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Three-dimensional visualization of Hertwig's epithelial root sheath during tooth root development with the miniTESOS tissue clearing method.
Am J Transl Res
September 2024
Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Central Laboratory, Peking University School and Hospital of Stomatology No. 22 Zhongguancun South Avenue, Haidian District, Beijing 100081, PR China.
Article Synopsis
- Hertwig's epithelial root sheath (HERS) is crucial for regulating tooth root development, but its three-dimensional changes during this process are not well understood due to limitations of traditional techniques.
- Researchers developed a new tissue clearing method called mini TESOS to better visualize and study HERS in the mandibles of mice, focusing on the first and second molars.
- Key findings show that HERS exhibits distinct growth patterns at various stages of root development and goes through four specific morphological stages in the root bifurcation area, enhancing understanding of how tooth roots form.