Fibronectin Fragments and Inflammation During Canine Intervertebral Disc Disease.

Canine intervertebral disc disease (IVDD) represents a significant clinical problem in veterinary medicine, with similarities to the human pathology. Host-derived damage-associated molecular patterns like fibronectin fragments (FnF) that develop during tissue dysfunction may be of specific relevance to IVD pathologies by inducing an inflammatory response in resident cells. This project aimed to determine the presence and pathobiological role of FnF during IVD herniation in dogs, with a focus on inflammation.

Treatment strategies for vasculitis that affects the nervous system.

Vasculitis is a rare but severe disease. It is diagnostically challenging because patients present with nonspecific symptoms. The definitive diagnosis is therefore complicated, because many diagnostic procedures have to be performed.

Current therapies in ischemic stroke. Part B. Future candidates in stroke therapy and experimental studies.

Stroke still remains a major healthcare problem. The growing understanding of the mechanism of cell death in ischemia leads to new approaches in stroke treatment. The aim of neuroprotection is to reduce the post-stroke impairment and the overall costs that are accompanied in patients with severe disability.