Chemical proteomic profiling of lysine crotonylation using minimalist bioorthogonal probes in mammalian cells.

Protein lysine crotonylation has been found to be closely related to the occurrence and development of various diseases. Currently, site identification of crotonylation is mainly dependent on antibody enrichment; however, due to the cost, heterogeneity, and specificity of antibodies, it is desired to develop an alternative chemical tool to detect crotonylation. Herein, we report an alkynyl-functionalized bioorthogonal chemical probe, Cr-alkyne, for the detection and identification of protein lysine crotonylation in mammalian cells.

Exploring the bounded rationality in human decision anomalies through an assemblable computational framework.

Some seemingly irrational decision behaviors (anomalies), once seen as flaws in human cognition, have recently received explanations from a rational perspective. The basic idea is that the brain has limited cognitive resources to process the quantities (e.g.

A biofuel cell of (methyl violet/AuNPs)/FTO photoanode and bilirubin oxidase/CuCoO bio-photocathode inspired by the photoelectrochemistry activities of fluorescent materials/molecules.

Herein, we discuss the idea that fluorescent materials/molecules should logically show potential photoelectrochemistry (PEC) activity, and, in particular, the PEC of fluorescent small molecules (previously usually acting only as dye sensitizers for conventional semiconductors) is explored. After examining the PEC activities of some typical inorganic or organic fluorescent materials/molecules and by adopting methyl violet (MV) with the highest PEC activity among the examined fluorescent small molecules, a new and efficient (MV/Au nanoparticles (AuNPs))/fluorine-doped tin oxide (FTO) photoanode without conventional semiconductor(s) is prepared by layer-by-layer alternating the electrodeposition of AuNPs and the adsorption of MV. A bilirubin oxidase (BOD)/CuCoO/FTO bio-photocathode is prepared by electrodeposition, calcination and cast-coating.

Enhancing electrocatalytic hydrogen evolution engineering unsaturated electronic structures in MoS.

The search for efficient, earth-abundant electrocatalysts for the hydrogen evolution reaction (HER) has identified unsaturated molybdenum disulfide (MoS) as a leading candidate. This review synthesises recent advancements in the engineering of MoS to enhance its electrocatalytic properties. It focuses on strategies for designing an unsaturated electronic structure on metal catalytic centers and their role in boosting the efficiency of the hydrogen evolution reaction (HER).

Advanced reactivity-based sequencing methods for mRNA epitranscriptome profiling.

Currently, over 170 chemical modifications identified in RNA introduce an additional regulatory attribute to gene expression, known as the epitranscriptome. The development of detection methods to pinpoint the location and quantify these dynamic and reversible modifications has significantly expanded our understanding of their roles. This review goes deep into the latest progress in enzyme- and chemical-assisted sequencing methods, highlighting the opportunities presented by these reactivity-based techniques for detailed characterization of RNA modifications.

Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health.

The Conference 2024 provides a platform to promote the development of an innovative scientific research ecosystem for microbiome and One Health. The four key components - Technology, Research (Biology), Academic journals, and Social media - form a synergistic ecosystem. Advanced technologies drive biological research, which generates novel insights that are disseminated through academic journals.

Study protocol: A national cross-sectional study on psychology and behavior investigation of Chinese residents in 2023.

Introduction: This study protocol specifies the primary research line and theoretical framework of the 2023 Survey of the Psychology and Behavior of the Chinese Population. It aims to establish a consistent database of Chinese residents' psychological and behavioral surveys through multi-center and large-sample cross-sectional surveys to provide robust data support for developing research in related fields. It will track the public's physical and psychological health more comprehensively and systematically.

Radiation-induced aerobic oxidation solvent-derived peroxyl radicals.

Oxidation is a fundamental transformation in synthesis. Developing facile and effective aerobic oxidation processes under ambient conditions is always in high demand. Benefiting from its high energy and good penetrability, ionizing radiation can readily produce various reactive species to trigger chemical reactions, offering another option for synthesis.

Effects of School-Based Lifestyle Interventions on Cardiovascular Health in Chinese Children and Adolescents: A Post Hoc Analysis of a National Multicenter Study.

Background: We evaluated the effects of a national school-based lifestyle intervention program against childhood obesity on improving cardiovascular health (CVH), assessed using the recently introduced Life's Essential 8 metric framework.

Methods And Results: Our post hoc analysis of the national school-based lifestyle intervention targeting diet and physical activity included 94 schools with eligible students aged 7 to 17 years (intervention group n=30 629; control group n=26 581). We assessed CVH metrics by individual scores for 4 health behaviors (diet, physical activity, nicotine exposure, and body mass index) and 3 health factors (blood lipids, glucose, and pressure).

[Latent class analysis of therapeutic effects of Huoxiang Zhengqi Oral Liquid on patients with cold due to wind-cold and dampness stagnation].

The demographic characteristics, drug use, clinical symptoms and other data of the patients treated with Huoxiang Zhengqi Oral Liquid were collected. The latent class analysis(LCA) was performed to reveal the distribution of primary symptoms, and then the doubly robust estimation was employed to analyze the efficacy of different doses of Huoxiang Zhengqi Oral Liquid in different populations. A total of 11 273 patients were enrolled in this study, including 4 347 males and 6 926 females.

Advanced mechanisms and applications of microwave-assisted synthesis of carbon-based materials: a brief review.

The interaction of microwave radiation with carbon-based materials induces rapid, instantaneous heating. When combined with the plasma excitation capabilities of microwaves, this property presents novel avenues for synthesizing carbon-based materials that require high temperatures and catalytic activity. This review investigates the response of carbon-based materials to microwave radiation, analyzes the dielectric loss mechanism responsible for heat generation, and details the microwave plasma excitation mechanisms employed in the synthesis and processing of carbon-based materials.

Reacon: a template- and cluster-based framework for reaction condition prediction.

Computer-assisted synthesis planning has emerged as a valuable tool for organic synthesis. Prediction of reaction conditions is crucial for applying the planned synthesis routes. However, achieving diverse suggestions while ensuring the reasonableness of predictions remains an underexplored challenge.

A novel cerium-based metal-organic framework supported Pd catalyst for semi-hydrogenation of phenylacetylene.

Phenylacetylene is a detrimental impurity in the polymerisation of styrene, capable of poisoning catalysts even at ppm levels and significantly degrading the quality of polystyrene. The semi-hydrogenation of phenylacetylene to styrene instead of ethylbenzene is, therefore, an important industrial process. We report a novel cerium(iv)-based metal-organic framework (denoted as Ce-bptc), which comprises {Ce} clusters bridged by biphenyl-3,3',5,5'-tetracarboxylate linkers.

Projections of the Stroke Burden at the Global, Regional, and National Levels up to 2050 Based on the Global Burden of Disease Study 2021.

Background: Stroke is a pressing public health issue worldwide. This study aimed to forecast the future temporal trends and distribution characteristics of the global stroke burden.

Methods And Results: Global data on stroke incidence, prevalence, deaths, and disability-adjusted life years between 1990 and 2021 were obtained from the GBD (Global Burden of Disease) Study 2021.

Recent progress in carbon nanomaterials for highly flexible fibrous aqueous zinc-ion batteries.

Fibrous zinc-ion batteries (FZIBs) are ideal wearable energy storage devices with unparalleled utility in the next generation of flexible electronics. However, the conventional electrode materials still present challenges to achieve both good electrochemical performance and mechanical deformability. This hinders their large-scale production and commercial application.

Two new varieties of (Ericaceae) from Xizang, China.

Two new varieties from Xizang, China, i.e. Agapetesinterdictavar.

Sperm quality analyzer: A portable LED array microscope with dark-field imaging.

Sperm quality analysis plays an important role in diagnosing infertility, which is widely implemented by computer-assisted sperm analysis (CASA) of sperm-swimming imaging from commercial phase-contrast microscopy. A well-equipped microscope comes with a high cost, increasing the burden of assessment, and it also occupies a large volume. For point-of-care testing (POCT) of sperm quality, these factors are confronted with the challenges of low-cost and portable instruments.

Synthetic circRNA therapeutics: innovations, strategies, and future horizons.

Small molecule drugs are increasingly emerging as innovative and effective treatments for various diseases, with mRNA therapeutics being a notable representative. The success of COVID-19 vaccines has underscored the transformative potential of mRNA in RNA therapeutics. Within the RNA family, there is another unique type known as circRNA.

Associations Between Atherosclerosis and Subsequent Cognitive Decline: A Prospective Cohort Study.

Background: This study aimed to examine whether baseline atherosclerosis was associated with subsequent short-term domain-specific cognitive decline.

Methods And Results: This research was based on the BRAVE (Beijing Research on Aging and Vessel) study, a population-based prospective cohort study of adults aged 40 to 80 years, free of dementia. At baseline (wave 1, 2019), cognitive assessments and atherosclerosis measures, including carotid intima-media thickness, carotid plaques, coronary artery calcification, and brachial-ankle pulse wave velocity were conducted.

Robust tetra-armed poly (ethylene glycol)-based hydrogel as tissue bioadhesive for the efficient repair of meniscus tears.

Repair and preservation of the injured meniscus has become paramount in clinical practice. However, the complexities of various clinic stitching techniques for meniscus repair pose challenges for grassroots doctors. Hence, there is a compelling interest in innovative therapeutic strategies such as bioadhesives.

Entropy in catalyst dynamics under confinement.

Entropy during the dynamic structural evolution of catalysts has a non-trivial influence on chemical reactions. Confinement significantly affects the catalyst dynamics and thus impacts the reactivity. However, a full understanding has not been clearly established.