558 results match your criteria: "Paraneoplastic Diseases* Dermatology"
Lupus erythematosus and dermatomyositis.
Clin Dermatol
December 2024
Department of Dermatology, Yale School of Medicine, New Haven, CT. Electronic address:
Dr. Irwin Braverman, a luminary in our field of dermatology, united his love of internal medicine with dermatology to pioneer our understanding of the cutaneous manifestations of systemic disease. His meticulous documentation of physical examination findings in his book Skin Signs of Systemic Disease became fundamental to the training of dermatologists worldwide for decades.
View Article and Find Full Text PDFLife-threatening dermatoses.
Clin Dermatol
December 2024
Department of Dermatology, Yale University School of Medicine, New Haven, CT. Electronic address:
While rare, life-threatening dermatoses encompass various inflammatory, infectious, vasculitic/vasculopathy, paraneoplastic, and neoplastic skin diseases. Complications include skin barrier dysfunction, secondary infection, and internal organ involvement. Skin signs may serve as a critical window into systemic disease.
View Article and Find Full Text PDFAdult-Onset Acquired Ichthyosis Revealing an Underlying Colon Adenocarcinoma.
Cureus
November 2024
Dermatology, University of Illinois Chicago, Chicago, USA.
Article Synopsis
First reported case of thymoma-associated multiorgan autoimmunity induced by COVID-19.
J Dermatol
December 2024
Department of Dermatology, Tokyo Medical University, Tokyo, Japan.
Article Synopsis
- - Thymoma-associated multiorgan autoimmunity (TAMA) involves symptoms like skin issues, liver dysfunction, and enteritis, similar to graft-versus-host disease (GVHD), but occurs without prior stem cell or bone marrow transplants and is linked to thymoma.
- - A 64-year-old woman with myasthenia gravis and thymoma developed skin rashes after a COVID-19 infection, initially suspected to be a drug reaction, but despite treatment adjustments, her condition worsened and led to severe gastrointestinal symptoms.
- - The patient's diagnosis of TAMA was confirmed through skin biopsy showing GVHD-like changes, and her decline included complications from infections, ultimately resulting in her death, with COVID-
Thymoma-Associated Multiorgan Autoimmunity (TAMA) Presenting as a Graft Versus Host Disease-Like Erythroderma.
J Cutan Pathol
January 2025
Department of Dermatology, West Virginia University School of Medicine, Morgantown, West Virginia, USA.
Article Synopsis
Uncommon and Unusual Variants of Autoimmune Bullous Diseases.
Indian Dermatol Online J
August 2024
Department of Dermatology, Venereology and Leprology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Article Synopsis
- Autoimmune blistering diseases (AIBDs) are skin conditions caused by the body's immune system attacking certain proteins, leading to blister formation, and can be categorized into intraepidermal and subepidermal types.
- The objective of this review is to raise awareness about rare and uncommon AIBD variants, such as pemphigus herpetiformis and anti-laminin 332 pemphigoid, among others.
- By discussing these unusual variants, the review aims to assist healthcare professionals in the early diagnosis and treatment of these conditions.
Vulvar ulcers as a rare manifestation of hematologic malignancy.
JAAD Case Rep
October 2024
Dermatology and Venereology Department, Coimbra Local Health Unit, Coimbra, Portugal.
Update on Palmar Fasciitis and Polyarthritis Syndrome: A systematic review.
Joint Bone Spine
September 2024
Department of Dermatology, Peking Union Medical College Hospital, State Key Laboratory of Complex Severe and Rare Diseases, Chinese Academy of Medical Science and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, 100730, China. Electronic address:
Objectives: This systematic review aims to (1) summarize the clinical, laboratory, and imaging characteristics of Palmar Fasciitis and Polyarthritis Syndrome (PFPAS) patients and (2) evaluate the effectiveness of different treatments.
Methods: We conducted a systematic search of three electronic databases (Scopus, Embase, and PubMed) from inception to December 31, 2023. We presented demographic and clinical features, along with laboratory factors and imaging examinations of PFPAS patients.
Acrokeratosis paraneoplastica (Basex syndrome) with trachyonychia preceding the diagnosis of squamous cell carcinoma of the lung.
Dermatol Online J
April 2024
Department of Dermatology, Tulane University, New Orleans USA Department of Dermatology, Roswell Park Comprehensive Cancer Center, Buffalo USA.
Article Synopsis
State-of-the-art diagnosis of autoimmune blistering diseases.
Front Immunol
June 2024
Department of Dermatology, Allergology and Venerology, University of Lübeck, Lübeck, Germany.
Article Synopsis
- - Autoimmune blistering disorders (AIBDs) include various conditions such as pemphigus and pemphigoid, characterized by blisters and skin lesions that can have diverse appearances, making accurate diagnosis essential for treatment and prognosis.
- - Diagnosis typically combines clinical evaluation with the detection of specific autoantibodies, utilizing tests like enzyme-linked immunosorbent assay (ELISA) and direct immunofluorescence microscopy (IFM), which is considered the gold standard.
- - Recent advancements in molecular identification of target antigens have led to new diagnostic methods and treatment approaches, enhancing the ability to detect specific antibodies related to various AIBDs.
Scleroderma and scleroderma-like syndromes.
Front Immunol
June 2024
Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
Systemic sclerosis is a systemic connective tissue disease whose main pathophysiological mechanism is a progressive fibrosis of internal organs and skin leading to thickening and induration. Blood vessels may also be involved. However, systemic scleroderma is not the only disease causing cutaneous sclerosis.
View Article and Find Full Text PDFRisk of systemic cancer in patients with acquired perforating dermatosis. A double case-control retrospective study.
Arch Dermatol Res
June 2024
Dermatology Department, Department of Medicine and Psychiatry, Hospital Universitario Marqués de Valdecilla, University of Cantabria, IDIVAL, Avenida de Valdecilla s/n, Santander, Cantabria, 39008, Spain.
Sweet syndrome with peripheral neuropathy in a patient with metastatic clear cell renal cell carcinoma.
BMJ Case Rep
April 2024
Dermatology clinic, Brugg, Switzerland.
A female patient in her 70s with a newly diagnosed clear cell renal cell carcinoma (ccRCC) with osseous metastasis presented with sudden onset erythematous painful blistering skin lesions on the dorsum of both hands, with associated intermittent fever episodes. Blood tests showed elevated inflammatory marker levels (C reactive protein 257.8 mg/dL, leucocytes 17.
View Article and Find Full Text PDFAltered serum metabolome as an indicator of paraneoplasia or concomitant cancer in patients with rheumatic disease.
Ann Rheum Dis
July 2024
Medical Clinic 5. Hematology, Oncology, Rheumatology, Heidelberg University, Heildelberg University Hospital, Heidelberg, Baden-Württemberg, Germany
Objectives: A timely diagnosis is imperative for curing cancer. However, in patients with rheumatic musculoskeletal diseases (RMDs) or paraneoplastic syndromes, misleading symptoms frequently delay cancer diagnosis. As metabolic remodelling characterises both cancer and RMD, we analysed if a metabolic signature can indicate paraneoplasia (PN) or reveal concomitant cancer in patients with RMD.
View Article and Find Full Text PDFIf not angioedema, what is it? Diagnostic approach to facial edema.
J Dtsch Dermatol Ges
April 2024
Departamento de Eczema de Contacto e Inmunoalergia, Servicio de Dermatología Médico-Quirúrgica y Venereología, Hospital Universitario San Cecilio, Granada, Spain.
Article Synopsis
- Facial edema is a common issue in patients visiting allergology and dermatology clinics, but diagnosing its cause can be difficult for doctors.
- Facial angioedema has multiple underlying causes, such as histaminergic and bradykinergic responses, which need to be differentiated from other conditions like infections and autoimmune diseases.
- A thorough diagnostic strategy is crucial for conducting the right tests and administering effective treatment for facial edema-related conditions.
Neutrophilic Dermatosis of the Hands: A Case Report.
Acta Dermatovenerol Croat
December 2023
Nooshin Bagherani, MD, PhD, Tehran University of Medical Sciences, Italy Street, Tehran, Iran;
Article Synopsis
- - Neutrophilic dermatosis of the hands (NDDH) is a recently identified localized variant of Sweet's syndrome, characterized by violaceous papulonodules on the hands, lacking true vasculitis findings, as outlined by Strutton et al. (1996) and Galaria et al. (2000).
- - A 46-year-old man presented with a painful, ulcerative lesion on his left hand, which started as a small papule and progressively worsened despite various treatments for suspected bacterial or fungal infections.
- - Upon examination, the lesion measured 4×7 cm and was associated with atrophic scars from previous similar lesions; laboratory tests indicated leukocytosis and altered liver function
Acrokeratosis neoplastica (Bazex syndrome): Report of two cases and literature review.
Heliyon
March 2024
Department of Legal Medicine, 6-20-2, Shinkawa, Mitaka-shi, Tokyo, 181-8611, Japan.
Article Synopsis
- The skin can indicate internal diseases, with Bazex syndrome being a specific condition that shows erythematous hyperkeratosis and yellowish scales on palms and soles.
- There is a notable link between Bazex syndrome and certain cancers, particularly squamous cell carcinomas (SCC), which raises its importance in early cancer detection.
- The text presents cases of Bazex syndrome associated with SCC in the glottis and lung, while also providing insights on the disease's clinical manifestations and pathogenesis.
Paraneoplastic dermatoses in a patient with gastric adenocarcinoma: cutaneous clues to internal malignancy.
Lancet Oncol
March 2024
Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address:
New-onset of pemphigus following COVID-19 infection: A case report.
SAGE Open Med Case Rep
February 2024
Division of Dermatology, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
Article Synopsis
- * A case study discusses a patient whose pemphigus was triggered by COVID-19, showing improvement with treatments like prednisone and mycophenolate mofetil after 9 months.
- * The unique histological findings prompted the hypothesis that COVID-19 may lead to the release of pemphigus antigens, and clinicians should be cautious about distinguishing it from paraneoplastic pemphigus, especially when specific staining patterns are observed.
Dataset for: Autoantibody profiles in patients with immune checkpoint inhibitor-induced neurological immune-related adverse events.
Data Brief
April 2024
Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neurology with Experimental Neurology, Charitéplatz 1, 10117 Berlin, Berlin, Germany.
Article Synopsis
- The rise of cancer immunotherapy, particularly immune checkpoint inhibitors (ICIs), has led to improved survival rates for various cancers, but it also brings significant risks of autoimmunity, including severe neurological side effects.
- The study focuses on understanding the role of neuronal autoantibodies in ICI-treated patients, exploring their prevalence and potential correlation with adverse neurological effects.
- This research is the first comprehensive comparison of neuronal autoantibody profiles between ICI-treated cancer patients with and without neurological immune-related adverse events, offering important insights for future clinical and research applications.
Comments on the first European guideline for paraneoplastic autoimmune multiorgan syndrome.
J Eur Acad Dermatol Venereol
July 2024
Department of Dermatology, Christian Hospital Unna, Unna, Germany.
Reply to 'Comments on the first European guideline for paraneoplastic autoimmune multiorgan syndrome'.
J Eur Acad Dermatol Venereol
July 2024
Department of Health Sciences, Section of Dermatology, University of Florence, Florence, Italy.
Adult-onset linear IgA bullous dermatosis: a retrospective single-center cohort study of 81 patients and literature review.
Int J Dermatol
July 2024
Department of Dermatology, Mayo Clinic, Rochester, MN, USA.
Article Synopsis
- Linear IgA bullous dermatosis (LABD) is a rare autoimmune disorder that can be caused by medications or associated with malignancies; this study aimed to identify differentiating characteristics in patients with idiopathic, drug-induced, or malignancy-related LABD.
- A total of 81 patients were studied, revealing that those with drug-induced or malignancy-associated LABD had a significantly shorter disease duration and quicker diagnosis and improvement compared to idiopathic cases.
- The findings suggest the importance of screening for underlying health issues like malignancy or inflammatory bowel disease in newly diagnosed LABD patients, although the study had limitations such as retrospective data collection and lack of diverse participants.
Article Synopsis
- Bullous pemphigoid (BP) and malignant acanthosis nigricans (AN) were observed in a patient with gastric adenocarcinoma, but they had different behaviors in relation to cancer progression.
- BP did not show any correlation with the relapse and remission of gastric cancer, while the malignant AN did reflect the paraneoplastic effects of the cancer.
- The case highlights the unusual coexistence of BP and malignant AN, which has not been documented before in the context of malignancy.
Paraneoplastic Dermatoses and Cutaneous Metastases.
Clin Geriatr Med
February 2024
Department of Dermatology, Tulane University School of Medicine, 1430 Tulane Avenue #8036, New Orleans, LA 70112, USA.