3 results match your criteria: "Pediatric Oncology and Children's Research Center[Affiliation]"
Skin Cancer Induction by the Antimycotic Drug Voriconazole Is Caused by Impaired DNA Damage Detection Due to Chromatin Compaction.
J Invest Dermatol
November 2024
Department of Dermatology, University Regensburg, Regensburg, Germany. Electronic address:
Article Synopsis
- Voriconazole (VOR), an anti-fungal drug, can cause phototoxicity and skin cancer by impairing the DNA repair process known as nucleotide excision repair (NER).
- VOR affects NER not by changing the expression of related genes but by binding to heterochromatin, disrupting the acetylation of histone H3, which is necessary for effective DNA repair.
- Using histone deacetylase inhibitors to restore H3 acetylation can reverse the NER inhibition caused by VOR, suggesting a potential therapeutic strategy to prevent its harmful effects.
Multiplex DNA fluorescence in situ hybridization to analyze maternal vs. paternal C. elegans chromosomes.
Genome Biol
March 2024
Biozentrum, University of Basel, 4056, Basel, Switzerland.
Recent advances in microscopy have enabled studying chromosome organization at the single-molecule level, yet little is known about inherited chromosome organization. Here we adapt single-molecule chromosome tracing to distinguish two C. elegans strains (N2 and HI) and find that while their organization is similar, the N2 chromosome influences the folding parameters of the HI chromosome, in particular the step size, across generations.
View Article and Find Full Text PDFB- and T-cell acute lymphoblastic leukemias evade chemotherapy at distinct sites in the bone marrow.
Haematologica
May 2023
University Children's Hospital Zürich, Pediatric Oncology and Children's Research Center, Balgrist Campus AG, Lengghalde 5, 8008 Zürich.
Persistence of residual disease after induction chemotherapy is a strong predictor of relapse in acute lymphoblastic leukemia (ALL). The bone marrow microenvironment may support escape from treatment. Using three-dimensional fluorescence imaging of ten primary ALL xenografts we identified sites of predilection in the bone marrow for resistance to induction with dexamethasone, vincristine and doxorubicin.
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