1 results match your criteria: "Peking Union Medical College Beijing 100050 China sisyimb@hotmail.com.[Affiliation]"
Ahmpatinin Bu, a new HIV-1 protease inhibitor, from sp. CPCC 202950.
RSC Adv
January 2018
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Peking Union Medical College Beijing 100050 China
Article Synopsis
- Two new linear peptides, Ahmpatinin Bu (1) and statinin Bu (2), along with a unique pyrrolidine derivative and three known pepstatin derivatives, were isolated from a specific strain of bacteria (CPCC 202950).
- The structures of these compounds were determined using advanced techniques like Marfey's analysis and chiral-phase HPLC, and an unusual amino acid was identified in compound 1.
- All isolated compounds, particularly Ahmpatinin Bu (1), showed potential as HIV-1 protease inhibitors, with compound 1 exhibiting significant activity with an IC value of 1.79 nM; a preliminary analysis of their structure-activity relationships was also discussed.