View Article and Find Full Text PDFNail Whispers Revealing Dermatological and Systemic Secrets: An Analysis of Nail Disorders Associated With Diverse Dermatological and Systemic Conditions.
Cureus
September 2023
Dermatology, Venereology and Leprology, B.J. Medical College and Civil Hospital, Ahmedabad, IND.
Article Synopsis
- Nail disorders cover various conditions, including infections and skin diseases, making their clinical evaluation vital for accurate diagnosis and treatment.
- This study at B.J. Medical College analyzed 300 patients with nail changes over two years, using thorough examinations and assessments to gather data.
- Findings revealed a higher prevalence of nail disorders in females (57%) and the most common condition was onychomycosis (24.33%), especially among housewives aged 21-40 years.
Stevens-johnson Syndrome and Toxic Epidermal Necrolysis: An Overview of Diagnosis, Therapy Options and Prognosis of Patients.
Recent Adv Inflamm Allergy Drug Discov
November 2023
Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala 133 207, Haryana, India.
Article Synopsis
- Stevens-Johnson Syndrome (SJS) and Toxic-Epidermal Necrolysis (TEN) are serious, medication-induced skin conditions affecting mucus membranes and the epidermis, with annual incidence rates of about 1 to 2 per million people; SJS has a mortality rate of 1-5%, while TEN has a much higher rate of 25-35%.
- Both conditions are characterized by severe skin detachment, mucocutaneous discomfort, and potential long-term effects on survivors, particularly in the elderly, who may experience reduced quality of life and life expectancy.
- The majority of cases are caused by specific drugs, including carbamazepine and sulfonamides,
Atypical Presentation of Herpes Simplex Virus Infection in an Immunocompromised Patient.
Cureus
April 2023
Medicine, Imam Abdulrahman Bin Faisal University, Dammam, SAU.
Immunocompromised patients are at risk of developing atypical herpes simplex virus (HSV) infection, which can be easily misdiagnosed. We present a case of a 69-year-old female who was receiving methotrexate and tofacitinib for a known case of rheumatoid arthritis. She was admitted to the ICU under neurology care after presenting with status epilepticus secondary to bacterial meningitis.
View Article and Find Full Text PDFAutoimmune Skin Conditions: Autoimmune Blistering Disease.
FP Essent
March 2023
Department of Dermatology - Penn State College of Medicine, 700 HMC Crescent Road, Hershey, PA 17033.
Article Synopsis
- There are two main types of autoimmune blistering skin diseases: bullous pemphigoid, which causes tense blisters in older adults, and pemphigus vulgaris, which results in flaccid blisters due to different underlying mechanisms.
- Diagnosis of both conditions involves physical exams, biopsies, and blood tests.
- Treatment typically involves corticosteroids and immunosuppressants, with rituximab recently identified as the preferred medication for pemphigus vulgaris.
Linear Immunoglobulin A (IgA) Bullous Dermatosis Mimicking Stevens-Johnson Syndrome.
Cureus
October 2022
Dermatology, Lewis Katz School of Medicine, Temple University, Philadelphia, USA.
Article Synopsis
- - Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disease characterized by linear IgA deposits, often leading to misdiagnoses, especially in older patients.
- - Clinically, LABD presents as polycyclic lesions, and differentiating it from conditions like SJS/TEN requires timely skin biopsies and immunofluorescence for accurate diagnosis.
- - The main treatment for LABD is oral dapsone, while SJS/TEN may be treated with cyclosporine or a mix of intravenous immunoglobulin and corticosteroids, highlighting the need for careful medical management.
Ocular Involvement in Pemphigus Vulgaris Without Skin Lesions: A Case Report.
Cureus
June 2022
Internal Medicine, Mercy General Hospital, Carmichael, USA.
Pemphigus vulgaris (PV) is an autoimmune disorder affecting the skin and mucous membranes. The condition may be confused with a number of disorders, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and erythema multiforme (EM), all of which are life-threatening. Immunohistological and histochemical analyses remain the optimal methods for differentiating these diseases.
View Article and Find Full Text PDFPotential shared therapeutic and hepatotoxic mechanisms of Tripterygium wilfordii polyglycosides treating three kinds of autoimmune skin diseases by regulating IL-17 signaling pathway and Th17 cell differentiation.
J Ethnopharmacol
October 2022
Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, China. Electronic address:
Article Synopsis
- The study investigates Tripterygium wilfordii polyglycosides (TWP), a traditional Chinese medicine known for its anti-inflammatory and immunosuppressive effects, particularly in treating autoimmune skin diseases like psoriasis, systemic lupus erythematosus, and pemphigus.* -
- Researchers utilized network pharmacology to identify potential targets and mechanisms of TWP, analyzing numerous databases to understand both its therapeutic benefits and possible liver toxicity associated with long-term use.* -
- Results revealed 41 shared targets for TWP's effects on autoimmune diseases, highlighting the IL-17 signaling pathway's significance, and experimental models confirmed TWP's efficacy in reducing inflammation and improving skin conditions.*
Article Synopsis
- - Researchers have noted that pemphigus foliaceus (PF), an autoimmune skin condition, can develop after a SARS-CoV-2 infection.
- - Previously, there was only one documented case of PF linked to the use of Bamlanivimab, raising the possibility of it being a drug-related condition.
- - This report introduces the first case of PF occurring solely due to COVID-19 infection, without any associated drug use.
Aseptic Meningitis in Oral Medicine: Exploring the Key Elements for a Challenging Diagnosis: A Review of the Literature and Two Case Reports.
Int J Environ Res Public Health
March 2022
Oral Medicine Unit, Department of Neurosciences, Reproductive and Oral Sciences, "Federico II" University of Naples, 80131 Naples, Italy.
Article Synopsis
- Aseptic meningitis (AM) is a serious condition marked by inflammation of the protective membranes of the brain and spinal cord, often identified by specific immune responses, but poses diagnostic challenges due to nonspecific symptoms.
- In oral medicine, rare cases of AM can arise from various causes, such as systemic diseases with oral symptoms (e.g., Behçet's disease, Sjögren syndrome), medications, and viral infections like herpes simplex.
- The review provides insights into the clinical signs, diagnostic techniques, treatment options, and prognosis for these conditions, featuring case studies to illustrate how oral medicine specialists play a crucial role in diagnosis within a multidisciplinary healthcare team.
Ethambutol-induced bullous skin lesions in lung infection.
Int J Mycobacteriol
May 2022
Salem VA Medical Center, Salem, VA; Virginia Tech Carilion School of Medicine, Roanoke, Virginia; Department of Infectious Disease, Salem VA Medical Center, Salem, VA, USA.
Article Synopsis
- - Mycobacterium kansasii is the second most common cause of non-tuberculous mycobacterial lung disease in the U.S., after Mycobacterium avium complex infection.
- - The standard treatment consists of a three-drug regimen: rifampin, isoniazid, and ethambutol.
- - Patients on this treatment can develop side effects like bullous skin lesions, necessitating a coordinated approach to identify second-line treatments if they experience intolerance to the first-line antibiotics.
Clinical Patterns and Clinicopathologic Correlation of 100 Patients with Erythroderma in a Tertiary Care Institute in India.
Skinmed
January 2022
Department of Dermatology, Venereology & Leprology PGIMER, Chandigarh, India.
Article Synopsis
- * Clinical evaluations included detailed medical histories, lab tests, imaging studies, and skin biopsies to diagnose the underlying causes of erythroderma in these patients.
- * The results revealed 34 cases of psoriasis, 28 of spongiotic dermatitis, and other conditions, with a clinical-pathologic correlation in about 78.3% of the cases, indicating that psoriasis and allergic reactions to drugs were the most common causes.
Suspected human intravenous immunoglobulin-induced acute haemolytic anaemia in a dog.
J Small Anim Pract
June 2022
Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.
Article Synopsis
- A 2-year-old mixed breed dog was diagnosed with pemphigus foliaceus after showing symptoms like crust and erosion on its nose for a year, confirmed through histopathological examination.
- The dog received human intravenous immunoglobulin due to poor response to previous treatments, but developed signs of haemolytic anaemia three days later, including rapid breathing and blood in urine.
- After ruling out other causes of haemolytic anaemia, two blood transfusions were given, and no further haemolysis was observed, highlighting the potential risk of this condition after administering human immunoglobulin in dogs.
Experience in the diagnosis and treatment of a drug-induced pemphigus.
Hua Xi Kou Qiang Yi Xue Za Zhi
December 2021
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Article Synopsis
- Drug-induced pemphigus (DIP) is a specific type of pemphigus whose features and treatment depend on the drugs that cause it.
- The article discusses a case of pemphigus vulgaris triggered by rifampin in a tuberculosis patient, alongside a review of literature on DIP's characteristics.
- It emphasizes the need for healthcare providers to carefully investigate potential drug triggers when diagnosing pemphigus vulgaris in clinical practice.
Pemphigus Herpetiformis-Type Drug Reaction Caused by Programmed Cell Death Protein-1 Inhibitor Treatment.
Clin Cosmet Investig Dermatol
August 2021
Department of Dermatology, The Fifth People's Hospital of Hainan Province, Branch of National Clinical Research Center for Skin and Immune Disease, Haikou, 570206, People's Republic of China.
Article Synopsis
- Reports of immune-related side effects from programmed cell death protein-1 inhibitors are increasing, with this case focusing on a unique skin reaction.*
- A 56-year-old man treated with tislelizumab for lung cancer developed pemphigus herpetiformis-type reaction, characterized by itching, rashes, and blisters.*
- Diagnosis was supported by specific lab findings, marking the first documented case of this drug-induced skin reaction linked to PD-1 inhibitor treatment.*
Consider drug induced pemphigus before establishing a diagnosis of paraneoplastic pemphigus (PNP).
Int Immunopharmacol
October 2021
The Hershey Medical Center Department of Dermatology, Hershey, PA, United States.
Article Synopsis
- Vesiculobullous lesions of the skin are diverse dermatological disorders that may arise from infections, inflammation, drug reactions, genetic factors, and autoimmune conditions, making precise diagnosis crucial for effective treatment and patient outcomes.
- A study involving 150 patients at Liaquat National Hospital analyzed the clinicopathological characteristics of these lesions, with a majority of cases among elderly females, and identified various conditions with bullous pemphigoid and pemphigus vulgaris being the most prevalent.
- The involvement of direct immunofluorescence studies revealed that complement protein C3c was the most frequently identified protein, highlighting the importance of skin punch biopsy as a key diagnostic tool for managing vesiculobullous disorders.
Oroesophageal Pemphigus vulgaris Secondary to Lisinopril Use: A New Side Effect.
Cureus
April 2021
Gastroenterology, Allegheny Health Network, Pittsburgh, USA.
Article Synopsis
- Pemphigoid diseases are autoimmune disorders characterized by blistering, affecting mucocutaneous tissues, including conditions like pemphigus vulgaris and pemphigus foliaceous.
- Certain medications like non-steroidal anti-inflammatory drugs, penicillamine, and ACE inhibitors can trigger drug-induced pemphigoid.
- This report highlights a previously unreported case of pemphigus vulgaris associated with the ACE inhibitor lisinopril.
Case Report: Complete and Fast Recovery From Severe COVID-19 in a Pemphigus Patient Treated With Rituximab.
Front Immunol
May 2021
Molecular and Cell Biology Laboratory IDI-IRCCS, Rome, Italy.
Article Synopsis
- COVID-19 is a serious respiratory illness caused by the SARS-CoV-2 virus, posing extra risks for patients with chronic autoimmune diseases like pemphigus, which causes blisters on the skin and mucous membranes.
- Pemphigus is treated with immunosuppressants, including rituximab (RTX), which is effective but can increase infection risk due to prolonged B-cell depletion.
- In a specific case, a pemphigus patient experienced severe inflammation from RTX use, but recovered well with corticosteroid treatment, highlighting treatment complexities during the pandemic.
Intraepithelial autoimmune blistering dermatoses: Clinical features and diagnosis.
J Am Acad Dermatol
June 2021
Department of Dermatology, Mayo Clinic, Rochester, Minnesota; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
Article Synopsis
- * The article covers the background, how common these conditions are, their clinical features, and how they’re diagnosed.
- * It discusses various types of pemphigus, including pemphigus foliaceus and pemphigus vulgaris, among others, plus their unique characteristics and causes.