Characterization and interactions between piperine and ezetimibe in their Anti-hyperlipidemic efficacy using Biopharmaceutics and Pharmacokinetics.

Background: Piperine, a secondary metabolite, affects the antihyperlipidemic effect of Ezetimibe (EZ). Hyperlipidemia is one of the independent risk factors for cardiovascular disorders such as atherosclerosis. Antihyperlipidemic drugs are essential for reducing cardiovascular events and patient mortality.

Preparation, Isolation, and Structural Characterization of Lewis Base Iminium Salts of 1,8-Diazabicyclo[5.4.0]undec-7-ene and Their Application as Green Reagents in an Aqueous Medium.

We report a state-of-the-art synthesis and isolation procedure for 13 Lewis base iminium salts (LBI) of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), confirming their structures meticulously by different spectral data.

Modified frankincense resin stabilized gold nanoparticles for enhanced antioxidant and synergetic activity in in-vitro anticancer studies.

For the first time, Frankincense resin (FR) has been carboxymethylated to produce CMFR - AuNPs and the conjugate was utilized for the Doxorubicin drug loading. The carboxymethylation of the carboxylic, phenolic, and hydroxyl functional groups of FR has been developed into carboxymethylated Frankincense resin (CMFR). A novel CMFR-AuNPs was synthesized using the developed CMFR as a stabilizing and reducing agent.

Morin attenuated the global cerebral ischemia via antioxidant, anti-inflammatory, and antiapoptotic mechanisms in rats.

Global cerebral ischemia is one of the major causes of memory and cognitive impairment. Hyperactivation of acetylcholine esterase (AChE), oxidative stress, and inflammation are reported to cause memory and cognitive impairment in global cerebral ischemia. Morin, a flavonoid, is reported to have neuroprotective properties through its antioxidant and anti-inflammatory in multiple neurological diseases.

Phytochemical profile and hepatoprotective potentiality of Phyllanthus genus: a review.

The Phyllanthus genus is very important plant traded as a raw herbal medicine in India. Commonly known as 'Bhumyamalaki' (Phyllanthus species) has been used for the prevention and treatment of jaundice. Phyllanthus is rich in diversity of bioactive compounds such as lignans, alkaloids, terpenoids, flavonoids, and tannins.

Microwave-assisted synthesis of Limonia acidissima Groff gum stabilized palladium nanoparticles for colorimetric glucose sensing.

Herein, we present a novel microwave-assisted method for the synthesis of palladium nanoparticles (PdNPs) supported by Limonia acidissima Groff tree extract gum. The synthesized PdNPs were characterized using various analytical techniques, including FTIR, SEM, TEM, UV-visible, and powder XRD analyses. TEM and XRD analysis confirmed that the synthesized LAG-PdNPs are highly crystalline nature spherical shapes with an average size diameter of 7-9 nm.

Tangeretin confers neuroprotection, cognitive and memory enhancement in global cerebral ischemia in rats.

Global cerebral ischemia is commonly associated with neurological deficits, including cognitive and memory impairments. The present study aims to investigate the neuroprotective, cognitive, and memory enhancement effects of Tangeretin, a flavonoid against global cerebral ischemia in rats. Bilateral common carotid artery occlusion (BCCAO) and reperfusion injury method was used to induce global cerebral ischemia in rats.

Jamun Seed-Derived Nitrogen-Doped Carbon Dots: A Novel Microwave-Assisted Synthesis for Ultra-Bright Fluorescence and Mn Detection.

For the synthesis of heteroatom-doped carbon nanostructures, biomass is considered as a promising option. Utilizing the microwave-assisted method, we have demonstrated an easy and straightforward one-pot synthesis of nitrogen-doped luminous carbon dots (NCDs) from jamun seed powder and guanidine hydrochloride. Structural and morphological analyses were performed using various analytical techniques.

A concise review on recent advances in catalytic asymmetric hydrogenation.

Accounts on the recent (over the past 10 years) catalytic asymmetric hydrogenation reaction-based achievements with different catalysts to generate natural products and synthetic targets such as fragrances, pharmaceutical agents, and agrochemicals are mentioned in this present concise review. Mechanistic steps, chemoselectivity with higher functional group tolerance by employing transition metal-based chiral catalysts (Ir-, Rh-, Ni-, Ru-, Fe-, Mn-, Pd-, Co-, and Zn-based organometallic chiral complexes), and biocatalysts and their importance on the genesis of chirality coupled with higher turnover numbers are also described.

Tuning between Nuclear Organization and Functionality in Health and Disease.

The organization of eukaryotic genome in the nucleus, a double-membraned organelle separated from the cytoplasm, is highly complex and dynamic. The functional architecture of the nucleus is confined by the layers of internal and cytoplasmic elements, including chromatin organization, nuclear envelope associated proteome and transport, nuclear-cytoskeletal contacts, and the mechano-regulatory signaling cascades. The size and morphology of the nucleus could impose a significant impact on nuclear mechanics, chromatin organization, gene expression, cell functionality and disease development.

Microwave-assisted Synthesis, Characterization, Photocatalytic Degradation of Antibiotics, and Fluorometric Selective Sensing Activity of g-CN Supported CuO Composites.

Herein, we have designed for the fabrication of a series of g-CN/CuO composite by using one-step microwave-assisted synthesis for the degradation of antibiotics and detection of nano-molar range of toxic heavy metal ions. The synthesized g-CN/CuO composites were analyzed and characterized to know the structure, phase, surface area, absorption region, bandgap, and size of the composites. From the observation of TEM and XRD measurements, g-CN/CuO composites have hexagonal shape with average diameter of the particles is 25 ± 5 nm.

An in-silico investigation of fluoride ions impact on pancreatic lipase.

Fluorine is a halogen beneficial to teeth and bones at a lower concentration. But in excess, it is a toxin and causes adverse effects. Fluoride is toxic to enzymes generally when it inhibits the enzyme activity involved in metabolic pathways.

Biogenic Synthesis of Carboxymethyl Cashew Gum Modified Gold Nanoparticles and its Sensitive and Selective Calorimetric Detection of Hg Ions and Catalytic Reduction of Methyl Red.

In the present study, we have successfully synthesized and characterized carboxy methyl cashew gum modified gold nanoparticles (CMCG-AuNPs) via a microwave-assisted method and used as a calorimetric probe for selective detection of Hg ions as well as catalytic reduction of methyl red in an aqueous medium. The effect of different parameters including concentration and irradiation time on the formation of CMCG-AuNPs was also investigated. The presence of strong surface plasmon resonance (SPR) peak in the visible region indicated the formation of AuNPs.

An efficient biosynthesis of palladium nanoparticles using Bael gum and evaluation of their catalytic and antibacterial activity.

We report a facile microwave-assisted synthesis of palladium nanoparticles (PdNPs) using Bael gum (BG) and it's carboxymethylated (CMBG) derivative. The prepared nanoparticles (BG@PdNPs and CMBG@PdNPs) were evaluated for antibacterial and catalytic activity in the reduction of organic dye pollutants. The developed synthetic method is simple, low cost and eco-friendly, wherein the process requires no additional reducing or capping agents.

ABHD11-AS1: An Emerging Long Non-Coding RNA (lncRNA) with Clinical Significance in Human Malignancies.

The aberrant expression of lncRNAs has been linked to the development and progression of different cancers. One such lncRNA is ABHD11 antisense RNA 1 (ABHD11-AS1), which has recently gained attention for its significant role in human malignancies. ABHD11-AS1 is highly expressed in gastric, lung, breast, colorectal, thyroid, pancreas, ovary, endometrium, cervix, and bladder cancers.

Data on host specificity and symbiotic association between indigenous BD1 strain and (green gram).

The main objective of this study is to use bio-inoculants in relative to specific legume plant diversity for, enhanced nodulation and plant growth. Method involves organically based selection of 36 rhizobial strains, of which 6 strains were isolated to assess the efficiency of relative host-specific inoculation on nodulation and development in legumes viz. All promising combinations of the preferred rhizobial strain inoculants were tested under sterile conditions for improving nodulation and to screen the best isolate to be evaluated for its enhanced characteristics through inoculation by field trial in various soils.

derived mycotoxins in food and the environment: Prevalence, detection, and toxicity.

species are the paramount ubiquitous fungi that contaminate various food substrates and produce biochemicals known as mycotoxins. Aflatoxins (AFTs), ochratoxin A (OTA), patulin (PAT), citrinin (CIT), aflatrem (AT), secalonic acids (SA), cyclopiazonic acid (CPA), terrein (TR), sterigmatocystin (ST) and gliotoxin (GT), and other toxins produced by species of plays a major role in food and human health. Mycotoxins exhibited wide range of toxicity to the humans and animal models even at nanomolar (nM) concentration.

Granny Smith Apple Extract Lowers Inflammation and Improves Antioxidant Status in L-arginine-induced Exocrine Pancreatic Dysfunction in Rats.

Objectives: Granny Smith is a cultivated hybrid variety of apple with a high antioxidant content relative to all other species of apple. Acute pancreatitis (AP) is an instantly emerging inflammatory condition with a high mortality rate. The preferred treatment is restricted to symptomatic relief and supportive care.

In-situ fabrication of novel flower like MoS/CoTiO nanorod heterostructures for the recyclable degradation of ciprofloxacin and bisphenol A under sunlight.

Effectual degradation of toxic water contaminants is a crucial step in water purification and designing an efficient semiconductor based hybrid structure photocatalyst is a good approach to achieve this. Benefiting from the combination of semiconductors, a series of novel visible-light active flower-like MoS/CoTiO nanorod heterostructures with excellent morphological contact interface were prepared through a facile in-situ hydrothermal process. These heterostructures were well characterized and demonstrated high photocatalytic performance for ciprofloxacin (CIP) and bisphenol A (BPA) under sunlight irradiation.

Microsecond simulation analysis of carbonic anhydrase - II in complex with (+)-cathechin revealed molecular interactions responsible for its amelioration effect on fluoride toxicity.

Fluorosis is a chronic condition caused by overexposure to fluoride, marked by impaired dental, skeletal, and non-skeletal health. In presence of excess fluoride ions, in severe cases calcification of the ligaments observed. Earlier studies have suggested that the disruption of carbonic anhydrase activity via ionic homeostasis change was associated with F toxicity.

Microwave-assisted preparation of a silver nanoparticles/N-doped carbon dots nanocomposite and its application for catalytic reduction of rhodamine B, methyl red and 4-nitrophenol dyes.

In the current work, a silver nanoparticles/nitrogen-doped carbon dots (AgNPs/NCDs) nanocomposite was prepared by a microwave-assisted method that does not require additional reducing or stabilizing agents. Multiple analytical techniques were used to characterize the prepared nanocomposite. The nanocomposite exhibited a surface plasmon resonance (SPR) absorption peak at 420 nm, indicating the development of AgNPs with NCDs.

GSK-3 Inhibitors as New Leads to Treat Type-II Diabetes.

In India as well as globally, diabetes is in a state of high risk and next to cardiovascular disease. As per the WHO, the risk of diabetes is expected to rise about 511 million by 2030. In quest of novel targets for type-2 diabetes, many targets were elucidated, such as Glycogen Synthase Kinase-3 (GSK-3), Dipeptidyl Peptidase (DPP-IV), PPAR-γ, α-Glucosidase, α-Amylase, GLP-1, and SGLT.

Role of Thr199 residue in human β-carbonic anhydrase-II pH-dependent activity elucidated by microsecond simulation analysis.

Carbonic anhydrases catalyze the reversible hydration of carbon dioxide to form bicarbonate, a reaction required for many functions such as carbon assimilation, pH acid-base homeostasis, respiration and photosynthesis via a zinc-hydroxide mechanism for carbon dioxide hydration. In earlier studies, it was revealed that Carbonic anhydrases are inactive at pH 7.5 and active at pH 8.

Data on fluoride concentration profile in groundwater of rural habitats in Mahabubnagar district, Telangana, India.

Fluoride is an undesirable chemical in drinking water that can have dreadful concerns on health. The objective of this study is to establish the concentration profile of fluoride in groundwater used as drinking water in 31 rural habitats in Mahabubnagar district, Telangana State, India. Drinking water samples from bore wells/hand pumps were collected from different locations in the study area and analyzed for fluoride levels using a spectrophotometer.