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Efficacy of bisphosphonates in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: a prospective open study.

Clin Exp Rheumatol

July 2019

Medical Research Ctr.of Orthopaedics, Chinese Academy of Medical Sciences; Beijing Key Lab. for Genetic Res.of Skeletal Deformity; Dept.of Central Laboratory, Peking Union Medical College Hosp., Peking Union Med. College and Chinese Academy of Med.Science.

Article Synopsis
  • The study aimed to assess the effectiveness of bisphosphonates in treating spinal bone marrow edema in patients with SAPHO syndrome.
  • A total of 30 patients participated, receiving pamidronate disodium, and showed significant improvements in pain and inflammation after treatment, with notable reductions in several clinical measures.
  • The findings suggest that bisphosphonates are an effective first-line treatment option for managing SAPHO syndrome symptoms, particularly for those experiencing spinal bone marrow edema.
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