6 results match your criteria: "Peking Union Med College[Affiliation]"

Serum IgG4 elevation in SAPHO syndrome: does it unmask a disease activity marker?

Clin Exp Rheumatol

March 2020

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Article Synopsis
  • SAPHO syndrome is a rare inflammatory disorder characterized by symptoms like synovitis, acne, and osteitis, and this study examines the role of serum IgG4 levels in these patients.
  • Among 52 patients studied, 23% had elevated serum IgG4 levels, which were linked to higher pain and disease activity scores compared to those with normal IgG4 levels.
  • The findings suggest that high sIgG4 levels are prevalent in SAPHO syndrome and may indicate increased disease activity, warranting further research.
View Article and Find Full Text PDF

Efficacy of bisphosphonates in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: a prospective open study.

Clin Exp Rheumatol

July 2019

Medical Research Ctr.of Orthopaedics, Chinese Academy of Medical Sciences; Beijing Key Lab. for Genetic Res.of Skeletal Deformity; Dept.of Central Laboratory, Peking Union Medical College Hosp., Peking Union Med. College and Chinese Academy of Med.Science.

Article Synopsis
  • The study aimed to assess the effectiveness of bisphosphonates in treating spinal bone marrow edema in patients with SAPHO syndrome.
  • A total of 30 patients participated, receiving pamidronate disodium, and showed significant improvements in pain and inflammation after treatment, with notable reductions in several clinical measures.
  • The findings suggest that bisphosphonates are an effective first-line treatment option for managing SAPHO syndrome symptoms, particularly for those experiencing spinal bone marrow edema.
View Article and Find Full Text PDF

Association of GTF2I and GTF2IRD1 polymorphisms with systemic lupus erythematosus in a Chinese Han population.

Clin Exp Rheumatol

December 2015

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.

Objectives: Systemic lupus erythematosus (SLE) is the most common systemic autoimmune disease which likely involves complex interactions between genes and the environment. Two large-scale genome-wide association studies (GWAS) have implicated many loci as genetic risk factors associated with primary Sjögren's syndrome (pSS). Among them there are a number of pSS associated gene polymorphisms including the MHC-II, STAT4, IRF5, BLK, and TNIP1 genes that are shared with SLE.

View Article and Find Full Text PDF

Low rate of resistant hypertension in Chinese patients with hypertension: an analysis of the HOT-CHINA study.

J Hypertens

December 2013

Division of Hypertension, FuWai Hospital and Cardiovascular Institute, Peking Union Med College, Chinese Academy of Medical Sciences, Beijing, China.

Objective: The rate of resistant hypertension in China is unknown. This is an analysis of resistant hypertension based on Hypertension Optimal Treatment Study in China.

Methods: The study was conducted in 148 cities in mainland China from April 2001 to February 2002, which included 54,590 hypertensive patients (≥18 years of age), and used a five-step treatment programme.

View Article and Find Full Text PDF

This study was undertaken to investigate the prevalence of sequence variants in LCA5 in patients with Leber congenital amaurosis (LCA), early-onset retinal dystrophy (EORD), and autosomal recessive retinitis pigmentosa (arRP); to delineate the ocular phenotypes; and to provide an overview of all published LCA5 variants in an online database. Patients underwent standard ophthalmic evaluations after providing informed consent. In selected patients, optical coherence tomography (OCT) and fundus autofluorescence imaging were possible.

View Article and Find Full Text PDF

Chitosan chip and application to evaluate DNA loading on the surface of the metal.

Biomed Mater

February 2009

Key Laboratory of Biomedical Materials of Tianjin, Institute of Biomedical Engineering, Peking Union Med College, Chinese Academy of Medical Sciences, Tianjin 300192, People's Republic of China.

The plasmid DNA (pDNA) loading by cationic polymers or/and cationic lipids is essential for gene therapy, especially for metal implants such as stents and artificial joints. Polycations can condense with pDNA by self-assembly, forming polyplexes spontaneously as a result of electrostatic interactions to carry and transfer pDNA in vivo. Cationic polymers, such as chitosan, can also protect pDNA from degradation by DNase.

View Article and Find Full Text PDF