24,532 results match your criteria: "Paraneoplastic Encephalomyelitis"
Orphanet J Rare Dis
December 2024
Department of Neurology, ERN EURO-NMD Center, University Hospital Brno, Brno, Czech Republic.
Background: Myasthenia gravis (MG) is a rare autoimmune disorder with significant clinical implications, including life-threatening myasthenic crises and exacerbations. Understanding real-world treatment patterns, especially associated direct medical costs, is essential for the effective management of healthcare delivery.
Methods: We conducted a descriptive cohort study using health administrative claims data from the Czech Republic covering more than 1,500 prevalent MG patients.
Front Immunol
December 2024
Department of Neurology, Medical University of Vienna, Vienna, Austria.
The discovery of autoantibodies directed against muscle-specific kinase (MuSK) in "seronegative" myasthenia gravis (MG) patients marked a milestone in MG research. In healthy muscle, MuSK regulates a phosphorylation pathway, which is essential for the development and maintenance of acetylcholine receptor (AChR) clusters at the neuromuscular junction. Autoantibodies directed against MuSK are predominantly of the IgG4 subclass, but there is increasing evidence that IgG1-3 could also contribute to the pathology underlying MuSK-MG.
View Article and Find Full Text PDFRev Inst Med Trop Sao Paulo
December 2024
Universidade Federal da Bahia, Hospital Universitário Professor Edgard Santos, Salvador, Bahia, Brazil.
The Zika virus (ZIKV) has been associated with several complications, including acute transverse myelitis (ATM), an acute inflammation of the spinal cord, with rapid development of motor, sensory and dysautonomic symptoms. It is a rare disease, and its clinical features, as well as differences in relation to idiopathic ATMs, are still not completely known. The objective of this paper is to review the literature in search of clinical features and complementary exams of ATM post-ZIKV infection, alone or in association with other neurological conditions (mixed diseases), as well as its treatments and prognoses.
View Article and Find Full Text PDFJAAPA
January 2025
At Widener University in Chester, Pa., Lori Felker is director and an associate professor in the Institute for Physician Assistant Education, Kripa Dholakia is an assistant professor in the Institute for Physical Therapy Education, Wendy Wachter-Schutz is director and an associate professor in the Institute for Occupational Therapy Education, Mary T. Rourke is director and an associate professor in the Institute for Graduate Clinical Psychology, and Kathleen M. Youse is director and an associate professor in the Institute for Speech-Language Pathology. The authors have disclosed no potential conflicts of interest, financial or otherwise.
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is the most common type of autoimmune encephalitis. The initial presentation can vary from subtle mental status changes to more severe symptoms such as seizures, coma, or death. This case report outlines the interdisciplinary and collaborative approach to diagnosing and treating a patient with anti-NMDAR autoimmune encephalitis.
View Article and Find Full Text PDFBeijing Da Xue Xue Bao Yi Xue Ban
December 2024
Department of Rheumatology and Immunology, Peking University Shougang Hospital, Beijing 100144, China.
Rheumatoid arthritis (RA) and myasthenia gravis (MG) are two distinct autoimmune diseases. Compared with the general population, the incidence of RA is notably higher among patients with MG. Similarly, the rate of MG in patients diagnosed with RA is also significantly increased.
View Article and Find Full Text PDFZh Nevrol Psikhiatr Im S S Korsakova
December 2024
Altai State Medical University, Barnaul, Russia.
Objective: To analyze the epidemiological and clinical characteristics of myasthenia gravis (MG) in the Altai region (AR).
Material And Methods: One hundred and twenty-two patients with a verified diagnosis of MG, living in the AR, took part in the study. To collect data, a questionnaire was developed, the data of which formed the basis for the study.
J Assoc Physicians India
December 2024
Junior Resident, Department of Medicine, AIIMS, Delhi, India.
Paraneoplastic neurological syndromes (PNS) are mostly immune-mediated, tumor-associated disorders. Earlier the 2004 PNS criteria were used which are now partially outdated due to advances in PNS research and also identification of new phenotypes and antibodies that have transformed the diagnostic approach to PNS; hence, a new criterion was proposed in 2016. They can have multifarious presentations, ranging from behavioral abnormalities to altered sensorium and coma.
View Article and Find Full Text PDFNeurology
January 2025
From the Department of Neuro-Ophthalmology (S.H.W.), Moorfields Eye Hospital NHS Foundation Trust; Departments of Ophthalmology and Neurology (S.H.W.), Guy's and St Thomas' NHS Foundation Trust; Department of Ophthalmology (S.H.W.), Faculty of Life Sciences & Medicine, King's College London; Department of Clinical and Movement Neuroscience (S.H.W.), UCL Queen Square Institute of Neurology, University College London, United Kingdom; Department of Ophthalmology and Visual Sciences (R.A., W.T.C., T.D., J.R.E., C.A.A., L.B.D.L.), Kellogg Eye Center, University of Michigan, Ann Arbor; Departments of Ophthalmology, Neurology, and Neurosurgery (E.R.E., S.K.), Mayo Clinic, FL; Survey Research Center (J.R.E.), Institute for Social Research, University of Michigan, Ann Arbor; and Division of Neurology (C.B.-T.), Department of Medicine, University Health Network and University of Toronto, Ontario, Canada.
Background And Objectives: Ocular myasthenia gravis (OMG) causes disabling ocular symptoms of ptosis and diplopia, but a validated disease-specific patient-reported outcome measure (PROM) has not been reported. We sought to validate a novel PROM for OMG, OMG Rating Scale Questionnaire (OMGRate-q), as a measure of visual functioning to support patient-centered care.
Methods: This was a prospective study of patients aged 18 years and older with OMG receiving care at 3 medical centers (January 2022-October 2023).
P R Health Sci J
December 2024
Third-year medical student at the University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico.
This is the case of a 22-year-old female who arrived at our institution after experiencing refractory insomnia, disorganized behavior, inappropriate laughter, and anorexia. Upon admission, a physical examination revealed mutism, irritability, and visual hallucinations. Infectious, metabolic, and other, alternative, causes for the presenting symptoms were excluded.
View Article and Find Full Text PDFNeurol Neuroimmunol Neuroinflamm
January 2025
Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neurology and Experimental Neurology.
Background And Objectives: The characteristics of persistent long-term symptoms and their contribution to subjective quality of life remain unclear in patients with NMDAR encephalitis. In this study, we aimed to evaluate postacute neuropsychiatric symptoms, subjective cognitive complaints, and disease coping mechanisms and identify predictors of health-related quality of life (HRQoL) after N-methyl-D-aspartate receptor (NMDAR) encephalitis.
Methods: This cross-sectional observational study investigated patients with NMDAR encephalitis in the postacute phase.
Neurology
January 2025
From the Department of Neurology, Aarhus University Hospital, Denmark.
Background And Objectives: Previous studies on incident myasthenia gravis (MG) have shown inconsistent results. In this study, we determined the MG incidence rates (IRs) over a 36-year period to detect potential trends in MG incidence over time and for different age groups.
Methods: In this nationwide population-based study from 1985 to 2021, we identified patients aged 18 and older with a primary MG diagnosis in the Danish National Patient Registry.
J Neurol
December 2024
Department of Neurology, Gulhane Medical Faculty, University of Health Sciences, Ankara, Turkey.
Background: Variable incidence and prevalence rates of myasthenia gravis (MG) have been reported over time from different geographical regions. We aimed to determine incidence and prevalence of MG in Turkey and contribute to the development of proper national health policies.
Methods: Patients with G70.
J Neurol
December 2024
Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Background: Several innovative treatments are expected for myasthenia gravis (MG) in the coming years. Healthcare payers usually require cost-effectiveness analyses before reimbursement. We aimed to investigate resource utilization and direct medical costs for patients with MG treated with intravenous immunoglobulin (IVIg) to inform such analyses.
View Article and Find Full Text PDFJ Neurol
December 2024
Copenhagen Neuromuscular Center, Rigshospitalet, Copenhagen, Denmark.
Background: Early detection and diagnosis of myasthenia gravis (MG) is important to improve the chance of remission and overall prognosis. This study aims to investigate the factors affecting the diagnostic delay of MG thereby highlighting the challenges in the diagnostic process.
Methods: We conducted a retrospective study examining characteristics and factors involved in the diagnostic process of MG.
Praxis (Bern 1994)
November 2024
Palliative Care, Kantonsspital Graubünden, Chur.
On the palliative care ward, we treated a man with a small cell lung cancer who was suffering from vertigo for six years, however the vertigo got stronger the last six months with pronounced coordination disorders. After several examinations, the cause was a paraneoplastic neurologic syndrome (PNS) with Hu-antibodies. PNS are various neurological malfunctions, which occur mostly in certain patterns.
View Article and Find Full Text PDFPeerJ
December 2024
Department of Neurology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Medicine (Baltimore)
December 2024
Department of Neurology, Second Affiliated Hospital of Naval Medical University, Shanghai Changzheng Hospital, Shanghai, China.
Rationale: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune encephalitis characterized by diverse neurological and psychiatric symptoms. It predominantly affects young women, particularly those with ovarian teratomas. However, cases without teratomas are also commonly reported, often exhibiting poorer treatment responses and higher relapse rates.
View Article and Find Full Text PDFBMC Neurol
December 2024
Department of Neurology, Guangdong Sanjiu Brain Hospital, Guangzhou, Guangdong, China.
Objective: Anti-IgLON5 disease is a rare autoimmune mediated disease. It is mainly featured by sleep-related disturbance, parkinsonism, chorea and limb ataxia. Previous studies had clarified its clinical manifestations and predisposing genes.
View Article and Find Full Text PDFActa Med Acad
August 2024
Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Background: Paraneoplastic Neurological Syndromes (PNS) constitute a heterogeneous cluster of disease manifestations related to various cancers. Small Cell Lung Cancer (SCLC) is strongly related to PNS. This narrative review conducted a survey in the available PubMed literature to highlight the appearance of PNSs in SCLC cases and discuss published research highlights on the subject so that general practitioners can be acquainted with the medical phenomenon present in SCLC patients.
View Article and Find Full Text PDFBMJ Case Rep
December 2024
Internal Medicine - Hematology/Oncology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Neurocase
December 2024
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Eur J Neurol
January 2025
Neuromuscular Diseases Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau; and Institut de Recerca Sant Pau, IR-SantPau, Barcelona, Spain.
Front Immunol
December 2024
Department of Neurology, Rambam HealthCare Campus, Haifa, Israel.
Objective: It is unknown whether delay in diagnosis affects morbidity reportedly in paraneoplastic syndromes (PNS). We aimed to explore various aspects of PNS, including prevalence, clinical characteristics, diagnostic criteria, and treatment outcomes.
Methods: We studied n-PNS diagnosis between 2016 to 2023, and included only patients with positive onconeural antibodies, who developed cancer, and exhibited a recognizable PNS phenotype.
Front Immunol
December 2024
Encephalopathy and Psychology Department, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China.
Muscle-specific kinase (MuSK) myasthenia gravis (MG) is relatively rare and has a higher incidence of myasthenic crisis compared with other subtypes. However, there is still a lack of effective treatment for refractory MuSK MG. We report the case of a 70-year-old female MuSK MG patient with recurrent fluctuations who stabilized on telitacicept in combination with anti-CD20 B-cell depletion therapy.
View Article and Find Full Text PDFJ Ayub Med Coll Abbottabad
December 2024
Liaquat National Hospital, Karachi-Pakistan.