Clinicopathological analysis of 39 patients with corneal tumor.

Purpose: Corneal tumors are rare in clinical practice. There was a paucity of data on the incidence of various corneal tumors, their clinical and pathological features and surgical management, especially on large patient samples.

Methods: The medical records of 39 patients with corneal tumors referred to Zhongshan Ophthalmic Center, Sun Yat-sen University, China from Jan 1,1996 to Dec 31,2002 were reviewed retrospectively.

Ocular surface frostbite secondary to ethyl chloride spray.

Context: Ethyl chloride (EC) is a fast-acting vapo-coolant spray that provides rapid, transient, local analgesia for minor invasive procedures. Although the application of EC has decreased, it can be used as a cryoanalgesic agent in minor surgical procedures.

Objective: Despite the widespread use of EC as a local anesthetic, there are few reported cases of serious adverse side effects.

Hyaluronan production and hyaluronan synthase expression in three human conjunctiva-derived cell strains.

Purpose: The conjunctiva maintains the health of the ocular surface by protecting the eye from pathogen invasion, injury, and dryness. In this study, we investigated the regulation of hyaluronan (HA) synthesis by cytokines in conjunctiva-derived cells.

Methods: Cultured primary cells derived from human conjunctivas that had been removed as surgical specimens were transfected with an immortalizing gene (human papilloma virus 16 E6/E7).

Intralesional interferon for extensive squamous papilloma of the eyelid margin.

Eyelid margin papillomas are challenging because complete excision may be cosmetically unacceptable. Interferon has been previously reported as an effective treatment for conjunctival papillomas. We report successful treatment of a large upper eyelid margin papilloma with intralesional interferon.

The evaluation of human papillomavirus and p53 gene mutation in benign and malignant conjunctiva and eyelid lesions.

Papillomas and squamous cell carcinomas are the most common conjunctival and eyelid lesions. The etiology is still unclear and recently human papillomavirus infection and p53 gene mutation have been taken into consideration. The aim of our study was the evaluation of HPV DNApresence and p53 gene mutation in 45 benign and 38 malignant squamous lesions of the conjunctiva and eyelid.

[Atypical cutaneous infections with genital HPV].

Not only does genital "high risk HPV 16" play a significant role in cervical carcinomas, it is also the most commonly found mucosal virus in groups of well-defined but atypical infections on the skin. In this group are included 1. Bowen disease, 2.

IgG4-related sclerosing disease of the breast successfully treated by steroid therapy.

IgG4-related sclerosing disease was first identified and defined in the twenty-first century. In this pathology, the serum IgG4 level increases and IgG4-positive plasma cells and lymphocytes infiltrate organs such as the pancreas, salivary glands, lacrimal glands, kidneys, and the retroperitoneum. Presented in this report is a case of IgG4-related sclerosing disease that occurred in the breast and was treated successfully with steroid therapy.

Serological markers for papillomavirus infection and skin tumour development in the rodent model Mastomys coucha.

This study used the rodent Mastomys coucha latently infected with Mastomys natalensis papillomavirus (MnPV) and Mastomys coucha PV2 (McPV2), which induce skin papillomas and anogenital condylomas, respectively, to investigate PV antibody responses as serological markers during pathogenesis. In a case-control study (137 animals), virus and tumour prevalence correlated with the seroresponse against the early E2 and late L1 viral proteins. A prospective study (53 animals) revealed for the first time the course of these antibody responses during all stages of a natural PV infection.

The use of a radiofrequency unit for excisional biopsy of eyelid papillomas.

Purpose: To describe a technique for excisional biopsy of eyelid papillomatous lesions using a radiofrequency (RF) unit.

Method: In this prospective, interventional case series, 64 patients with eyelid papillomatous lesions underwent excisional biopsy using an RF unit.

Results: The upper eyelid was involved in 34.

Conjunctival squamous cell carcinoma due to ocular prostheses: a case report and review of literature.

Conjunctival squamous cell carcinoma (SCC) is a rare finding in everyday clinical practice, but is the most common malignancy of the ocular surface. The incidence of this malignancy in the United States is 0.03 per 100,000 persons.

Eyelid tumors: histopathological and clinical study performed in County Hospital of Oradea between 2000-2007.

The work assessment is to analyze eyelid tumors diagnosed in the last years in our hospital. We found 471 tumoral and pseudotumoral cases, in which malignant tumors predominated, with 255 cases. The most affected age range was the sixth decade and the majority of tumors were located to lower eyelid.

[Causes of epiphora in diagnosed and treated patients in Department of Ophthalmology in Military Institute of Health Service].

Purpose: Analysis of causes of epiphora in patients which have been examined in Department of Ophthalmology in Military Institute of Health Service from 2004 to 2007.

Material And Methods: The study has comprised 330 subjects: 241 women and 89 men (mean age 58.85 +/- 19.

Seborrheic keratosis of the conjunctiva: a case report.

Seborrheic keratosis is a benign epithelial neoplasia that occurs mainly in the skin of the eyelids and face. We describe a case of seborrheic keratosis of the conjunctiva confirmed by histopathology. A 72-year-old man presented with a recurrent conjunctival mass involving the nasal side of his right eye.

Canaliculitis with a papilloma-like mass caused by a temporary punctal plug.

Absorbable plugs are used before attempting permanent occlusion to observe whether the patient will be amenable to treatment for dry eye. Little is known about the complications of absorbable plugs. The authors present a case of canaliculitis with a papilloma-like mass caused by long-standing unabsorbed collagen plug that had been placed 3 years earlier.

Novel intronic germline FLCN gene mutation in a patient with multiple ipsilateral renal neoplasms.

Multiple renal tumors of diverse morphology are rare and typically seen in Birt-Hogg-Dubé syndrome. Birt-Hogg-Dubé syndrome is a rare inherited cancer syndrome caused by a germline mutation in the folliculin (FLCN) gene, but the genetic causes for histologic diversity of renal tumors in Birt-Hogg-Dubé syndrome have not been elucidated. We describe here a 64-year-old man with a novel germline mutation in the FLCN gene who presented with 3 phenotypically distinct renal tumors in the same kidney, which were histologically classified as oncocytoma (1.

Clinicopathological features of eyelid skin tumors. A retrospective study of 5504 cases and review of literature.

Eyelid tumors are the most common neoplasm in daily ophthalmology practice and encompass a wide variety of benign and malignant tumors. In this retrospective study, we report the clinical and histological features of 5504 eyelid skin tumors diagnosed at the Laboratory of Ophthalmopathology of the Hôpital Ophtalmique Jules Gonin, Lausanne, Switzerland, between January 1989 and December 2007. Benign tumors largely predominated over malignant ones, representing 84% of cases in this series, and the 5 most frequent subtypes were squamous cell papilloma (26%), seborrheic keratosis (21%), melanocytic nevus (20%), hidrocystoma (8%), and xanthoma/xanthelasma (6%).

Pattern of ocular tumors in the eastern region of Nepal.

Background: ocular tumors are commonly encountered in ophthalmic practice.

Objective: to study the clinical pattern of ocular tumors in the eastern region of Nepal.

Materials And Methods: the hospital records of patients with ocular tumors treated at B P Koirala Institute of Health Sciences in the eastern region of Nepal over a period of 5 years (April 2003 - March 2008) were studied retrospectively.

Detection of canine oral papillomavirus DNA in conjunctival epithelial hyperplastic lesions of three dogs.

Papillomavirus infections are responsible for plaques and papillomas in various locations on the skin and in mucous membranes. The aim of this report was to describe morphologic features of a viral pigmented conjunctival plaque and 2 conjunctival squamous papillomas in 3 dogs, and to investigate these lesions for the presence of papillomavirus DNA by polymerase chain reaction (PCR), DNA sequence analysis, and in situ hydridization (ISH). Histopathology revealed in all neoplasms various degrees of epithelial hyperplasia, acanthosis, and hyperkeratosis with koilocytosis.

Eyelid neoplasms in the Beijing Tongren Eye Centre between 1997 and 2006.

Background And Objective: To examine the spectrum of eyelid neoplastic specimens obtained at the Beijing Tongren Eye Centre between 1997 and 2006.

Patients And Methods: A total of 2,639 eyelid neoplasms were included in the study.

Results: Of the 2,639 eyelid specimens, 2,276 (86.

Long-term success rate of perforated punctal plugs in the management of acquired punctal stenosis.

Purpose: To give the long-term success rates of punctal dilatation with insertion of perforated punctal plugs (PPP) for the management of acquired punctal stenosis.

Methods: A series of 44 eyes of 26 patients who underwent PPP implantation for the management of acquired punctal stenosis were retrospectively evaluated in terms of the severity of acquired punctal stenosis, associated eyelid disorders, implantation technique of PPP, and long-term success rate of PPP for the treatment of epiphora. In all patients, punctal dilation was performed prior to the insertion of plugs.

The role of infectious agents in the etiology of ocular adnexal neoplasia.

Given the fact that infectious agents contribute to around 18% of human cancers worldwide, it would seem prudent to explore their role in neoplasms of the ocular adnexa: primary malignancies of the conjunctiva, lacrimal glands, eyelids, and orbit. By elucidating the mechanisms by which infectious agents contribute to oncogenesis, the management, treatment, and prevention of these neoplasms may one day parallel what is already in place for cancers such as cervical cancer, hepatocellular carcinoma, gastric mucosa-associated lymphoid tissue lymphoma and gastric adenocarcinoma. Antibiotic treatment and vaccines against infectious agents may herald a future with a curtailed role for traditional therapies of surgery, radiation, and chemotherapy.

Detection of human papillomavirus in pterygium and conjunctival papilloma by hybrid capture II and PCR assays.

Aim: To elucidate the putative role of human papillomavirus (HPV) infection in pterygium and conjunctival papilloma.

Methods: Hybrid capture II (HC-II) and polymerase chain reaction (PCR) assays were performed to detect HPV in pterygium (42 samples obtained from 40 patients) and conjunctival papilloma (8 samples from 6 patients). The amount of HPV DNA was evaluated by measurement of relative light units (RLUs) on a luminometer.

[Clinical and pathological analysis of 2639 cases of eyelid tumors].

Objective: To describe the histopathologic spectrum and patient characteristics of eyelid tumors in Beijing Tongren Hospital.

Methods: It was a claims database analysis. A total of 2639 eyelid tumors verified histopathologically from January 1997 to December 2006 were included in the study.