3,167 results match your criteria: "Pakistan Kidney & Liver Institute & Research Center PKLI&RC[Affiliation]"
COVID-19-induced extracorporeal circulation coagulation during continuous renal replacement therapy: A cross-sectional study.
Medicine (Baltimore)
October 2024
Division of Renal Medicine, Peking University Shenzhen Hospital, Peking University, Shenzhen, China.
After the control policies of the COVID-19 epidemic were lifted in China from December 5th, 2022, there was an increase in the demand for hemodialysis and continuous renal replacement therapy (CRRT) at our center, and patients experienced hypercoagulable blood states more frequently. This study aimed to investigate the effect of COVID-19 on extracorporeal coagulation during CRRT. All CRRT records were gathered from the Hemodialysis Center at our hospital from December 5th, 2022 to February 4th, 2023, and analyzed the incidence and risk factors associated with extracorporeal coagulation.
View Article and Find Full Text PDFBioengineering of glucan coated silver nanoparticles as dynamic biomedical compound; in vitro and in vivo studies.
Microb Pathog
December 2024
Microbial Biotechnology Laboratory, Institute of Zoology, University of the Punjab, Lahore, Pakistan. Electronic address:
The use of silver nanoparticles (AgNPs) gaining importance for the treatment of microbial infections and are in great demand due to their efficient broad antibacterial action but there is only one problem that silver nanoparticles can cause tissue damage. Therefore, the present study evaluated antimicrobial potential and intricacy of glucan coated silver nanoparticles in comparison with free silver nanoparticles. In this study, glucan coated silver nanoparticles (Glucan-AgNPs) by using Pleurotus spps.
View Article and Find Full Text PDFUnmasking the Rarity: A Case Report on Platypnea-Orthodeoxia Syndrome With Successful Resolution Through Patent Foramen Ovale Closure.
J Med Cases
November 2024
Department of Cardiology, McLaren Flint Hospital, Flint, MI, USA.
Article Synopsis
- Platypnea-orthodeoxia syndrome (POS) is a rare condition where a person experiences breathlessness and low oxygen levels when standing, but feels better when sitting or lying down, contrasting with orthopnea which worsens when lying flat.
- A case study highlighted a 79-year-old woman with various health issues, including chronic kidney disease and a history of pulmonary embolism, who was found to have a severe patent foramen ovale (PFO) that likely contributed to her POS symptoms.
- After successfully closing the PFO with a medical device, the patient showed significant improvement and was discharged within two days, emphasizing the importance of recognizing and treating POS to prevent serious health risks.
Moderating effect of sleep quality in the relationship between coping and distress among medical students.
Front Psychiatry
October 2024
Department of Psychology, University of Sargodha, Sargodha, Pakistan.
Introduction: The present study examined the moderating effects of sleep quality in the relationship between coping and distress among medical college students. Present study was conducted to ensure the mental health of medical students and to dig out the reasons behind their disturbed health which can directly impact their performance at work.
Methods: The study utilized a cross-sectional survey and was distributed to students at various medical institutions in the Punjab province of Pakistan from October 2019 to June 2020.
Coincidence of HCV and chronic kidney disease-a systematic review and meta-analysis.
BMC Public Health
October 2024
Division of Molecular Virology, Center of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.
Background: There are reported studies of Hepatitis C and chronic kidney disease association. However, how this liver virus infection affects the general population's susceptibility to the onset of the kidney disease is still unknown.
Methods: To determine if a positive anti-HCV serologic status is linked to a greater incidence of chronic kidney disease in the general adult population, a systematic evaluation of the published medical literature since 2015 was conducted.
Article Synopsis
- * Despite strong evidence supporting their benefits, SGLT2 inhibitors are not widely adopted in hospitals for heart failure patients due to concerns about potential side effects and lack of clear guidelines.
- * The review emphasizes the need for more specific safety data and guidelines for starting SGLT2 inhibitors in the hospital setting, suggesting that early use may have significant clinical benefits.
Safety Evaluation and antioxidant potential of new probiotic strain (NMCC-path-14) in Balb/c mice by sub-acute repeated dose toxicity.
Heliyon
October 2024
MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, 133207, India.
Article Synopsis
- - Probiotics, especially the strain Bacillus subtilis (NMCC-path-14) isolated from buffalo, are being researched for their health benefits, including the prevention of gastrointestinal issues and diarrhea.
- - In a study with Balb/c mice, NMCC-path-14 showed no adverse effects over a 28-day treatment, indicating a no-observed-adverse-effect level (NOAEL) greater than 1 × 10 CFU/animal/day.
- - The treatment improved various health indicators, such as increasing food intake and hemoglobin levels, while also enhancing antioxidant enzyme activity and promoting a beneficial gut bacteria balance, suggesting NMCC-path-14 could be a safe probiotic for humans.
Navigating the triple threat: Management of post-ESWL urinoma, steinstrasse, and obstructive uropathy: A challenging case report.
Radiol Case Rep
December 2024
Department of Urology & MIS, Millat Hospital /Foundation, Sadiqabad, Pakistan.
Article Synopsis
- Urinoma formation is a rare complication that can occur after extracorporeal shock wave lithotripsy (ESWL), especially when combined with a condition called steinstrasse, complicating treatment in obstructive uropathy.
- Urinoma refers to a collection of urine outside the kidney's collecting system, usually in the retroperitoneal or perirenal space, and timely diagnosis and treatment are crucial to avoid further complications.
- A case report details a patient who experienced both urinoma and steinstrasse following right-side ESWL treatment for kidney stones, ultimately requiring a nephrostomy tube, trans-ureteral lithotripsy, and percutaneous nephrolithotomy for management.
Clinicopathological characteristics and outcomes of adult patients with idiopathic membranoproliferative glomerulonephritis according to an immunofluorescence-based classification.
J Nephrol
November 2024
Department of Histopathology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan.
Article Synopsis
- The study classifies membranoproliferative glomerulonephritis (MPGN) into two types: immune complex-mediated and complement-mediated, based on immunofluorescence results, using data from a 20-year period at a major medical institution in Pakistan.
- Out of 213 patients, the majority (76.5%) were found to have immune complex-mediated MPGN, with both groups showing similar demographics and clinical presentations, but differing treatment outcomes.
- Immune complex-mediated MPGN had better remission rates and renal survival compared to complement-mediated MPGN, which had higher progression to end-stage kidney disease (ESKD) and greater overall mortality.
A Comparison of the Outcomes of COVID-19 Vaccinated and Nonvaccinated Patients Admitted to an Intensive Care Unit in a Low-Middle-Income Country.
Crit Care Res Pract
October 2024
Department of Anaesthesiology, Aga Khan University Hospital, Karachi P. O. Box 3500, Pakistan.
Patients critically afflicted with coronavirus disease 2019 (COVID-19) often need intensive care unit (ICU) admission, despite comprehensive vaccination campaigns. The challenges faced by healthcare systems in low-middle-income countries, including limited infrastructure and resources, play a pivotal role in shaping the outcomes for these patients. This study aimed to meticulously compare outcomes between COVID-19 vaccinated and nonvaccinated patients admitted to the ICU.
View Article and Find Full Text PDFAn international, multi-center study evaluated rituximab therapy in childhood steroid-resistant nephrotic syndrome.
Kidney Int
December 2024
Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Trust, London, UK. Electronic address:
Article Synopsis
- The study investigated the effectiveness and safety of rituximab for treating childhood steroid-resistant nephrotic syndrome (SRNS) across 28 pediatric nephrology centers globally.
- Researchers found that children with a longer history of calcineurin inhibitors (CNIs) treatment before rituximab had lower remission rates compared to those with shorter treatment periods.
- Overall, rituximab showed enhanced remission rates in a portion of SRNS patients, was mostly safe, and achieving complete remission was linked to better kidney survival outcomes.
Gullian Barre syndrome secondary to heat stroke: a case report.
Intern Emerg Med
October 2024
FCPS Neurology, Diplomate American Board of Neurophysiology, Assistant Professor, Section of Neurology, Department of Medicine, Clinical Neurophysiology Lab, Aga Khan University Hospital, Karachi, Pakistan.
Article Synopsis
- Heat waves in countries like Pakistan are leading to increased cases of heat stroke, which can cause severe health issues like multi-organ dysfunction.
- A case study describes a previously healthy 49-year-old man who developed neurological symptoms and kidney injury after intense exercise in a heat wave, initially misdiagnosed as heat stroke.
- Further tests revealed the man had Guillain-Barré Syndrome as a rare complication of heat stroke, and he showed significant improvement following treatment with plasmapheresis, marking a unique instance in Pakistan.
Surgical management and outcomes of renal tumors with inferior vena cava extension among children: a single center retrospective study from Pakistan.
BMC Pediatr
October 2024
Department of Pediatric Surgery, Aga Khan University Hospital Karachi, Stadium Road, Karachi, 74800, Sindh, Pakistan.
Article Synopsis
- The study focused on renal tumors with inferior vena cava (IVC) and intracardiac (IC) extension in pediatric patients treated at Aga Khan University Hospital in Karachi, Pakistan, over an 18-year period.
- A total of 18 out of 61 patients presented with IVC/IC extension, predominantly involving Wilms tumor, with most surgeries resulting in tumor regression and a low mortality rate.
- The study found a higher incidence of tumor extension compared to previous literature, highlighting the need for multi-center research to improve surgical management and patient outcomes in similar settings.
Bovine lactoferrin alleviates aflatoxin B1 induced hepatic and renal injury in broilers by mediating Nrf2 signaling pathway.
Poult Sci
December 2024
Department of Basic Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi Province, 712100, China. Electronic address:
Article Synopsis
- - Aflatoxin B1 (AFB1) is a harmful mycotoxin affecting poultry health, particularly causing issues like reduced feed intake and weight gain in broiler chicks, which leads to liver and kidney damage.
- - The study investigates the protective effects of bovine lactoferrin (bLF) against AFB1 toxicity, showing that bLF helped maintain normal liver and kidney function by regulating harmful biomarkers and reducing oxidative stress.
- - BLF supplementation normalized gene expressions related to apoptosis and antioxidant defense pathways that were disrupted by AFB1 exposure, suggesting it could be a beneficial dietary addition for poultry to combat AFB1-induced damage.
Hyponatremia Prevalence in Decompensated Chronic Liver Disease: Insights from a Tertiary Care Hospital.
Cureus
September 2024
Department of Medicine, DHQ (District Headquarter) Teaching Hospital, Gujranwala, PAK.
Background: Liver cirrhosis is a prominent global contributor to mortality, and hyponatremia is a common complication in patients with decompensated chronic liver disease (DCLD). Hyponatremia is characterized by kidney impairment when eliminating solute-free water. The presence of contradictory findings in existing literature prompted this study.
View Article and Find Full Text PDFAntiurolithic activity of Zaleya pentandra (L.) C Jeffrey in ethylene glycol-induced calcium oxalate crystal rat model; A scientific validation of traditional use for kidney stone prevention.
J Ethnopharmacol
January 2025
Riphah Institute of Pharmaceutical Sciences, Riphah International University, Raiwind Campus, Lahore, Pakistan.
Ethnopharmacological Relevance: Traditional herbal remedies have been used for treating nephrolithiasis, but the relevant scientific evidence is limited. Zaleya pentandra (L.) C.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigated BK polyomavirus infection in organ transplant recipients, focusing on its prevalence and implications for kidney transplant recipients experiencing BK virus-associated nephropathy (BKVAN).
- - Conducted over a year with 108 renal transplant patients, the study found that 16.7% had detectable BK viruria, particularly in females and those aged 41-60, mostly occurring 7-9 months post-transplant.
- - Notable correlations were observed between age, gender, and viral load, with older recipients showing higher viral levels, emphasizing the need for regular screening and potential immunosuppression adjustments.
Article Synopsis
- * Recent efforts to stop smoking haven't been put into action yet, and it’s important to see what could happen if smoking rates stay the same or improve.
- * Researchers used models to predict health outcomes by 2050 based on different scenarios of smoking rates, showing that cutting smoking could greatly improve health and life expectancy.
A step forward in cardiovascular and renal protection: advocating for finerenone's use in Pakistan.
Int Urol Nephrol
October 2024
King Edward Medical University, Lahore, 54000, Pakistan.
Article Synopsis
- * CKD is particularly critical for patients with end-stage renal disease (ESRD) who are undergoing maintenance hemodialysis (MHD).
- * ESRD patients face high rates of health issues and death largely due to the complications from CKD and its impact on heart health.
Urea to Treat Hyponatremia Due to Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Systematic Review and Meta-Analysis.
Am J Kidney Dis
October 2024
Department of Medicine Aga Khan University Hospital, Karachi, Pakistan.
Article Synopsis
- The systematic review and meta-analysis aimed to evaluate the effectiveness, safety, and tolerability of using urea to treat hyponatremia caused by SIADH, addressing previously raised concerns in the medical community.
- The study analyzed existing observational research from multiple databases, focusing on patients with SIADH-related low sodium levels and including trials that measured outcomes like serum sodium concentration and any adverse effects from urea administration.
- Results showed that urea treatment led to a significant improvement in serum sodium levels, particularly in more severe cases of hyponatremia, indicating it may be an effective treatment option despite some variability in outcomes.
Defining the Etiology of Renal Allograft Dysfunction Using Banff 2019 Classification: Correlation with Post-Transplant Duration and Creatinine Levels-A Comprehensive Analysis of 200 Renal Biopsies at a Tertiary Care Medical Center Hospital.
Int J Surg Pathol
October 2024
Department of Pathology and Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
Objective: Chronic kidney disease is a growing global health issue, contributing significantly to morbidity and mortality. The incidence of end-stage renal disease (ESRD) is approximately 100 per million population. Renal transplantation remains the cornerstone treatment for ESRD, with a projected 20-year survival rate of 60%.
View Article and Find Full Text PDFEfficacy and safety of mavacamten for the treatment of hypertrophic cardiomyopathy: an updated systematic review and meta-analysis of randomized controlled trials.
Ann Med Surg (Lond)
October 2024
Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA.
The efficacy and safety profile of mavacamten, a cardiac myosin inhibitor for the treatment of hypertrophic cardiomyopathy (HCM) is not well-established, prompting the need for an updated meta-analysis. The authors conducted an extensive search across multiple electronic databases, including Embase, MEDLINE (via Pubmed), and CENTRAL, to identify randomized controlled trials (RCTs) assessing the efficacy and safety of mavacamten in HCM. Review Manager 5.
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