147 results match your criteria: "Pasteur 2 Hospital[Affiliation]"

Impact of neoadjuvant therapy on angioplastic lobectomy: a retrospective study.

Interdiscip Cardiovasc Thorac Surg

December 2024

Department of Thoracic Surgery, Pasteur 1 Hospital, University Hospital of Nice, Nice, France.

Objectives: The efficacy of neoadjuvant therapy (NT) prior to angioplastic lobectomy (AL) in non-small cell lung cancer is unclear. This study assessed its impact on morbidity, mortality and 5-year survival.

Methods: We retrospectively analysed 114 patients who underwent AL at 2 tertiary centres from January 2000 to December 2020.

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Infratuberositary slope-decreasing anterior closed wedge proximal tibial osteotomy is safe and shows rapid bone healing.

Knee Surg Sports Traumatol Arthrosc

December 2024

Osteotomy Committee of the German Knee Society (Deutsche Kniegesellschaft e.V.), Schwarzenbek, Germany.

Purpose: Different techniques of slope-decreasing anterior closed-wedge proximal tibial osteotomy (ACW-PTO) have been described. To determine the peri- and post-operative complication rate and obtain data on bone healing in ACW-PTO with an infratuberositary approach.

Methods: A total of 170 consecutive ACW-PTO of two sports-orthopaedic centres were retrospectively evaluated (97 and 73, respectively).

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[Vascularized composite allografts in France: An update].

Ann Chir Plast Esthet

December 2024

Department of Plastic and Reconstructive Surgery, Institut Universitaire Locomoteur et du Sport, Pasteur 2 Hospital, University Côte d'Azur, Nice, France.

Vascularized composite allografts (VCA) encompass the face, upper limb, trachea, penis, abdominal wall, and, more recently, uterus transplants. They offer unique reconstructive possibilities to overcome the limitations of traditional reconstructive techniques. Unlike solid organ transplants (heart, liver, kidney, lung, etc.

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Introduction: Perioperative analgesia after total knee arthroplasty (TKA) reduces morphine consumption and speeds up rehabilitation. The primary objective of this study was to compare the pain experienced by patients with an adductor canal and posterior capsule block with those with a continuous femoral nerve block combined with a popliteal sciatic nerve block. The secondary objectives were to analyze the time to recovery from early walking, length of hospital stay, and block-related complications between the two groups.

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Background: Reconstruction of the axillary fossa represents a surgical challenge given the functional implications for mobility of the upper limb. The posterior brachial flap is a solution of choice for this indication, providing fine and functional local reconstruction, but little is known about its perforasome. This study aimed to identify the location of the perforator, analyze perfusion flow, and link vessel distribution, and propose an aesthetic refinement to the surgical technique by medializing the skin paddle to conceal aesthetic scarring at the donor site.

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Anterior transfer of the long head of triceps nerve to the terminal part of the anterior division of the axillary nerve through two incisions: A cadaveric feasibility study.

Hand Surg Rehabil

December 2024

Clinique Bizet, 22 bis Rue Georges Bizet, 75116 Paris, France; Institut de Chirurgie Nerveuse et du Plexus Brachial, 92 Boulevard de Courcelles, 75017 Paris, France; Clinique Nollet Paris, 23 Bue Brochant, 75017 Paris, France.

Purpose: Restoring shoulder function after axillary nerve injury is always a challenge. Transferring a branch of the radial nerve destined to the triceps onto the anterior division of the axillary nerve has become the preferred technique. However, this is not always possible, especially when the axillary nerve is severely injured around the posterior part of the humeral neck.

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Lip lift with advancement flap as nasal columella reconstruction.

Ann Chir Plast Esthet

January 2025

Department of Plastic, Reconstructive Surgery, Institut Universitaire Locomoteur et du Sport, Pasteur 2 Hospital, University Côte d'Azur, Nice, France. Electronic address:

Basocellular carcinomas are characterized by their non-deep spread neoplastic nature. Although treatment typically proceeds without complication, excision in critical facial regions can lead to aesthetically undesirable defects. Furthermore, elderly patients often express aesthetic concerns, particularly regarding the thinning of the upper lip over time.

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Hand and wrist complete degloving: A case report and litterature review.

Ann Chir Plast Esthet

October 2024

Department of Plastic and Reconstructive Surgery, Institut Universitaire Locomoteur et du Sport, Pasteur 2 Hospital, University Côte d'Azur, Nice, France. Electronic address:

Introduction: Complete hand degloving injuries are traumatic avulsion injuries causing the skin to pull away from the underlying tissues and are most often caused by industrial machinery. We present the case of a degloving trauma of the whole fingers, hand, and wrist resulting in a "watch hand" by analogy with the "ring finger" and discuss alternatives and recommendations from the rare cases described of similar traumas.

Case Presentation: A 33-year-old manual worker, a non-smoker with no significant medical or surgical comorbidities, was admitted for a complete skin avulsion of the left hand and wrist following a work-related accident with a trommel-type industrial roller.

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Posterior arm perforator flap for coverage of the scapular area.

Ann Chir Plast Esthet

January 2025

Department of Plastic and Reconstructive Surgery, institut universitaire locomoteur et du sport, Pasteur 2 Hospital, University Côte d'Azur, 30, voie Romaine, 06001 Nice, France. Electronic address:

We report on using a pedicled posterior brachial perforator flap to cover a defect of the infraspinous fossa. The first description of the posterior brachial flap came from Masquelet in 1985, and there are very few reports of this flap in the literature, mainly in its pedicled form limited to axillary covers. Scapular soft tissue defect with bone exposure can be covered by several techniques.

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Safety, tolerability, and efficacy of fasudil in amyotrophic lateral sclerosis (ROCK-ALS): a phase 2, randomised, double-blind, placebo-controlled trial.

Lancet Neurol

November 2024

Department of Neurology, Klinikum rechts der Isar, Technical University Munich, School of Medicine and Health, Munich, Germany; German Center for Neurodegenerative Diseases, Site Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. Electronic address:

Background: Fasudil is a small molecule inhibitor of Rho-associated kinase (ROCK) and is approved for the treatment of subarachnoid haemorrhage. In preclinical studies, fasudil has been shown to attenuate neurodegeneration, modulate neuroinflammation, and foster axonal regeneration. We aimed to investigate the safety, tolerability, and efficacy of fasudil in patients with amyotrophic lateral sclerosis.

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Intrafocal Pinning in Distal Extraarticular Radius Fracture: A Retrospective Study Based on Patient Age.

Plast Reconstr Surg Glob Open

October 2024

Department of Plastic and Reconstructive Surgery, Institut Universitaire Locomoteur et du Sport, Pasteur 2 Hospital, University Côte d'Azur, Nice, France.

Article Synopsis
  • Percutaneous intrafocal pinning is a surgical method for treating certain types of distal radius fractures, particularly when there is minimal comminution; this study examines its role and when it should be used.
  • A retrospective analysis of 49 patients revealed that complications, especially secondary displacements, were common, particularly in patients over 50 years old, prompting a reconsideration of this technique's suitability for older adults.
  • The study suggests that plate osteosynthesis is preferred as a first-line treatment for all patients, recommending intrafocal pinning only for younger patients when necessary, accompanied by strict immobilization for 6 weeks.
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Results of the AMIC® method in patients operated on for an osteochondral lesion of the talar dome (OLTD) at a mean follow-up of 34 months. A retrospective multicenter study.

Orthop Traumatol Surg Res

October 2024

Service de Chirurgie Orthopédique et Traumatologique, Hôpital d'Instruction des Armées Sainte-Anne, 2 Boulevard Sainte-Anne, 83000, Toulon, France.

Background: Symptomatic osteochondral lesions of the talar dome (OLTD) represent a real therapeutic challenge. In the absence of appropriate treatment, these lesions can evolve into tibiotalar osteoarthritis. Stage 3 lesion of the SFA classification and resistant to medical non-operative treatment may require surgical treatment.

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Purpose: To provide a detailed examination of the arterial blood supply to the middle third of the nasal skin through cadaveric dissections, identifying the primary arterial sources and their precise locations.

Methods: Cadaveric dissections were performed on 14 hemifaces from fresh specimens. The main feeding arteries and their branches were carefully dissected under magnification.

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Purpose: To explore the future of former anatomy tutors, their perception of the impact that the anatomy near-peer teaching (NPT) program have had on them, in terms of academic performance, professional development, personal growth, long-term anatomical knowledge, and views on body donor ethics. Additionally, we compared their academic performance with non-tutor peers in terms of ranking at the National Qualifying Examination (NQE).

Methods: A voluntary survey was emailed to all anatomy tutors from 2005 to 2024, using an online Google Forms questionnaire including closed and open-ended questions across four themes.

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Article Synopsis
  • The study investigates the effectiveness and safety of rozanolixizumab in treating patients with muscle-specific tyrosine kinase (MuSK) autoantibody-positive generalized myasthenia gravis (gMG), which is a severe form of the condition.
  • Conducted as a randomized, double-blind, placebo-controlled phase III trial, it involved participants aged 18 and older who were randomly assigned to receive either rozanolixizumab (at two different dosages) or a placebo over 6 weeks.
  • Results showed significant improvements in the Myasthenia Gravis Activities of Daily Living (MG-ADL) scores for both doses of rozanolixizumab compared to placebo, with manageable side effects reported;
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The effect of common parameters of bipolar stimulation on brain evoked potentials.

Clin Neurophysiol

November 2024

Neurosurgery Department, Pasteur 2 Hospital, University Hospital of Nice, France; UR2CA PIN, Université Côte d'Azur, France. Electronic address:

Objective: To identify optimal bipolar stimulation parameters for robust generation of brain evoked potentials (BEPs), namely the interelectrode distance (IED) and the intensity of stimulation (IS), in cortical and axonal stimulation.

Methods: In 15 patients who underwent awake surgery for brain tumor removal, BEPs were elicited at different values of IED and IS, respectively: 5 mm-5 mA, 5 mm-10 mA, and 10 mm-10 mA. The number of BEPs elicited by stimulation, as well as the delays and amplitudes of the N1 waves were compared between the different groups of stimulation parameters and according to the stimulated brain structure (cortical vs.

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Article Synopsis
  • Microsurgical free tissue transfer is critical for repairing significant bone or soft tissue injuries but is often seen as unfeasible in low- and middle-income countries due to the need for specialized training and resources.
  • A program in Cambodia, supported by non-governmental organizations, successfully performed 56 free flap surgeries from 2004 to 2023, training local surgeons while treating various reconstruction needs.
  • Despite facing a higher failure rate compared to high-income countries, the majority (83.3%) of patients showed improvement or complete resolution of their original issues, highlighting the potential for better outcomes with targeted solutions in low-resource settings.*
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Prediction of transfusion risk after total knee arthroplasty: use of a machine learning algorithm.

Orthop Traumatol Surg Res

September 2024

University Institute of Locomotor and Sport (IULS), Pasteur 2 Hospital, Nice, 30 Voie Romaine, 06000 Nice, France. Electronic address:

Introduction: Total knee arthroplasty (TKA) carries a significant hemorrhagic risk, with a non-negligible rate of postoperative transfusions. The blood-sparing strategy has evolved to reduce blood loss after TKA by identifying the patient's risk factors preoperatively. In practice, a blood count is often performed postoperatively but rarely altering the patient's subsequent management.

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Article Synopsis
  • ALS is a disease that affects nerve cells and usually leads to severe muscle problems and a short life expectancy of 3-5 years.
  • The study explored how cholesterol and its levels in muscle might relate to the problems caused by ALS, showing that ALS patients had more cholesterol in their muscles.
  • Researchers noticed that certain genes related to cholesterol movement were overactive in ALS patients, suggesting that cholesterol buildup might be linked to the severity of their muscle issues.
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Purpose: The aberrant anterior tibial artery (ATA) runs along the posterior surface of the tibial cortex making it, particularly, at risk during high tibial osteotomy (HTO). This study aimed to analyze the prevalence of the ATA according to global morphotype and its anatomical features in consideration of knee surgery.

Methods: This retrospective study included 1589 knees on magnetic resonance imaging (MRI) studies with long-leg radiographs.

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Feasibility and Safety of Lateral and Posterolateral Percutaneous Vertebroplasty of Osteolytic C1-C2 Lesions under Computed Tomography Guidance and Local Anesthesia.

J Vasc Interv Radiol

December 2024

Department of Radiology, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Department of Radiology, European Georges Pompidou Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.

Purpose: To evaluate the safety and effectiveness of lateral or posterolateral percutaneous vertebroplasty (PVP) of osteolytic C1-C2 lesions performed under computed tomography (CT) guidance and local anesthesia.

Materials And Methods: A retrospective study of 16 consecutive patients (11 females and 5 males; aged from 24 to 86 years; median age, 65.5 years) who underwent 17 lateral or posterolateral PVP was performed.

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Comment on: Autonomic and Enteric Profiling May Help Predict Response to Diverse Obesity Therapies.

Obes Surg

September 2024

Centre Hospitalier Universitaire de Nice - Digestive Surgery and Liver Transplantation Unit, Archet 2 Hospital, 151 Route Saint Antoine de Ginestière, BP 3079, Cedex 3, Nice, France.

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Vascularized posterior interosseous nerve graft for digital neurovascular bundle reconstruction.

Hand Surg Rehabil

September 2024

Department of Plastic and Reconstructive Surgery, Institut Universitaire Locomoteur et du Sport, Pasteur 2 Hospital, Côte d'Azur University, Nice, France.

Introduction: Despite the progress in microsurgery in recent decades, neurovascular bundle defects during ring finger injuries still pose challenges for the surgeon. Usually, a reversed venous graft and a non-vascularized nerve graft are utilized to reconstruct this defect. One of the most common challenges encountered when using a venous graft is the caliber mismatch between the graft and the digital arterial ends.

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Purpose: The objective is to evaluate the orientation of the trochlear groove in patients with objective patellar instability (OPI) compared to a control group. The hypothesis is that the trochlear groove angle (TGA) is correlated with the severity of the trochlear dysplasia.

Methods: From 2019 to 2023, magnetic resonance imaging of 82 knees with OPI were compared with 82 control knees.

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Treatment decisions for neovascular age-related macular degeneration (nAMD) in the setting of individualised treatment regimens are adapted to disease activity. The main marker of disease activity and trigger for re-treatment with anti-vascular endothelial growth factor (anti-VEGF) agents is the presence of retinal fluid on optical coherence tomography (OCT). Recently, attention has focused on the impact of residual retinal fluid on nAMD management.

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