184 results match your criteria: "Paris Saint Joseph Hospital[Affiliation]"

Multi-ancestry polygenic risk scores for venous thromboembolism.

Hum Mol Genet

September 2024

Transdivisional Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Dr, Rockville, MD 20850, United States.

Article Synopsis
  • Venous thromboembolism (VTE) poses significant health risks, with a notable difference in incidence rates between Black and White Americans.
  • Researchers developed polygenic risk scores (PRSs) for VTE using data from both European and African-ancestry populations to enhance predictive capability.
  • Results showed that multi-ancestry PRSs slightly outperformed ancestry-specific ones in predicting VTE risk, indicating potential benefits in using diverse data for better risk assessment across populations.
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Background: The effectiveness of physiotherapist-led Cognitive Behavioural Interventions (CBI) with or without physiotherapy is still unclear.

Objective: This systematic review (PROSPERO registration number CRD42022321073) aims to determine the effectiveness of physiotherapist-led CBI with or without physiotherapy in comparison to physiotherapy alone on quality of life, disabilities and catastrophization.

Methods: MEDLINE, Web of Science, Science Direct, and PEDro were searched for randomized controlled trials that investigate the use of CBI versus conventional physiotherapy in chronic NSLBP.

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The peptidyl-prolyl isomerase Pin1 controls GM-CSF-induced priming of NADPH oxidase in human neutrophils and priming at inflammatory sites.

Int Immunopharmacol

August 2024

INSERM-U1149, CNRS-ERL8252, Université de Paris-Cité, Centre de Recherche sur l'Inflammation, Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Paris F-75018, France. Electronic address:

The production of superoxide anions and other reactive oxygen species (ROS) by neutrophils is necessary for host defense against microbes. However, excessive ROS production can induce cell damage that participates in the inflammatory response. Superoxide anions are produced by the phagocyte NADPH oxidase, a multicomponent enzyme system consisting of two transmembrane proteins (gp91phox/NOX2 and p22phox) and four soluble cytosolic proteins (p40phox, p47phox, p67phox and the small G proteins Rac1/2).

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Background: Cervical cancer is the fourth most common cancer among women worldwide, both for incidence and mortality. Prevention relies on screening with a Pap test to detect precancerous lesions, which can then be treated. Access to this screening is currently both improvable and inequitable.

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Hepatocellular carcinoma (HCC) typically presents with a primary hepatic mass. Nevertheless, on rare occasions, the initial presentation can be exclusively related to extrahepatic metastases and the most common sites of metastases are the lungs, lymph nodes, bones, and adrenal glands. While, bone metastases are generally accompanied by multiple metastatic spreads elsewhere in the body or previously diagnosed HCC, cases of solitary bone metastases with no liver lesion at imaging have been reported.

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Article Synopsis
  • A Gram-negative bacillus, commonly linked to respiratory infections in animals, is also sporadically found in humans, mainly affecting those with weakened immune systems.
  • This text presents the first known case of acute bronchitis in an immunocompromised patient post-double-lung transplantation, where the bacterium was identified in lung fluid samples.
  • The case highlights the need for increased awareness among healthcare professionals regarding this bacterium, particularly its resistance to antibiotics, and emphasizes the need for more research on its impact and treatment in vulnerable patient populations.
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Aseptic meningitis and Fabry disease.

Ann Clin Transl Neurol

June 2024

Internal Medicine Department, Reference Centre for Lysosomal Diseases, Groupe Hospitalier Diaconesses Croix Saint-Simon, Paris, France.

Article Synopsis
  • Fabry disease results from a deficiency in the enzyme alpha-galactosidase A, leading to a buildup of glycosphingolipids and causing various health issues, including neurologic symptoms like neuropathic pain and strokes, with aseptic meningitis being a potential complication.
  • A study reviewed patients from 1995 to 2023, finding that 3.7% experienced aseptic meningitis, with additional data from published cases leading to a total of 29 patients analyzed, predominantly young adults.
  • The findings indicate that many of these patients were unaware they had Fabry disease before their meningitis episode, and the underlying causes of the inflammation in these cases are still not fully understood.
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Background: Heparin-bonded expanded polytetrafluoroethylene (hb-ePTFE) synthetic grafts are an alternative to autologous vein grafts (AVG) for surgical bypass interventions in lower limb peripheral arterial disease (LLPAD). However, the clinical benefits of hb-ePTFE grafts have not been reviewed systematically for patients undergoing below-the-knee (BK) surgical bypass. This study aimed to meta-analyze available data on the utility of hb-ePTFE in patients undergoing BK surgical bypass.

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Background: We designed this study based on both a physician practice survey and real-world patient data to: (1) evaluate clinical management practices in extensive-stage small cell lung cancer (ES-SCLC) among medical centers located across France; and (2) describe first-line treatment patterns among patients with ES-SCLC following the introduction of immunotherapy into clinical practice.

Methods: A 50-item questionnaire was completed by physicians from 45 medical centers specialized in SCLC management. Responses were collected from June 2022 to January 2023.

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Atezolizumab plus modified docetaxel, cisplatin, and fluorouracil as first-line treatment for advanced anal cancer (SCARCE C17-02 PRODIGE 60): a randomised, non-comparative, phase 2 study.

Lancet Oncol

April 2024

Clinical Investigation Centre 1431, University Hospital of Besançon, Besançon, France; Department of Oncology, University Hospital of Besançon, Besançon, France; National Institute of Health and Medical Research (INSERM), Unit 1098, University of Bourgogne Franche-Comté, Besançon, France; Oncology Multidisciplinary Group (GERCOR), Paris, France; Fédération Francophone de Cancérologie Digestive, Paris, France.

Article Synopsis
  • The study investigates the combination of the modified docetaxel, cisplatin, and fluorouracil (mDCF) regimen with atezolizumab as a first-line treatment for advanced squamous cell carcinoma of the anus, building on mDCF’s established efficacy.
  • Conducted across 21 centers in France, the phase 2 study randomly assigned participants to receive either the combination therapy or mDCF alone, focusing on 12-month progression-free survival as the primary endpoint.
  • With 97 participants enrolled, the study found a median follow-up of 26.5 months, providing valuable insights into the potential benefits of combining immunotherapy with standard chemotherapy.
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Article Synopsis
  • - The study focused on identifying risk factors for placenta accreta spectrum (PAS) in women with previous cesarean deliveries and either placenta previa or a low-lying placenta, using data from 2013 to 2015.
  • - Out of over 520,000 deliveries, 396 women met the criteria, with 108 diagnosed with PAS, showing a significant correlation between the number of prior cesareans and the rate of PAS, which could range from 5% to 63%.
  • - Key risk factors for developing PAS included having a BMI of 30 or higher, previous uterine surgeries, past postpartum hemorrhage, multiple cesarean deliveries, and presence of placenta previa, indicating that risk stratification is
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Background: The prevalence and risk factors of posttraumatic stress disorder after cesarean delivery, outside high-risk contexts, remain unclear.

Objective: This study aimed to assess posttraumatic stress disorder prevalence and risk factors at 2 months postpartum among a general population of women with cesarean delivery.

Study Design: This was a prospective ancillary cohort study of the Tranexamic Acid for Preventing Postpartum Hemorrhage after Cesarean Delivery (TRAAP2) trial, conducted in 27 French hospitals from 2018 to 2020, enrolling women expected to undergo cesarean delivery before or during labor at ≥34 weeks of gestation.

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Objectives: To describe the characteristics of patients with Sjögren's disease (SjD) and inclusion-body myositis (IBM), and how they compare to SjD patients with other inflammatory myopathies (IM).

Methods: Patients were retrospectively recruited from 13 French centers and included if they met the ACR/EULAR criteria for SjD and for IM. They were categorized as SjD-IBM if sub-criteria for IBM were met, or as SjD-other IM if not.

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Éditorial.

J Med Vasc

March 2024

Vascular Medicine, Paris Saint-Joseph Hospital Group, 185, rue Raymond Losserand, 75014 Paris, France. Electronic address:

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Tidal volume in mechanically ventilated patients: Searching for Cinderella's shoe rather than 6 mL/kg for all.

Anaesth Crit Care Pain Med

June 2024

Réanimation Polyvalente, Centre Hospitalier de Cayenne, Cayenne, French Guiana; Tropical Biome et Immunopathologie CNRS UMR-9017, Inserm U 1019, Université de Guyane, French Guiana.

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Introduction: During the coronavirus disease 2019 (COVID-19) pandemic, the Gustave Roussy Cancer Center introduced teleconsultation via telephone, as an alternative to face-to-face consultation to reduce patient hospital visits. This study was designed to assess patient and doctor satisfaction with this modality of care in oncology patient care during the period of the pandemic and beyond.

Methods: We designed two questionnaires based on validated scores to assess satisfaction from teleconsultation in patients (EORTC OUT-PATSAT 35 and Telemedicine Satisfaction Questionnaire [TSQ] scores) and doctors (Telehealth Usability Questionnaire [TUQ]), and anxiety levels in both groups (anxiety section of the Hospital Anxiety and Depression Scale [HADS], HADS-A).

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BACKGROUND: The discovery of a saliva-based micro–ribonucleic acid (miRNA) signature for endometriosis in 2022 opened up new perspectives for early and noninvasive diagnosis of the disease. The 109-miRNA saliva signature is the product of miRNA biomarkers and artificial intelligence (AI) modeling. We designed a multicenter study to provide external validation of its diagnostic accuracy.

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Multi-ancestry polygenic risk scores for venous thromboembolism.

medRxiv

January 2024

Transdivisional Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, USA.

Article Synopsis
  • Venous thromboembolism (VTE) significantly affects health outcomes and shows disparities in incidence between Black and White Americans, necessitating improved risk assessment methods.* -
  • Polygenic risk scores (PRSs) derived from diverse ancestry data performed better than traditional PRSs, indicating their potential for accurately identifying high-risk individuals for VTE in both European and African ancestries.* -
  • The study found that using multi-ancestry PRSs could enhance risk stratification, with individuals in the highest risk category having a substantially increased likelihood of VTE, suggesting a path towards personalized treatment approaches.*
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Background: Lung or heart-lung transplantation (LT/HLT) for severe pulmonary hypertension (PH) as the primary disease indication carries a high risk of waiting list mortality and post-transplant complications. France and the UK both have coordinated PH patient services but with different referral pathways for accessing LT services.

Methods: We conducted a comparative analysis of adult PH patients listed for LT/HLT in the UK and France.

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The Networked Interaction between Probiotics and Intestine in Health and Disease: A Promising Success Story.

Microorganisms

January 2024

Master Program in "Food, Nutrition and Microbiome", Department of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.

Probiotics are known to promote human health either precautionary in healthy individuals or therapeutically in patients suffering from certain ailments. Although this knowledge was empirical in past tomes, modern science has already verified it and expanded it to new limits. These microorganisms can be found in nature in various foods such as dairy products or in supplements formulated for clinical or preventive use.

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Femoral head fractures are rare traumatic injuries that are usually associated with hip dislocations. Open reduction and internal fixation are performed when indicated, but can be associated with a higher risk of avascular necrosis. We report the case of a 24-year-old patient with a Pipkin type II fracture dislocation of the femoral head fixed via a minimally invasive three-dimensional navigated internal fixation technique.

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Aims: Post-traumatic periprosthetic acetabular fractures are rare but serious. Few studies carried out on small cohorts have reported them in the literature. The aim of this work is to describe the specific characteristics of post-traumatic periprosthetic acetabular fractures, and the outcome of their surgical treatment in terms of function and complications.

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