An amplified electrochemical sensor employing one-step synthesized nickel-copper-zinc ferrite/carboxymethyl cellulose/graphene oxide nanosheets composite for sensitive analysis of omeprazole.

In this work, a signal amplification strategy was designed by the fabrication of a highly sensitive and selective electrochemical sensor based on nickel-copper-zinc ferrite (NiCuZnFeO)/carboxymethyl cellulose (CMC)/graphene oxide nanosheets (GONs) composite modified glassy carbon electrode (GCE) for determination of omeprazole (OMP). The one-step synthesized NiCuZnFeO/CMC/GONs nanocomposite was characterized by scanning electron microscopy, energy-dispersive X-ray spectroscopy, transmission electron microscopy and X-ray diffraction techniques. Then, the NiCuZnFeO/CMC/GONs/GCE was applied to study the electrochemical behavior of the OMP.

Theoretical and experimental investigation of anticancer activities of an acyclic and symmetrical compartmental Schiff base ligand and its Co(ii), Cu(ii) and Zn(ii) complexes.

A compartmental Schiff base ligand, 2,2'-((((((2-hydroxypropane-1,3-diyl)bis(oxy))bis(2,1-phenylene))bis(methylene))bis(azanylylidene))bis(methanylylidene))bis(4-bromophenol) (HL) and its complexes with cobalt(ii), copper(ii) and zinc(ii) including, [Co(HL)] (1), [Cu(L)(μ-1,3-OAc)]·MeOH (2) and [Zn(HL)] (3) were prepared using template synthesis and characterised by elemental analysis, FT-IR and H NMR spectroscopies and single-crystal X-ray diffraction. In the structure of complexes 1 and 3 the metal atom has a MNO environment with tetrahedral geometry while complex 2 has a binuclear structure with a MNO environment and square planar geometry around the copper atom. The ability of all compounds to interact with the nine biomacromolecules (BRAF kinase, CatB, DNA gyrase, HDAC7, rHA, RNR, TrxR, TS and Top II) are investigated by docking calculations.