571 results match your criteria: "Pavol Jozef Safarik University in Kosice[Affiliation]"

Article Synopsis
  • The paper investigates the preparation and characterization of ZnS nanoparticles bioconjugated with bovine serum albumin, leading to a stable nanosuspension with specific particle size and zeta potential.
  • It explores the interactions between ZnS and albumin through fluorescence techniques, identifying key parameters like quenching and binding constants, and highlighting that tryptophan is more closely situated to the binding site than tyrosine.
  • The study also assesses the cellular effects of the nanosuspension on multiple myeloma cells, showing its nontoxic potential for drug delivery, while examining structural changes in albumin and conducting thermal and stability analyses.
View Article and Find Full Text PDF

The main aim of the present study is to investigate the indirect effect of the association between thin-ideal internalisation (1), muscular-ideal internalization (2) and body dissatisfaction (BD) through the general social appearance comparison separately among boys and girls. 154 adolescents (mean age 18.2 years, SD = 0.

View Article and Find Full Text PDF

Thiothrix and Sulfurovum genera dominate bacterial mats in Slovak cold sulfur springs.

Environ Microbiome

September 2023

Department of Microbiology, Institute of Biology and Ecology, Faculty of Science, Pavol Jozef Safarik University in Kosice, Srobarova 2, Kosice, 041 54, Slovakia.

Microbiota of sulfur-rich environments has been extensively studied due to the biotechnological potential of sulfur bacteria, or as a model of ancient life. Cold terrestrial sulfur springs are less studied compared to sulfur-oxidizing microbiota of hydrothermal vents, volcanic environments, or soda lakes. Despite that, several studies suggested that sulfur springs harbor diverse microbial communities because of the unique geochemical conditions of upwelling waters.

View Article and Find Full Text PDF

This paper presents teachers' perspectives and experiences with the implementation of formative assessment (FA) into chemistry lessons at the secondary school level through Formative Assessment Classroom Techniques (FACTs). The research had a qualitative character and was based on semistructured interviews focused on: the definition and previous use of FA, implementation experience, and teachers' beliefs, attitudes, and abilities. The research describes five cases-chemistry teachers participating in a professional development program.

View Article and Find Full Text PDF

Phocomelia is a congenital limb deformity in which the proximal part of the upper or lower limb does not develop. Occasionally the malformed limb may be located ectopically. We present a frontal phocomelia in a three-year-old girl with right-hand phocomelia and thoracoschisis.

View Article and Find Full Text PDF

Identification of therapeutic targets for treating fibrotic diseases and cancer remains challenging. Our study aimed to investigate the effects of TGF-β1 and TGF-β3 on myofibroblast differentiation and extracellular matrix deposition in different types of fibroblasts, including normal/dermal, cancer-associated, and scar-derived fibroblasts. When comparing the phenotype and signaling pathways activation we observed extreme heterogeneity of studied markers across different fibroblast populations, even within those isolated from the same tissue.

View Article and Find Full Text PDF

Genetic Basis of sp. K1 Adaptation Mechanisms to Extreme Environmental Conditions.

Life (Basel)

August 2023

Department of Microbiology, Institute of Biology and Ecology, Faculty of Sciences, Pavol Jozef Safarik University in Kosice, Srobarova 2, 041 54 Kosice, Slovakia.

Anthropogenic pollution often leads to the generation of technosols, technogenic soils with inhospitable conditions for all living organisms including microbiota. Aluminum production near Ziar nad Hronom (Slovakia) resulted in the creation of a highly alkaline and heavy-metal-rich brown mud landfill, from which a bacterial strain of a likely new species of the genus , sp. K1, was isolated.

View Article and Find Full Text PDF
Article Synopsis
  • Two types of half-sandwich complexes featuring a thiadiazole-based ligand have been synthesized and characterized, showing hydrolytic stability and the ability to oxidize NADH.
  • Iridium complexes (2 and 4) demonstrated higher catalytic activity and greater lipophilicity compared to ruthenium complexes (1 and 3), while also showing minimal interaction with reduced glutathione.
  • Biological analyses revealed that complexes 2 and 4 were selective against human fibroblasts and showed moderate inhibition of cancer cell activity, particularly complex 4, indicating potential for development as new anticancer drugs, especially for cisplatin-resistant tumors.
View Article and Find Full Text PDF

Background: Traumatic brain injury (TBI) is one of the most common trauma-related diagnoses among the elderly population treated in emergency departments (ED). Identification of patients with increased or decreased risk of intracranial bleeding is of clinical importance. The objective of this study was to evaluate the implication of cutaneous impact location (CIL) on the prevalence of intracranial injury after suspected or confirmed TBI irrespective of its severity.

View Article and Find Full Text PDF

Based on available literature sources, we have listed the genera and species of springtails (Collembola) of Iran located in Southwest Asia. In total, 301 named species of Collembola are listed in catalogue. This includes 286 described species in 109 genera from 20 families recorded from Iran.

View Article and Find Full Text PDF

Release of Monomers from Dental Composite Materials into Saliva and the Possibility of Reducing the Toxic Risk for the Patient.

Medicina (Kaunas)

June 2023

Department of Medical and Clinical Biophysics, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Trieda SNP 1, 040 11 Košice, Slovakia.

: The objective of this study was (1) to measure the amount of monomers released into the saliva depending on the time elapsed after the hardening of the composite and on the type of monomer used; and (2) with the prolongation of the light-curing procedure, to publish information on whether it would be possible to influence the level of leached monomers. : HPLC technique was used to monitor the levels of the unpolymerized monomers Bis-GMA, Bis/EMA, TEGDMA, and UDMA from the four commonly used composite materials, released into the saliva of a volunteer with intact dentition. The levels were monitored in 3 time periods during 24 h after composite hardening.

View Article and Find Full Text PDF

Breast cancer is the most prevalent cancer type in women worldwide. It proliferates rapidly and can metastasize into farther tissues at any stage due to the gradual invasiveness and motility of the tumor cells. These crucial properties are the outcome of the weakened intercellular adhesion, regulated by small guanosine triphosphatases (GTPases), which hydrolyze to the guanosine diphosphate (GDP)-bound conformation.

View Article and Find Full Text PDF

Purpose: The development of sensitive and non-invasive biomarkers for the early detection of CRC and determination of their role in the individual stages of CRC.

Methods: MMP-9 expression in serum and tissue, and BDNF expression in plasma were detected using the ELISA method. MMP-9 and BDNF in the tissue were also determined by immunohistochemical staining.

View Article and Find Full Text PDF

The Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) is an instrument to screen substance-use-related health risks. However, little is known whether the ASSIST could be further shortened while remaining psychometrically sound across different countries, languages, gender identities, and sexual-orientation-based groups. The study aimed to validate a shortened 11-item ASSIST (ASSIST-11).

View Article and Find Full Text PDF

This study focuses on the preparation and characterization of zinc-based alloys containing magnesium, calcium, and manganese. The alloys were prepared by the melting of pure elements, casting them into graphite molds, and thermo-mechanically treating them via hot extrusion. The phase compositions of the samples were analyzed using X-ray diffraction technique and SEM/EDX analysis.

View Article and Find Full Text PDF

We designed a study with the objective to determine the long-term radiation effects of gamma rays, originating from a single shot of Co at a dose of 2 Gy on the 7-month-old male mice of the ICR line in 30 days after the irradiation. The aim of this study was to characterize the behavior of animals using the Open Field test, immuno-hematological status, and morpho-functional changes in the central nervous system of mice. Irradiated animals displayed significantly different behavior in the OF in comparison with the control group.

View Article and Find Full Text PDF

Background: BRASH syndrome (bradycardia, renal failure, atrioventricular nodal blockade, shock, and hyperkalemia) is a rare clinical condition with potentially severe outcomes. Patients with BRASH syndrome can present with diverse signs and symptoms and are usually in critical condition, but if recognized early, the syndrome is treatable and may have a favorable prognosis.

Case Presentation: This case study presents a 74-year-old patient with a history of multiple chronic conditions who was brought to the emergency department with a suspected cerebrovascular accident, altered mental status, and bradycardia.

View Article and Find Full Text PDF

Endoscopic discectomy of the herniated intervertebral disc and changes in quality-of-life EQ-5D-5L analysis.

Medicine (Baltimore)

June 2023

Department of Neurosurgery, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, and Louis Pasteur University Hospital, Košice, Slovak Republic.

Herniated lumbar discs are a common cause of low back pain, which can negatively impact the quality of life of working-age individuals. This study aimed to evaluate changes in the quality of life in patients with sciatica who underwent endoscopic discectomy, a minimally invasive surgical procedure. The study (ClinicalTrials.

View Article and Find Full Text PDF
Article Synopsis
  • Nomophobia (NMP) is the fear of losing access to smartphones and ICT, and the study aimed to explore its prevalence among secondary school students in the Czech Republic.
  • A survey of 373 students revealed that 71% exhibited a very mild form of NMP, while 2% showed severe symptoms; girls displayed higher dependency on mobile phones than boys.
  • The study emphasizes the need for further research to identify risk factors and develop prevention strategies for NMP among teenagers.
View Article and Find Full Text PDF

Since the beginning of unicellular life, dissimilation reactions of autotrophic sulfur bacteria have been a crucial part of the biogeochemical sulfur cycle on Earth. A wide range of sulfur oxidation states is reflected in the diversity of metabolic pathways used by sulfur-oxidizing bacteria. This metabolically and phylogenetically diverse group of microorganisms inhabits a variety of environments, including extreme environments.

View Article and Find Full Text PDF

A colloidal solution of magnetic nanoparticles (MNPs) modified with biocompatible positively charged poly-L-lysine (PLL) with an oleate (OL) layer employed as an initial coating was produced as a potential MRI contrast agent. The effect of various PLL/MNPs' mass ratios on the samples' hydrodynamic diameter, zeta potential, and isoelectric point (IEP) was studied by the dynamic light-scattering method. The optimal mass ratio for MNPs' surface coating was 0.

View Article and Find Full Text PDF

Background And Aims: Despite its inclusion in the 11th revision of the International Classification of Diseases, there is a virtual paucity of high-quality scientific evidence about compulsive sexual behavior disorder (CSBD), especially in underrepresented and underserved populations. Therefore, we comprehensively examined CSBD across 42 countries, genders, and sexual orientations, and validated the original (CSBD-19) and short (CSBD-7) versions of the Compulsive Sexual Behavior Disorder Scale to provide standardized, state-of-the-art screening tools for research and clinical practice.

Method: Using data from the International Sex Survey (N = 82,243; Mage = 32.

View Article and Find Full Text PDF

A pilot analysis of the tear fluid of patients with multiple sclerosis (MS) collected by glass microcapillary was performed using various experimental methods: liquid chromatography-mass spectrometry, Raman spectroscopy, infrared spectroscopy, and atomic-force microscopy. Infrared spectroscopy found no significant difference between the tear fluid of MS patients and the control spectra; all three significant peaks were located at around the same positions. Raman analysis showed differences between the spectra of the tear fluid of MS patients and the spectra of healthy subjects, which indicated a decrease in tryptophan and phenylalanine content and changes in the relative contributions of the secondary structures of the polypeptide chains of tear proteins.

View Article and Find Full Text PDF

Amyloid fibrils have immense potential to become the basis of modern biomaterials. The formation of amyloid fibrils in vitro strongly depends on the solvent properties. Ionic liquids (ILs), alternative solvents with tunable properties, have been shown to modulate amyloid fibrillization.

View Article and Find Full Text PDF