465 results match your criteria: "Paoli Calmettes Institute[Affiliation]"
Neoplasia
August 2020
Laboratory of Solid Tumor Genetics, University Hospital of Nice-Côte d'Azur University, Nice, France; Laboratory of Solid Tumor Genetics, Institute for Research on Cancer and Aging of Nice (IRCAN), CNRS UMR 7284/INSERM U1081, Nice, France. Electronic address:
The detection of specific alterations by genetic analyses has been included in the diagnostic criterions of the World Health Organization's classification of soft tissues tumors since 2013. The presence of a SS18 rearrangement is pathognomonic of synovial sarcoma (SS). MDM2 amplification is strongly correlated to well-differentiated or dedifferentiated liposarcoma (DDLPS) in the context of sarcoma.
View Article and Find Full Text PDFInt J Gynecol Cancer
December 2020
Surgery, Paoli-Calmettes Institute, Marseille, Provence-Alpes-Côte d'Azur, France.
Introduction: Enhanced Recovery After Surgery (ERAS) has been proven to decrease the length of hospital stay without increasing re-admission rates or complications. There are limited data on the satisfaction of patients undergoing minimally invasive surgery for gynecologic malignancy within ERAS programs. The aim of this study was to evaluate patient satisfaction after minimally invasive surgery for gynecologic malignancy within the ERAS program using the 'Evaluation du Vécu de l'Anésthésie Génerale (EVAN-G)' questionnaire.
View Article and Find Full Text PDFJCO Oncol Pract
November 2020
Department of Radiation Oncology, University of California, Los Angeles, CA.
Purpose: Magnetic resonance-guided radiation therapy (MRgRT) has recently become commercially available, offering the opportunity to accurately image and target moving tumors as compared with computed tomography-guided radiation therapy (CTgRT) systems. However, the costs of delivering care with these 2 modalities remain poorly described. With localized unresectable hepatocellular carcinoma as an example, we were able to use time-driven activity-based costing to determine the cost of treatment on linear accelerators with CTgRT compared with MRgRT.
View Article and Find Full Text PDFAnn Surg Oncol
October 2020
Department of Digestive Surgical Oncology - Liver Transplantation Unit, University Hospital of Besançon, Besançon Cedex, France.
Background: Synchronous prostate cancer (PC) and rectal cancer (RC) is a rare clinical situation. While combining curative-intent management for both cancers can be challenging, available data for guiding the multidisciplinary strategy are lacking.
Methods: Consecutive patients undergoing rectal resection for a mid-low RC with synchronous PC treated at 9 tertiary-care centers between 2008 and 2018 were included.
J Geriatr Oncol
November 2020
Department of Medical Oncology, Paoli-Calmettes Institute, Marseille, France; Head of Geriatric Oncology, Paoli-Calmettes Institute, Marseille, France.
Almost half of the new cases of colorectal cancer concern patients aged ≥70 years. However, very few clinical trials have specifically included older patients. As a consequence, the treatment of these patients is controversial because the balance between clinical benefits and toxicities remains uncertain.
View Article and Find Full Text PDFSurg Innov
October 2020
Paoli Calmettes Institute and CRCM, CNRS, INSERM, Aix Marseille Université, Marseille, Provence-Alpes-Côte d'Azu, France.
. Only few cases of robotic latissimus dorsi flap reconstruction (RLDFR) have been reported in indication of reconstruction for breast cancer (BC). We report our experience of combined robotic nipple-sparing mastectomy (R-NSM) and RLDFR, and analyze technique, indications, and reproducibility.
View Article and Find Full Text PDFEndosc Ultrasound
January 2020
Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy, Craiova, Romania.
Background: Recent advances in EUS techniques (real-time EUS elastography and contrast-enhanced EUS) have allowed a better characterization of focal pancreatic masses. Mean strain histograms (SHs) are considered a good parameter for the semi-quantitative evaluation of focal pancreatic masses, alongside complementary contrast-enhanced EUS parameters which can be quantified during both the early arterial and late venous phase.
Materials And Methods: The study design was prospective, blinded, and multicentric, assessing real-time EUS elastography and contrast-enhanced EUS results for the characterization of focal pancreatic masses using parametric measurements, in comparison with pathology which is the gold standard.
Cancer Radiother
June 2020
Department of Medical Oncology, Salah Azaiez Institute, 1006 Tunis, Tunisia.
Purpose: The aim of this study was to extensively describe the epidemiological, clinical and therapeutic outcomes of adolescents and young adults (AYA) population with classical Hodgkin Lymphoma (cHL). Then, a comparison between AYAs and adults and between the subgroups of AYAs treated with the same adult protocol was accomplished to further inform on optimal therapy approach of choice for adolescent patients.
Material And Methods: In this mono-centric, retrospective study, we reviewed the medical records.
Eur J Cancer
April 2020
Medical Oncology, Gustave Roussy, Villejuif, France.
Introduction: Papillary renal cell carcinoma (PRCC) represents 10%-15% of renal carcinomas. No standard treatments exist for metastatic PRCC (mPRCC) patients. Axitinib is indicated as second-line treatment in metastatic clear cell renal carcinoma, and we aim to assess the efficacy of this vascular endothelial growth factor receptor inhibitor in front line for mPRCC.
View Article and Find Full Text PDFMinerva Urol Nephrol
April 2021
Department of Surgical Oncology 2, Paoli-Calmettes Institute, Marseille, France -
Background: Sarcopenia is suspected to influence the complication rates in patients undergoing radical cystectomy (RC). The aim of our study was to assess variations in sarcopenia in patients scheduled for neoadjuvant cisplatin-based chemotherapy (NAC) and RC for muscle invasive bladder cancer (MIBC) and to explore the impact of sarcopenia on complications linked to NAC or surgery.
Methods: Between 2012 and 2017, 82 consecutive patients who underwent NAC and RC for cT2-T4 N0 MIBC were retrospectively selected.
Bone Marrow Transplant
June 2020
Department of Clinical Hematology, Caen University Hospital, F-14000, Caen, France.
The combination of carmustine, etoposide, cytarabine, and melphalan (BEAM) as conditioning regimen prior to autologous stem-cell transplantation (ASCT) remains the standard of care for patients with mantle cell lymphoma (MCL) who are eligible for transplantation. The replacement of carmustine with bendamustine (BeEAM) was described as a promising alternative in non-Hodgkin lymphoma. The aim of this retrospective study was to compare the BeEAM with the BEAM regimen in MCL patients in the frontline setting.
View Article and Find Full Text PDFRadiother Oncol
April 2020
Medical Oncology Department, Claudius Regaud Institute, IUCT-Oncopole, Toulouse, France.
Br J Surg
June 2020
Department of Digestive Surgery and Liver Transplantation, Toulouse University Hospital, Toulouse, France.
Background: Biliary fistula is one of the most common complications after hepatectomy. This study evaluated the effect of transcystic biliary drainage during hepatectomy on the occurrence of postoperative biliary fistula.
Methods: This multicentre RCT was carried out from 2009 to 2016 in nine centres.
Eur J Surg Oncol
May 2020
Department of Surgical Oncology, Gustave Roussy Cancer Campus, 114, rue Edouard vaillant, 94800, Villejuif, France.
Purpose: Psammocarcinoma (PK) is a rare disease of unknown origin. We aimed to report the characteristics, management and survival of patients operated on for PK within the French Network for Rare Peritoneal Malignancies (RENAPE) expert centers.
Patients And Methods: All consecutive cases of PK operated within all 26 RENAPE centers between 1997 and 2018 were retrospectively analyzed.
Endosc Ultrasound
November 2019
Endoscopy Unit, Paoli Calmettes Institute, Marseille, France.
Hepaticogastrostomy (HGS) has been reported for the management of palliative malignant hilar stricture and involves draining the left liver as rescue therapy. For the management of this complex stenosis, another new option for draining the right liver under EUS guidance was introduced. Ten publications involving 38 patients have been reported in the literature, in which the following two main techniques have been described: direct puncture of the right liver from the bulbus and the bridge technique allowing the drainage of the right liver across the left liver through HGS.
View Article and Find Full Text PDFEndosc Ultrasound
November 2019
Endoscopic Unit, Paoli-Calmettes Institute, Marseille Cedex, France.
EUS-guided biliary drainage (BD) is an option to treat obstructive jaundice when ERCP drainage fails. These procedures represent alternatives to surgery and percutaneous transhepatic BD and have been made possible through the continuous development and improvement of EUS scopes and accessories. The development of linear sectorial array EUS scopes in early 1990 brought a new approach to the diagnostic and therapeutic dimensions of echoendoscopy capabilities, opening the possibility to perform puncture over a direct ultrasonographic view.
View Article and Find Full Text PDFIn Vivo
June 2020
Anatomic Pathology Department, Salah Azaiez Institute, Tunis, Tunisia.
Background: Epithelial ovarian cancer (EOC) is the major gynecological cause of cancer deaths. Annexin A1 (ANXA1) protein has been implicated in the aggressiveness of several cancer types.
Materials And Methods: This study retrospectively assessed ANXA1 expression in epithelial cells of 156 pre-chemotherapy EOC samples and 34 normal ovarian samples from patients treated at Salah Azaiez Institute.
Clin Lymphoma Myeloma Leuk
February 2020
CHU of Nice, Hematology Department, Cote D'Azur University, Nice Sophia Antipolis University, Nice, France; INSERM U1065, Mediterranean Center of Molecular Medecine, Cote D'Azur University, Nice, France. Electronic address:
Introduction: The standard first-line treatment for acute myeloid leukemia (AML) is a combination of cytarabine and anthracyclines. To date, there is no commonly agreed-on regimen for patients who are ineligible for this therapy because of cardiac comorbidities or prior exposure to anthracyclines. We compared 3 anthracycline-free regimens currently used in France.
View Article and Find Full Text PDFCancer
March 2020
Department of Hematology and Cell Therapy, Saint-Antoine Hospital, Paris, France.
Background: In adult patients with acute myeloid leukemia (AML), a matched sibling donor (MSD) is considered the first choice for an allogeneic transplantation. However, a female donor for a male recipient is a poor prognostic factor. The authors compared haploidentical (HAPLO) donors with female MSDs.
View Article and Find Full Text PDFCancer Biomark
June 2020
Department of Immuno-Histo-Cytology, Salah Azaiez Institute, Tunis, Tunisia.
Background: Male breast cancer (MBC) is a rare and aggressive disease. Thus, identification of new therapeutic targets is crucial.
Objective: Our objective was to evaluate the protein expression of MARCKS (Myristoylated Alanine-Rich C-Kinase Substrate) in MBC and to investigate its prognostic value.
Semin Radiat Oncol
January 2020
Department of Radiotherapy, Gustave Roussy Cancer Campus, Villejuif, France.; Département Effets Biologiques des Rayonnements, Institut de Recherche Biomédicale des Armées, Brétigny-sur-Orge, France.; Ecole du Val-de-Grâce, French Military Health Academy, Paris, France.. Electronic address:
Pancreas
September 2020
From the Departments of Digestive Oncology.
Objectives: Acinar cell carcinoma is a rare tumor of the pancreas. Our current series aimed to assess the clinical and morphological features of pancreatic acinar cell carcinoma and to evaluate the treatment strategies and prognosis.
Methods: This retrospective study was conducted in 3 French referral centers.
World J Surg Oncol
November 2019
Department of Surgical Oncology, Paoli Calmettes Institute, Marseille, France.
Background: Robotic latissimus dorsi-flap reconstruction (RLDFR) after skin-sparing mastectomy (SSM) for breast cancer (BC) has been performed through a single nipple incision. We report results of SSM with RLDFR, mainly with analysis of feasibility, morbidity, indications, and technique standardization.
Methods: We determined characteristics of patients, previous treatment of BC, and type of reconstruction.
Eur J Nucl Med Mol Imaging
January 2020
Nuclear Medicine, Jean Perrin Cancer Institute, Clermont-Ferrand, France.
Positron emission tomography/computed tomography (PET/CT) is a nuclear medicine functional imaging technique with proven clinical value in oncology. PET/CT indications are continually evolving with fresh advances made through research. French practice on the use of PET in oncology was framed in recommendations based on Standards-Options-Recommendations methodology and coordinated by the French federation of Comprehensive Cancer Centres (FNLCC).
View Article and Find Full Text PDFAnn Oncol
December 2019
Clinical Research Division, Gustave Roussy Cancer Campus, Villejuif, France.
Background: In 2013, the French National Cancer Institute initiated the AcSé program to provide patients with secure access to targeted therapies outside of their marketed approvals. Efficacy and safety was then assessed using a two-stage Simon phase II trial design. When the study design was designed, crizotinib was approved only as monotherapy for adults with anaplastic lymphoma kinase plus non-small-cell lung cancers (NSCLC).
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