Two-year outcome of phacogoniotomy for advanced primary angle-closure glaucoma with cataracts: a multicentre study.

Purpose: To report the 2-year effective and safety profile of integrated phacoemulsification with intraocular lens implantation (PEI), goniosynechialysis (GSL) and 120° goniotomy (GT) in advanced primary angle-closure glaucoma (PACG) and cataracts.

Design: Multicentre prospective study.

Methods: 201 eyes of 196 patients who received combined PEI+GSL+ GT were assessed at baseline and re-evaluated at days 1, 7, and at 1, 3, 6, 12 and 24 months postsurgery.

Differences in Fibroinflammatory Activity Shown on Ga-FAPI-04 and F-FDG PET/CT in the Two Subtypes of IgG4-Related Disease.

IgG4-related disease (IgG4-RD) is a highly heterogeneous autoimmune disease. Recently, 2 subtypes of IgG4-RD, proliferative and fibrotic, were defined according to patients' clinicopathologic characteristics. The purpose of this study was to determine the difference in fibroinflammatory activity shown on Ga-FAPI-04 and F-FDG PET/CT in the proliferative and fibrotic IgG4-RD subtypes.

Comparison of [Ga]Ga-Fibroblast Activation Protein Inhibitor-04 and [F]FDG PET Imaging for Solitary Fibrous Tumor and Preliminary Application of FAP-Targeted Radiopharmaceutical Therapy.

Solitary fibrous tumor (SFT) is a rare sarcoma of mesenchymal origin. Although generally benign, SFTs carry the risk of recurrence and metastasis, with limited effective treatment options. The aims of this study are to compare the performance of fibroblast activation protein inhibitor (FAPI), [Ga]Ga-DOTA-FAPI-04 (denoted as [Ga]Ga-FAPI-04), and conventional [F]FDG PET/CT in patients with recurrent or metastatic SFTs head to head and to preliminarily explore the value of FAP-targeted radiopharmaceutical therapy with Lu for SFT patients.

Drug-associated pancreatic cancer: insights from real-world pharmacovigilance and network pharmacology.

Background: Pancreatic cancer's high mortality rate necessitates our study, which aims to identify potential risk drugs and speculate on the underlying mechanisms.

Research Design And Methods: All pertinent reports from the FDA Adverse Event Reporting System database were extracted. The disproportionality analysis was used in signal detection and data on patient age, sex, weight, time to onset were collected.

[Development and application of gustatory evoked potentiometer].

Human taste is an important function of chemical perception. In recent years, brain taste evoked potentials have received more and more attention as a feasible tool for objective assessment of taste dysfunction. This paper reviews the main characteristics of gustatory evoked potential signals, the most widely used recording and processing techniques, and the scientific advances and relevance of gustatory evoked potentials in many important applications.

Dictamnine alleviates DSS-induced colitis mice by inhibiting ferroptosis of enterocytes via activating Nrf2-Gpx4 signaling pathway.

Background: The treatment of ulcerative colitis (UC) remains a huge challenge worldwide. Dictamnine is a natural product derived from Dictamnus dasycarpus Turcz. root bark and possesses multi-pharmacological properties, including anti-inflammation effects.

In vivo pharmacodynamic study of the novel polymyxin MRX-8.

In previous studies, polymyxin MRX-8 demonstrated potent in vitro antibacterial activity with a reduced nephrotoxicity risk and an improved PK/PD profile compared with polymyxin B. In this study, the in vivo antibacterial efficacy of intravenously administered MRX-8 was evaluated in murine models of systemic infection (induced by intraperitoneal injection), lung infection (induced by intratracheal route inoculation), and ascending urinary tract infection (induced by intraurethral inoculation) with P. aeruginosa, K.

Arnebinfuranoids A-G, seven unique heterodimers of meroterpenoids from Arnebia euchroma.

Seven previously undescribed heterodimers (1-7) with unusual carbon-carbon bond linkages for monomeric meroterpenoids and a known compound (8) were isolated from the roots of Arnebia euchroma (Royle) Johnst. Their structures were elucidated by extensive spectroscopic methods and quantum chemical calculations of electronic circular dichroism spectra. Further careful NMR analysis revealed that the chemical shift differences of the methylene protons affected by remote chirality were related to the relative configurations of the heterodimers (1-6).

Antiviral prenylated C-C derivatives containing a methylenedioxyl group from the roots of Illicium brevistylum.

Five previously undescribed prenylated C-C compounds (1-3 and 5-6) and four known prenylated C-C compounds (4 and 7-9) were isolated from the roots of Illicium brevistylum A. C. Smith.

Integrating a multi-omics strategy framework to screen potential targets in cognitive impairment-related epilepsy.

Epilepsy is a prevalent neurological disorder that affects over 70 million individuals worldwide and is often associated with cognitive impairments. Despite the widespread impact of epilepsy and cognitive impairments, the genetic basis and causal relationships underlying these conditions remain uncertain, prompting us to conduct a comprehensive investigation into the molecular mechanisms involved. In this study, we utilized statistical data from the third National Health and Nutrition Examination Survey (NHANES III) to evaluate correlation and large-scale pan-phenotype genome-wide association study (GWAS) data to establish genetic correlation and causality.

Proteomic- and metabolomic-based mechanisms of androgen-mediated right ventricular maladaptive remodeling under pressure overload.

Background: Right ventricular (RV) maladaptive remodeling has been demonstrated to be more severe in males than in females under similar afterload, with androgen potentially involved. However, the mechanism remains unknown.

Methods: We performed RV proteomics and metabolomics in male and castrated rats with pulmonary artery banding (PAB) or sham surgery.

Developmental and reproductive toxicity (DART) study of a novel SARS-CoV-2 tetravalent recombinant protein vaccine (SCTV01E) in rats.

SCTV01E, a novel SARS-CoV-2 tetravalent protein vaccine containing recombinant spike proteins of Alpha (B.1.1.

Healthy lifestyle habits, educational attainment, and the risk of 45 age-related health and mortality outcomes in the UK: A prospective cohort study.

Objectives: This study aimed to evaluate to what extent lifestyle habits, contribute to associations between EA and various conditions, and test the variability in risk reduction for specific health conditions linked to a healthy lifestyle across different EA levels.

Design, Setting, Participants, And Measurements: Data were analyzed from 341,632 UK Biobank participants without baseline cardiovascular disease or cancer (2006-2010). A healthy lifestyle score (0-5) was created by assigning one point for each of five habits: a healthy diet, sufficient physical activity, non-current smoking, moderate alcohol consumption, and low-risk sleep duration.

PCK1 inhibits cGAS-STING activation by consumption of GTP to promote tumor immune evasion.

Hypoxia induces immunosuppressive phenotypes in tumor cells even in the presence of cytosolic DNA accumulation. The mechanisms by which tumor cells suppress hypoxia-induced cGAS-STING activation for immune evasion remain largely unclear. Here, we demonstrate that hypoxic stimulation induces JNK1/2-mediated S151 phosphorylation of phosphoenolpyruvate carboxykinase 1 (PCK1), a rate-limiting enzyme in gluconeogenesis.

Evaluation of Safety and Pharmacokinetics of DDCI-01, a Phosphodiesterase Type 5 Inhibitor, in Healthy Participants.

Aim: The aim of this study was to evaluate the safety, tolerability, and pharmacokinetics of single escalating oral doses of DDCI-01 (a novel, highly selective, long-acting phosphodiesterase type 5 inhibitor) administered via capsules to healthy volunteers.

Methods: This randomized, double-blind, placebo-controlled, single ascending dosing, Phase Ia clinical study involved 52 healthy volunteers who were randomized (3:1 ratio) to receive a single oral dose of DDCI-01 (1.25, 2.

Effects of vitamin D and calcium supplementation on bone of young adults after thyroidectomy of differentiated thyroid carcinoma.

Purpose: Differentiated thyroid carcinoma (DTC) is the most frequent endocrine cancer, with a high incidence in young population. Patients with postoperative DTC are usually considered with increased risk of bone loss, possibly due to the thyroid stimulating hormone (TSH) suppression therapy. However, it remains unclear whether vitamin D and calcium supplementation is beneficial on bone metabolism of young patients with vitamin D malnutrition after thyroidectomy of DTC.

Reduced local functional connectivity correlates with atypical performances in children with autism spectrum disorder.

To characterize local functional connectivity (FC) differences in children with autism spectrum disorder (ASD) compared to typically developed (TD) children, and to analyze the correlation between local FC and the atypical behavior in autistic children. Thirty children with ASD and 25 TD children were recruited. Participants underwent rs-fMRI scans, and regional homogeneity (ReHo) of specific brain regions was measured.

Characteristics and prognostic analysis of Pneumocystis jirovecii pneumonia in connective tissue diseases patients with interstitial lung disease: a retrospective study.

Introduction: Pneumocystis jirovecii pneumonia (PJP) is a common opportunistic infection. With the wide application of glucocorticosteroids and immunosuppressants, the incidence and mortality rates of PJP in connective tissue disease (CTD) patients with interstitial lung disease (ILD) are increasing.

Methods: We retrospectively enrolled consecutive CTD-ILD patients with PJP in our center between January 2014 and December 2022.

Ultrasound-Guided Serratus Anterior Plane Block Combined with Modified Parasternal Block in Pediatric Patients Undergoing Auricular Reconstruction Surgery Results in Superior Quality of Recovery Compared to a Standalone Serratus Anterior Plane Block.

Background: Serratus anterior plane block (SAPB) and parasternal block (PSB) are used in multimodal analgesia strategies to improve postoperative comfort and recovery. Their combined effectiveness for pediatric auricular reconstruction (AR) patients needs clarification.

Methods: A study was conducted on 100 children aged 8 to 12 undergoing autologous rib cartilage transplant in AR.

The screening value of mammography for breast cancer: an overview of 28 systematic reviews with evidence mapping.

Background: The effectiveness of mammography screening in reducing breast cancer mortality and the accuracy of various mammography techniques have been widely studied. However, the quality and findings of existing systematic reviews and meta-analyses require comprehensive evaluation.

Methods: A systematic literature search was conducted in the Cochrane Library, EMBASE, and PubMed for systematic reviews published up until December 20, 2022.