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Fibrinolysis as a Causative Mechanism for Bleeding Complications on Extracorporeal Membrane Oxygenation: A Pilot Observational Prospective Study.
Anesthesiology
July 2024
Paris Cite University-INSERM U-1140, Innovative Therapies in Haemostasis, Paris, France.
Article Synopsis
- ECMO (extracorporeal membrane oxygenation) is linked to a high risk of bleeding, and this study aimed to explore how ECMO affects fibrinolysis markers over time in these patients.
- In the study involving 30 patients, key fibrinolysis markers like tPA and D-dimer increased significantly in bleeding patients before a hemorrhagic event, while nonbleeding patients showed a decreasing trend in these markers.
- Results indicated that higher tPA levels were associated with bleeding events, suggesting that monitoring these fibrinolytic markers could be crucial in managing patients on ECMO.