[The value of sequential organ failure assessment and its dynamic changes in predicting mortality in hematology intensive care unit].

To investigate the value of Sequential Organ Failure (SOFA) score and its dynamics (ΔSOFA) in predicting mortality in hematology care unit (HCU) . A retrospective clinical study was conducted on 79 critically ill hematologic patients admitted to the Center for Critical Care Medicine, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences, between May and June 2024. SOFA scores and ΔSOFA were calculated within 2 days before and after HCU admission.

[The state of the art: diagnosis and therapeutic interventions of clonal hematopoiesis of indeterminate potential and clonal cytopenias of undetermined significance].

Clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenias of undetermined significance (CCUS) are included in both fifth edition of the World Health Organization classification (WHO 2022) and International Consensus Classification (ICC). Recently three models were developed for prediction of myeloid neoplasms risk and clinical trials are initiated to investigate potential treatments for CHIP and CCUS. Challenges in diagnosis and therapeutic intervention of CHIP and CCUS were discussed.

Risk Stratification Prediction of Endometrial Cancer Using Microstructural Mapping Based on Time-Dependent Diffusion MRI.

Time-dependent diffusion MRI (t-dMRI) has potential in characterizing microstructural features; however, its value in imaging endometrioid endometrial adenocarcinoma (EEA) remains uncertain. Patients surgically confirmed with EEA were finally enrolled in our study. The t-dMRI data were acquired using pulsed gradient spin echo sequence and oscillating gradient spin echo sequences.

Integration of Three-dimensional Visualization Reconstruction Technology with Problem-Based Learning in the Clinical Training of Resident Physicians Specialized in Pheochromocytoma.

Objective: We examined the effectiveness of integrating three-dimensional (3D) visualization reconstruction technology with Problem-Based Learning (PBL) in the clinical teaching of resident physicians focusing on pheochromocytoma.

Methods: Fifty resident physicians specializing in urology at Peking Union Medical College Hospital were randomly divided into two groups over the period spanning January 2022 to January 2024: an experimental group and a control group. The experimental group underwent instruction utilizing a pedagogical approach that integrated 3D visualization reconstruction technology with PBL, while the control group used a traditional teaching model.

Co-delivery of axitinib and PD-L1 siRNA for the synergism of vascular normalization and immune checkpoint inhibition to boost anticancer immunity.

Immune checkpoint inhibition (ICI) has become the mainstay of immunotherapy for the treatment of renal cell carcinoma (RCC). However, only a small portion of patients exhibit a positive response to PD-1/PD-L1 blockade therapy and the key reason is that RCC belongs to a vascular-rich tumor for promoting immunosuppression. Specifically, the dysfunctional tumor vasculature hinders effector T cell infiltration and induces immunosuppressive tumor microenvironment via the release of cytokine, which attenuates the therapeutic efficacy of ICI.

Serum microRNA-24-based nomogram predicts prognosis for patients with resected pancreatic cancer.

Pancreatic cancer (PCa) is one of the malignant tumors with an extremely poor prognosis. Rare biomarkers exist for predicting the outcomes of PCa patients. This study aimed to develop a nomogram model based on serum microRNA-24 (miR-24) and clinicopathological factors to predict overall survival (OS) and treatment response to conventional adjuvant chemotherapy (ACT) in patients with PCa.

Association of circadian syndrome and lung health: A population-based cohort study.

Background: Few studies have explored the association between circadian syndrome (CircS) and lung health.

Objective: To access the relationship between CircS and lung health.

Methods: This prospective cohort study enrolled 6,252 adults.

Comparison of the Effectiveness of Inguinal Lymphangiography and Transjugular Intrahepatic Portosystemic Shunt (TIPS) Creation in Cirrhosis-Related Chylous Ascites.

To investigate the effectiveness of ethiodized oil lymphangiography and TIPS creation in cirrhosis-related chylous ascites, ten patients were included between January 2019 and December 2023. After the failure of conservative treatment, patients received ethiodized oil lymphangiography to identify and embolize the chylous leakage first, and then the TIPS procedure was conducted. Symptoms of chylous leakage were not controlled after ethiodized oil lymphangiography, including patients' weight increase, abdominal circumference increase, and serum albumin level decrease.

Blood transcriptome signature as indicator and predictor for efficacy of abrocitinib in treatment of atopic dermatitis.

Atopic dermatitis (AD) patients exhibit significant blood transcriptome alterations, reflecting systemic inflammation. The effects of abrocitinib, a Janus kinase 1 inhibitor, on the blood transcriptome of AD remain unclear. This study aim to investigate abrocitinib's effects on the blood transcriptome in AD patients and identify transcriptomic predictors of treatment efficacy.

Greenness, Nighttime Light, and Couple Fecundability: A National Cohort Study Between 2014-2020.

Background: Reduced greenness and increased nighttime light (NTL) have been associated with adverse health outcomes; however, the impacts of greenness and NTL on human fecundability remain uncertain.

Methods: Data was collected from 14,239,365 couples across 31 provinces in China. Greenness exposure was estimated using the Normalized Difference Vegetation Index (NDVI) within 1000-meter buffer zones, while NTL data was derived from the Visible and Infrared Imaging Suite Day Night Band aboard satellites, both based on individual residential addresses.

Biodegradable and antibacterial edible films based on egg yolk granules/gelatin/CMC with e-poly-l-lysine: Application in fresh chicken meat preservation.

Novel biodegradable and antibacterial edible films were fabricated by incorporating E-poly-l-lysine (EPL) into egg yolk granules, gelatin, and sodium carboxymethyl cellulose matrices. With increasing EPL concentration (0.3-0.

Comprehensive pan-cancer single-cell analysis reveals glycolysis-related signatures as predictive biomarkers for immunotherapy response and their role in bladder Cancer.

Glycolysis is a vital metabolic biological process in tumor progression and immune modulation. This study comprehensively investigated the roles of glycolysis in pan-cancer, especially in bladder cancer. Exploration of 34 single-cell RNA sequencing (scRNA-seq) cohorts, eight ICI-treated bulk RNA-seq cohorts, and TCGA bulk pan-cancer RNA-seq cohorts uncovered a Glycolysis.

Effect of family physician contract service on patients' perceived quality of primary child healthcare in urban China: Analysis using propensity score matching.

Objectives: The family physician contract service (FPCS) policy has been implemented for several years within primary healthcare (PHC) institutions in China. However, the specific impact of the FPCS on patients' perceived quality of primary child healthcare remains unclear. Therefore, this study investigates the effect of the FPCS on the perceived quality of primary child healthcare in urban China.

Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis.

Early life experience modulates resilience to stress in later life. Previous research implicated maternal care as a key mediator of behavioral responses to the adversity in adolescence, but details of molecular mechanisms remain elusive. Here, we show social stress activates transcription factor C/EBPβ in mPFC neurons of adolescent mice, which transcriptionally upregulates Dnm1l and promotes mitochondrial dysfunction, thereby conferring stress susceptibility in adolescent mice.

CKLF1 disrupts microglial efferocytosis following acute ischemic stroke by binding to phosphatidylserine.

Efferocytosis is crucial for the clearance of apoptotic cells (ACs) following acute ischemic stroke (AIS), however, its mechanism remains unclear. This study reveals that chemokine-like factor 1 (CKLF1) disrupts efferocytosis by promoting AC finding and internalization while impairing AC degradation in microglia. CKLF1 deficiency reduced the proportion of ACs and lowered levels of damage-associated molecular patterns.

1-Epilupinine enhances cognition and reduces inflammation in scopolamine-induced dementia model mice.

Dementia is a growing global public health concern. The search for effective anti-dementia drugs with fewer side effects, particularly in the early stages of the disease, is a key focus of current research. Natural compounds like 1-Epilupinine (ELP) may offer therapeutic potential for cognitive improvement and neuroprotection.

Association of α-Klotho with anti-Aging effects of Ganoderma lucidum in animal models.

Ethnopharmacological Relevance: Aging is a complex, universal process characterized by structural and functional decline across multiple organs. Ganoderma lucidum (G. lucidum), a renowned traditional Chinese medicinal fungus, has long been recognized for its anti-aging properties.

A comprehensive and systemic review of the Gentiana: ethnobotany, traditional applications, phytochemistry, pharmacology, and toxicology in the Mongolian Plateau.

Ethnopharmacological Relevance: Gentiana is the largest genus within the Gentianaceae family, comprising around 400 species that are widely distributed in temperate alpine regions worldwide, including the Mongolian Plateau. Despite their broad distribution, no comprehensive review on the distribution, ethnobotany, traditional uses, phytochemistry, pharmacology, and toxicology of Gentiana species in the Mongolian plateau.

Aim: This paper aims to provide the first detailed summary of Gentiana species distributed in the Mongolian Plateau, including those in Mongolia.

Comparative analysis of femtosecond, picosecond, and nanosecond laser techniques for transseptal puncture: An in vitro study with pathological correlation.

Background: Advanced precision laser technologies for transseptal puncture are still under exploration. Femtosecond lasers, renowned for their high precision and minimal collateral damage, exhibit significant potential in transseptal puncture applications.

Objective: This study investigated the feasibility, effectiveness and pathological effects of femtosecond, picosecond, and nanosecond lasers for transseptal puncture in vitro.

Multimodal mass spectrometry imaging reveals spatial metabolic reprogramming in diabetic liver disease.

Diabetic liver injury (DLI) is a significant complication of diabetes mellitus, leading to severe liver dysfunction and non-alcoholic fatty liver disease (NAFLD). Understanding the metabolic alterations and reprogramming in DLI is critical for identifying therapeutic targets. Despite the prevalence of DLI, its underlying metabolic mechanisms remain poorly understood, and effective treatments are lacking.

Two new cyclopentanoid monoterpenes from the fruits of .

Two new cyclopentanoid monoterpenes, catalpovatins A-B (-), together with nine known compounds (-), were isolated from the fruits of G. Don. The structures of these compounds were elucidated based on their spectroscopic data.

Association of obstructive sleep apnea with cardiovascular events in acute coronary syndrome patients with dual risk of remnant cholesterol and low-grade inflammation: a post-hoc analysis of the OSA-ACS study.

Purpose: Obstructive sleep apnea (OSA) is a recognized cardiovascular risk factor, yet the benefits of intervention remain uncertain due to the heterogeneity among OSA patients. We aimed to explore the association of OSA with cardiovascular outcomes in acute coronary syndrome (ACS) patients with dual risk of elevated remnant cholesterol (RC) and low-grade inflammation indicated by high-sensitivity C-reactive protein (hs-CRP).

Methods: This study is a post-hoc analysis of OSA-ACS project enrolled 1833 ACS patients from January 2015 to December 2019, who underwent a sleep study, categorized into four groups by median levels of RC and hs-CRP: RC and low-grade inflammation risk (RCIR), low-grade inflammation risk (LDIR), RC risk (RCR), and no residual risk.

MRI-based neuroimaging alterations in immune-related skin diseases: a comprehensive review.

The skin, as the largest organ in the human body, serves as the primary physical barrier and plays a crucial role in the immune defense process. Immune-related skin diseases encompass a spectrum of complex dermatological conditions characterized by aberrant immune responses, including the production of autoantibodies and dysregulation of inflammatory mediators. Growing evidence suggest a heightened prevalence of comorbid neuropsychiatric disorders among patients with immune-related skin diseases, indicative of potential shared pathogenesis.

Associations between triglyceride-glucose index combined with waist circumference and heart failure in individuals with different body mass indices: a cross-sectional study using NHANES 2011-2020 data.

Introduction: The incidence of heart failure (HF), a cardiovascular disease, has been widely reported to be gradually increasing. Although the triglyceride-glucose (TyG) index is associated with the risk of HF, this relationship may be affected by differences in nutritional status among individuals with varying levels of obesity. Waist circumference combined with the TyG index may be more accurately associated with HF.