12 results match your criteria: "Paris. France (B.C.-V.); and University Paris-Descartes[Affiliation]"
Management of esogastric cancer in older patients.
Ther Adv Med Oncol
August 2024
Department of Digestive Surgery, Saint Louis Hospital, APHP, Université Paris Cité, Paris, France.
Article Synopsis
- Esogastric cancers commonly affect patients over 75, yet there's a lack of specific guidelines for their treatment, which is crucial due to the cancers' poor prognosis.
- Optimizing care through personalized approaches like geriatric assessments, prehabilitation, and minimally invasive surgeries can enhance treatment outcomes and reduce morbidity.
- Adaptations to treatment such as dose reductions for chemotherapy and exploring immunotherapy may benefit older patients, highlighting the need for better supportive care and further research in this demographic.
Remote Ischemic Conditioning With Medical Management or Reperfusion Therapy for Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.
Neurology
April 2024
From the Department of Neurology (Q.L., X.F., B.J., B.L., M.Y., Z.Q., Y.D.), The 903rd Hospital of The Chinese People's Liberation Army, Hangzhou; Intensive Care Unit of Department of Neurology (J.G.), Ningbo Medical Center Lihuili Hospital; Department of Neurology (H.-S.C.), General Hospital of Northern Theater Command, Shenyang, China; Department of Neurology (R.A.B.), Aarhus University Hospital, Denmark; Department of Neurology (D.C.H.), Medical College of Georgia, Augusta University, Augusta; Neurology and Stroke Center (F.P.), Versailles Mignot Hospital, Paris, France; Department of Neurology (P.K.), University of Cincinnati, OH; Department of Medicine and Neurology (B.C.V.C.), Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Boston Medical Center (M.A., T.N.N.), Boston University Chobanian and Avedisian School of Medicine, MA; Department of Neurology (J.L.S.), University of California in Los Angeles; Department of Neurology and Neurosurgery (R.G.N.), University of Pittsburgh Medical Center, PA; Department of Neurology (H.S.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou; and Department of Neurology (Q.Y.), Xinqiao Hospital of Army Medical University, Chongqing, China.
Background And Objectives: Remote ischemic conditioning (RIC) is a low-cost, accessible, and noninvasive neuroprotective treatment strategy, but its efficacy and safety in acute ischemic stroke are controversial. With the publication of several randomized controlled trials (RCTs) and the recent results of the RESIST trial, it may be possible to identify the patient population that may (or may not) benefit from RIC. This systematic review and meta-analysis aims to evaluate the effectiveness and safety of RIC in patients with ischemic stroke receiving different treatments by pooling data of all randomized controlled studies to date.
View Article and Find Full Text PDFEffect of the Factor XIa Inhibitor Asundexian According to Baseline Infarct Pattern and on MRI Covert Infarct Outcomes.
Stroke
February 2024
Department of Medicine (Neurology), Population Health Research Institute, McMaster University, Hamilton, ON, Canada (A.S., X.L., T.H., S.J.C., R.G.H.).
Background: Exploratory analysis of the phase 2 PACIFIC-Stroke (Program of Anticoagulation via Inhibition of FXIa by the Oral Compound BAY 2433334-Non-Cardioembolic Stroke) randomized trial suggested that asundexian, an oral factor XIa inhibitor, prevents recurrent stroke and transient ischemic attacks in patients with atherosclerotic stroke. In this post hoc exploratory analysis, we hypothesized that asundexian would be more effective in patients enrolled with large, multiple, or cortical acute infarcts on magnetic resonance imaging than in patients enrolled with a single small subcortical acute infarct, and asundexian would prevent incident cortical covert infarcts.
Methods: In this placebo-controlled double-blinded randomized controlled trial, patients with mild-to-moderate noncardioembolic ischemic stroke were assigned to asundexian (10, 20, or 50 mg once daily) or placebo, in addition to antiplatelet therapy.
Global Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events: A 1-Year Follow-up.
Neurology
January 2023
From the Department of Neurology (T.N.N., P.K., Anvitha Sathya, H.C.L., Andreas Charidimou, Judith Clark, S.K.F., J.R.R.), Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine; Department of Radiology (T.N.N., M.M.Q., P.K., Mohamad Abdalkader, Anvitha Sathya, H.C.L., N.L.K.), Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine; Department of Radiation Oncology (M.M.Q.), Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine; Department of Stroke Neurology (H.Y.), National Hospital Organization, Osaka National Hospital, Japan; Department of Neurology (R.M., Petra Sedova), International Clinical Research Centre, St Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic; 2nd Department of Neurology (Anna Czlonkowska, M.A.K.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Internal Medicine and Cardiology (Petra Sedova), University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Neurology (O.Y.M.), Alexandria University Stroke and Neurointervention Unit, Egypt; Department of Neurology (H.R.V., K.U.), Cleveland Clinic; Centre Hospitalier de l'Université de Bordeaux (E.L.), INSERM, Bordeaux Population Health Research Center, France; Second Department of Neurology (Georgios Tsivgoulis, Lina Palaiodimou), "Attikon" University Hospital, National and Kapodistrian University of Athens, Greece; Ohio Health Riverside Methodist Hospital (A.I.L.); Neurology Department (J.D., Robin Lemmens), Leuven University Hospital, Belgium; University of Tennessee Health Science Center (V.I., N.G.); Cooper Neurological Institute (J.E.S., J.W.), Cooper University Hospital, Camden, NJ; Department of Neurology (Shadi Yaghi), Rhode Island Hospital, Brown University, Providence; Stroke Center (D.A.S.), Centro Hospitalar Universitário Lisboa Central-CHULC, Portugal, CEEM; Institute of Anatomy (D.A.S.), Faculdade de Medicina, Universidade de Lisboa, Portugal; Department of Neurology (Mahmoud Mohammaden, D.C.H.), Grady Memorial Hospital, Emory University School of Medicine, Atlanta, GA; Department of Neurology (E.S.K.), Akershus University Hospital, University of Oslo, Norway and Department of General Practice, University of Oslo, Norway; Division de Neurologia Vascular (V.P.L.), Departmento de Neurologia, Institute for Neurological Research-FLENI, Buenos Aires, Argentina; Stroke Unit (S.D.S.), Ramos Mejia Hospital, Buenos Aires, Argentina; Department of Medicine and Neurology (B.C.V.C.), Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia; Royal North Shore Hospital (Alice Ma), Sydney, Australia; Department of Neurophysiology (J.O.T), Liverpool Hospital, New South Wales, Australia; Department of Neurology (M.W.P.), Liverpool Hospital, New South Wales, Australia; Departments of Neurology (Shaloo Singal) and Radiology (L.-A.S.), Monash Medical Centre, Australia; Stroke and Aging Research Group (Shaloo Singhal), School of Clinical Sciences at Monash Health, Monash University, Australia; Department of Neurology (Rodrigo Tomazini Martins), Mater Hospital, Brisbane, Australia; Department of Neurology (Chris Enzinger), Medical University of Graz, Austria; Department of Neurology and Division of Neuroradiology (T.G.), Vascular and Interventional Radiology, Medical University of Graz, Austria; Department of Neurology (Aminur Rahman), Sir Salimullah Medical College, Mitford, Dhaka, Bangladesh; Hopital Erasme (T.B., N.L.), Brussels, Belgium; Department of Neurology (S.D.R., F.V.), Universitair Ziekenhuis Brussel, Center for Neurosciences, Vrije Universiteit Brussel, Belgium; Department of Neurology (P.V.), University Hospitals Antwerp; Department of Translational Neuroscience (P.V.), University of Antwerp, Belgium; Hospital das Clínicas (A.B.C., I.L.S.), São Paulo University, Brazil; Department of Neurology and Interventional Neuroradiology (R.C.T.H.), Hospital de Base de São José do Rio Preto, São Paulo, Brazil; Department of Neurology (L.O.N., I.B.S.), Hospital São Carlos, Fortaleza, Ceará, Brazil Stroke Unit (Rodrigo Targa Martins), Neurology, Nossa Senhora da Conceição Hospital, Porto Alegre, Brazil; Moinhos de Vento Hospital (D.L.M.C.), Brazil; Hospital de Base do Distrito Federal (L.C.R.), Brasilia, Brazil; St. Anna University Hospital (T.S., Rosen Kalpachki, F.A.), Sofia, Bulgaria; Department of Neurology (Luciana Catanese), McMaster University, Hamilton, Canada; Department of Diagnostic Radiology (E.A.C.), Halifax Infirmary, Dalhousie University, Halifax, Canada; Departments of Clinical Neurosciences and Radiology (M.G., M.D.H.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Canada; Royal University Hospital (M.E.K., Lissa Peeling), Saskatoon, Saskatchewan, Canada; Department of Neurology (H.K.), Hurvitz Brain Sciences Program, Sunnybrook Health Sciences Centre, Division of Neurology, Department of Medicine, University of Toronto, Canada; Hopital Enfant Jesus (Pascale Lavoie), Centre Hospitalier de l'Université Laval, Quebec City, Canada; Toronto Western Hospital (A.P.), University of Toronto, Canada; Neuroradiology Department (R.R.), Instituto de Neurocirugía Dr. Asenjo, Santiago, Chile; Department of Neurology (H.-S.C.), General Hospital of Northern Theater Command, Shen Yang, China; Department of Neurology (Y.C., Shuiquan Yang), Foshan Sanshui District People's Hospital, China; Interventional Neuroradiology (X.H., Z.M.), Beijing Tiantian Hospital, China; Department of Neurology (M.R.B.), Sestre Milosrdnice University Hospital Center, Croatia; Department of Neurology (Marina Bralic), Clinical Hospital Center Rijeka, Croatia; Sveti Duh University Hospital - Zagreb (H.B.), Department of Neurology, Croatia; J.J. Strossmayer University of Osijek (H.B.), Faculty of Medicine, Department of Neurology and Neurosurgery, Osijek, Croatia; Department of Neurology (A.B.C.-Q.), Hospital Departamental Universitario del Quindío San Juan de Dios, Colombia; Department of Neurology (O.E.L.-S.), Clínica de la Costa, Barranquilla, Colombia; Department of Neurology (Martin Cabal), Faculty Hospital Ostrava, Czech Republic; Department of Neurology (D.T.), Blansko Hospital, Czech Republic; Oblastní Nemocnice Trutnov a.s. (Petr Fibrich), Czech Republic; Department of Neurology (R.H.), Comprehensive Stroke Center, Charles University Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic; Neurology (H.H.), Hospital Příbram, Czech Republic; Uherskohradišťská Hospital (E.H.), Czech Republic; Department of Neurology (D.H.), Thomayer University Hospital Prague, Czech Republic; Neurocenter (L.J.), Regional Hospital Liberec, Czech Republic; Neurology (Jana Kadlcikova), Hospital Vyskov, Czech Republic; Regional Hospital Karlovy Vary (Igor Karpowicz), Czech Republic; Ostrava (L.K.), Czech Republic; Na Homolce Hospital (Martin Kovar), Czech Republic; Department of Neurology (D.L.), Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Czech Republic; Department of Neurology (J.N.E.S.O.), Krajská zdravotní, a.s.-Hospital Chomutov, Chomutov, Czech Republic; Karvina Mining Hospital (H.P.), Czech Republic; Neurology (Martin Reiser), České Budejovice Hospital, Czech Republic; Department of Neurology and Centre of Clinical Neuroscience (Petra Rekova), First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic; Department of Neurology (V.R.), University Hospital Plzen, Czech Republic; Department of Neurology (O.S.), Hospital Jihlava, Czech Republic; Department of Neurology (M.Š.), Masaryk University Faculty of Medicine, University Hospital Brno, Czech Republic; Oblastni Nemocnice Kladno (L.S.), Czech Republic; Central Military Hospital in Prague (Martin Sramek), Czech Republic; Nemocnice Třinec (Lenka Zakova), Czech Republic; Copenhagen University Hospital (H.C., N.D.), Denmark; Stroke Center (H.K.I., T.C.T.), Rigshospitalet, University of Copenhagen, Denmark; Neurovascular Center (T.W.), Zealand University Hospital, University of Copenhagen, Roskilde, Denmark; El hussein Alzahar University Hospital (Khalid Sobh), Egypt; Neurocenter (P.Y.), Turku University Hospital, Turku University, Finland; Department of Radiology (K.A.), Turku University Hospital, Finland; Department of Neurology (Daniel Strbian), Helsinki University Hospital and University of Helsinki, Finland; Bayonne Hospital Neurology (P.B.), Stroke Unit, France; Libourne Hospital Neurology (Philippe Casenave), Stroke Unit, France; Centre Hospitalier d'Arcachon-Neurologie (Maria Dan), France; Agen Hospital Neurology (J.-M.F.), Stroke Unit, France; Neuroradiologie Interventionelle (J.-C.G.), Brest University Hospital, France; Neurochirurgie (E.M.), Brest University Hospital, France; Department of Neurology (C.S.), Rothschild Foundation Hospital, Paris, France; Lariboisiere Hospital (Peggy Reiner), Paris, France; Bordeaux University Hospital Neurology (F.R.), Stroke Unit, France; Department of Neurology (F.O.B.), University Hospital, Goethe University, Frankfurt, Germany; Department of Neurology (Stefan Boskamp, Michael Rosenkranz), Albertinen Krankenhaus, Hamburg, Germany; Department of Neurology and Stroke (Joshua Mbroh, S.P.), Eberhard-Karls University, Tuebingen, Germany; Hertie Institute for Clinical Brain Research (Joshua Mbroh, S.P.), Eberhard-Karls University, Tuebingen, Germany; Department of Neurology (Simon Nagel), Klinikum Ludwigshafen, Ludwigshafen/Rhein, Germany; Department of Neurology (Simon Nagel, P.A.R.), Heidelberg University Hospital, Germany; Department of Neurology and Experimental Neurology (C.H.N.), Center for Stroke Research Berlin, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Germany; Universitätsklinikum Hamburg-Eppendorf (Götz Thomalla), Klinik und Poliklinik für Neurologie, Hamburg, Germany; Second Department of Neurology (Theodoros Karapanayiotides, Ioanna Koutroulou), AHEPA University Hospital, Aristotle University of Thessaloniki, School of Medicine, Faculty of Health Sciences, Greece; Stroke Unit (O.K.), Metropolitan Hospital, Piraeus, Greece; Hospital General San Juan de Dios (J.D.B.G.), Guatemala; Mazumdar Shaw Medical Center (V.H.), Bangalore, Karnataka, India; Department of Neurology (Bindu Menon), Apollo Specialty Hospitals Nellore, Andhra Pradesh, India; Department of Neurology (Shashank Nagendra), Grant Medical College and Sir JJ Hospital, Mumbai, India; Mazumdar Shaw Medical Center (C.P.), Bangalore, Karnataka, India; Sree Chitra Tirunal Institute for Medical Sciences and Technology (P.N.S.), Trivandrum, Kerala, India; Department of Neurology (N.A.K.P.), Faculty of Medicine Udayana University, Sanglah General Hospital Denpasar, Bali, Indonesia; Dr. Soetomo General Hospital Surabaya (A.F.S.), Universitas Airlangga, Indonesia; Stroke Research Group (A.G.), Head of Stroke Care Unit, Department of Neurology, Vali-e-Asr Hospital, School of Medicine, Zanjan University of Medical Sciences, Iran; Neurosciences Research Center (Mehdi Farhoudi, E.S.H.), Imam Reza Hospital, Tabriz University of Medical Sciences, Iran; Neurology Department (T.A.R., S.I.S.), Hillel Yaffe Medical Center, Hadera, Israel; Neurointerventional Unit (S.A.K., Levite Ronen), Shamir Medical Center, Israel; Stroke Unit (Maurizio Acampa), University of Siena, Italy; Stroke Center IRCCS Sacro Cuore Don Calabria (A.A.), Verona, Italy; Dipartimento di Neuroradiologia Diagnostica e Interventistica Policinico Universitario IRCCS San Martino (Lucio Castellan, C.R.B.), Genova, Italy; Neurology and Stroke Unit (M.L., Michele Romoli), Ospedale Bufalini, Cesena, Italy; Neuroscience Section (R.O., Simona Sacco), Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; Interventional Neurovascular Unit (Leonardo Renieri), Careggi University Hospital, Florence, Italy; Neurological Department (Andrea Salmaggi, Davide Sangalli), "Alessandro Manzoni" Hospital, ASST Lecco, Via dell'Eremo, Italy; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Neurologia e Rete Stroke Metropolitana, Italy; Department of Neurosurgery (R.D., N.K.), Iwate Prefectural Central Hospital, Japan; Department of Neurology (H.F.), Japanese Red Cross Matsue Hospital, Japan; Department of Neurosurgery (T.F.), National Hospital Organization Osaka National Hospital, Japan; Department of Endovascular Surgery (K.F.), Tokyo Medical and Dental University, Japan; Department of Neurosurgery (H.I., N.S.), Kobe City Medical Center General Hospital, Japan; NTT Medical Center Tokyo (Takuya Kanamaru), Japan; Department of Neurology (Ryuhei Kono), Kin-ikyo Chuo Hospital, Japan; Shiroyama Hospital (K.M.), Japan; Department of Neurology (Manabu Sakaguchi), Osaka General Medical Center, Japan; Department of Neurology (Kenichiro Sakai), The Jikei University School of Medicine, Japan; Department of Neurology (Kazutaka Sonoda), Saiseikai Fukuoka General Hospital, SFGH, Japan; Stroke Center (Kenichi Todo), Osaka University Hospital, Japan; Department of Neurology (Fumio Miyashita), Kagoshima City Hospital, Japan; Department of Neurology (N.T.), Japanese Red Cross Kyoto Daini Hospital, Japan; Department of Stroke and Cerebrovascular Diseases (Y.M.), University of Tsukuba Hospital, Japan; Comprehensive Strokology (S.M.), Fujita Health University School of Medicine, Toyoake, Japan; Department of Neurology (N.O.), Kobe City Medical Center General Hospital, Japan; Department of Neurology (Seigo Shindo), Japanese Red Cross Kummoto Hospital, Japan; Osaka Red Cross Hospital (Y.T.), Japan; Department of Neurology (Takeshi Yoshimoto), National Cerebral and Cardiovascular Center, Japan; Department of Cerebrovascular Medicine (Kazunori Toyoda), National Cerebral and Cardiovascular Center, Japan; Cerebrovascular Medicine (T.U.), Stroke Center, Saga Medical Centre Koseikan, Japan; Stroke Medicine (Yoshiki Yagita), Kawasaki Medical School, Japan; Department of Neurology and Stroke Treatment (Takehiro Yamada), Japanese Red Cross Kyoto Daiichi Hospital, Japan; Advanced Brain Research (N.Y.), Tokushima University, Japan; Yokohama Brain and Spine Center (R.Y.), Japan; Department of Stroke Neurology (Yukako Yazawa), Kohnan Hospital, Sendai, Japan; Toyonaka Municipal Hospital (Y.S.), Japan; Kenyatta University Teaching (P.K.W.), Referral and Research Hospital, Kenya; Department of Neurology (J.-H.B.), Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Neurology (S.B.L.), Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, South Korea; Department of Neurology (K.-D.S.), National Health Insurance Service Ilsan Hospital, Goyang, Korea; Department of Neurology (S.-I.S.), Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea; Department of Urgent Neurology (A.A.A.), University Clinic of Neurology, University Ss. Cyril and Methodius-Faculty of Medicine, Skopje, North Macedonia; Hospital Sultan Abdul Halim (Y.C.C.), Malaysia; Department of Medicine (W.A.W.Z.), National University of Malaysia; Department of Surgery (A.S.J.), National University of Malaysia; Neurovascular Unit and Neurology Department (F.G.-R., A.I.-V.), University Hospital Jose Eleuterio Gonzalez, Universidad Autonoma de Nuevo Leon, Mexico; Department of Neurology (M.M.-M.), Hospital de especialidades del Centro Médico Nacional Siglo XXI IMSS, Mexico; "Nicolae Testemitanu" State University of Medicine and Pharmacy (S.G., Pavel Leahu); Emergency Medicine Institute (L.P., S.G.), Chisinau, Republic of Moldova; Amsterdam University Medical Centers Amsterdam (J.M.C., L.A.R.), the Netherlands; Departments of Neurology (D.W.J.D.) and Neurology and Radiology (D.H.K.D.-N.), Erasmus University Medical Center Rotterdam, the Netherlands; Department of Medicine (Annemarei Ranta), University of Otago-Wellington, and Department of Neurology, Wellington Hospital, New Zealand; Department of Neurology (T.Y.W.), Christchurch Hospital, New Zealand; Department of Medical Records (T.T.A.), Federal Medical Centre, Owo, Ondo State, Nigeria; Neurology Unit (A.H.B., K.W.W.), University of Ilorin, Nigeria; Neurology Unit (E.O.N.), Department of Medicine, Federal Medical Centre Owerri, Neurology Unit, Federal Medical Centre, Owerri, Nigeria; Neurology Unit, Department of Medicine, (T.A.S.) Federal Medical Center, Owo, Ondo State, Nigeria; Department of Neurology (O.M.R.), Akershus University Hospital, Norway, and Institute of Clinical Medicine, University of Oslo, Norway; Department of Neurology (E.C.S.), Oslo, Oslo, Norway and The Norwegian Air Ambulance Foundation, Norway; Central Stroke Unit (A.M.A.H.), Neuroscience Directorate, Khoula Hospital, Ministry of Health, Oman; Lahore General Hospital (S.A., U.R.), Pakistan; Departamento de Neurología (L.R.-K., M.Á.V.), Hospital Nacional Edgardo Rebagliati Martins,Essalud, Lima, Perú; St. Luke's Medical Center (P.M.Y.), Global City, Philippines; St. Luke's Medical Center (J.S.H.D., M.C.P.-F., C.O.C.), Quezon City, Philippines; Department of Neurology (W.B.), Specialist Hospital Konskie, Collegium Medicum, Jan Kochanowski University, Kielce, Poland; Clinic of Neurology (Aleksander Debiec, J.S.), Military Institute of Medicine, Warsaw, Poland; Department of Neurology (Malgorzata Dorobek), Central Clinical Hospital of the Ministry of Interior and Administration (M.D.), Warsaw, Poland; Department of Neurology (B.M.L.-R.), St. Jadwiga Provincial Specialist Hospital in Opole, Institute of Medical Sciences, University of Opole, Poland; Department of Neurology (A.L.-B.), Leszek Giec Upper Silesian Medical Centre of the Silesian Medical University in Katowice, School of Health Sciences, Medical University of Silesia in Katowice, Poland; 1st Department of Neurology (H.S.-J.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Neurology in Sandomierz (Piotr Sobolewski), Collegium Medicum, Jan Kochanowski University in Kielce, Sandomierz, Poland; Department of Neurology (M.W.), Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland; Department of Neurology (J.Z.-T.), Central Clinical Hospital of the Ministry of Interior, Warsaw, Poland; Department of Neurology (J.Z.-T.), Central Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, Poland; Neuroradiology Department-Centro Hospitalar de Vila Nova de Gaia/Espinho (A.P.A.), Portugal; Neurology Department (Mariana Rocha), Centro Hospitalar Vila Nova de Gaia/Espinho; Department of Neurology (Pedro Castro), Centro Hospitalar Universitário de São João, Portugal; Stroke Unit-Hospital Pedro Hispano (V.T.C., P.V.F.), Matosinhos, Portugal; Stroke Unit (Patricia Ferreira, A.P.N.), Centro Hospitalar Universitário de Lisboa Central, Portugal; Stroke Unit (Luisa Fonseca), Medicine Department, Centro Hospitalar Universitário de São João, Portugal; Department of Neurology (J.P.M.), Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal; Hospital de Santa Maria-Centro Hospitalar Lisboa Norte (T.P.M.), Portugal; Department of Neurology (Miguel Rodrigues), Hospital Garcia de Orta, Almada, Portugal; Centro Hospitalar Universitário de São João (M.L.S.), Portugal; Bucarest University Emergency Hospital (Adela Dimitriade), Romania; Department of Neurology (C.F.-P.), County Clinic Hospital, Faculty of Medicine, Transilvania University, Brasov, Romania; Department of Neurology King Fahad Hospital of the University Imam Abdulrahman bin Faisal University Dammam (M.A.H.), Saudi Arabia; Raffles Hospital (N.V.), Singapore; Department of Neurology (G.K., Miroslav Mako), Faculty Hospital Trnava, Slovakia; Jessenius Medical Faculty (G.K., M.M.), Martin, Commenius University, Bratislava, Slovakia; Department of Neurology (G.K.), Slovak Medical University, Bratislava; Complejo Hospitalario Universitario de Albacete (O.A.-M., F.H.-F.), Albacete, Spain; Interventional Neuroradiology (J.B.), Hospital Clínic de Barcelona, Spain; Comprehensive Stroke Center (A.R.-V.), Hospital Clínic de Barcelona, Spain; Department of Neurology (Unidad de Ictus) (A.C.-C.), Hospital Universitario Ramón y Cajal, Madrid, Spain; Stroke Unit (Francisco Moniche), Neurology Department, Hospital Universitario Virgen del Rocío, Spain; Department of Neurology (Joan Montaner, S.P.-S.), Hospital Universitario Virgen Macarena & Neurovascular Research Laboratory, Instituto de Biomedicina de Sevilla-IbiS, Spain; Department of Neuroradiology (M.J.G.S.), Hospital Universitario Rey Juan Carlos, Spain; Department of Neurology (M.G.R.), Hospital Universitario Rey Juan Carlos, Spain; Institute of Neuroscience and Physiology (K.J., A.N.), Department of Clinical Neuroscience, Sahlgrenska Academy, University of Gothenburg; Department of Neurology (K.J., A.N.), Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden; Department of Neurology (M.V.M., T.T.P.M.), Karolinska University Hospital & Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden; Interventional Neuroradiology (G.B.), University Hospitals of Geneva, Switzerland; Department of Neurology (Morin Beyeler, U.F.), Inselspital, Bern University Hospital; Neurocenter (Manuel Bolognese), Cantonal Hospital of Lucerne, Switzerland; Department of Neurology (E.C.), University Hospitals of Geneva, Switzerland; Diagnostic and Interventional Neuroradiology (T.D.), Bern University Hospital, University of Bern, Switzerland; Radiology and Nuclear Medicine (G.M.K.), Cantonal Hospital of Lucerne, Switzerland; University Hospital (E.K.), University of Zurich, Switzerland; Department of Neurology (C.Y.H.), Tainan Sin Lau Hospital, Taiwan; Department of Radiology (Surawan Boonyakarnkul), Ramathibodi Hospital, Mahidol University, Thailand; Department of Radiology (Anchalee Churojana), Siriraj Hospital, Mahidol University, Thailand; Eskisehir Osmangazi University (O.A., M.D.O.), Turkey; Istanbul Aydın University (A.B., Songul Senadim), Florya Medicalpark Stroke Center, Turkey; Cleveland Clinic Abu Dhabi (S.I.H., S.J.), UAE; Department of Stroke Medicine (Soma Banerjee, Joseph Kwan), Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, United Kingdom; Stroke (K.K.), Department of Medicine (K.K.), Nottingham University Hospitals NHS Trust, United Kingdom; Neuroradiology (Robert Lenthall), Nottingham University Hospitals NHS Trust, United Kingdom; Barking Havering and Redbridge University Hospitals (Ashok Matthews), Romford, United Kingdom; Royal London Hospital (K.W.), Barts Health NHS Trust, United Kingdom; St George's University Hospital (Liqun Zhang), London, United Kingdom; Valley Hospital Health System (D.A.), Neurosurgeons of NJ, New Jersey; Amita Health and University of Illinois-Chicago (K.S.A.); Inova Fairfax Hospital (Z.B.), Virginia; Neuroscience and Stroke Program (K.B., O.O.Z.), Bon Secours Mercy Health St Vincent Hospital, Toledo, OH; Loyola University Chicago Stritch School of Medicine (J.B.A.N.A., S.R.), Illinois; Inova Fairfax Hospital (S.A.C.), University of Virginia School of Medicine, Virginia; Rush University Medical Center (Michael Chen, Y.R.), Chicago, IL; Department of Neurology (Alex Chebl), Henry Ford Health System, Detroit, MI; Clinical Data Specialist (Jackie Cibulka), EBC Data Abstraction, University of Tennessee Health Science Center; Solution Architect II (Leon Cistrunk), Clinical Decision Support, University of Tennessee Health Science Center; Department of Radiology (Marco Colasurdo), University of Texas Medical Branch, Galveston, TX; Neurology (Alexandra Czap, S.A.S.), UTHealth McGovern Medical School, Houston, TX; Department of Neurology (A.H.), Yale University School of Medicine, New Haven; Brigham and Women's Hospital (S.D.A., A.A.D.), Boston; Baptist Health Medical Center-Little Rock (S.D., K.B.G.), Little Rock, AR; Neurointerventional Program (A.A.D.), Departments of Medical Imaging and Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, ON; Neuroendovascular Program (A.A.D.), Massachusetts General Hospital & Brigham and Women's Hospital, Harvard Medical School, Boston; Department of Neurology (M.R.E., N.S.R.), Massachusetts General Hospital, Boston; Department of Interventional and Vascular Neurology (Chizoba Ezepue), Neuroscience Center, SSM Health DePaul Hospital, St. Louis, Missouri; University of Iowa (Mudassir Farooqui, S.O.G.); Santa Barbara Cottage Hospital (Lauren Fink, R.A.T.), California; Department of Neurology (U.G.), Saint Louis University School of Medicine, Missouri; Department of Neurology (A.K.G., S.L.), Wake Forest Baptist Medical Center, NC; Wayne State University (M.H.G.N.P., A.M.K.), Detroit, MI; Department of Neurosciences and Comprehensive Stroke Center (M.H., Muhib Khan), Spectrum Health and Michigan State University College of Human Medicine; Department of Neurology (D.J.), Grady Memorial Hospital, Emory University School of Medicine; Department of Neurosurgery (P.T.K.), University of Texas Medical Branch; Department of Neurology (Rakesh Khatri), Texas Tech University Health Science Center, El Paso; HSHS St. John's Hospital (N.N.K.), Southern Illinois University School of Medicine, Springfield; Virginia Hospital Center (B.S.K.); Baptist Health Medical Group (M.K.K.), Baptist Health Lexington, KY; Division of Neurointerventional Radiology (A.L.K., A.S.P.), Department of Radiology, University of Massachusetts Medical Center, Worcester, MA; Community Memorial Hospital (S.L.-H.C.A.,S.C.R.N., N.E.T.), Ventura, CA; Vascular and Neurointerventional Services (G.L.), Saint Louis University, Missouri; Miami Cardiac & Vascular Institute (I.L.), Miami Neuroscience Institute, FL; Dartmouth Hitchcock Medical Center (T.G.L., D.M.R.-S.), Lebanon, NH; Department of Neurology & Neurosurgery (S.S.M.), ECU Health Medical Center, Greenville, NC; Department of Neurology (L.M.), University of Kansas Medical Center; West Virginia University (John Mancin, Ansaar Rai); Department of Neurology (H.M., A.B.R.), SUNY Upstate, Syracuse, NY; Department of Neurology (G.A.M.), Medical University of South Carolina; Department of Neurosurgery (Andre Monteiro, A.H.S.), University at Buffalo; Department of Neurology (F.N.), Pediatrics, Emory University, Georgia; Department of Neurology (K.N.), University of Arkansas for Medical Sciences, Arkansas; Ascension St Johns Medical Center (R.H.R.), Tulsa, OK; Riverside Regional Medical Center (Pankajavalli Ramakrishnan), Newport News, VA; Department of Neurology (Aaron Rothstein), Hospital of the University of Pennsylvania, Philadelphia; University of Colorado School of Medicine (S.S.O.), Aurora, CO; Miami Neuroscience Institute (A.K.S.), Miami; UNC School of Medicine (M.J.W.), North Carolina; University of Utah (K.-H.W.); Hue Central (H.V.L., Q.V.N.), Vietnam; Da Nang Hospital (T.N.P., T.T.N.), Da Nang, Vietnam; Bach Mai Hospital (H.T.P., M.D.T.), Hanoi, Vietnam; Department of Neurology (U.F.), Basel University Hospital, University of Basel, Switzerland; Neurology Service (P.M., Davide Strambo), Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland; Department of Neurology (S.O.M.), Federal University of Rio Grande do Sul, Porto Alegre; Hospital de Clínicas de Porto Alegre (S.O.M.), Brazil; and Department of Neurology (R.G.N.), University of Pittsburgh Medical Center, Pittsburgh. Ondrej Skoda is currently at the Department of Neurology, Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic.
Background And Objectives: Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), IVT, and mechanical thrombectomy over a 1-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020).
View Article and Find Full Text PDFComparative immune profiling of acute respiratory distress syndrome patients with or without SARS-CoV-2 infection.
Cell Rep Med
June 2021
Centre Hospitalier Universitaire de Rennes, SITI, Pôle Biologie, 35033 Rennes, France.
Article Synopsis
- Acute respiratory distress syndrome (ARDS) is a common complication in severe COVID-19 cases that often leads to ICU admission.
- Researchers studied three groups of patients to compare the immune responses associated with COVID-19 ARDS and found a unique immune cell signature in those patients.
- This specific immune profile could lead to personalized treatment approaches for COVID-19-related ARDS, improving overall patient care in the ICU.
SARS-CoV-2 and Stroke Characteristics: A Report From the Multinational COVID-19 Stroke Study Group.
Stroke
May 2021
Neurology Department, Neuroscience Institute, Geisinger Health System, PA (S. Shahjouei, A. Mowla, D.C., C.J.G., R.Z.).
[Figure: see text].
View Article and Find Full Text PDFTenecteplase vs Alteplase Before Endovascular Therapy in Basilar Artery Occlusion.
Neurology
March 2021
From the Department of Medicine and Neurology (F. Alemseged, G.S., L.C., B.Y., M.W.P., S.M.D., P.J.M., N.Y. B.C.V.C.), University of Melbourne, and Department of Radiology (C.W., S.B., R.D.), Royal Melbourne Hospital, Parkville, Australia; Stroke Unit (F. Alemseged, A.R., F.S., M.D.) and Department of Biomedicine and Prevention (F.D.), University Hospital of Tor Vergata, Rome, Italy; Department of Neurology (F.C.N.), Austin Health, Melbourne, Australia; Department of Neurology (V.P.), Institute of Neuroradiology (D.K.), and Dresden Neurovascular Center (V.P., D.K.), University of Technology Dresden, Germany; Department of Interventional Neuroradiology (G.B.), Sainte-Anne-Hospital, Paris, France; Department of Neurology (T.J.K.), Royal Adelaide Hospital, Australia; Department of Neurology (T.Y.W.), Christchurch Hospital, New Zealand; Division of Medicine (D.S.), Princess Alexandra Hospital, Brisbane, Australia; NEUROFARBA Department (F. Arba), Careggi University Hospital, Florence; ASST Valcamonica (A.M.), Department of Neurology, Esine, Italy; Department of Neurosciences (H.M.D.), Eastern Health, Melbourne; Department of Neurology (P.B.), Gold Coast University Hospital, Queensland; Department of Neurology (B.O.), Gosford Hospital, New South Wales; and Population Health and Immunity Division (N.Y.), The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
Objective: To investigate the efficacy of tenecteplase (TNK), a genetically modified variant of alteplase with greater fibrin specificity and longer half-life than alteplase, prior to endovascular thrombectomy (EVT) in patients with basilar artery occlusion (BAO).
Methods: To determine whether TNK is associated with better reperfusion rates than alteplase prior to EVT in BAO, clinical and procedural data of consecutive patients with BAO from the Basilar Artery Treatment and Management (BATMAN) registry and the Tenecteplase vs Alteplase before Endovascular Therapy for Ischemic Stroke (EXTEND-IA TNK) trial were retrospectively analyzed. Reperfusion >50% or absence of retrievable thrombus at the time of the initial angiogram was evaluated.
Comparative Genome Analysis of 33 Strains Reveals Characteristic Features of and Closely Related Species.
Pathogens
October 2020
RNA Bioinformatics and High-Throughput Analysis, Friedrich-Schiller-Universität Jena, 07743 Jena, Germany.
To identify genome-based features characteristic of the avian and human pathogen and related chlamydiae, we analyzed whole-genome sequences of 33 strains belonging to 12 species. Using a novel genome analysis tool termed Roary ILP Bacterial Annotation Pipeline (RIBAP), this panel of strains was shown to share a large core genome comprising 784 genes and representing approximately 80% of individual genomes. Analyzing the most variable genomic sites, we identified a set of features of that in its entirety is characteristic of this species: (i) a relatively short plasticity zone of less than 30,000 nt without a tryptophan operon (also in ), (ii) a characteristic set of of Inc proteins comprising IncA, B, C, V, X, Y (with homologs in and as closest relatives), (iii) a 502-aa SinC protein, the largest among spp.
View Article and Find Full Text PDFThrombolysis in Cerebral Infarction 2b Reperfusions: To Treat or to Stop?
Stroke
November 2020
Department of Neurology (T.R.M., U.F.), University Hospital Bern, Inselspital, University of Bern, Switzerland.
In patients undergoing mechanical thrombectomy, achieving complete (Thrombolysis in Cerebral Infarction 3) rather than incomplete successful reperfusion (Thrombolysis in Cerebral Infarction 2b) is associated with better functional outcome. Despite technical improvements, incomplete reperfusion remains the final angiographic result in 40% of patients according to recent trials. As most incomplete reperfusions are caused by distal vessel occlusions, they are potentially amenable to rescue strategies.
View Article and Find Full Text PDFEffects in Cancer Cells of the Recombinant l-Methionine Gamma-Lyase from Encapsulation in Human Erythrocytes for Sustained l-Methionine Elimination.
J Pharmacol Exp Ther
June 2019
Assistance Publique-Hôpitaux de Paris, Hospital Paul-Brousse, Villejuif, France (D.M., J.H., E.G., R.S.,); INSERM U935, Villejuif, France (D.M., C.D., F.H.-R., C.B.); University Paris-Sud, Villejuif, France (D.M., J.H., C.D., R.M., F.H.-R., C.B., R.S.); University Paris-Saclay, Paris, France (D.M., J.H., C.D., R.M., F.H.-R., C.B., R.S.); University of Urbino Carlo Bo, Urbino, Italy (L.R., F.P., M.M.); INSERM U1193, Villejuif, France (J.H., R.S.); INSERM U1197, Villejuif, France (R.M.); INRA-AgroParisTech, UMR 782 GMPA, Thiverval-Grignon, France (P.Bo.); Institut Jean-Pierre Bourgin, INRA-AgroParisTech, University Paris-Saclay, Versailles, France (P.Br.); CRH-Department of Protein Biochemistry and Proteomics, Palacký University, Olomouc, Czech Republic (D.K.); YGM Consult SAS, Paris, France (Y.G.-M.); CNRS UMR 8601, Paris, France (J.D.); Assistance Publique-Hôpitaux de Paris, Hospital Necker-Enfants Malades, Paris. France (B.C.-V.); and University Paris-Descartes, Paris, France (B.C.-V., J.D.).
Methionine deprivation induces growth arrest and death of cancer cells. To eliminate l-methionine we produced, purified, and characterized the recombinant pyridoxal 5'-phosphate (PLP)-dependent l-methionine -lyase (MGL)- BL929 from the cheese-ripening Transformation of an strain with the gene from optimized for expression led to production of the MGL-BL929. Elimination of l-methionine and cytotoxicity in vitro were assessed, and methylation-sensitive epigenetics was explored for changes resulting from exposure of cancer cells to the enzyme.
View Article and Find Full Text PDFGlucose Modifies the Effect of Endovascular Thrombectomy in Patients With Acute Stroke.
Stroke
March 2019
Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology (A.M.D., M.A., M. Goyal, B.K.M.), Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Canada.
Background and Purpose- Hyperglycemia is a negative prognostic factor after acute ischemic stroke but is not known whether glucose is associated with the effects of endovascular thrombectomy (EVT) in patients with large-vessel stroke. In a pooled-data meta-analysis, we analyzed whether serum glucose is a treatment modifier of the efficacy of EVT in acute stroke. Methods- Seven randomized trials compared EVT with standard care between 2010 and 2017 (HERMES Collaboration [highly effective reperfusion using multiple endovascular devices]).
View Article and Find Full Text PDFAcute Stroke Imaging Research Roadmap III Imaging Selection and Outcomes in Acute Stroke Reperfusion Clinical Trials: Consensus Recommendations and Further Research Priorities.
Stroke
May 2016
From the Department of Neurology, Dell Medical School, University of Texas at Austin (S.J.W.); Stroke Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD (M.L.); Department of Neurology (G.W.A., M.G.L.), Department of Radiology (R.B.), Neuroradiology Section, Department of Radiology (J.J.H., M.P.M., M.W.), Stanford University School of Medicine, CA; Department of Neurology, John Hunter Hospital, Hunter Medical Research Institute, University of Newcastle, Callaghan, New South Wales, Australia (A.B., M.W.P.); Departments of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia (B.C.V.C.); Department of Radiology, University of Iowa Hospitals and Clinics Iowa City (C.D.); Departments of Neurology (P.K.) and Neuroadiology (A.V.), University of Cincinnati, OH; Neurovascular Imaging Research Core and UCLA Stroke Center, Department of Neurology, University of California, Los Angeles (D.S.L.); Department of Radiology, AMC, Amsterdam, The Netherlands (C.B.L.M.M.); Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (B.K.M.); Institute of Neurosciences and Psychology, University of Glasgow, Southern General Hospital, Glasgow, Scotland, United Kingdom (K.W.M.); Texas Stroke Institute, Plano (A.J.Y.); Department of Neurology, The University of Tennessee Health Science Center, Memphis (A.V.A.); INSERM U894, Centre Hospitalier Sainte-Anne, Sorbonne Paris Cité, Paris, France (J.-C.B.); Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom (J.-C.B.); Department of Neurosurgery, State University of New York at Stony Brook (D.J.F.); Department of Neurology, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH (A.J.F.); Department of Radiology, Hospital Josep Tru
Background And Purpose: The Stroke Imaging Research (STIR) group, the Imaging Working Group of StrokeNet, the American Society of Neuroradiology, and the Foundation of the American Society of Neuroradiology sponsored an imaging session and workshop during the Stroke Treatment Academy Industry Roundtable (STAIR) IX on October 5 to 6, 2015 in Washington, DC. The purpose of this roadmap was to focus on the role of imaging in future research and clinical trials.
Methods: This forum brought together stroke neurologists, neuroradiologists, neuroimaging research scientists, members of the National Institute of Neurological Disorders and Stroke (NINDS), industry representatives, and members of the US Food and Drug Administration to discuss STIR priorities in the light of an unprecedented series of positive acute stroke endovascular therapy clinical trials.