Pain intensity and lower limb dynamic balance were related to the laterality judgment test of patients with patellofemoral pain.

Introduction: Laterality judgement evaluates the capacity to differentiate between the left and right sides of bodily parts. Cortical body representations are impaired in various musculoskeletal conditions, yet this remains unexplored in individuals with patellofemoral pain (PFP).

Objective: This study compared laterality judgement performance between individuals with PFP and asymptomatic controls.

Suspected heparin-induced thrombocytopaenia in pulmonary thromboendarterectomy: retrospective cohort.

Objectives: Heparin is given for anticoagulation during and after pulmonary thromboendarterectomy for chronic thromboembolic pulmonary hypertension. Our objective was to add to the limited data available on the incidence, management and outcomes of suspected heparin-induced thrombocytopaenia after pulmonary thromboendarterectomy for chronic thromboembolic pulmonary hypertension.

Methods: This retrospective single-centre study included consecutive patients with suspected heparin-induced thrombocytopaenia after pulmonary thromboendarterectomy done in 2005-2018.

Towards Improved Peptidic α-Ketoamide Inhibitors of the Plasmodial Subtilisin-Like SUB1: Exploration of N-Terminal Extensions and Cyclic Constraints.

After more than 15 years of decline, the Malaria epidemy has increased again since 2017, reinforcing the need to identify drug candidates active on new targets involved in at least two biological stages of the Plasmodium life cycle. The SUB1 protease, which is essential for parasite egress in both hepatic and blood stages, would meet these criteria. We previously reported the structure-activity relationship analysis of α-ketoamide-containing inhibitors encompassing positions P4-P2'.

Zirconium(IV)-Catalysed Hydrosilylation of Organic Carbonates and Polycarbonates Household Wastes into Alcohol Derivatives.

The Schwartz's reagent Cp2Zr(H)Cl is a well known stoichiometric reagent for the reduction of unsaturated organic molecules but it has rarely been used in catalytic transformations. Herein, we describe the reduction of a variety of organic carbonates using the catalyst Cp2Zr(H)Cl in combination with Me(MeO)2SiH (DMMS) as reductant. This method was further applied to the reductive depolymerization of some polycarbonate materials and yielded silylated alcohols and diols in mild conditions.

Advanced paranasal sinuses osteomas: a retrospective multicentric analysis on surgical management outcomes and intra- and postsurgical complications.

Background: This study examines the management and outcomes of large paranasal sinus osteomas (PSO), especially those abutting or encasing critical structures of the skull base and orbit.

Methodology: A multicentric retrospective analysis was conducted between June 2007 and September 2023. The study included surgically treated (regardless the type of approach chosen) PSO, exceeding 3 cm in diameter and/or located in critical anatomical areas.

Anesthetic Management of a Patient With Arnold Chiari Malformation and Syringomyelia During Laparoscopic Surgery With Neurologic Monitoring: A Case Report.

We describe a patient with severe Arnold Chiari Malformation and syringomyelia who underwent gynecological laparoscopy in an emergency context; no brain imaging was available. We here report the successful use of optic nerve sheath diameter (ONSD) and middle cerebral artery (MCA) velocity measurements as surrogate monitoring for cerebral blood flow and intracranial pressure, respectively. MCA velocity was low when assessed after peritoneal insufflation and ONSD increased to 6.

Predictive Factors of a Dominant Superficial Venous Drainage System in DIEP Flap Surgery With Preoperative Computed Tomography Angiography.

Background: Venous congestion due to superficial venous system dominance (SVD) in deep inferior epigastric perforator (DIEP) flap surgery occurs in approximately 2% of cases, with attendant sequelae and increased cost to healthcare systems. This study aimed to describe the predictive factors for SVD in DIEP flap breast reconstruction based on preoperative computed tomography angiography (CTA) findings.

Methods: All women who required takebacks for additional venous anastomosis to the cephalic vein because of SVD after DIEP flap breast reconstruction between 2015 and 2022 were included.

Feasibility and Acceptability of a Virtual "Dementia Awareness for Caregivers" Course in Brazil and India.

Objective: To establish whether a virtual dementia awareness course is feasible for caregivers of people with dementia in Brazil and India.

Methods: A pre/posttest single group, multisite feasibility study, mixed methods exploratory design was applied. Primary caregivers of people with dementia in Brazil and India took a 3 to 4-hour course adapted for online delivery, with 10 to 15 caregivers.

Surfacic networks.

Surfacic networks are structures built upon a 2D manifold. Many systems, including transportation networks and various urban networks, fall into this category. The fluctuations of node elevations imply significant deviations from typical plane networks and require specific tools to understand their impact.

First Observation of a Nuclear Recoil Peak at (100eV) with Crab: A Potential New Calibration Standard for Cryogenic Detectors.

Any experiment aiming to measure rare events, like Coherent Elastic neutrino-Nucleus Scattering (CE NS) or hypothetical Dark Matter scattering, via nuclear recoils in cryogenic detectors relies crucially on a precise detector calibration at sub-keV energies. The Crab collaboration developed a new calibration technique based on the capture of thermal neutrons inside the target crystal. Together with the Nucleus experiment, first measurements with a moderated Cf neutron source and a cryogenic detector were taken.

Percolation for 2D Classical Heisenberg Model and Exit Sets of Vector Valued GFF.

Our motivation in this paper is twofold. First, we study the geometry of a class of exploration sets, called , which are naturally associated with a 2D vector-valued Gaussian Free Field : . We prove that, somewhat surprisingly, these sets are a.

Correlates of mental health of people living with HIV co-infected with SARS-CoV-2: findings from the COVIDHIV study in France.

Background: The COVID-19 pandemic has severely affected vulnerable populations, especially individuals living with HIV/AIDS (PLWHA). The convergence of HIV/AIDS and COVID-19 presents unique challenges, exacerbating existing health concerns and magnifying the strain on individuals already grappling with compromised immune systems. This study aimed to investigate the mental well-being repercussions faced by PLWHA co-infected with SARS-CoV-2 in France.

A transdisciplinary, comparative analysis reveals key risks from Arctic permafrost thaw.

Permafrost thaw poses diverse risks to Arctic environments and livelihoods. Understanding the effects of permafrost thaw is vital for informed policymaking and adaptation efforts. Here, we present the consolidated findings of a risk analysis spanning four study regions: Longyearbyen (Svalbard, Norway), the Avannaata municipality (Greenland), the Beaufort Sea region and the Mackenzie River Delta (Canada) and the Bulunskiy District of the Sakha Republic (Russia).

Radiotherapy for oligoprogressive disease in non-small cell lung cancer treated with pembrolizumab in first-line setting: a retrospective study.

Background: Oligoprogression (OP) is common in patients with metastatic non-small cell lung cancer (mNSCLC) treated with immune checkpoint inhibitors (ICIs). This study aims to assess the benefit and the safety profile of ablative radiotherapy (RT) for OP in mNSCLC treated with pembrolizumab in first-line setting.

Methods: We retrospectively analyzed records of all consecutive mNSCLC patients who underwent treatment with pembrolizumab (+/- chemotherapy) in first-line setting and developed an OP treated with ablative RT while continuing pembrolizumab, in a French Hospital from 2019 to 2022.

Population Dynamics of the Exotic Flatworm in an Invaded Garden.

Population dynamics and the way abundance fluctuates over time may be key determinants of the invasion success of an introduced species. Fine-scale temporal monitoring of invasive species is rarely carried out due to the difficulties in collecting data regularly and over a long period. Thanks to the collaboration of an amateur naturalist, a unique dataset on the abundance of the invasive land flatworm was obtained during a 4-year survey of a French private garden, where up to 1585 were recorded in 1 month.

Pharmacological Enhancement of Adult Hippocampal Neurogenesis Improves Behavioral Pattern Separation in Young and Aged Male Mice.

Background: Impairments in behavioral pattern separation (BPS)-the ability to distinguish between similar contexts or experiences-contribute to memory interference and overgeneralization seen in many neuropsychiatric conditions, including depression, anxiety, posttraumatic stress disorder, dementia, and age-related cognitive decline. Although BPS relies on the dentate gyrus and is sensitive to changes in adult hippocampal neurogenesis, its significance as a pharmacological target has not been tested.

Methods: In this study, we applied a human neural stem cell high-throughput screening cascade to identify compounds that increase human neurogenesis.

Automated tight Lyapunov analysis for first-order methods.

We present a methodology for establishing the existence of quadratic Lyapunov inequalities for a wide range of first-order methods used to solve convex optimization problems. In particular, we consider (i) classes of optimization problems of finite-sum form with (possibly strongly) convex and possibly smooth functional components, (ii) first-order methods that can be written as a linear system on state-space form in feedback interconnection with the subdifferentials of the functional components of the objective function, and (iii) quadratic Lyapunov inequalities that can be used to draw convergence conclusions. We present a necessary and sufficient condition for the existence of a quadratic Lyapunov inequality within a predefined class of Lyapunov inequalities, which amounts to solving a small-sized semidefinite program.

Introducing subgen. a new and very small lineage sharing with () an identical, largely circum-Pacific distribution pattern.

The application of DNA data on a worldwide sampling has revolutionized the infrageneric classification of the highly diverse ectomycorrhizal genus . Based on collections made in New Zealand, East Asia and North America, this study describes a new subgenus , the ninth subgenus of . Even though BLASTn of the ITS sequences suggested affinities with species of subgenera and the phylogenetic analysis based on a five-locus DNA dataset placed the target samples in an independent major clade that is taxonomically equivalent to subgenus.

Racial-Ethnic Stratification in Work-Family Arrangements among Black, Hispanic, and White Couples.

Objective: This article builds on work-family scholarship to document racial-ethnic variation in couples' work-family arrangements, i.e., how couples respond to their work and family demands.