3 results match your criteria: "Peking University Health Science Center Beijing 100083[Affiliation]"

[Research progress on in vitro models of cardiomyocyte injury].

Zhongguo Zhong Yao Za Zhi

July 2021

Modern Research Center for Traditional Chinese Medicine,School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 100029,China.

Article Synopsis
  • Cardiovascular diseases pose significant risks to health, particularly emphasizing the concern over myocardial injury and the potential for new drug development through the unique properties of Chinese medicine.
  • Recent advancements in isolating cardiomyocytes have led to the creation of cost-effective and controllable in vitro models that simulate cardiomyocyte injury, which are essential for understanding mechanisms and testing treatments.
  • This study reviews various in vitro models representing diverse clinical conditions, assessing their principles, strengths, and challenges to support further exploration of myocardial injury and therapeutic options.
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Objective: To compare the relative risk of waist circumference (WC) and/or BMI on cardiovascular risk factors.

Methods: A cross-sectional data of 41 087 adults (19 567 male and 21 520 female) from the 2002 China National Nutrition and Health Survey were examined. According to the obesity definition of WGOC (BMI, 24 kg/m2 and 28 kg/m2; WC, male 85 cm and 95 cm for male, 80 cm and 90 cm for female), the study population were divided into 9 groups.

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The HCA587 gene, identified by serological analysis of recombinant cDNA expression library (SEREX) from a hepatocellular carcinoma (HCC) patient, encodes a new member of cancer-testis antigens. HCA587 mRNA expression in normal tissues and cancers has been previously reported. To estimate its immunogenicity to induce immune response, it is essential to analyze HCA587 expression at the protein level.

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