Increasing miR-1260b predicts the risk of gastric cancer in atrophic gastritis patients and regulates cell growth and metastasis of gastric cancer.

Background: Atrophic gastritis is of high risk of progressing to gastric cancer. Screening early gastric cancer and predicting the risk of atrophic gastritis developing into gastric cancer could improve the prognosis of gastric cancer.

Objective: This study evaluated the significance of miR-1260b in early gastric cancer and in the progression of atrophic gastritis to gastric cancer aiming to explore a reliable biomarker.

Revolutionizing Dual-Band Modulation and Superior Cycling Stability in GDQDs-Doped WO Electrochromic Films for Advanced Smart Window Applications.

Dual-band tungsten oxide (WO) electrochromic films are extensively investigated, yet challenges persist regarding complex fabrication processes and limited cyclic stability. In this paper, a novel approach to prepare graphdiyne quantum dots (GDQDs) doped WO films with a hexagonal crystal structure, is presented. Structural characterization reveals that the GDQDs/WO possesses a coral-like, loose structure with high crystallinity due to the synergistic modulation of morphology and crystallinity.

Feasibility of large language models for CEUS LI-RADS categorization of small liver nodules in patients at risk for hepatocellular carcinoma.

Background: Large language models (LLMs) offer opportunities to enhance radiological applications, but their performance in handling complex tasks remains insufficiently investigated.

Purpose: To evaluate the performance of LLMs integrated with Contrast-enhanced Ultrasound Liver Imaging Reporting and Data System (CEUS LI-RADS) in diagnosing small (≤20mm) hepatocellular carcinoma (sHCC) in high-risk patients.

Materials And Methods: From November 2014 to December 2023, high-risk HCC patients with untreated small (≤20mm) focal liver lesions (sFLLs), were included in this retrospective study.

Dysregulation of saliva and fecal microbiota as novel biomarkers of colorectal cancer.

The aim of this study was to investigate the biomarkers of salivary and fecal microbiota in Colorectal cancer (CRC). Initially, the study scrutinized the microbial community composition disparities among groups. Utilizing Lasso analysis, it sifted through operational taxonomic units (OTUs) to pinpoint distinctive features.

Optimization of pyrite cinder strengthening continuous acid decomposition of ilmenite by response surface methodology.

Pyrite cinder could release more heat to improve he acid decomposition reaction of ilmenite, lower concentrations of sulfuric acid, increase the amount of TiO waste acid reused, reduce titanium gypsum emissions, and promote the green and sustainable development of TiO. Using pyrite cinder as strengthening activator, the continuous acid decomposition conditions for ilmenite were optimized by using response surface methodology based on Box-Behnken design method. The acid decomposition conditions such as acid ilmenite ratio, acid concentration and pyrite cinder dosage mainly affected the reaction temperature, reaction equilibrium, reaction velocity, volatilization degree of water and sulfuric acid, ultimately affecting the solidification degree of the products and reaction yields.

In situ hydrothermal synthesis of visible light active sulfur doped TiO from industrial TiOSO solution.

A cost-effective industrial TiOSO solution was employed to fabricate visible light active sulfur-doped titanium dioxide (S-TiO) via a facile hydrothermal method. The effect of calcination temperature on morphology, particle size, crystallinity, and photocatalytic property of S-TiO was systematically investigated. Successful incorporation of sulfur into TiO was confirmed by carbon-sulfur analysis, X-ray photoelectron spectroscopy (XPS), and Energy dispersive spectrometer (EDS).

Dysregulation of miR-21-5p in children with obesity and its predictive value for metabolic syndrome.

Background: microRNAs (miRNAs) could mediate the glucose and lipid metabolism progress in metabolic syndrome (MetS).

Objectives: To analyze the value of miRNA (miR)-21-5p for MetS diagnosis in children with obesity. Function of miR-21-5p has been explored by the prediction of target genes and functional and pathway enrichment analysis.

Predicting Composition Evolution for a Sulfuric Acid-Dimethylamine System from Monomer to Nanoparticle Using Machine Learning.

Experimental and theoretical studies on the compositional changes of new particle formation in the nucleation and initial growth stages of acid-base systems (2 and 5 nm) are extremely challenging. This study proposes a machine learning method for predicting the composition change of the sulfuric acid-dimethylamine system in the transformation from monomer to nanoparticle by learning the structure and composition information on small-sized sulfuric acid (SA)-dimethylamine (DMA) molecular clusters. Based on this method and changes in components, we found that the sulfuric acid-dimethylamine growth was mainly through the alternate adsorption of (SA)(DMA), (SA)(DMA), and (SA) clusters at the early stage of nucleation, which accounted for about 70, 20, and 10%, respectively.

A cross-linked coating loaded with antimicrobial peptides for corrosion control, early antibacterial, and sequential osteogenic promotion on a magnesium alloy as orthopedic implants.

Magnesium (Mg)-based alloys have been recognized as desirable biodegradable materials for orthopedic implants. However, their clinical application has been limited by rapid degradation rates, insufficient antibacterial and osteogenic-promotion properties. Herein, a MgF priming layer was first constructed on AZ31 surface.

Research on equipment layout of multi-layer circular manufacturing cell based on NSGA III.

This paper investigates the layout optimization of multi-layer circular manufacturing cells (MCMC), a topic that has garnered limited attention compared to single-layer circular manufacturing cells (SCMC). With the continuous advancement of global intelligent manufacturing, MCMC has emerged as a viable solution, with several smart factories already implementing this model. Existing literature predominantly utilizes the NSGA II algorithm for SCMC layouts due to their relatively few objectives.

Electrophotocatalytic Thiocyanation and Sulfonylation Cyclization of Unactivated Alkenes.

We report an electrophotocatalytic process that enables the thiocyanation and sulfonylation/cyclization of alkenes. It is applicable to a wide range of unactivated alkenes, using the inexpensive photocatalyst 2,4,6-triphenylpyrylium tetrafluoroborate (TPPT) to produce a diverse array of heterocycles containing sulfonyl and thiocyano groups with good functional group tolerance. The protocol operates under mild, chemical oxidant- and transition-metal-free, with a broad scope of substrates.

Comparative effectiveness totally endoscopic thyroidectomy via completely submental tri-hole approach and transoral endoscopic thyroidectomy without insufflation.

Objective: This study aims to evaluate the therapeutic effectiveness of totally endoscopic thyroidectomy via the completely submental tri-hole approach and transoral endoscopic thyroidectomy without insufflation.

Methods: A total of 60 patients with thyroid tumors who were admitted to Panyu College Affiliated Hospital from August 2022 to August 2023 were collected in this study. The patients were divided into two groups, the transoral endoscopic thyroidectomy group (20 cases) and the totally endoscopic thyroidectomy via the completely submental tri-hole approach group (40 cases).

Core-shell Ni/SiO@ZrO catalyst for highly selective CO conversion accompanied by enhancing reaction stability.

CO RWGS reaction was considered to be a promising process for carbon dioxide conversion, however it retained a big challenge owing to methanation and metal sintering. Therefore, it was desperately needed to devise highly selective and stable catalyst. Herein, core-shell Ni/SiO@ZrO catalyst was successfully prepared via a combination of the wet impregnation and in-situ hydrothermal synthesis method, with ZrO as the coating shell.

The effect of vitamin D on the lipid profile in individuals with overweight or obesity: A meta-analysis and systematic review of randomized controlled trials.

Background And Aim: Previous studies have reported on the relationship between vitamin D and the lipid profile in individuals with obesity or overweight, but results have been inconsistent. Hence, we conducted this meta-analysis and systematic review of randomized controlled trials to assess the effect of vitamin D on the lipid profile in individuals with overweight or obesity.

Methods: A meticulous search strategy was used in various databases, and article published up to November 2023 were included.

Preparation and cell imaging of a nido-carborane fluorescent complex based on multi-component polymerization.

The biocompatibility of carborane was a difficult problem that had drawn a lot of study interest. Using multi-ion inlay binding, water-soluble polymers were created by encapsulating nido-carborane in diazaspirodecaniums such as para-poly-nido-carboanylazaspirodecanium [5,4] (p-PNC54), para-poly-nido-carboanylazaspirodecanium [6,5] (p-PNC65), meta-poly-nido-carboanylazaspirodecanium [5,4] (m-PNC54), and meta-poly-nido-carboanylazaspirodecanium [6,5] (m-PNC65). First, the active control 5-fluorouracil demonstrated strong activity against HeLa and HCT-116 cells but minimal cytotoxicity at 19.

An MgVO anode exhibiting enhanced rate capability and stability for lithium storage applications.

The development of anode materials with high rate performance as well as favourable working durability is key for next-generation lithium-ion batteries (LIBs). Here, MgVO is reported as an advanced anode material, using a facile and scalable solution combustion technology. The MgVO anode shows a "near-zero" volume change (<10% over 1000 cycles).

Regulatory Role of Long Noncoding RNAs LINC00449 in Hepatocellular Carcinoma Mechanism and Prognosis Via Sponge miR-329-3p/KIF5A Axis.

Background/aims: Hepatocellular carcinoma (HCC) is a globally prevalent malignant tumor with high recurrence and mortality rates. Long noncoding RNAs (lncRNAs) have been utilized to investigate the progression of various cancers, including HCC. The objective of this research is to explore the mechanism and prognostic impact of lncRNA LINC00449 on HCC.

Progress on the prevention of poultry Salmonella with natural medicines.

Salmonella infection is an acute and systemic disease of poultry, primarily affecting young birds. The mortality rate of chicken within one week of age can reach up to 40 %. Surviving individuals may become carriers of the bacteria, leading to latent infections that can result in bacterial residues in meat and egg products, posing serious threats to human food safety and health.

A visualization analysis of immune-related adverse reactions in pulmonary carcinoma.

Immunotherapy has emerged as a crucial advancement in pulmonary carcinoma treatment. Nevertheless, its unique side effects not only reduce patients' quality of life but also affect treatment efficacy, with severe cases potentially endangering the patient's life. This study uses bibliometric analysis to perform a comprehensive bibliometric analysis literature on IRAEs in lung cancer from 1991 to 2023, retrieved from the Web of Science database.

Exercise Mediates Noncoding RNAs in Cardiovascular Diseases: Pathophysiological Roles and Clinical Application.

Exercise-based cardiac rehabilitation is effective in improving cardiovascular disease risk factor management, cardiopulmonary function, and quality of life. However, the precise mechanisms underlying exercise-induced cardioprotection remain elusive. Recent studies have shed light on the beneficial functions of noncoding RNAs in either exercise or illness models, but only a limited number of noncoding RNAs have been studied in both contexts.

Generation of Ext1 Gene-Edited Mice Model Via Dual sgRNAs/Cas9 System and Phenotypic Analyses.

Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disease. Genetic linkage analyses have identified that mutations in the exostosin glycosyltransferase (EXT)1 and EXT2 genes are linked to HME pathogenesis, with EXT1 mutation being the most frequent. The aim of this study was to generate a mice model with Ext1 gene editing to simulate human EXT1 mutation and investigate the genetic pathogenicity of Ext1 through phenotypic analyses.

Structural Evolution Study of Titanium-Vanadium-Niobium Nanoparticles from Single to Multicomponent Systems.

In this article, the revised basin-hopping with mirror-rotation sampling combined with density functional theory, which was proposed by our previous study, was used to study the structural property of Ti ( = 3, = 1-7), V ( = 3, = 1-7), Nb ( = 3, = 1-7), and Ti V Nb ( = 1-7) systems. We found that equiatomic Ti V Nb ( = 1-7) systems do not change their lowest energy structures relative to the same size Ti ( = 3, = 1-7), V ( = 3, = 1-7), and Nb ( = 3, = 1-7) systems, and this indicates that the nanoparticles composed of titanium, vanadium, or niobium elements may have similar energy morphologies when the atomic number is the same. Based on the low-energy structural similarity of titanium-vanadium-niobium systems between single and multicomponent, we used the element space position replacement (ESPR) method to reconstruct the low-energy structure of Ti V Nb ( = 1-7) systems.