2,860 results match your criteria: "Papillary Necrosis"

DICER1 Mutations Do Not Always Indicate Dismal Prognosis in Pediatric Poorly Differentiated Thyroid Carcinomas.

Endocr Pathol

September 2023

Department of Pathology, Toronto General Hospital, University Health Network, 200 Elizabeth Street, 11th floor, Toronto, ON, M5G 2C4, Canada.

Progress in the field of pediatric thyroid pathology has linked DICER1 mutations to benign follicular cell-derived thyroid tumors (e.g., follicular adenoma with papillary architecture, follicular nodular disease), low-risk follicular cell-derived differentiated thyroid carcinomas and PDTCs enriched in fatal or recurrent/progressive disease.

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Differentiated high-grade thyroid carcinoma (DHGTC) is a new entity in the 2022 WHO classification. We aimed to investigate the incidence and clinicopathological features of differentiated HG thyroid carcinoma (DHGTC) and compare the clinicopathological parameters of DHGTC, DTC without HG features, and poorly differentiated thyroid carcinoma (PDTC). A total of 1069 DTCs including papillary thyroid carcinomas (PTCs) and follicular thyroid carcinomas (FTCs) were included in this study.

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Article Synopsis
  • Lenvatinib is a multikinase inhibitor used to treat unresectable or metastatic cancers, particularly thyroid cancer, but its effects on thyroid histology post-treatment are not well understood.
  • A study analyzed thyroid specimens from patients who underwent thyroidectomy after lenvatinib therapy, finding significant ischaemic changes and lower microvessel density (MVD) in lenvatinib-treated tissues compared to untreated ones.
  • The results suggest that lenvatinib causes specific alterations in cancer cells and affects non-cancerous thyroid tissue, potentially contributing to hypothyroidism seen in patients.
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Papilloma of the lung is a rare benign entity and can be solitary or multiple. Solitary papilloma is subclassified into three categories: squamous papilloma, glandular papilloma, and mixed squamous and glandular papilloma. Glandular papilloma is the rarest subtype among them and occurs mostly in the sixth decade without any relation to smoking, syndrome, or infection.

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Unlabelled: Mutations in the promoter of the telomerase reverse transcriptase (TERT) gene are the paradigm of a cross-cancer alteration in a noncoding region. TERT promoter mutations (TPM) are biomarkers of poor prognosis in cancer, including thyroid tumors. TPMs enhance TERT transcription, which is otherwise silenced in adult tissues, thus reactivating a bona fide oncoprotein.

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Background: The aim of this study was to use bioinformatics approaches to screen and identify the key genes of idiopathic calcium oxalate nephrolithiasis, and explore its potential molecular mechanism.

Methods: The GSE73680 kidney stone data set was downloaded from the Gene Expression Omnibus (GEO). R software (The R Foundation for Statistical Computing) was used to screen differentially expressed genes.

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Comparison and validation of different risk models for papillary renal cell carcinoma.

Urol Oncol

August 2023

Department of Urology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China; Department of Urology, Xiamen Clinical Research Center for Cancer Therapy, Xiamen, China. Electronic address:

Article Synopsis
  • * The VENUSS system outperformed other models (like ISUP, TNM, and Leibovich) in predicting recurrence-free survival (RFS), disease-specific survival (DSS), and overall survival (OS), achieving a high c-index.
  • * Analysis revealed that intermediate and high-risk patients according to the VENUSS model had notable genetic mutations and a higher presence of specific immune cells, indicating potential aggressive tumor characteristics.
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  • The study aimed to investigate the radial peripapillary capillaris (RPC) and intra-papillary capillaris (IPC) in patients with acute retinal necrosis (ARN) using optical coherence tomography angiography (OCTA).
  • Thirteen patients were analyzed, and while 12 showed no visual abnormalities through standard eye exams, OCTA revealed significant issues: 69% had RPC morphological abnormalities, and 62% showed a decrease in capillary networks.
  • The findings indicate that even in cases of ARN that appear mild and have good visual outcomes, there are underlying impairments in the capillaries, suggesting possible optic nerve damage.
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Metabolome Sequencing Reveals that Protein Arginine-N-Methyltransferase 1 Promotes the Progression of Invasive Micropapillary Carcinoma of the Breast and Predicts a Poor Prognosis.

Am J Pathol

September 2023

Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China. Electronic address:

Invasive micropapillary carcinoma (IMPC) of the breast is a special histopathologic type of cancer with a high recurrence rate and the biological features of invasion and metastasis. Previous spatial transcriptome studies indicated extensive metabolic reprogramming in IMPC, which contributes to tumor cell heterogeneity. However, the impact of metabolome alterations on IMPC biological behavior is unclear.

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Papillary thyroid carcinoma (PTC) is considered an indolent neoplasm but it may demonstrate aggressive behavior. We aimed to identify clinical and pathological characteristics and molecular signatures associated with aggressive forms of PTCs. We selected 43 aggressive PTC cases based on the presence of metastases at the time of diagnosis, the development of distant metastasis during follow-up, and/or biochemical recurrence, and 43 PTC patients that were disease-free upon follow-up, matching them according to age, sex, pT, and pN parameters.

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High Grade Differentiated Follicular Cell-Derived Thyroid Carcinoma Versus Poorly Differentiated Thyroid Carcinoma: A Clinicopathologic Analysis of 41 Cases.

Endocr Pathol

June 2023

Head and Neck Pathology Consultations, 22543 Ventura Blvd, Ste 220 PMB1034, Woodland Hills, CA, 91364, USA.

Article Synopsis
  • This study explores the differences in histological features and outcomes between high grade differentiated follicular cell-derived thyroid carcinoma (HGDFCDTC) and poorly differentiated thyroid carcinoma (PDTC) by reviewing 41 cases over 11 years.
  • The analysis found that key criteria related to metastatic risk included tumor invasiveness, age, gender, tumor size, and stage, rather than mitotic rate or Ki-67 index.
  • Results indicated that a significant portion of patients (41.2%) with HGDFCDTC developed metastases, highlighting a need for clearer criteria in distinguishing these types of thyroid neoplasms.
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Sickle Cell Disease (SSD) can present with acute painful crises, most commonly manifesting as diffuse bony pain; however, rare presentations of acute coronary syndrome, acute papillary necrosis, or multi-organ failure may also present in these patients. TTP has been rarely described in conjunction with sickle cell pain crisis (SS crisis). In both TTP and sickle cell crises, widespread platelet activation is present with thrombocytopenia as a result.

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Article Synopsis
  • Diabetes mellitus causes chronic high blood sugar due to insufficient insulin, primarily affecting the nervous system and leading to specific urological complications.
  • Urological patients with diabetes often present with common conditions but may also experience unique complications that can go unrecognized and potentially be life-threatening.
  • Effective treatment requires addressing both urological issues and the underlying diabetes to prevent further complications.
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Lung adenocarcinomas (LUADs) display a broad histological spectrum from low-grade lepidic tumors through to mid-grade acinar and papillary and high-grade solid, cribriform and micropapillary tumors. How morphology reflects tumor evolution and disease progression is poorly understood. Whole-exome sequencing data generated from 805 primary tumor regions and 121 paired metastatic samples across 248 LUADs from the TRACERx 421 cohort, together with RNA-sequencing data from 463 primary tumor regions, were integrated with detailed whole-tumor and regional histopathological analysis.

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Papillary thyroid carcinoma (PTC) is usually indolent; however, some rare subtypes of PTCs, such as columnar cell and hobnail subtypes, carry poor prognosis as an intermediate malignancy between differentiated carcinoma and anaplastic carcinoma. We present the case of a 56-year-old Japanese woman having PTC with aggressive behavior showing characteristic histological features of a predominantly fused follicular and focally solid (FFS) pattern. The fused follicular pattern is cribriform-like without intermingled vessels.

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Article Synopsis
  • The study re-evaluated 457 renal cell carcinoma (RCC) cases from the Netherlands Cohort Study using the latest 2022 classifications to identify any new subtypes.* -
  • While no new RCC entities were discovered, the grading indicated agreement with previous diagnoses in about 56.5% of cases, and restaging was noted in 65.5% according to updated TNM classifications.* -
  • Key findings included lymphovascular invasion in 14.4% of cases and tumor necrosis in 33.5%, with some cases showing sarcomatoid and rhabdoid differentiation.*
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ADP-ribosylation (ADPR) of proteins is catalyzed by ADP-ribosyltransferases, which are targeted by inhibitors (i.e. poly(ADP-ribose) polymerase inhibitors [PARPi]).

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Background: Papillary thyroid carcinoma PTC is the most prevalent of all thyroid carcinomas. On the other hand, Hashimoto's thyroiditis (HT), as part of the spectrum of autoimmune thyroid diseases, is a major cause of thyroid hypofunction worldwide. Several studies have aimed to indicate a possible correlation between PTC and HT over the years.

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The histopathologic heterogeneity of intraductal papillary mucinous neoplasms (IPMN) complicates the prediction of pancreatic ductal adenocarcinoma (PDAC) risk. Intratumoral regions of pancreaticobiliary (PB), intestinal (INT), and gastric foveolar (GF) epithelium may occur with either low-grade dysplasia (LGD) or high-grade dysplasia (HGD). We used digital spatial RNA profiling of dysplastic epithelium (83 regions) from surgically resected IPMN tissues (12 patients) to differentiate subtypes and predict genes associated with malignancy.

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Background: Gemstone spectral contrast-enhanced CT with virtual noncontrast (VNC) images and iodine maps can potentially reduce the number of required CT scans for thyroid lesions. However, data regarding the clinical utility of VNC images and iodine maps in characterizing thyroid lesions and distinguishing thyroid papillary carcinoma from nodular goiter are still limited.

Purpose: To determine whether VNC images and iodine density could reliably aid in characterizing thyroid lesions and distinguishing thyroid papillary carcinoma from nodular goiter compared with true noncontrast (TNC) images.

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To report our experience with the cases of TFEB rearranged RCC, with particular attention to the clinicopathological, immunohistochemical and molecular features of these tumors and to their predictive markers of response to therapy. We have retrieved the archives of 9749 renal cell carcinomas in the Institute of Urology, Peking University and found 96 rearranged RCCs between 2013 and 2022. Among these renal tumors, ten cases meet the morphologic, immunohistochemical and FISH characterization for TFEB rearranged RCC.

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Cystadenoma arising from the larynx is a rare benign minor salivary gland tumor that can show mucinous or papillary morphology. The epithelial lining of the salivary gland tumor can present with oncocytic features, which is attributed to an increased number of mitochondria. We present a rare case of oncocytic papillary cystadenoma (OPC) of the larynx which has a combination of these features.

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Hyaluronic acid (HA) injections into the oral mucosa have proven to be effective as a non-invasive method for the reconstruction of interproximal papillary defects in aesthetic areas. Despite being a minimally invasive and safe technique, certain side effects may occur after treatment.We report the first case of a patient with unilateral necrosis of the mucosa of the hard palate after HA filling in the maxillary anterior gingiva.

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