Mucoadhesive Multiparticulate Drug Delivery Systems: An Extensive Review of Patents.

Innovations in pharmaceutical research are striving for designing newer drug therapies to eradicate deadly diseases. Strategies for such inventions always flourish with keys and objectives of minimal adverse effects and effective treatment. Recent trends in pharmaceutical technology specify that mucoadhesive drug delivery system is particularly appropriate than oral control release, for getting local systematic delivery of drugs in GIT for an extended interval of time at a predetermined rate.

N-Doped carbon dots with pH-sensitive emission, and their application to simultaneous fluorometric determination of iron(III) and copper(II).

Simultaneous fluorometric determination of iron(III) and copper(II) without the use of any masking agent or additional treatment is achieved by using N-doped carbon dots (NCDs). The NCDs were hydrothermally prepared, have strongest excitation/emission peaks at 320/406 nm and a 47% quantum yield. Excitation-tunable emission is found to depend on solution pH values.

structural homology modeling of nif A protein of rhizobial strains in selective legume plants.

Symbiosis is a complex genetic regulatory biological evolution which is highly specific pertaining to plant species and microbial strains. Biological nitrogen fixation in legumes is a functional combination of nodulation by nod genes and regulation by nif, fix genes. Three rhizobial strains (, , and ) that we considered for analysis of nif A are proved to be the best isolates with respect to N fixing for ground nut, chick pea and soya bean (in vitro) out of 47 forest soil samples.

Facile Conversion of Toxic Cigarette Butts to N,S-Codoped Carbon Dots and Their Application in Fluorescent Film, Security Ink, Bioimaging, Sensing and Logic Gate Operation.

The present work is emphasized on converting toxic cigarette butts (CBs) into highly fluorescent N,S-codoped carbon dots by a facile hydrothermal approach and exploring their multiple applications. The as-produced carbon dots (CBCDs) exhibited bright and stable fluorescence with a quantum yield of 26% and used as a label-free probe for "on-off-on" sequential detection of Fe and ascorbic acid (AA). The fluorescence of CBCDs can be significantly quenched by Fe ions through static quenching and restored upon the subsequent addition of AA due to the reduction of Fe to Fe by AA.

Construction of self-assembled FeWO/g-CN nanosheet heterostructured Z-scheme photocatalysts for enhanced photocatalytic degradation of rhodamine B and tetracycline.

Although photocatalytic degradation is an ideal strategy for cleaning environmental pollution, it remains challenging to construct a highly efficient photocatalytic system by steering the charge flow in a precise manner. In this work, a novel, highly efficient, stable, and visible light active hybrid photocatalytic system consisting of FeWO and g-CN nanosheets (CNNs) has been successfully prepared by an self-assembly solvothermal approach. Several characterization techniques were employed to study the phase structures, morphologies, optical properties, surface composition and chemical state of the as-prepared samples.

Synthesis and biological evaluation of novel flavone/triazole/benzimidazole hybrids and flavone/isoxazole-annulated heterocycles as antiproliferative and antimycobacterial agents.

A series of new flavone/isoxazole fused heterocycles 5a-f and flavone/1,2,3-triazole/benzimidazole hybrid heterocycles compounds 7a-t were synthesized via an intramolecular cyclization and Cu(I)-catalyzed click 1,3-dipolar cycloaddition. The products were evaluated for their antiproliferative activity against human breast cancer cell line (MCF-7) using sulforhodamine B assay (SRB) and antimycobacterial activity using turbidometric assay. The majority of the tested compounds exhibited antiproliferative activity and antimycobacterial activity.

Green synthesis of highly fluorescent nitrogen - Doped carbon dots from Lantana camara berries for effective detection of lead(II) and bioimaging.

Here, we developed a simple green approach for the synthesis of highly fluorescent nitrogen doped carbon dots (NCDs) using Lantana camara berries. Optical and physicochemical properties of as synthesized NCDs were extensively studied by using various analytical techniques. NCDs exhibited bright fluorescence with Quantum yield as high as 33.

Optimization of high-yielding protocol for DNA extraction from the forest rhizosphere microbes.

Soil is major reservoir for microbes and harbors a vast microbial diversity. Soil microbiota plays a pivotal role in biogeochemical cycles, bioremediation, and in health and disease states of humans, animals, and plants. It is imperative to understand the microbial signatures which are specific in such an ecosystem to unravel their potential role and impact on environment.

Chryseomicrobium palamuruense sp. nov., a haloalkalitolerant bacterium isolated from a sediment sample.

A novel Gram-stain-positive, rod shaped, motile bacterium, designated strain PU1T, was isolated from a sediment sample collected from a drainage near hostel of Palamuru University, Mahabubnagar district, T.S, India (16°43'23″N 77°58'49″E). Cells of strain PU1T are positive for catalase, oxidase, phosphatase, lipase and urease, and negative for gelatinase, amylase, protease, cellulase, lysine decarboxylase and ornithine decarboxylase.

Simultaneous determination of rosuvastatin and amlodipine in human plasma using tandem mass spectrometry: Application to disposition kinetics.

The liquid chromatography-tandem mass spectrometric assay method for the simultaneous determination of rosuvastatin and amlodipine in human plasma using deuterated analogs as internal standards has been developed and validated. The analytes were extracted from 100 μL aliquots of human plasma via liquid-liquid extraction using a mixture of ethyl acetate and n-hexane (80:20, v/v) as an extraction solvent. The optimized mobile phase was composed of 0.

A pH-triggered delayed-release chronotherapeutic drug delivery system of aceclofenac for effective management of early morning symptoms of rheumatoid arthritis.

Context: Rheumatoid arthritis (RA) is differentiated as an early morning exacerbation of the core arthritis condition associated with increase in pain and stiffness in joints and necessitate for medication.

Objective: The aim of the present work was to develop and optimise a pH-triggered delayed-release colon-specific aceclofenac microspheres and to accomplish chronotherapy of RA.

Methods: A 3-factor, 3-level Box-Behnken design (BBD) was used to optimise selected variables.

Streptosporangium terrae sp. nov., a novel actinomycete isolated from the rhizosphere of Callistemon citrinus (Curtis), India.

A novel actinomycete strain, designated VRC21(T), was isolated from the rhizosphere of Callistemon citrinus collected from Hyderabad, India. The morphological and chemotaxonomic properties of strain VRC21(T) was consistent with the characteristics of members of the genus Streptosporangium, that is, the formation of sporangia on aerial mycelium, coiled unbranched hyphae within the spore vesicle, the presence of meso-diaminopimelic acid in the cell wall, and madurose and galactose as major whole-cell sugars. Diagnostic polar lipids were phosphatidylethanolamine, diphosphatidylglycerol, phosphatidylglycerol, phosphatidylinositol and phosphatidylinositol-mannosides.

Isolation and characterization of novel lipase gene LipHim1 from the DNA isolated from soil samples.

Metagenomics is a magnificent tool to isolate genes from unknown/uncharacterized species and also from organisms that cannot be cultured. In this study, we constructed a metagenomic library from isolated DNA of soil samples collected from Palamuru University campus premises, in Mahabubnagar district of Andhra Pradesh, India. We isolated a novel lipase gene LipHim1, which has an open reading frame of 591 base pairs and encodes ∼23 kDa protein consisting of 196 amino acids.

Plant growth regulation of Bt-cotton through Bacillus species.

Deccan plateau in India periodically experiences droughts due to irregular rain fall and the soil in many parts of the region is considered to be poor for farming. Plant growth promoting rhizobacteria are originally defined as root-colonizing bacteria, i.e.

Identification of opportunistic pathogenic bacteria in drinking water samples of different rural health centers and their clinical impacts on humans.

International drinking water quality monitoring programs have been established in order to prevent or to reduce the risk of contracting water-related infections. A survey was performed on groundwater-derived drinking water from 13 different hospitals in the Mahabubnagar District. A total of 55 bacterial strains were isolated which belonged to both gram-positive and gram-negative bacteria.