Meta-analyses of the effects of high-intensity interval training in elite athletes-part I: mean effects on various performance measures.

Introduction: Meta-analysts have found that high-intensity interval training (HIIT) improves physical performance, but limited evidence exists regarding its effects on highly trained athletes, measures beyond maximum oxygen uptake ( O), and the moderating effects of different types of HIIT. In this study, we present meta-analyses of the effects of HIIT focusing on these deficits.

Methods: The effects of 6 types of HIIT and other moderators were derived from 34 studies involving highly trained endurance and elite athletes in percent units via log-transformation from separate meta-regression mixed models for sprint, time-trial, aerobic/anaerobic threshold, peak speed/power, repeated-sprint ability, O, and exercise economy.

Understanding tinnitus symptom dynamics and clinical improvement through intensive longitudinal data.

Intensive longitudinal sampling enhances subjective data collection by capturing real-time, dynamic inputs in natural settings, complementing traditional methods. This study evaluates the feasibility of using daily self-reported app data to assess clinical improvement among tinnitus patients undergoing treatment. App data from a multi-center randomized clinical trial were analysed using time-series feature extraction and nested cross-validated ordinal regression with elastic net regulation to predict clinical improvement based on the Clinical Global Impression-Improvement scale (CGI-I).

Testing measurement invariance in a conditional likelihood framework by considering multiple covariates simultaneously.

This article addresses the problem of measurement invariance in psychometrics. In particular, its focus is on the invariance assumption of item parameters in a class of models known as Rasch models. It suggests a mixed-effects or random intercept model for binary data together with a conditional likelihood approach of both estimating and testing the effects of multiple covariates simultaneously.

Meta-analyses of the effects of high-intensity interval training in elite athletes - part II: relationships between the mean effects on various performance measures.

Introduction: Our recent meta-analyses have demonstrated that high-intensity interval training (HIIT) causes a range of mean changes in various measures and predictors of endurance and sprint performance in athletes. Here, we extend the analyses to relationships between mean changes of these measures and consider implications for understanding and improving HIIT that were not apparent in the previous analyses.

Methods: The data were mean changes from HIIT with highly trained endurance and elite other (mainly team sport) athletes in studies where two or more measures or predictors of performance were available.

Spin Excitations of High Spin Iron(II) in Metal-Organic Chains on Metal and Superconductor.

Many-body interactions in metal-organic frameworks (MOFs) are fundamental for emergent quantum physics. Unlike their solution counterpart, magnetization at surfaces in low-dimensional analogues is strongly influenced by magnetic anisotropy (MA) induced by the substrate and still not well understood. Here, on-surface coordination chemistry is used to synthesize on Ag(111) and superconducting Pb(111) an iron-based spin chain by using pyrene-4,5,9,10-tetraone (PTO) precursors as ligands.

Heparin Differentially Regulates the Expression of Specific miRNAs in Mesenchymal Stromal Cells.

In regenerative medicine, stromal cells are supposed to play an important role by modulating immune responses and differentiating into various tissue types. The aim of this study was to investigate the influence of heparin, frequently used as an anticoagulant in human platelet lysate (HPL)-supplemented cell cultures, on the expression of non-coding RNA species, particularly microRNAs (miRNA), which are pivotal regulators of gene expression. Through genomic analysis and quantitative RT-PCR, we assessed the differential impact of heparin on miRNA expression in various stromal cell types, derived from human bone marrow, umbilical cord and white adipose tissue.

BaTiO Nanoparticle Interfaces in Contact: Ferroelectricity Drives Tribochemically Induced Oxygen Radical Formation.

Chemical transformations at metal oxide interfaces that are triggered by mechanical energy set the basis for applications in the fields of tribo- and mechanochemistry, ceramic and composite processing, and piezoelectric devices. We investigated the early stages of tribochemically initiated radical chemistry of structurally well-defined TiO and BaTiO nanoparticles in argon or in oxygen atmosphere. Electron paramagnetic resonance spectroscopy enabled the determination of the chemical nature and concentration of paramagnetic surface species which form upon uniaxial powder compaction at room temperature.

Stress and the City: Mental Health in Urbanized vs. Rural Areas in Salzburg, Austria.

Background: Living in the city is associated with a higher risk of suffering from stress, anxiety, and depression. Due to an increase of migration to the city, the association between mental health and city life is highly relevant to society.

Methods: We analyzed data of 9573 participants (Ø 55.

Young athletes' mental well-being is associated with smartphone social networking application usage and moderated by performance level and app type.

Smartphones and social media have become an integral part of human daily life and they influence mental well-being. These accounts have been researched in the general population, but not in athletes. This is critical given enhanced physical and emotional stressors in athletes versus non-athletes.

Inside Ceramics and Between MgO Grains: Solid-State Synthesis of Intergranular Semiconducting or Magnetic Spinels.

Configurations of composite metal oxide nanoparticles are typically far off their thermodynamic equilibrium state. As such they represent a versatile but so far overlooked source material for the intergranular solid-state chemistry inside ceramics. Here, it is demonstrated how the admixture of Fe and In ions to MgO nanoparticles, as achieved by flame spray pyrolysis, can be used to engage ion exsolution, phase separation, and subsequent spinel formation inside the network of diamagnetic and insulating MgO grains.

Chronic tinnitus is associated with aging but not dementia.

Aim: Aging is related to deterioration of bodily and neural functions, leading to various disorders and symptoms, including the development of dementia, hearing loss, or tinnitus. Understanding how these phenomena are intertwined and how aging affects those is crucial for prevention and the future development of interventions.

Methods: We utilized the UK Biobank which includes a total of 502,382 participants between 40 and 70 years old.

To change, but not to preserve! Norm conformity following control threat only emerges for change norms but not for status quo norms.

Collectively pursuing social change may help people experience a sense of agency through their group when personal control is threatened, thereby restoring their sense of control. Accordingly, we proposed and found in two studies ( = 177 & 178) that following an experimentally manipulated threat to personal control, group members conform only to ingroup norms (vs. non-norms) framed as proposing social change, but not to those framed as preserving the status quo (in Study 1, we found this only for highly identified group members).

Hitting the Rewind Button: Imagining Analogue Trauma Memories in Reverse Reduces Distressing Intrusions.

Background: Intrusive re-experiencing of trauma is a core symptom of posttraumatic stress disorder. Intrusive re-experiencing could potentially be reduced by 'rewinding', a new treatment approach assumed to take advantage of reconsolidation-updating by mentally replaying trauma fast-backward.

Methods: The present analogue study was the first to investigate 'rewinding' in a controlled laboratory setting.

Apologizing for Intergroup Criticism Reduces Rejection of Public Health Officials' Pro-Vaccine Messages.

Compared to other medical experts, public health officials face added scrutiny of their pro-vaccine messages due to distrust of the US federal government. We consider reactions to such critical messages through the lens of conversational norms. Conversational pragmatics suggest that polite communication is essentially cooperative in nature, avoiding criticism of the other or excessive praise of the self.

Collective action control: Ubiquitous processes and cultural differences.

Humans have two superpowers: reaching desired end-states (goals) and working together (cooperation). We conceptualize these two capabilities as one: collective action control. We discuss ubiquitous processes and (potential) cultural differences in collective action control in the context of two established frameworks-social identity and norms-as well as an emerging attribution of intent perspective.

ADP-heptose attenuates -induced dendritic cell activation.

Sophisticated immune evasion strategies enable to colonize the gastric mucosa of approximately half of the world's population. Persistent infection and the resulting chronic inflammation are a major cause of gastric cancer. To understand the intricate interplay between and host immunity, spatial profiling was used to monitor immune cells in infected gastric tissue.

G-quadruplex forming regions in GCK and TM6SF2 are targets for differential DNA methylation in metabolic disease and hepatocellular carcinoma patients.

The alarming increase in global rates of metabolic diseases (MetDs) and their association with cancer risk renders them a considerable burden on our society. The interplay of environmental and genetic factors in causing MetDs may be reflected in DNA methylation patterns, particularly at non-canonical (non-B) DNA structures, such as G-quadruplexes (G4s) or R-loops. To gain insight into the mechanisms of MetD progression, we focused on DNA methylation and functional analyses on intragenic regions of two MetD risk genes, the glucokinase (GCK) exon 7 and the transmembrane 6 superfamily 2 (TM6SF2) intron 2-exon 3 boundary, which harbor non-B DNA motifs for G4s and R-loops.