Altered neural cell junctions and ion-channels leading to disrupted neuron communication in Parkinson's disease.

Parkinson's disease (PD) is a neurological disorder that affects the movement of the human body. It is primarily characterized by reduced dopamine levels in the brain. The causative agent of PD is still unclear but it is generally accepted that α-synuclein has a central role to play.

A Systematic Review of Updated Mechanistic Insights Towards Alzheimer's Disease.

Background: Alzheimer's disease (AD) is a degenerative neurological disorder that impairs memory, cognitive abilities, and the ability to do everyday activities. This neurodegenerative disease is growing increasingly common as the world's population ages. Here, we reviewed some of the key findings showing the function of Aβ peptide, oxidative stress, free radical damage Triggering Receptors Expressed cn Myeloid Cells 2 (TREM2), Nitric Oxide (NO) and gut microbiota in the aetiology of AD.

New Approaches and Advancements in Drug Development from Phenolic P-coumaric Acid.

P-coumaric acid is a common dietary polyphenol present in fruits, vegetables, and cereals in conjugated and free form. The toxicity profile of the drug is very low, and it exhibits many pharmacological actions (antihypertensive, anti-inflammatory, anticancer, antimicrobial activity, antidiabetic, anticancer, and antioxidant effect). P-coumaric acid also acts as a free radical scavenger and inhibits various enzymes, which generate free radicals.

Twitter sentiment analysis using ensemble based deep learning model towards COVID-19 in India and European countries.

As of November 2021, more than 24.80 crore people are diagnosed with the coronavirus in that around 50.20 lakhs people lost their lives, because of this infectious disease.

Design and Implementation of an ML and IoT Based Adaptive Traffic-Management System for Smart Cities.

The rapid growth in the number of vehicles has led to traffic congestion, pollution, and delays in logistic transportation in metropolitan areas. IoT has been an emerging innovation, moving the universe towards automated processes and intelligent management systems. This is a critical contribution to automation and smart civilizations.

Vitex negundo protects against cerebral ischemia-reperfusion injury in mouse via attenuating behavioral deficits and oxidative damage.

Global cerebral ischemia/reperfusion (I-R) injury often results in an irreparable brain damage like behavioral impairment and neuronal death. This neurological complication involves diverse intricate pathological mechanisms like oxidative stress, inflammation, and apoptosis. Recently, the therapeutic value of plant-based polyphenols has gained researcher's attention.

Nature and sources of ionic species in rainwater during monsoon periods in and around sixteenth-seventeenth century CE monuments in Yamuna River basin, India.

The nature and sources of ionic species were studied in the monsoon rainwater collected from two monuments of the sixteenth-seventeenth century CE in the Yamuna River basin from 2016 to 2018. The results showed the acidic pH of the rainwater with high dissolved SO and NO, and soil-derived components (Ca, Mg, and K). The anionic (SO, NO, Cl, F, and HCO) and cationic (Ca, Mg, K, NH, and Na) concentrations showed regional differences in yearly contribution mainly from the fossil fuel combustion, soil dust, and farm residue burning.

A Heterogeneous Ensemble Forecasting Model for Disease Prediction.

The manuscript presents a bragging-based ensemble forecasting model for predicting the number of incidences of a disease based on past occurrences. The objectives of this research work are to enhance accuracy, reduce overfitting, and handle overdrift; the proposed model has shown promising results in terms of error metrics. The collated dataset of the diseases is collected from the official government site of Hong Kong from the year 2010 to 2019.

Deterministic and probabilistic health risk assessment techniques to evaluate non-carcinogenic human health risk (NHHR) due to fluoride and nitrate in groundwater of Panipat, Haryana, India.

Human interferences have caused groundwater contamination in alluvial aquifers which subsequently affects the health of exposed population. In the present study, 74 groundwater samples from the semi-arid region of Panipat district, falling under Yamuna sub-basin, India was evaluated to know the potential non-carcinogenic human health risk in local adult and child population. The major objective of the present study was to know the non-carcinogenic human health risk due to intake of fluoride and nitrate contaminated water, using two different approaches: deterministic and probabilistic (Monte Carlo simulation).

Characterisation of phosphate solubilising bacteria in sandy loam soil under chickpea cropping system.

With the aim to explore the possible role of phosphate-solubilizing bacteria (PSB) in phosphorus (P) cycling in agricultural soils, we isolated PSB inhabiting naturally in the sandy loam soils under chickpea cropping of Patiala (Punjab State). A total of 31 bacterial isolates showing solubilizing activities were isolated on Pikovskaya agar plates. The potent phosphate solubilizers were selected for further characterization.

Avifauna in the Panipat Region, Haryana (India).

Avifaunal study was carried out in the Panipat region, Haryana (India) at 56 locations. 91 birds species were observed during the study, of which, 39 species were aquatic. House sparrow was found to be dominant followed by bank myna, house crow and Indian myna.

Diversity of birds at Panipat refinery, Haryana (India).

Avifaunal study was carried out in Panipat refinery area before and after commissioning. A total of 63 birds were observed during the study, of which 39 and 49 birds were present during 1992 and 2001 respectively. Of these, 25 birds were common during both the study period.