4 results match your criteria: "Paris-Saclay University and Versailles Saint-Quentin-en-Yvelines University[Affiliation]"
The singular French PCSK9-p.Ser127Arg gain-of-function variant: A significant player in cholesterol levels from a 775-year-old common ancestor.
Atherosclerosis
December 2024
Paris Cité University and Sorbonne Paris Nord University, INSERM UMRS 1148, Laboratory for Vascular Translational Science (LVTS), F-75018, Paris, France. Electronic address:
Article Synopsis
- PCSK9 is crucial for regulating LDL-cholesterol and certain variants, like p.Ser127Arg, lead to higher cholesterol levels and are mainly found in France, with few in South Africa and Norway due to a common ancestor effect.
- The study analyzed 14 p.Ser127Arg carriers from eight families and compared them with other variants to understand their genetic background and health impact.
- Results indicated that the common ancestor lived about 775 years ago, and carriers of p.Ser127Arg had significantly higher LDL-C levels, suggesting it may have a stronger effect on cholesterol levels compared to other mutations.
Translational research on cognitive impairment in chronic kidney disease.
Nephrol Dial Transplant
October 2024
Department of Physiology, Faculty of Pharmacy, University of Belgrade, Serbia.
Article Synopsis
- * Both traditional risk factors (like diabetes and high blood pressure) and kidney-specific factors (such as uremic toxins and chronic inflammation) can damage the blood-brain barrier and promote neuroinflammation, leading to cognitive impairments.
- * Recent animal model studies suggest new prevention and treatment strategies, focusing on the role of the blood-brain barrier, physical activity, and innovative therapies like SGLT2 inhibitors and GLP-1 receptor agonists in addressing cognitive decline in kidney disease.
Understanding adolescent consumption patterns and attitudes towards the "puff" on the path to a smoke-free generation: a 2022 French perspective.
Front Public Health
October 2024
Department of Epidemiology and Public Health, Raymond Poincaré Hospital, Garches, France.
Article Synopsis
- Tobacco use is a big problem in France, causing 75,000 deaths each year, and the country wants to have a smoke-free generation by 2032.
- A study in 2022 showed that many French teens are aware of and have tried a product called the "puff," which is more popular than cigarettes among them.
- Most teens think the "puff" is dangerous and polluting, but it still appeals to them because of its fun flavors and trendy image, which could make it harder to reach the smoke-free goal.
Cognitive disorders in patients with chronic kidney disease: Approaches to prevention and treatment.
Eur J Neurol
September 2023
INSERM (Institut National de la Santé et de la recherche médicale) Unit 1018, Clinical Epidemiology, CESP (Centre d'Epidemiologie et de Santé des Populations), Hôpital Paul Brousse, Paris-Saclay University and Versailles Saint-Quentin-en-Yvelines University, Villejuif, France.
Background: Cognitive impairment is common in patients with chronic kidney disease (CKD), and early intervention may prevent the progression of this condition.
Methods: Here, we review interventions for the complications of CKD (anemia, secondary hyperparathyroidism, metabolic acidosis, harmful effects of dialysis, the accumulation of uremic toxins) and for prevention of vascular events, interventions that may potentially be protective against cognitive impairment. Furthermore, we discuss nonpharmacological and pharmacological methods to prevent cognitive impairment and/or minimize the latter's impact on CKD patients' daily lives.