3,533 results match your criteria: "Pediatrics Rotavirus"
Cell Biochem Funct
December 2024
Department of OS & OT, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Group A rotavirus (RVA) is a major cause of severe gastroenteritis in infants and young children globally, despite the availability of live-attenuated vaccines. Challenges such as limited efficacy in low-income regions, safety concerns for immunocompromised individuals, and cold-chain dependency necessitate alternative vaccine strategies. Subunit vaccines, which use specific viral proteins to elicit immunity, provide a safer and more adaptable approach.
View Article and Find Full Text PDFEur J Pediatr
December 2024
Department of Pediatric Infectious Diseases, University of Health Sciences Dr. Behçet Uz Childrens Hospital, İzmir, Turkey.
Unlabelled: Infectious gastroenteritis is an important cause of morbidity and mortality, especially in nations with middle and low incomes. In a pediatric gastroenteritis patient, the aim was to determine the therapeutic impact of using the Gastrointestinal Panel in our clinical practice. A single-center retrospective study was designed to evaluate children who were admitted to the hospital for gastroenteritis and had a gastrointestinal panel between August 2021 and January 2024.
View Article and Find Full Text PDFCureus
November 2024
Paediatrics, NMC Specialty Hospital, Dubai, ARE.
Acute Haemorrhagic Oedema of Infancy (AHOI), also known as Acute Hemorrhagic Edema of Infancy (AHEI), is characterized by purpuric skin lesions, edema, and fever. It is classified as a form of cutaneous leukocytoclastic vasculitis. Clinically, AHOI presents with targetoid, purplish spots on the face and limbs, accompanied by the sudden onset of peripheral edema.
View Article and Find Full Text PDFPediatrics
December 2024
Division of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.
Pediatrics
December 2024
Department of Pediatrics, Children's Hospital of Philadelphia (CHOP), Philadelphia, Pennsylvania.
Background And Objectives: Many neonatal intensive care units (NICUs) do not give rotavirus vaccines to inpatients due to a theoretical risk of horizontal transmission of vaccine strains. We aimed to determine incidence and clinical significance of vaccine-strain transmission to unvaccinated infants in a NICU that routinely administers pentavalent rotavirus vaccine (RV5).
Methods: This prospective cohort study included all patients admitted to a 100-bed NICU for 1 year.
Pediatric Health Med Ther
November 2024
Department of Medical Microbiology, Mogadishu Somalia Turkey Recep Tayyip Erdogan Training and Research Hospital, Mogadishu, Somalia.
Purpose: Rotavirus is the leading cause of severe and fatal diarrhea in African children. The aim of this study is to investigate the prevalence of rotavirus in children with acute gastroenteritis admitted to a tertiary hospital in Somalia.
Patients And Methods: 5804 children who applied with complaints of acute gastroenteritis between January 2020 and December 2023 were examined retrospectively.
BMC Med Inform Decis Mak
December 2024
Kenya Medical Research Institute- Center for Global Health Research (KEMRI-CGHR), P.O Box 1578-40100, Kisumu, Kenya.
SAGE Open Nurs
November 2024
Department of Clinical Nursing, School of Nursing and Public Health, University of Dodoma, Dodoma, Tanzania.
Introduction: Childhood diarrhea remains a leading cause of death in children under 5 years of age worldwide, although the disease is both preventable and treatable. Effective caregiver involvement, rotavirus vaccinations, and parallel diarrhea prevention are critical.
Objectives: This study aimed to assess caregiver's knowledge of childhood diarrheal disease prevention, rotavirus vaccination knowledge, and associated factors in Dodoma, Tanzania.
J Infect Dis
November 2024
Division of Viral Diseases, NCIRD, CDC, Atlanta, GA, USA.
Background: Rotavirus vaccines are moderately protective against illness in high mortality settings compared with low mortality settings. Vaccine effectiveness (VE) evaluations may clarify our understanding of these disparities, but estimates among key subpopulations and against rare outcomes are not available in many analyses due to sample size. We combined 25 datasets from test-negative design case-control evaluations in 24 countries that enrolled children with medically-attended diarrhea, laboratory-confirmed rotavirus stool testing, and documented vaccination status.
View Article and Find Full Text PDFViruses
November 2024
Department of Pediatrics, Akita University Graduate School of Medicine, Akita-shi 010-8543, Japan.
Rotavirus vaccines carry a small risk of intussusception mainly 1-7 days after vaccination in the United States of America, Europe, Australia, and Latin America where the background rate of intussusception is relatively low. Such risks are undetectable in Africa and India where the background rate is the lowest. Because few studies were carried out in high-background-rate countries such as Japan, we examined how intussusception occurred in infants living in Akita prefecture, Japan, while the vaccines were sold in the private market.
View Article and Find Full Text PDFJ Med Virol
November 2024
Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan.
Ital J Pediatr
November 2024
General Director Local Health Agency Na3 Sud , via Marconi, Torre del Greco, 66-80059, Italy.
Lab Invest
November 2024
Department of Pediatric Surgery, Children's Hospital of Nanjing Medical University, Nanjing, China. Electronic address:
The canonical Hippo-YAP1 signaling pathway is crucial for liver development and regeneration, but its role in repair and regeneration of intrahepatic bile duct in biliary atresia (BA) remains largely unknown. YAP1 expression in the liver tissues of patients with BA and Rhesus rotavirus-induced experimental BA mouse models were examined using quantitative reverse transcriptase-PCR and double immunofluorescence. Mouse EpCAM-expressing cell-derived liver organoids were generated and treated with Hippo-YAP1 pathway activators (Xmu-mp-1 and TRULI) or an inhibitor (Peptide17).
View Article and Find Full Text PDFInt J Infect Dis
January 2025
Takeda Pharmaceuticals International AG, Zürich, Switzerland. Electronic address:
Ital J Pediatr
November 2024
Pediatrics Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
J Clin Med
October 2024
Clinic of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.
Diarrhea frequently occurs after vascular organ transplantation, including kidney transplants. This may result from non-infectious factors, adverse effects of immunosuppressive medications, or infections caused by various pathogens, including viruses, bacteria, fungi, or parasites, for example, intestinal protozoan parasites such as spp., which are particularly dangerous for immunocompromised patients.
View Article and Find Full Text PDFJ Med Virol
November 2024
Department of Pediatrics, College of Medicine and Health Sciences, UAE University, Al-Ain, UAE.
Vaccine
January 2025
Center for Child Health, Pediatric Research Office (CCH/PRO), Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Background: Rotavirus (RV) remains the most common cause of morbidity and mortality due to acute gastroenteritis (AGE) in children under five. In Indonesia, RV is responsible for 60 % of severe AGE and 40 % of non-severe AGE in these children. This study assessed the cost-effectiveness of introduction of rotavirus vaccines (RVV) into the National Immunization Program in Indonesia.
View Article and Find Full Text PDFOpen Forum Infect Dis
November 2024
Division of Infectious Diseases, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Vaccines (Basel)
September 2024
Department of Pharmaceutical Chemistry, Vaccine Analytics and Formulation Center, University of Kansas, Lawrence, KS 66047, USA.
In this work, we describe compatibility assessments of a recombinant, trivalent non-replicating rotavirus vaccine (t-NRRV) candidate with a mock trivalent Sabin inactivated polio vaccine (t-sIPV). Both t-sIPV and t-NRRV are incompatible with thimerosal (TH), a preservative commonly used in pediatric pentavalent combination vaccines (DTwP-Hib-HepB) distributed in low- and middle-income countries (LMICs), preventing the development of a heptavalent combination. The compatibility of t-NRRV with a mock DTwP-Hib-HepB formulation is described in a companion paper.
View Article and Find Full Text PDFGut Pathog
October 2024
The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
Background: Enteric infections are hypothesized to be associated with intussusception in children. A small increase in intussusception following rotavirus vaccination has been seen in some settings. We conducted post-marketing surveillance for intussusception following rotavirus vaccine, Rotavac introduction in India and evaluated association of intussusception with enteric pathogens.
View Article and Find Full Text PDFCureus
September 2024
Child Health, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, OMN.
Objectives The study aims to assess interns' perceptions of Integrated Management of Childhood Illness (IMCI) pre-service education at Sultan Qaboos University (SQU). Specifically, it evaluates how IMCI training during phases 2 and 3 influences interns' clinical practice readiness and knowledge acquisition. The findings will inform evidence-based enhancements to IMCI training programs, ensuring they meet interns' educational needs and optimize clinical skills acquisition.
View Article and Find Full Text PDFVirology
December 2024
Department of Pediatrics, Vanderbilt University Medical Center, 2200 Children's Way, Suite 2404, Nashville, TN, 37232, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Medical Center North, 1161 21st Ave. South, Suite D-2220, Nashville, TN, 37232, USA. Electronic address:
Fusion-associated small transmembrane (FAST) proteins are nonstructural viral proteins that induce cell-cell fusion. FAST proteins, which previously were identified in the genomes of double-stranded RNA viruses, typically contain an acylated N-terminal ectodomain, central transmembrane domain, and C-terminal endodomain with a polybasic region. Using sequence homology and protein motif prediction, we identified accessory proteins in a subset of avian deltacoronaviruses as putative FAST proteins.
View Article and Find Full Text PDFMed Princ Pract
October 2024
Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, Republic of Korea.