Teaching Pathological Physiology of Sepsis Using a High Fidelity Simulator.

A good knowledge of the theoretical foundations of medicine helps students and physicians to better recognize and treat patients with complex medical conditions, including sepsis and septic shock. The article describes the authors' experience in implementing the analysis of sepsis and septic shock using a high-fidelity simulated clinical scenario in the course of pathological physiology for preclinical medical students. The unique aspect of our approach is the integration of core physiology concepts, such as homeostasis, causality, structure-function relationships, and fundamental pathophysiology concepts (e.

[Comparing standard microbiological methods for identification of Staphylococcus aureus and MRSA with the automated BD MAXTM StaphSR system].

Objectives: Staphylococcus aureus is part of the human microbiota, but at the same time, it is capable of causing a wide range of diseases. Due to the ever-increasing resistance to antimicrobial agents and the existence of methicillin-resistant S. aureus (MRSA) strains, there is a real possibility of carrying even this resistant bacterium, which can subsequently cause a severe infection.

[Occurrence of methicillin-resistant Staphylococcus aureus strains at the University Hospital Olomouc].

Objective: This study aimed to evaluate the occurrence of methicillin-resistant Staphylococcus aureus (MRSA) at the University Hospital Olomouc (UHO) over a 10-year period (2013-2022).

Material And Methods: Data was obtained from the ENVIS LIMS laboratory information system (DS Soft, Czech Republic, Olomouc) of the Department of Microbiology, UHO, for the period 1/1/2013-31/12/2022. Standard microbiological procedures using the MALDI-TOF MS system (Biotyper Microflex, Bruker Daltonics) were applied for the identification.

Survival of Eurasian lynx in the human-dominated landscape of Europe.

Survival and cause-specific mortality rates are vital for evidence-based population forecasting and conservation, particularly for large carnivores, whose populations are often vulnerable to human-caused mortalities. It is therefore important to know the relationship between anthropogenic and natural mortality causes to evaluate whether they are additive or compensatory. Further, the relation between survival and environmental covariates could reveal whether specific landscape characteristics influence demographic performance.

Parental impact on adherence of young children to 24-h movement behaviour guidelines: the Czech FAMIly Physical Activity, Sedentary behaviour and Sleep study.

Human movement behaviour typically unfolds in 24-h cycles, with children being additionally influenced by their parents. Therefore, the aim of this study was to investigate the adherence of 3-10-year-old children to the World Health Organization's (WHO) 24-h movement behaviour guidelines in relation to the behaviours of their mothers/fathers. Data from the Czech cross-sectional FAMIly Physical Activity, Sedentary behaviour and Sleep study included 381 families (with at least one child aged 3-10 years) from urban and rural areas across all three regions of Czechia.

Isolation, cytotoxicity evaluation, and molecular docking of 3,4,3'-tri--methylflavellagic acid from (DC.) Guill. & Perr. root.

Cancer kills about 10 million people every year. Medicinal plants remain a major source in the global search for anticancer drugs. In this study, 3,4,3'-tri--methylflavellagic acid (MFA) was isolated from the methanol root extract of .

General principles of communication among nurses in a long-term care unit: a best practice implementation project.

Introduction: In health care, effective communication enhances teamwork and safety by minimizing adverse events. Evidence suggests that ongoing education should include communication skills training, as interprofessional communication relies on tools that facilitate seamless interaction.

Objective: This project aimed to improve communication practices among nurses in a long-term care unit by promoting evidence-based recommendations.

Skin Hydration by Natural Moisturizing Factors, a Story of H-Bond Networking.

Dry skin is a common condition that is experienced by many. Besides being particularly present during the cold season, various diseases exist all year round, leading to localized xerosis. To prevent it, the skin is provided with natural moisturizing factors (NMFs).

The effects of regular exercise on cognitive and cardiometabolic health in testicular cancer survivors subjected to platinum-based chemotherapy.

Background: Platinum-based chemotherapy provides curative treatment to more than 95% of patients with testicular germ cell tumor but it has negative cardiometabolic and neurological effects. Regular exercise can alleviate late chemotherapy-related toxicities. We examined the impact of a 6-month supervised aerobic-strength training on cognitive and cardiometabolic health and residual level of platinum in cancer survivors.

Which items of the movement assessment battery for children are most sensitive for identifying children with probable developmental coordination disorder? Results from a large-scale study.

Introduction: Despite the widespread use of the Movement Assessment Battery for Children, 2nd edition (MABC-2), little is known about the sensitivity or specificity of the individual items to detect probable Developmental Coordination Disorder (p-DCD). This study examined which specific MABC-2 items were most sensitive to identify children with p-DCD and which items would predict p-DCD.

Methods: Based on a large dataset including European and African children aged 3-16 years (n = 4916, typically developing (TD, 49.

[O-arm Versus C-arm: Comparison of the Learning Curves and Accuracy in Transpedicular Screw Fixation of Lumbar Spondylolisthesis].

Purpose Of The Study: The annual number of spinal fusion procedures has been increasing and is well documented worldwide. The O-arm is slowly becoming the standard for transpedicular screw insertion. The accuracy and safety of this method have been confirmed by many studies.

Long-read structural and epigenetic profiling of a kidney tumor-matched sample with nanopore sequencing and optical genome mapping.

Carcinogenesis often involves significant alterations in the cancer genome, marked by large structural variants (SVs) and copy number variations (CNVs) that are difficult to capture with short-read sequencing. Traditionally, cytogenetic techniques are applied to detect such aberrations, but they are limited in resolution and do not cover features smaller than several hundred kilobases. Optical genome mapping (OGM) and nanopore sequencing [Oxford Nanopore Technologies (ONT)] bridge this resolution gap and offer enhanced performance for cytogenetic applications.

Psychometric analysis of the three item loneliness scale in the Czech Republic.

Background: There is a growing importance of loneliness measurement through valid and reliable instruments. However, to establish valid and reliable measures, there is a need to explore their psychometric properties in different research settings and language environments. For this reason, this study aimed to validate the Three Item Loneliness Scale (TILS) in the Czech Republic within a Slavonic language environment.

Assessment of sensory impairment in older adults with dementia.

Background: Over 55 million people worldwide are living with dementia. The rate of cognitive decline increases with age, and loss of senses may be a contributing factor.

Objectives: This study aimed to analyze hearing, olfactory function, and color vision in patients with dementia.

Click beetle larvae from Cretaceous Burmese amber represent an ancient Gondwanan lineage.

The click beetles (Elateridae) represent the major and well-known group of the polyphagan superfamily Elateroidea. Despite a relatively rich fossil record of Mesozoic Elateridae, only a few species are described from the Upper Cretaceous Burmese amber. Although Elateridae spend most of their lives as larvae, our knowledge on immature stages of this family is limited, which is especially valid for the fossils.

TMJ Metastasis: Evaluation of 3 Patients.

Metastases of the articular process, temporomandibular joint (TMJ), are rare findings. Their frequency is around 5% of patients with metastatic involvement of the mandible. The most common primary tumor is adenocarcinoma of the lung in women and adenocarcinoma of the prostate in men.

Solid-State Photoswitching of Hydrazones Based on Excited-State Intramolecular Proton Transfer.

The development of new photochromic systems is motivated by the possibility of controlling the properties and functions of materials with high spatial and temporal resolution in a reversible manner. While there are several classes of photoswitches operating in solution, the design of systems efficiently operating in the solid state remains highly challenging, mainly due to limitations related to confinement effects. Triaryl-hydrazones represent a relatively new subclass of bistable hydrazone photoswitches exhibiting efficient / photochromism in solution.

Comparison of Two Chelator Scaffolds as Basis for Cholecystokinin-2 Receptor Targeting Bimodal Imaging Probes.

: Dual-modality probes, combining positron emission tomography (PET) with fluorescence imaging (FI) capabilities in a single molecule, are of high relevance for the accurate staging and guided resection of tumours. We herein present a pair of candidates targeting the cholecystokinin-2 receptor (CCK2R), namely [Ga]Ga-CyTMG and [Ga]Ga-CyFMG. In these probes, the SulfoCy5.

W-Class States-Identification and Quantification of Bell-CHSH Inequalities' Violation.

We discuss a family of W-class states describing three-qubit systems. For such systems, we analyze the relations between the entanglement measures and the nonlocality parameter for a two-mode mixed state related to the two-qubit subsystem. We find the conditions determining the boundary values of the negativity, parameterized by concurrence, for violating the Bell-CHSH inequality.

Assessment of L. and Lipophosphonoxin (DR-6180) Combination for Wound Repair: Bridging the Gap Between Phytomedicine and Organic Chemistry.

L. (AE) has a rich tradition of use in wound healing improvement across various cultures worldwide. In previous studies, we revealed that L.

Socioeconomic predictors of preventive health check-ups by a general practitioner in the Czech Republic.

Health is one of the Sustainable Development Goals. The importance of health promotion is growing in the context of an aging population and increasing life expectancy. Prevention is often underestimated and neglected by citizens.

The Longer, the Better: Continuous Glucose Monitoring Use for ≥90% Is Superior to 70%-89% in Achieving Tighter Glycemic Outcomes in Children with Type 1 Diabetes.

The recommended threshold for the time spent on continuous glucose monitoring (CGM) is established at 70%. However, glucose outcomes in children with type 1 diabetes (CwD) using CGM for a different proportion of time within this threshold have not been evaluated yet. The study aims to compare glycemic parameters among CwD who spent 70%-89% and ≥90% on CGM using the population-wide data from the Czech national pediatric diabetes registry ČENDA.