19 results match your criteria: "Pal Children Hospital[Affiliation]"

Background: Minimal residual disease (MRD) is one of the most valuable independent prognostic factors in acute lymphoblastic leukemia (ALL). Bone marrow (BM) aspiration, however, is an invasive process. Previous studies have shown that microRNAs (miR) and extracellular vesicle (EV)-related miRs show different expression profiles at the presence of malignant cells compared to healthy controls.

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Safety of chronic hypertonic bicarbonate inhalation in a cigarette smoke-induced airway irritation guinea pig model.

BMC Pulm Med

April 2022

Department of Oral Biology, Faculty of Dentistry, Semmelweis University, Nagyvárad tér 4, Budapest, 1089, Hungary.

Background: Cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) are often associated with airway fluid acidification. Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene leads to impaired bicarbonate secretion contributing to CF airway pathology. Chronic cigarette smoke (CS) -the major cause of COPD- is reported to induce acquired CFTR dysfunction underlying airway acidification and inflammation.

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Child healthcare in Hungary.

Turk Pediatri Ars

September 2020

National Institute of Child Health (OGYEI), National Institute for Health Development (NEFI), National Public Health and Medical Officer Services (ÁNTSZ) Budapest, Hungary.

We describe the strengths and challenges of the child healthcare system in Hungary. The number of children has been steadily decreasing since 1982. The number of live births per thousand population has decreased from 12.

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The health visitor network in Hungary: a unique system in Europe.

Turk Pediatri Ars

September 2020

Department of Family Care Methodology, Faculty of Health Science, Semmelweis University, Budapest, Hungary.

The Hungarian health visitor network, established in 1915, is a unique system in Europe. Health visitors are highly qualified healthcare professionals whose traditional role is to promote and improve the physical, mental, and social well-being of families. They are specialised in women's health, pregnancy, mother, infant and child care, as well as the health protection of adolescents.

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Background: Shortcomings of inhaled antibiotic treatments for Pseudomonas aeruginosa infection in patients with cystic fibrosis (CF) include poor drug penetration, inactivation by sputum, poor efficiency due to protective biofilm, and short residence in the lung.

Methods: Eligible patients with forced expiratory volume in 1 s (FEV) ≥25% of predicted value at screening and CF with chronic P. aeruginosa infection were randomly assigned to receive 3 treatment cycles (28 days on, 28 days off) of amikacin liposome inhalation suspension (ALIS, 590 mg QD) or tobramycin inhalation solution (TIS, 300 mg BID).

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We overview here the new data about the epileptic spectrum disorders within the frame of perisylvian epileptic network since our first trial to synthetize knowledge about this system epilepsy (Halász et al., 2005). We found evidences for a continual features relating together syndromes constituting this spectrum disorder in several fields: in sharing genetic origin, in common perisylvian human communication circuitry, in NREM sleep related potentiation of interictal epileptiform discharges of the centro-temporal spike phenomenon and in the discharge related cognitive impairment, reflecting functional deficits in human communication abilities.

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Effect of maternal depression and anxiety on mother's perception of child and the protective role of social support.

J Reprod Infant Psychol

September 2018

d Department of Family Care and Methodology , Faculty of Health Sciences, Semmelweis University, Institute for Health Promotion and Clinical Methodology, Budapest , Hungary.

Objective: The purpose of this study was to investigate the impact of postpartum depressive and anxiety symptoms on maternal perception of the infant and the protective role of social support.

Background: Adverse effects of perinatal depression on mother-child interaction are well documented; however, the role of maternal perception has not been examined.

Methods: We used the data of 431 women enrolled in a prospective study in a single maternity unit.

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Possible roles of genetic variations in chemotherapy related cardiotoxicity in pediatric acute lymphoblastic leukemia and osteosarcoma.

BMC Cancer

July 2018

Department of Genetics, Cell- and Immunobiology, Semmelweis University, 1089 Nagyvárad tér 4., 6 em, Budapest, 611, Hungary.

Background: The treatment of acute lymphoblastic leukemia (ALL) and osteosarcoma (OSC) is very effective: the vast majority of patients recover and survive for decades. However, they still need to face serious adverse effects of chemotherapy. One of these is cardiotoxicity which may lead to progressive heart failure in the long term.

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Variation in the TEK gene is not associated with asthma but with allergic conjunctivitis.

Int J Immunogenet

June 2018

Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.

The Tie2 receptor is an important player in angiogenesis. The Tie2 mRNA and protein are abundantly expressed in the lungs and the associated pathway also has an important role in the development and function of the eye. Tie2 is encoded by the TEK gene in humans.

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During the last decades, the prevalence of allergy has dramatically increased. Allergen-specific immunotherapy is the only currently available medical intervention that has the potential to affect the natural course of the disease, but there are still many questions and unmet needs hindering its widespread use to fulfill its treatment potential and maximize its benefits for the society. To provide a comprehensive phenome-wide overview in sublingual immunotherapy, using ragweed allergy as a target, we planned and carried out a longitudinal, prospective, observational, open-label study (DesensIT).

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Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium.

Pharmacogenomics

July 2017

Division of Pharmacoepidemiology & Clinical Pharmacology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.

Aim: International collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics in Childhood Asthma (PiCA) consortium.

Materials & Methods: Investigators of each study participating in PiCA provided data on the study characteristics by answering an online questionnaire.

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Hypersensitivity reactions are the most frequent dose-limiting adverse reactions to -derived asparaginase in pediatric acute lymphoblastic leukemia (ALL) patients. The aim of the present study was to identify associations between sequence-based Human Leukocyte Antigen Class II region alleles and asparaginase hypersensitivity in a Hungarian ALL population. Four-digit typing of and loci was performed in 359 pediatric ALL patients by using next-generation sequencing method.

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Purpose: Several lines of evidence indicate that the Hippo/Yes-associated protein 1 (YAP1) pathways might play a role in the pathogenesis of asthma. To investigate the possible role of the Hippo/YAP1 pathway in the pathogenesis of asthma or its phenotypes.

Methods: The levels of gene expressions of the members of the Hippo/YAP1 were compared.

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Pharmacogenetics of anthracyclines.

Pharmacogenomics

June 2016

Department of Genetics, Cell- and Immunobiology, Semmelweis University, H-1089 Budapest, Nagyvárad tér 4, Hungary.

Anthracyclines constitute a fundamental part of the chemotherapy regimens utilized to treat a number of different malignancies both in pediatric and adult patients. These drugs are one of the most efficacious anticancer agents ever invented. On the other hand, anthracyclines are cardiotoxic.

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Article Synopsis
  • L-asparaginase is crucial for treating pediatric acute lymphoblastic leukaemia (ALL), but hypersensitivity reactions (HSRs) pose significant challenges.
  • Genetic variants in the GRIA1 and GALNT10 genes were studied in 576 pediatric ALL patients to understand their impact on ASP HSR risk.
  • Variants in GRIA1 showed different associations with hypersensitivity based on ALL subtype and gender, suggesting that genetic factors may play a role in the risk of HSRs to L-asparaginase in these patients.
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Novel genes in Human Asthma Based on a Mouse Model of Allergic Airway Inflammation and Human Investigations.

Allergy Asthma Immunol Res

November 2014

Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary. ; Heim, Pal Children Hospital, Budapest, Hungary. ; Csertex Research Laboratory, Budapest, Hungary.

Purpose: Based on a previous gene expression study in a mouse model of asthma, we selected 60 candidate genes and investigated their possible roles in human asthma.

Methods: In these candidate genes, 90 SNPs were genotyped using MassARRAY technology from 311 asthmatic children and 360 healthy controls of the Hungarian (Caucasian) population. Moreover, gene expression levels were measured by RT PCR in the induced sputum of 13 asthmatics and 10 control individuals.

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In interaction with gender a common CYP3A4 polymorphism may influence the survival rate of chemotherapy for childhood acute lymphoblastic leukemia.

Pharmacogenomics J

June 2015

1] Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary [2] Heim Pal Children Hospital, Budapest, Hungary [3] Csertex Research Laboratory, Budapest, Hungary.

CYP3A4 has an important role in the metabolisms of many drugs used in acute lymphoblastic leukemia (ALL) therapy; still, there are practically no publications about the role of CYP3A4 polymorphisms in ALL pharmacogenomics. We genotyped eight common single-nucleotide polymorphisms (SNPs) in the CYP3A4 and CYP3A5 genes in 511 children with ALL and investigated whether they influenced the survival of the patients. We involved additional 127 SNPs in 34 candidate genes and searched for interactions with respect to the survival rates.

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Background: During orthodontic treatment, the various elements that constitute the fixed appliance undergo different processes. As a result of a change of the surface, elution/coverage of metals on the surface can be observed in the process of corrosion/passivation.

Material And Methods: Scanning electron microscopy with an energy-dispersive X-ray analytical system (SEM-EDX) was used to analyze the composition of stainless steel elements of orthodontic fixed appliances (before and after orthodontic treatment), to obtain the composition of the surface of the elements.

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Two metastasis-associated proteins, CD44v6 and NM23-H1, are expressed by normal lymphoid cells, the former serving as activation marker and the latter as a constitutive protein. CD44v6 is considered as a marker of poor prognosis of various hematological cancers but its expression was not demonstrated in childhood acute lymphoblastic leukaemia (ALL). On the other hand, NM23-H1 is considered as a differentiation inhibitory factor in various hematological cancers and as a marker of poor prognosis.

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