Simultaneous progressive multifocal leukoencephalopathy, Epstein-Barr virus (EBV) latent infection and cerebral parenchymal infiltration during chronic lymphocytic leukemia.

We report a non-HIV patient who had B chronic lymphocytic leukemia (CLL) with progressive multifocal leukoencephalopathy (PML) and diffuse cerebral leukemic parenchymal infiltration in the presence of JC virus and Epstein-Barr virus (EBV) cerebral co-infection. Multiple subcortical hypodensities lining the cortico-subcortical junction were present within the white matter on computerized tomography (CT) scan, with large areas of high signal intensity on T2-weighted sequences on magnetic resonance imaging (MRI). JCV DNA was identified in peripheral blood nuclear cells and cerebrospinal fluid polymerase chain reaction (PCR) DNA/DNA hybridization plus Southern blot analysis.

Biological role of alpha-fetoprotein in the endocrinological field: data and hypotheses.

alpha-Fetoprotein (AFP), depending on the surrounding conditions, exerts different functions by different mechanisms. (1) A regulatory effect on the concentration of the unbound form of its various ligands (e.g.

Hereditary benign telangiectasia: two case reports.

We present two cases of hereditary benign telangiectasia (HBT) in which the genetic findings are compatible with an autosomal dominant hypothesis. The lesions persisted indefinitely for many years without effect on the general health of the patients. The term hereditary benign telangiectasia distinguishes the disorder from the more serious hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber).

Insulin secretion in adult rats after intrauterine exposure to mild hyperglycemia during late gestation.

We investigated the effects of intrauterine mild hyperglycemia during late fetal life on glucose regulation and insulin secretion in adult rats. Unrestrained pregnant rats were continuously infused with glucose during the last week of pregnancy to induce mild hyperglycemia (6.5-8 mM).

Granulomatous angiitis and cerebral amyloid angiopathy presenting as a mass lesion.

A woman, who presented with clinical and radiological signs of a right temporal mass suggestive of a brain tumour, was found to have granulomatous angiitis associated with cerebral amyloid angiopathy; the diagnosis was confirmed by biopsy. She is still well 13 years after excision of the lesion. The association of granulomatous angiitis and cerebral amyloid angiopathy constitutes a peculiar variety of central nervous system micro-angiopathy.

Longitudinal immunoblotting variations of auto-antibody reactivity of patients with systemic lupus erythematosus.

The purpose of this study was to examine longitudinally the different patterns of nuclear and cytoplasmic antigen recognition by sera from patients with SLE during clinical flare and remission using immunoblotting (IB) techniques. Serum samples (n = 150) were obtained from 35 SLE patients during a follow-up period averaging 4.7 years.

"Spontaneous" oral hygiene: a predictor for future preventive behavior?

The aim of this study was to establish whether a patient's "spontaneous" hygiene could be a reliable predictor of his or her tendency to maintain a certain permanent level of hygiene. The sample comprised 147 private periodontal patients whose plaque indices were recorded before (index 1) and after (index 2) a standardized hygiene program was carried out. According to their initial indices the patients were distributed in 10 classes (Class 0: from 0 to 10% using O'Leary's plaque index, class 1: from 11% to 20%, etc.

Improvement of oral hygiene habits: a psychological approach. 2-year data.

The present communication attempts to determine the effects of individual interviews, conducted by a psychologist, on unmotivated patients' oral hygiene habits. For this investigation, 26 subjects were selected according to the following main criteria: (a) patients with good motor skills (to make sure that poor hygiene was due to poor compliance and not to poor dexterity); (b) patients suffering from periodontitis of Cl II and Cl III of the Modified Nomenclature of the American Academy of Periodontology; (c) patients, who had never been taught toothbrushing techniques prior to attending 4 routine sessions on oral hygiene, and who in spite of understanding the pathogenic relation between plaque and disease, were unable to reach a plaque index score beneath the 50% level. The 26 selected patients were divided randomly into 2 equal groups.

Cefotaxime optimal dosage in adult patients. A reappraisal.

Cefotaxime, a third generation cephalosporin, is used throughout the world over a wide range of doses. The purpose of this paper is to discuss the rationale for determination of the optimal dosage and of adequate modes of administration. Among the factors determining in vivo activity, the most important are: (1) the time dependence of the antibacterial effect of cephalosporins, (2) the limited effect of increasing the drug concentration in contact with the bacteria and (3) the absence of a significant post-antibiotic effect.