Translucency and contrast ratio of dimetharcyrlate resin based dental materials after bleaching: an in-vitro study.

Objective: To compare the translucency and contrast ratio of 13 different resin based restorative materials and to evaluate the effect of 2 different bleaching methods on the translucency and contrast ratio of these materials.

Methods: In this study, a total of 260 samples were prepared, 20 from each of 13 different dimethacrylate-based restorative materials. Then, each material group was divided into 4 subgroups.

18β-glycyrrhetinic acid Mitigates bisphenol A-induced liver and renal damage: Inhibition of TNF-α/NF-κB/p38-MAPK, JAK1/STAT1 pathways, oxidative stress and apoptosis.

Bisphenol A (BPA) has been commonly used in various consumer products, including water bottles, food containers, and canned food linings. However, there are concerns about its potential toxicity to human health, particularly its impact on the liver and kidneys. The objective of this research was to investigate the potential ameliorative effects of 18β-glycyrrhetinic acid (GA) against BPA-induced hepatotoxicity and nephrotoxicity in rats.

Sex differences in clinical and polysomnographic features of obstructive sleep apnea: The Turkish sleep apnea database (TURKAPNE) cohort.

Background: Previous reports from relatively small clinical cohorts have suggested that the clinical presentation of obstructive sleep apnea (OSA) differs between men and women.

Objective: We aimed to explore sex differences in clinical and polysomnographic features of OSA in a large nationwide registry.

Methods: Participants from the ongoing Turkish Sleep Apnea Database (TURKAPNE) Study from 34 centers were included in the current analysis.

The association of parental phubbing behavior with digital game use in preschool children.

The term "phubbing" is a combination of the words "phone" and "snubbing" and is explained as preferring the virtual environment to real communication by engaging with a smartphone during social interaction. Our study included 191 children aged 3-6 attending preschool education. The parents of the children were contacted via an online survey to provide information about their sociodemographic, general phubbing, digital game addiction tendencies, and social skills scale scores.

Milk ladder: Who? When? How? Where? with the lowest risk of reaction.

The milk ladder (ML) approach, which is the gradual reintroduction of the milk allergen from the least allergenic forms to the most allergenic forms into the diet of the patients, has been utilized mostly in non-IgE-mediated but in some countries also in IgE-mediated-CMPA due to its possible benefits which include nutrition, quality of life and tolerance induction. Despite increasing interest, so far, there is no guideline on ML; thus, the use of this approach shows discrepancies among healthcare professionals as many factors such as dietary habits, patient history, test results, workload, and facilities of the hospitals, the anxiety of the parents/patients may affect the decision on how, when, where and whom to use ML. Here, we reviewed current data on implementing the ML, suggested a 4-step ML including receipts and amounts, and shared our experience on optimal patient selection, appropriate time and steps for initiating ML, and time intervals between the steps targeting the lowest risk of reaction.

The effects of microsurgical varicocelectomy performed for infertility on premature ejaculation.

Purpose: To investigate the effects of varicocelectomy on premature ejaculation (PE) in patients with varicocele and infertility.

Methods: A total of 82 sexually active patients aged 18 years or over who had undergone microscopic subinguinal varicocelectomy with a clinical diagnosis of varicocele in 14 urology clinics between October 2021 and March 2023 with primary infertility were evaluated prospectively Patients were evaluated using the Turkish validated form of the 'Premature Ejaculation Diagnostic Tool' (PEDT) scale. A PEDT score of 11 or above was taken to indicate the presence of PE.

Plasma metabolomic signatures after oral administration of ritonavir in COVID-19 treatment via chemometrics-assisted UPLC/Q-TOF/MS/MS.

Understanding the pharmacodynamics of ritonavir through metabolomics offers insights into its side effects and helps in the development of safer therapies. This study aimed to investigate the effects of ritonavir treatment on the metabolic profiles of rabbits via a metabolomics approach, with the objective of elucidating its impact on various biochemical pathways and identifying relevant biomarkers. The rabbits were divided into control and ritonavir-treated groups, and their plasma samples were analyzed via ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF/MS/MS).

Effects of valproic acid, levetiracetam, carbamazepine, and oxcarbazepine on thyroid function tests in children.

Objective: The aim of the study was to evaluate the effects of commonly used medications for epilepsy on thyroid function tests in children.

Methods: Epileptic children treated with valproic acid, levetiracetam, carbamazepine, and oxcarbazepine were retrospectively examined along with a healthy control group. Levels of free thyroxine 4 and thyroid-stimulating hormone were compared.

Seeking greener pastures: attitudes towards brain drain among turkish medical students.

Background: Medical brain drain is a critical issue for healthcare systems worldwide. This study investigated attitudes toward brain drain and influencing factors among medical students at Pamukkale University.

Methods: A cross-sectional study was conducted with 1,129 students (80.

Evaluation of Motor Skills With Functional Dexterity Test in Children With ADHD and Comparison With Healthy Controls.

Objective: The study aimed to investigate whether the fine motor skills measured by the Functional Dexterity Test (FDT) in ADHD children differ from healthy controls. The second aim was to assess the applicability of the FDT assessment method among ADHD children.

Method: The FDT results as an objective assessment of hand skills were compared between 7 and 17 years old ADHD cases ( = 146) and age and gender-matched healthy controls ( = 213).

Optimization of swim depth across diverse taxa during horizontal travel.

Semiaquatic taxa, including humans, often swim at the air-water interface where they waste energy generating surface waves. For fully marine animals however, theory predicts the most cost-efficient depth-use pattern for migrating, air-breathing species that do not feed in transit is to travel at around 2 to 3 times the depth of their body diameter, to minimize the vertical distance traveled while avoiding wave drag close to the surface. This has rarely been examined, however, due to depth measurement resolution issues at the surface.

When tomorrow comes too late-the silent threat: why people delay needed medical care in Türkiye.

Background: Healthcare demand procrastination is a public health concern in Türkiye, with limited research available. This study examines the prevalence of healthcare procrastination and identifies associated factors among patients at Pamukkale University Hospital.

Methods: This cross-sectional study was conducted from 2 to 13 February 2023 in Denizli and involved 503 patients from 15 outpatient clinics.

Coronary Artery Dissection in Drug-Coated Balloon Angioplasty: Incidence, Predictors, and Clinical Outcomes.

Coronary dissection is a potential occurrence after lesion preparation for percutaneous coronary intervention (PCI). Unlike stents, drug-coated balloons (DCBs) do not allow to cover dissections, thus demanding an assessment of their safety in this setting. This study aimed to evaluate the incidence, predictors, and clinical outcomes of dissections occurring with DCB-based PCI for de novo coronary artery disease.

Affective modulation of emotional reactivity in euthymic patients with bipolar disorder.

Background: Affective modulation of startle reflex (AMSR) is a widely used experimental tool for assessing emotional reactivity. Previous research has shown inconsistent findings of emotional reactivity in amplitude in bipolar patients (BP). This study examined emotional reactivity (ER) in euthymic BP compared to healthy controls using both subjective and objective measures.

Interaction of lysozyme with solid supports cryogels containing imidazole functional group.

This paper details the preparation of acrylamide-based supermacroporous cryogels and their application in removing lysozyme from aqueous solutions. N-Vinyl imidazole was copolymerized with acrylamide as a comonomer to impart pseudo-specificity to the cryogels, forming poly(AAm-VIM) cryogel. Characterization studies to assess the physical and chemical properties of the synthesized cryogels involved swelling tests, Fourier Transform Infrared Spectroscopy (FTIR), elemental analysis, Field Emission Scanning Electron Microscopy (FESEM), and Thermogravimetric Analysis (TGA-DTA).

Profiling of Toll-like Receptors and Related Signaling Mediators in the Pathogenesis of Morphea.

Introduction: Morphea, also known as localized scleroderma, is a rare fibrosing inflammatory disease of unknown pathogenesis.

Objectives: Although the genetic basis for morphea is important, reports on the evaluation of Toll-like receptors (TLR) in this disease is quite limited. We aimed to evaluate TLR expression levels and serum IL-6, IL-17A, TGF-β1, FGF, and VEGF levels in patients with morphea and compare these results with healthy controls.

Examining the Role of System Acceptance and Community Feeling in Predicting Nursing Students' Online Learning Satisfaction.

Online learning has transitioned from being optional to a mandatory experience in nursing education. Consequently, it is crucial to understand nursing students' satisfaction and the factors influencing it to create and implement a successful online learning environment. This study aimed to examine the roles of system acceptance and community feeling in predicting nursing students' online learning satisfaction.

Impact of Laparoscopic Sleeve Gastrectomy on Pulmonary Arterial Stiffness and Right Ventricular Function in Obese Patients.

Introduction: Pulmonary hypertension (PH) is a serious condition associated with high morbidity and mortality, with obesity identified as a significant risk factor. Pulmonary arterial stiffness (PAS) is an early marker of PH, often preceding clinical symptoms. While laparoscopic sleeve gastrectomy (LSG) has been shown to improve various cardiac parameters in obese patients, its impact on PAS and right ventricular (RV) function in the absence of PH remains unclear.

Can HALP (Hemoglobin, albumin, lymphocyte, and platelet) score distinguish malignant and benign causes of extrahepatic cholestasis in patients with extrahepatic bile duct obstruction?

Objective: Cholestatic diseases are common and classified as benign or malignant based on their etiology. HALP is a unique nutritional immune marker that combines indicators of nutritional status, including hemoglobin and albumin, with immune function markers like lymphocyte and platelet counts. We investigated the HALP score's ability to differentiate between benign and malignant causes in extrahepatic cholestasis patients.

Inhibitor development upon switching from plasma-derived to recombinant factor VIII in previously untreated patients with severe hemophilia A: the PUP-SWITCH study.

Background: The SIPPET randomized clinical trial showed that in previously untreated patients (PUPs) with severe hemophilia A, treatment with plasma-derived factor (F)VIII (pdFVIII) within the first 50 exposure days (EDs) was associated with a lower cumulative incidence of inhibitors than with recombinant FVIII (rFVIII). Switching to rFVIII beyond 50 EDs with pdFVIII is a treatment often implemented by many centers. The question is whether or not this switch may induce a risk of inhibitor development.

Two New Species of Oak Gall Wasp (Hymenoptera: Cynipidae, Cynipini) from Türkiye.

Two new species of the genus Andricus Hartig, 1840 (Cynipidae: Cynipini), Andricus ismaili Tataroğlu & Katılmış sp. n. asexual generation on Quercus infectoria Olivier and Andricus musaazmazi Tataroğlu & Katılmış sp.

New species of gall wasps (Hymenoptera: Cynipidae: Aulacideini and Phanacidini) inducing galls on plants of the genera Sonchus and Crepis (Asteraceae) in Romania (Dobrogea Province) and notes on their parasitoids.

Two new species of herb gall wasps (Hym., Cynipidae) developing on plants in the genera Sonchus L. and Crepis L.

Gall wasp (Cynipoidea: Cynipidae and Diplolepididae) fauna of the Eastern Black Sea Region (Türkiye).

In the period between October 2017 and September 2019, field studies were conducted with the aim of elucidating the gall wasp (Hymenoptera: Cynipidae and Diplolepididae) fauna of the Eastern Black Sea Region (Northeastern Türkiye). Gall samples were collected from 695 different localities within the research area, comprising a total of seven provinces (Artvin, Bayburt, Giresun, Gümüşhane, Ordu, Rize and Trabzon). As a result of these investigations, a total of 90 species belonging to 18 genera were recorded.