590 results match your criteria: "Pediatrics Hand-Foot-and-Mouth Disease"
Metabolomic analysis reveals an important role of sphingosine 1-phosphate in the development of HFMD due to EV-A71 infection.
Antimicrob Agents Chemother
December 2024
Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Hand, foot, and mouth disease (HFMD) is a serious pediatric infectious disease that causes immeasurable physical and mental health burdens. Currently, there is a lack of information on the mechanisms of HFMD severity and early diagnosis. We performed metabolomic profiling of sera from 84 Enterovirus A71 (EV-A71) infections and 45 control individuals.
View Article and Find Full Text PDFCorrelation analysis of serum inflammatory cytokine levels and immune markers in children with severe hand, foot and mouth disease.
J Int Med Res
December 2024
Emergency Department, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Objective: To identify the correlation between serum inflammatory cytokines and immune markers in children with severe hand, foot and mouth disease (HFMD).
Methods: Paediatric patients with severe or mild HFMD from Linping Campus, the Second Affiliated Hospital of Zhejiang University, were included in this retrospective study. Data comprising demographic characteristics, clinical symptoms and signs, laboratory findings and other factors were collected.
The neurological damage caused by enterovirus 71 infection is associated with hsa_circ_0069335/miR-29b/PMP22 pathway.
J Virol
December 2024
Pediatric Emergency Department, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Enterovirus 71 (EV71) infection is usually accompanied by neurological damage, which is the leading cause of death in children with hand-foot-mouth disease. In this study, we demonstrated that EV71 infection can cause pathological damage in the nervous system, such as neuronal vacuolar degeneration, shrinkage of some neurons, edema of brain tissues in the hippocampus, and a decreased number of Nissl bodies in the infarction area. Also, EV71 infection caused apparent structural damage to Schwann cells, including a decreased number of cytoplasmic organelles and severe damage of rough endoplasmic reticulum and mitochondria.
View Article and Find Full Text PDFChildhood acute flaccid myelitis, including the first confirmed cases of enterovirus D68 myelitis, in Singapore and Southeast Asia.
J Paediatr Child Health
November 2024
Neurology Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore.
Article Synopsis
Characterization of oral microbiota of children with hand, foot, and mouth disease caused by enterovirus A 71.
BMC Infect Dis
November 2024
Department of Pediatrics, Suqian Hospital Affiliated to Xuzhou Medical University, Suqian, Jiangsu, 223800, People's Republic of China.
Article Synopsis
- The study aimed to investigate changes in the oral microbiome of children with hand, foot, and mouth disease (HFMD) caused by enterovirus A 71 (EV-A71) compared to healthy children.
- Using 16 S rRNA gene sequencing, researchers analyzed oral swabs from 80 children, revealing significant differences in microbial diversity and composition between the two groups.
- Results showed that children with EV-A71 HFMD had reduced microbial diversity, particularly a decrease in the genera Capnocytophaga and Leptotrichia, indicating potential links between oral microbiota and HFMD.
Genetic diversity and spread of recombinant coxsackievirus A4 in hand, foot, and mouth disease cases in Bangkok, Thailand: 2017-2023.
Sci Rep
November 2024
Department of Pediatrics, Faculty of Medicine, Center of Excellence in Clinical Virology, Chulalongkorn University, Bangkok, Thailand.
Article Synopsis
- The study focuses on the genetic diversity and spread of Coxsackievirus A4 (CVA4), a main cause of hand, foot, and mouth disease, in Bangkok, Thailand, from 2017 to 2023.
- It found that the predominant CVA4 genotype during this period shifted from C1 in 2017 to C3 in 2019, with evidence of intertypic recombination and variation among genotypes.
- The research emphasizes the importance of monitoring CVA4's genetic diversity to identify new strains quickly and improve public health surveillance and response efforts in Thailand.
NLRP3 inflammasome activation contributes to acute liver injury caused by CVA6 infection in mice.
BMC Infect Dis
November 2024
Department of Infectious Diseases, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, 450018, China.
Article Synopsis
Managing hand-foot-mouth disease in children: More of counseling, less of medicines.
J Family Med Prim Care
September 2024
Department of Paediatrics and Neonatology, Era's Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India.
Article Synopsis
Long-Term Immunogenicity Study of an Aluminum Phosphate-Adjuvanted Inactivated Enterovirus A71 Vaccine in Children: An Extension to a Phase 2 Study.
Vaccines (Basel)
August 2024
Department of Pediatrics, National Taiwan University Children's Hospital, Taipei City 100226, Taiwan.
Article Synopsis
- Enterovirus A71 (EV-A71) is a virus that can cause serious health issues like hand, foot, and mouth disease and complications such as encephalitis in young children.
- A study followed 227 children aged 2 months to less than 6 years who received an inactivated EV71 vaccine (EV71vac) to assess its long-term immunity for up to 5 years.
- Results showed consistently high neutralizing antibody levels against various EV-A71 subgenotypes, with no reported long-term safety issues, indicating strong and lasting immunity in children.
Clinical and molecular epidemiology of enterovirus infections in cerebrospinal fluid samples, 2019-2023.
J Med Virol
September 2024
Department of Respiratory Sciences, University of Leicester, Leicester, UK.
Article Synopsis
- A study analyzed 47 children with non-polio enterovirus (NPEV) CNS infections and compared them to 129 controls, revealing a significant drop in hospital admissions during pandemic restrictions (13% vs. 33%).
- The median age of affected children was 41 days and they exhibited distinct clinical features: less irritability but higher rates of fever, respiratory rates, heart rates, and abnormal cerebrospinal fluid (CSF) profiles compared to controls.
- Additionally, phylogenetic analysis indicated that the NPEVs in these cases came from various regions worldwide, including Europe, North America, South America, the Middle East, Africa, South Asia, East/Southeast Asia, and Australia
Epidemiological characterization of hand, foot, and mouth disease among hospitalized children from 2014 to 2023 in a hospital in Henan Province: Longitudinal surveillance study.
J Med Virol
September 2024
College of Public Health, Zhengzhou University, Zhengzhou, China.
Article Synopsis
- Hand, foot, and mouth disease (HFMD) is an infectious illness caused by enteroviruses, and a study in Zhengzhou, China, analyzed the epidemiological characteristics of hospitalized children with HFMD from 2014 to 2023.
- The research found that 7.8% of cases were severe, with peak incidences occurring from May to July and a notable impact from the COVID-19 pandemic on the severity of cases.
- A Seasonal ARIMA model was used to predict future hospitalization trends, indicating a seasonal decline in HFMD cases and significant reductions in severe cases due to vaccination and public health measures during the pandemic.
Epidemiology of childhood enterovirus infections in Hangzhou, China, 2019-2023.
Virol J
August 2024
Department of Clinical Laboratory, The Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Child Health, 3333 Binsheng road, Hangzhou, 310052, China.
Article Synopsis
- Human enteroviruses are common globally and can cause various diseases, posing significant health risks, especially in children.
- The study focused on the prevalence of enterovirus infections in children in Hangzhou, China, before and after the COVID-19 outbreak, analyzing samples from January 2019 to May 2023.
- Out of over 34,000 samples, 3.4% tested positive for enteroviruses, with the highest positivity rates seen in younger children and a notable peak during June and July; meanwhile, severe serotypes appear to be decreasing.
Tackling Inflammatory and Infectious Nail Disorders in Children.
Cutis
July 2024
Eden N. Axler and Dr. Lipner are from the Israel Englander Department of Dermatology, Weill Cornell Medicine, New York, New York. Dr. Bellet is from the Department of Dermatology and the Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina.
Article Synopsis
- * The review covers various inflammatory conditions like nail psoriasis and nail lichen planus, along with infectious issues such as onychomycosis and conditions related to hand, foot, and mouth disease.
- * The goal is to enhance understanding of these disorders among dermatologists to improve diagnosis and treatment for affected children.
A Hand-Foot-and-Mouth Disease Outbreak in an Atypical Population of College Students.
J Prim Care Community Health
August 2024
Johns Hopkins University, Baltimore, MD, USA.
Article Synopsis
- - An unusual outbreak of Hand-foot-and-mouth disease (HFMD) occurred among college students at a university in the mid-Atlantic U.S., affecting 138 students from August to November 2018.
- - The outbreak was linked to CVA6, a less common virus associated with HFMD, and included typical signs and symptoms that were detailed alongside campus mitigation strategies.
- - This case report emphasizes the need for clinicians to recognize HFMD in older adolescents and young adults, as they may encounter similar cases in primary care and community settings.
Article Synopsis
- The research introduces a new model for tracking infectious diseases using contact tracing and estimates the effective reproduction number (Re) for diseases in a specific area, focusing on hand, foot, and mouth disease (HFMD) in Chongqing, China from 2015 to 2019.
- The study utilized data analysis and programming to construct a spatiotemporal database for HFMD, revealing that the optimal search radius for the model is 1.5 km, and the Re values showed significant variation, with a median of 2.42.
- Results demonstrated a close correlation between the new spatiotemporal model's Re values and the traditional SEIR model, and the findings were visually represented on GIS maps
Single nucleotide polymorphism of Notch1 gene rs3124599 allele is associated with the severity of CVA6-related HFMD in the Chinese Han population.
BMC Infect Dis
July 2024
Department of Infectious Diseases, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, 450018, China.
Article Synopsis
- The study explores the link between Notch1 gene polymorphisms and the severity of hand, foot, and mouth disease (HFMD) caused by coxsackievirus A6 (CVA6), highlighting a potential genetic factor in disease severity.
- It involved 196 Chinese Han patients, with 97 classified as severe and 99 as mild cases, using mRNA analysis and genotyping techniques to assess Notch1 variants.
- Results showed that specific Notch1 polymorphisms, particularly the rs3124599 AA genotype, are associated with increased risk for severe HFMD, alongside elevated Notch1 mRNA levels in more severely affected patients.
Clinical Features and Characteristics of Hand, Foot, and Mouth Disease Caused by Recent Coxsackievirus A6: Five Cases in Japan from 2019 to 2022.
Infect Dis Rep
June 2024
Department of Pediatrics, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara City 252-0329, Japan.
Article Synopsis
- Hand, foot, and mouth disease (HFMD) is commonly caused by enteroviruses, with Coxsackievirus A6 (CV-A6) now being a leading strain globally.
- A report details five cases of CV-A6-associated HFMD in Japan from 2019 to 2022, noting that these cases were mild and self-limiting, with skin symptoms differing from typical HFMD presentations.
- Phylogenetic analysis revealed that the CV-A6 strain causing these cases formed a significant epidemic cluster in 2011, indicating an ongoing evolution in the disease's manifestation.
The Hand, Foot, and Mouth Disease Sentinel Surveillance System in South Korea: Retrospective Evaluation Study.
JMIR Public Health Surveill
July 2024
Department of Preventive Medicine, College of Medicine, The Catholic University of Korea, R6117, Omibus Park, 222 Banpo-daero, Seocho-gu, Seoul, 06591, 82 0231478383, 82 025323820, Republic of Korea.
Article Synopsis
- South Korea's HFMD surveillance system, established in 2009, monitors the incidence and disease burden of hand, foot, and mouth disease through about 100 pediatric clinics reporting cases.
- This study assessed the system's effectiveness from 2017 to 2022, particularly during and after the COVID-19 pandemic, by evaluating factors like timeliness and completeness using CDC guidelines.
- Results indicated a temporary decrease in completeness and sensitivity during the pandemic, but these recovered by 2022, while system stability was found to be weak that year.*
Impaired arginine/ornithine metabolism drives severe HFMD by promoting cytokine storm.
Front Immunol
July 2024
Department of Genetic Medicine, Dongguan Children's Hospital Affiliated to Guangdong Medical University, Dongguan, China.
Article Synopsis
- - The Hand, Foot and Mouth Disease (HFMD) is a serious global health issue affecting children, with severe cases linked to a dangerous immune reaction called cytokine storm, yet effective treatments are lacking.
- - This study used a mouse model to explore how metabolic disruptions, particularly in arginine/ornithine metabolism, contribute to the development of cytokine storms in severe HFMD.
- - The research found that the compound spermine, a metabolite of ornithine, can reduce inflammation and potentially serve as a new treatment strategy for managing severe HFMD.
Enteroviruses Associated with Hand Foot and Mouth Disease in Navi Mumbai, Maharashtra, India in 2022.
Indian J Pediatr
July 2024
ICMR-National Institute of Virology, Mumbai Unit, Mumbai, Maharashtra, India.
Article Synopsis
- * CVA6 was notably linked to an atypical rash that spread beyond typical locations like hands and mouth, affecting areas like the face and trunk, while co-infections and recurrent cases were also observed.
- * Molecular analysis categorized CVA6 as group D3 and CVA16 as group B1c, emphasizing the importance of monitoring changes in the clinical features of enteroviruses associated with HFMD.
Clinical features of hand, foot and mouth disease caused by Coxsackievirus A6 in Xi'an, China, 2013-2019: A multicenter observational study.
Acta Trop
September 2024
Department of Pediatric, Xi'an Central Hospital, Xi'an 710003, China. Electronic address:
Article Synopsis
- The study aimed to explore the clinical features of hand, foot, and mouth disease (HFMD) linked to coxsackievirus A6 (CVA6) to aid in early diagnosis, analyzing data from over 7,200 patients treated in multiple hospitals from 2013 to 2019.
- Among patients with clinically diagnosed HFMD, positive detection rates for CVA6, enterovirus 71 (EV-A71), and coxsackievirus A16 (CVA16) were found, with CVA6 being the most prevalent (31.0%).
- The study revealed that patients with CVA6 had a higher average age at onset, a significantly more common presence of fever (82.
Hand, foot, and mouth disease: could EPs® 7630 be a treatment option? A prospective randomized open-label multicenter clinical study.
Front Pediatr
May 2024
Pediatric Infectious Diseases, Faculty of Medicine, Hacettepe University, Ankara, Türkiye.
Article Synopsis
- Hand, foot, and mouth disease (HFMD) is a viral infection in children caused by enteroviruses and coxsackieviruses, with no specific treatment options available.
- A clinical study with 208 children investigated the effects of EPs® 7630, an herbal medicine, on HFMD symptoms, revealing significantly shorter illness duration and lower hospitalization rates in the treatment group compared to controls.
- The results suggest that EPs® 7630 is a potentially effective and safe herbal treatment for HFMD, with only minor side effects reported.
Epidemiological and Clinical Profile of Hand, Foot, and Mouth Disease in Children in a Tertiary Care Center in Jammu.
Cureus
April 2024
Department of Community Medicine, Acharya Shri Chander College of Medical Sciences and Hospital, Jammu, IND.
Article Synopsis
- Hand, foot, and mouth disease (HFMD) is a viral infection primarily affecting children under five, mainly caused by Coxsackievirus A-16 and Enterovirus A-71, with outbreaks frequently reported in India over the past two decades.
- A six-month study at Acharya Shri Chander College of Medical Sciences analyzed 112 children with HFMD to understand their symptoms and demographics, showing the highest incidence in August and a predominance of cases in younger children (0-3 years).
- The study found that 61% of the cases were male, with common symptoms including a vesiculopapular rash on the hands and feet and painful swallowing; 27% had a family history of HFMD,
Inferring B-cell derived T-cell receptor induced multi-epitope-based vaccine candidate against enterovirus 71: a reverse vaccinology approach.
Clin Exp Vaccine Res
April 2024
School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, India.
Article Synopsis
- Enterovirus 71 is a virus that causes hand-foot and mouth disease, particularly in children, and currently there is no approved vaccine due to the virus's evolving genome.
- Researchers have developed a new vaccine using T-cell epitopes from the virus and added an adjuvant to enhance immune response.
- The vaccine's design shows promising immunogenicity, safety for human use, and effectiveness in stimulating a strong immune response according to computational analysis.
Evolution, recombination and geographic spreading of global Coxsackievirus A6.
J Clin Virol
August 2024
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID). National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, No.155 Changbai Road, Beijing 102206, PR China; National Polio Laboratory, WHO WPRO Regional Polio Reference Laboratory, National Health Commission Key Laboratory for Biosafety, National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, PR China. Electronic address:
Article Synopsis
- The study examines the growing public health concern of Hand, Foot, and Mouth Disease (HFMD) linked to Coxsackievirus A6 (CVA6), focusing on its recombination, transmission patterns, and evolutionary traits.
- Researchers analyzed 73 CVA6 sequences from HFMD patients in China, combined with over 1000 existing genomes, to identify phylogenetic features and key mutations in the virus.
- The findings reveal 24 recombinant forms of CVA6, highlight eastern China as a major transmission hub, and pinpoint specific amino acid variations that may influence the virus's behavior and pathogenicity.