The Impact of Coronal Configuration of the Proximal Femur on its Mechanical Properties and the Validation of a New Theoretical Model: Finite Element Analysis and Biomechanical Examination.

Objective: This study aims to establish the coronal configuration of the proximal femur as an independent factor for its mechanical properties and provide validation for the theoretical model "fulcrum-balance-reconstruction."

Methods: The digital 3D femur model constructed with the lower extremity high-resolution computed tomography of a senior subject was applied with the axial compression of 2100N under 5 different α angles of 10°, 5°, 0°, -5°, -10°. The equivalent stress distribution of the femoral geometric model under each angle were calculated.

Prevention and control strategies of general surgeons under COVID-19 pandemic.

The novel coronavirus SARS-CoV-2 and the disease caused by it, COVID-19, have spread to virtually all countries worldwide within just a few months. The economic and sanitary impact has been enormous. In March 2020, the World Health Organization declared COVID-19 a pandemic.

[Predictive value of white blood cell, procalcitonin and high-sensitivity C-reactive protein for the bloodstream infection in the super-elderly critically-ill patients].

To investigate the ability of white blood cell (WBC), procalcitonin (PCT) and high-sensitivity C-reactive protein (hs-CRP) in the super-elderly patients with bloodstream infection. It was a retrospective study. A total of 77 patients (≥85 years) admitted to the ICU of Peking Union Medical College Hospital from June, 2016 to December, 2017 were enrolled.

Surgery management for sporadic small (≤2 cm), non-functioning pancreatic neuroendocrine tumors: a consensus statement by the Chinese Study Group for Neuroendocrine Tumors (CSNET).

The incidence of small (≤2 cm), non-functioning pancreatic neuroendocrine tumors (NF-pNETs) increased in the last decades. Before making appropriate strategy for patients with NF-pNETs ≤2 cm, pathological confirmation is vital. Incidentally diagnosed, sporadic small NF-pNETs may bring aggressive behavior and poor prognosis, such as extrapancreatic extension, lymph nodal metastasis, distant metastasis and recurrence, even causing disease-related death.

Reliability and validity of the Chinese version of the questionnaire of olfactory disorders (QOD) when used with patients having olfactory dysfunction.

To cross-culturally adapt the Questionnaire of olfactory disorders (QOD) into a Chinese version, and then evaluate its reliability and validity for testing patients with olfactory dysfunction. A Chinese version of the QOD was evaluated for test-retest reliability, split-half reliability, and internal consistency. The validity analysis included components of content validity and criterion-related validity, as well as comparisons between The Medical Outcomes Study's36-Item ShortForm Health Survey(SF-36)questionnaire and the WHO Quality of Life-BREF (WHOQOL-BREF)questionnaire.

[Effect of propofol on thrombospondin-1 expression in cultured newborn rat cortical astrocytes].

Objective: To investigate the effect of propofol on the expression of thrombospondin-1 (THBS-1) mRNA and protein in purified newborn rat cortical astrocytes in vitro.

Methods: Astrocytes were isolated from newborn rat cortex and grown in culture before exposure to propofol at 3, 10, 30, 100 or 300 µmol/L for 6 h, 12, or 24 h. The mRNA level of THBS-1 was detected by RT-PCR, and the protein level of THBS-1 was detected by immunofluorescence cytochemistry and Western blotting.

Surgical removal of a giant vegetation on permanent endocavitary pacemaker wire and lead.

Pacemaker lead infections are rare. There are only about 0.4%-1.

[Clinical analysis of primary facial nerve neuroma].

Objective: To analyze the clinical features of facial nerve neuroma about its diagnosis and management.

Methods: Ten patients with facial nerve neuroma were analyzed retrospectively from February 1993 to August 2005. The period of follow-up varied from 1.

[The effect of SonoVue in endocardial border delineation and myocardial perfusion].

Objective: To evaluate the enhancement of endocardial border delineation and displaying of myocardial perfusion by the contrast agent SonoVue intravenously.

Methods: Under mode of fundamental imaging and nonlinear imaging respectively, 90 patients were injected with SonoVue and observed for improvement of endocardial border delineation by two dimension echo. In the meantime, displaying of myocardial perfusion by SonoVue was also investigated under mode of nonlinear imaging.

[Synergistic effect of all-trans retinoic acid and herpes simplex virus thymidine kinase gene on glioma].

Background & Objective: Gap junctional intercellular communication (GJIC) is the main mechanism mediating the bystander effect in herpes simplex virus thymidine kinase (HSV-tk) gene therapy. All-trans retinoic acid (ATRA) may augment the therapeutic efficacy of HSV-tk gene therapy by both upregulating GJIC in glioma cells and inhibiting tumor growth. This study was designed to investigate the synergistic effect of ATRA and HSV-tk gene therapy in treatment of glioma.

[Vogt-Koyanagi-Harada syndrome: glucocorticoid therapy and visual prognosis].

Objective: To evaluate the efficacy of glucocorticoid therapy in patients with Vogt-Koyanagi-Harada (VKH) syndrome.

Methods: One hundred and thirty-six patients with VKH were treated with two regimens of oral prednisone. Regimen 1: Fifty-one patients with VKH were treated at the uveitic stage with prednisone, starting from 2 mg/kg/day tapering gradually and shifting to alternate-day treatment.

[A case-control study of endogenous estrogen and risk of Alzheimer's disease].

Objective: To investigate the risk of Alzheimer's disease (AD) associated with endogenous estrogen.

Methods: A population based, m: n matched case-control study was conducted, including 115 female AD patients identified from sample population aged 55 years or older as cases and 1,041 non-cognitive impairment individuals from same population matched for age and sex as controls.

Results: Age at natural menopause had significant effect on AD using multivariate analysis.