Development of soft computing-based models for forecasting water quality index of Lorestan Province, Iran.

The Water Quality Index (WQI) is widely used as a classification indicator and essential parameter for water resources management projects. WQI combines several physical and chemical parameters into a single metric to measure the status of Water Quality. This study explores the application of five soft computing techniques, including Gene Expression Programming, Gaussian Process, Reduced Error Pruning Tree (REPt), Artificial Neural Network with FireFly (ANN-FFA), and combinations of Reduced Error Pruning Tree with bagging.

Bioflavonoid combination attenuates diabetes-induced nephropathy in rats via modulation of MMP-9/TIMP-1, TGF-β, and GLUT-4-associated pathways.

Background: Diabetic nephropathy represents a significant microvascular complication of diabetes, characterized by extracellular matrix accumulation, loss of cell-cell junctions, microalbuminuria, and diminished creatinine clearance. Despite its prevalence, therapeutic options dedicated to this condition are currently lacking. Natural products like bioflavonoids have garnered attention for their potential therapeutic benefits.

Role of MMP-9 and NF-κB in Diabetic Retinopathy: Progression and Potential Role of Bioflavonoids in the Mitigation of Diabetic Retinopathy.

"Diabetes mellitus" is a chronic metabolic disorder manifested by elevated blood glucose levels, primarily due to insufficient insulin production or resistance to insulin. Long-term diabetes results in persistent complications like retinopathy, cardiomyopathy, nephropathy, and neuropathy, causing significant health risks. The most alarming microvascular consequence allied with diabetes is "diabetic retinopathy," distinguished by the proliferation of anomalous blood vessels in the eye, mainly in the retina, resulting in visual impairment, diabetic macular edema, and retinal detachment if left untreated.

Drug Repositioning: A Monetary Stratagem to Discover a New Application of Drugs.

Drug repurposing, also referred to as drug repositioning or drug reprofiling, is a scientific approach to the detection of any new application for an already approved or investigational drug. It is a useful policy for the invention and development of new pharmacological or therapeutic applications of different drugs. The strategy has been known to offer numerous advantages over developing a completely novel drug for certain problems.

Nose-to-brain drug delivery for the treatment of glioblastoma multiforme: nanotechnological interventions.

Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor with a short survival rate. Extensive research is underway for the last two decades to find an effective treatment for GBM but the tortuous pathophysiology, development of chemoresistance, and presence of BBB are the major challenges, prompting scientists to look for alternative targets and delivery strategies. Therefore, the nose to brain delivery emerged as an unorthodox and non-invasive route, which delivers the drug directly to the brain the olfactory and trigeminal pathways and also bypasses the BBB and hepatic metabolism of the drug.

Review on Monoclonal Antibodies (mAbs) as a Therapeutic Approach for Type 1 Diabetes.

Monoclonal antibodies have been successfully utilized in a variety of animal models to treat auto-immune illnesses for a long time. Immune system responses will either be less active or more active depending on how the immune system is operating abnormally. Immune system hypoactivity reduces the body's capacity to fight off various invading pathogens, whereas immune system hyperactivity causes the body to attack and kill its own tissues and cells.

Insights on Quercetin Therapeutic Potential for Neurodegenerative Diseases and its Nano-technological Perspectives.

The neurodegeneration process begins in conjunction with the aging of the neurons. It manifests in different parts of the brain as Aβ plaques, neurofibrillary tangles, Lewy bodies, Pick bodies, and other structures, which leads to progressive loss or death of neurons. Quercetin (QC) is a flavonoid compound found in fruits, tea, and other edible plants have antioxidant effects that have been studied from subcellular compartments to tissue levels in the brain.

Secure Data Aggregation Based on End-to-End Homomorphic Encryption in IoT-Based Wireless Sensor Networks.

By definition, the aggregating methodology ensures that transmitted data remain visible in clear text in the aggregated units or nodes. Data transmission without encryption is vulnerable to security issues such as data confidentiality, integrity, authentication and attacks by adversaries. On the other hand, encryption at each hop requires extra computation for decrypting, aggregating, and then re-encrypting the data, which results in increased complexity, not only in terms of computation but also due to the required sharing of keys.

Pharmacological Profile of Novel Anti-cancer Drugs Approved by USFDA in 2022: A Review.

Background: For any drug molecule, it is mandatory to pass the drug approval process of the concerned regulatory authority, before being marketed. The Food and Drug Administration (FDA), throughout the year, approves several new drugs for safety and efficacy. In addition to new drug approvals, FDA also works on improving access to generic drugs, aimed to lower the cost of drugs for patients and improve access to treatments.

Pharmacokinetic assessment of cefpodoxime proxetil in diabetic rats.

Purpose: In diabetes, multi-organ level dysfunction arising from metabolic complications is reported to influence the pharmacokinetics (PK) profile of many drugs. Hence, the present study was planned in rats to evaluate the effect of diabetes on the PK profile of cefpodoxime, a widely prescribed oral antibiotic.

Method: PK profile of cefpodoxime was assessed after oral administration of cefpodoxime proxetil (10 and 20 mg/kg) and intravenous () administration of cefpodoxime sodium (10 mg/kg) in normal and streptozotocin induced diabetic rats.

Global Trends of Cosmeceutical in Nanotechnology: A Review.

Nanotechnology suggests different innovative solutions to augment the worth of cosmetic products through the targeted delivery of content that manifests scientific innovation in research and development. Different nanosystems, like liposomes, niosomes, microemulsions, solid lipid nanoparticles, nanoform lipid carriers, nanoemulsions, and nanospheres, are employed in cosmetics. These nanosystems exhibit various innovative cosmetic functions, including site-specific targeting, controlled content release, more stability, improved skin penetration and enhanced entrapment efficiency of loaded compounds.

Analysis of photoplethysmogram signal to estimate heart rate during physical activity using fractional fourier transform - A sampling frequency independent and reference signal-less method.

Background And Objective: Acquiring accurate and reliable health information using a PPG signal in wearable devices requires suppressing motion artifacts. This paper presents a method based on the Fractional Fourier transform (FrFT) to effectively suppress the motion artifacts in a Photoplethysmogram (PPG) signal for an accurate estimation of heart rate (HR).

Methods: By analyzing various PPG signals recorded under various physiological conditions and sampling frequencies, the proposed work determines an optimal value of the fractional order of the proposed FrFT.

Medicinal Plants Used as an Alternative to Treat Gingivitis and Periodontitis.

For various ailments, natural remedies have been traditionally used. To defend against common disorders, medicinal plants are progressively used as nutritional supplements. Gingivitis and periodontitis are widespread and can affect most of the world's population.

A Review on Green Synthesis of Silver Nanoparticles and its Role against Cancer.

Cancer is a fatal disease with a collection of related diseases in various body parts. The conventional therapies cannot show the desired results of treatment due to their imprecise targeting, deprived drug delivery, and side effects. Therefore, it is required to make the drug engineered so that it can target only cancerous cells and inhibit its growth and proliferation.

Altered neural cell junctions and ion-channels leading to disrupted neuron communication in Parkinson's disease.

Parkinson's disease (PD) is a neurological disorder that affects the movement of the human body. It is primarily characterized by reduced dopamine levels in the brain. The causative agent of PD is still unclear but it is generally accepted that α-synuclein has a central role to play.

A Systematic Review of Updated Mechanistic Insights Towards Alzheimer's Disease.

Background: Alzheimer's disease (AD) is a degenerative neurological disorder that impairs memory, cognitive abilities, and the ability to do everyday activities. This neurodegenerative disease is growing increasingly common as the world's population ages. Here, we reviewed some of the key findings showing the function of Aβ peptide, oxidative stress, free radical damage Triggering Receptors Expressed cn Myeloid Cells 2 (TREM2), Nitric Oxide (NO) and gut microbiota in the aetiology of AD.

Twitter sentiment analysis using ensemble based deep learning model towards COVID-19 in India and European countries.

As of November 2021, more than 24.80 crore people are diagnosed with the coronavirus in that around 50.20 lakhs people lost their lives, because of this infectious disease.

Design and Implementation of an ML and IoT Based Adaptive Traffic-Management System for Smart Cities.

The rapid growth in the number of vehicles has led to traffic congestion, pollution, and delays in logistic transportation in metropolitan areas. IoT has been an emerging innovation, moving the universe towards automated processes and intelligent management systems. This is a critical contribution to automation and smart civilizations.

Vitex negundo protects against cerebral ischemia-reperfusion injury in mouse via attenuating behavioral deficits and oxidative damage.

Global cerebral ischemia/reperfusion (I-R) injury often results in an irreparable brain damage like behavioral impairment and neuronal death. This neurological complication involves diverse intricate pathological mechanisms like oxidative stress, inflammation, and apoptosis. Recently, the therapeutic value of plant-based polyphenols has gained researcher's attention.

A Heterogeneous Ensemble Forecasting Model for Disease Prediction.

The manuscript presents a bragging-based ensemble forecasting model for predicting the number of incidences of a disease based on past occurrences. The objectives of this research work are to enhance accuracy, reduce overfitting, and handle overdrift; the proposed model has shown promising results in terms of error metrics. The collated dataset of the diseases is collected from the official government site of Hong Kong from the year 2010 to 2019.