Mitral valve-in-valve and valve-in-ring procedures: Midterm outcomes in a French nationwide registry.

Objectives: Report contemporary outcomes in patients included in the Mitragister registry and treated with transcatheter mitral valve implantation for failed surgical annuloplasty rings or deteriorated bioprosthesis.

Background: Midterm survival rates have been reported, but little is known about contemporary morbimortality endpoints.

Methods: The primary safety outcome was the technical success rate.

Comparing brain asymmetries independently of brain size.

Studies examining cerebral asymmetries typically divide the l-R Measure (e.g., Left-Right Volume) by the L + R Measure to obtain an Asymmetry Index (AI).

Urinary Tract Endometriosis: A Multidisciplinary Fight Against a Silent Enemy.

Study Objective: To demonstrate the safety and feasibility of laparoscopic robotic assisted approach to urinary tract endometriosis.

Design: This is an educational video to explain the main steps of robotic assisted ureteroneocystostomy owing to endometriosis.

Setting: Tertiary care university hospital.

Diagnosis and staging of cardiac masses: additional value of CMR with F-FDG-PET compared to CMR with CECT.

Purpose: Characterization of malignant cardiac masses is usually performed with cardiac magnetic resonance (CMR) and staging with whole-body contrast-enhanced computed tomography (CECT). In this study, our objective was to evaluate the role of Fluor-fluorodeoxyglucose positron emission tomography (F-FDG-PET) with CMR for both characterization and staging of cardiac masses.

Methods: Patients with cardiac masses who underwent CMR, CECT, and F-FDG-PET were retrospectively identified.

The Role of TRP Channels in Nicotinic Provoked Pain and Irritation from the Oral Cavity and Throat: Translating Animal Data to Humans.

Tobacco smoking-related diseases are estimated to kill more than 8 million people/year and most smokers are willing to stop smoking. The pharmacological approach to aid smoking cessation comprises nicotine replacement therapy (NRT) and inhibitors of the nicotinic acetylcholine receptor, which is activated by nicotine. Common side effects of oral NRT products include hiccoughs, gastrointestinal disturbances and, most notably, irritation, burning and pain in the mouth and throat, which are the most common reasons for premature discontinuation of NRT and termination of cessation efforts.

Epidemiology and complications of anaesthesia in the French centres that participated to NECTARINE: A secondary analysis.

Introduction: Neonatal and infant anaesthesia are associated with a high risk of perioperative complications. The aim of the current study was to describe those risks in France using the French data from the NECTARINE study.

Material And Methods: Data from the French centres that participated to the NECTARINE study were analysed.

Epstein-Barr Virus in Childhood and Adolescent Classic Hodgkin Lymphoma in a French Cohort of 301 Patients.

Objective: The aim was to analyze the role of Epstein-Barr virus (EBV) in the bioclinical characteristics of patients treated for classic Hodgkin lymphoma (cHL) in France.

Methods: Biopathologic data of 301 patients treated for a cHL in/or according to the EuroNet PHL-C1 trial between November 2008 and February 2013 were centrally reviewed.

Results: Median age at diagnosis was 14 (3 to 18) years and the F/M ratio 0.

Artificial intelligence for oral and maxillo-facial surgery: A narrative review.

Artificial Intelligence (AI) is a set of technologies that simulate human cognition in order to address a specific problem. The improvement in computing speed, the exponential production and the routine collection of data have led to the rapid development of AI in the health sector. In this review, we propose to provide surgeons with the essential technical elements to help them understand the possibilities offered by AI and to review the current applications of AI for oral and maxillofacial surgery (OMFS).

Adenosine Blood Level: A Biomarker of White Matter Damage in Very Low Birth Weight Infants.

Background: Very low birth weight infants are at risk of developing periventricular white matter lesions. We previously reported high blood adenosine levels in premature infants and infants with low birth weight. We asked whether blood adenosine levels could be related to the vulnerability of the maturing white matter to develop lesions.

Tailoring maintenance chemotherapy upon response to induction chemotherapy as compared with pemetrexed continuation maintenance in advanced non-squamous NSCLC patients: Results of the IFCT-GFPC-1101 multicenter randomized phase III trial.

Background: Benefit from maintenance in advanced non-squamous non-small cell lung cancer (NS-NSCLC) might favor switch maintenance after disease stabilization (SD) and continuation after objective response (OR). This trial assessed a maintenance strategy conditioned by response to cisplatin-gemcitabine (CG) with G continuation for patients with OR or switch to pemetrexed (P) for patients with SD as compared with a control arm based on the Paramount regimen.

Methods: Eligibility criteria: age 18-70 years, ECOG PS 0-1, untreated stage IV NS-NSCLC without EGFR or ALK alteration, ineligibility to bevacizumab.

How common is ventilator-associated pneumonia after coronavirus disease 2019?

Purpose Of Review: The first studies on COVID-19 patients with acute respiratory distress syndrome (ARDS) described a high rate of secondary bacterial ventilator-associated pneumonia (VAP). The specificity of VAP diagnoses in these patients are reviewed, including their actual rate.

Recent Findings: Published studies described high rates of bacterial VAP among COVID-19 patients with ARDS, and these VAP episodes are usually severe and of specifically poor prognosis with high mortality.

HAP and VAP after Guidelines.

Nosocomial pneumonia is associated with worsened prognosis when diagnosed in intensive care unit (ICU), ranging from 12 to 48% mortality. The incidence rate of ventilation-acquired pneumonia tends to decrease below 15/1,000 intubation-day. Still, international guidelines are heterogeneous about diagnostic criteria because of inaccuracy of available methods.

Clinical phenotype and cytokine profile of adult IgA vasculitis with joint involvement.

Objective: Joint involvement can be observed during the course of adult IgA vasculitis (IgAV). However, clinical picture, prognosis, or pathophysiological data associated with this condition have been overlooked. We aimed to describe the clinical characteristics and outcome of IgAV patients with joint involvement and look to a specific cytokine profile.

Integration of multimodal data in the developing tooth reveals candidate regulatory loci driving human odontogenic phenotypes.

Human odontogenic aberrations such as abnormal tooth number and delayed tooth eruption can occur as a symptom of rare syndromes or, more commonly, as nonsyndromic phenotypes. These phenotypes can require extensive and expensive dental treatment, posing a significant burden. While many dental phenotypes are heritable, most nonsyndromic cases have not been linked to causal genes.

Overexpression of IgG2 in patients resembling IgG4-related disease with normal IgG4.

IgG4-Related Disease (IgG4-RD) results from tissue infiltration by IgG4-expressing plasma cells and lymphocytes, leading to fibrosis and organomegaly. Clinical presentation is remarkably variable according to organ involvement, and high IgG4 serum concentration, initially considered a diagnostic hallmark of IgG4-RD, tends to be forgone as an indispensable criterion for its diagnosis; it can indeed be absent in some patients, highlighting the diversity of presentation of this dysimmune condition. Nevertheless, elevation of IgG4 serum concentration in suggestive settings remains an argument in favour of IgG4-RD, and while other IgG subclasses can be elevated, this biological feature lacks any diagnostic value.

Prevalence and Determinants of Transient Congenital Hypothyroidism in Children With Eutopic Gland in France: A Retrospective Cohort Study.

Context: The increase in the incidence of congenital hypothyroidism (CH) reported worldwide may partly be explained by an increase in the transient form of CH.

Objective: We aimed to estimate the proportion of transient CH (TCH) in France, and to identify associated neonatal and young child characteristics.

Methods: We used probabilistic record linkage to link children with eutopic gland born between 2006 and 2012 recorded in the national French CH registry and the French national health data system (SNDS).