Prepartum Dietary Supplementation of Potassium Humate Improves Postpartum Lactation Performance, Metabolic Profile of Multiparous Cows, and Immune Response of Their Calves.

This research was carried out to determine the effects of potassium humate on the lactation performance and metabolic parameters of dairy cows during the transition period. Potassium humate was added to the concentrate feed at the following levels: (a) control (0%), (b) 0.5%, (c) 1%, (d) 1.

Effect of Ideal Amino Acid Ratio of Arginine to Lysine on Intake, Nutrient Digestibility, Growth Performance, Antibody Titers of Newcastle Disease and Infectious Bronchitis Disease, and Carcass Characteristics of Broilers.

This study aimed to assess the effects of different arginine (Arg) to lysine (Lys) ratios on feed intake, nutrient digestibility, growth performance, carcass characteristics, and antibody titers of Newcastle disease (ND) and infectious bronchitis (IB) disease in broilers during 35 days of trial. For this purpose, a total of 816 day-old broiler birds having an average weight of 38 ± 3 g were divided into six dietary treatments in such a way that each treatment had eight replicates and each replicate had 17 birds. The treatments were 0.

Targeting Cutaneous Leishmaniasis with Thiadiazine Thione Derivatives: An In Vivo Study of Its Anti-Inflammatory, Anti-Pyretic, Anti-Nociceptive, and Anti-Sedative Properties.

Thiadiazine thione (THTT) has gained significant interest owing to its pharmacological potentials, particularly its antiparasitic and anti-inflammatory properties. Leishmaniasis is a clinical syndrome caused by infection with species and is associated with an inflammatory response and nociception. The available treatments against leishmaniasis are inadequate, as they are associated with high cost, toxicity, and increased resistance.

The Effect of Offspring Gender Composition on Modern Contraceptive Uptake Among Married Women of Reproductive Age in Pakistan: A Facility-Based Cross-Sectional Study.

Pakistan is confronted with the formidable challenge of high population growth, which is compounded by cultural norms that prioritize male offspring, leading to adverse implications for family planning efforts and demographic trends. Despite efforts to promote contraception, including a national family planning program, Pakistan continues to struggle with low and stagnant contraceptive prevalence rates among married women. The influence of gender composition on modern contraceptive uptake remains underexplored, necessitating research to elucidate its impact on reproductive behavior.

Nicotinamide Mononucleotide Restores NAD Levels to Alleviate LPS-Induced Inflammation via the TLR4/NF-κB/MAPK Signaling Pathway in Mice Granulosa Cells.

Inflammation disrupts the normal function of granulosa cells (GCs), which leads to ovarian dysfunction and fertility decline. Inflammatory conditions such as polycystic ovary syndrome (PCOS), primary ovarian insufficiency (POI), endometriosis, and age-related ovarian decline are often associated with chronic low-grade inflammation. Nicotinamide mononucleotide (NMN) is an important precursor of NAD and has gained attention for its potential to modulate cellular metabolism, redox homeostasis, and mitigate inflammation.

A Cross-Sectional Multivariable Analysis of the Quality of Hemodialysis Patients' Life in Lahore City, Pakistan.

Chronic kidney disease (CKD) is a severe health problem with dire consequences for the quality of life of millions of individuals and their families around the globe. This quantitative study analyzes the factors associated with hemodialysis patients' quality of life (QoL) in Lahore City, Pakistan. Primary data from a sample of 384 patients were collected through regular visits to the hospital.

Smokeless tobacco: knowledge, attitudes and usage in Pakistan.

Background: Smokeless tobacco (SLT) encompasses products that are not burnt but instead consumed orally or nasally. One-third of tobacco is consumed in the smokeless form in South Asia. Despite its widespread usage, there has been limited empirical research on the prevalence and factors influencing SLT consumption in Pakistan.

Dissecting the genetic basis of fruiting efficiency for genetic enhancement of harvest index, grain number, and yield in wheat.

Background: Grain number (GN) is one of the key yield contributing factors in modern wheat (Triticum aestivum) varieties. Fruiting efficiency (FE) is a key trait for increasing GN by making more spike assimilates available to reproductive structures. Thousand grain weight (TGW) is also an important component of grain yield.

Design, Synthesis and in Silico Molecular Docking Studies of Adamantanyl hydrazinylthiazoles as Potential Anti-diabetic Agents.

Diabetes mellitus is a widespread disease that poses a major threat to millions of people. To address this issue, we have synthesized seventeen new 4-(adamantan-1-yl)-(2-(arylidene)hydrazinyl)thiazoles via Hantzsch synthetic approach. The molecular structures of all the compounds were confirmed using spectroscopic techniques.

Monster of the Night: Identifying Pakistani Gender-Based, Religious, and Cultural Influences on Sleep Paralysis Among University Students.

The present study has explored the folk knowledge about the phenomenon of sleep paralysis in Pakistani society. The research aimed to gain a nuanced glimpse focusing on three major factors, culture, religion, and gender, that influence the lived experiences of those who face sleep paralysis. In this qualitative research, to have a holistic perception of indigenous knowledge about it, we selected both male and female participants who have experienced sleep paralysis.

Commentary on "preoperative cardiology consultations for geriatric patients with hip fractures rarely provide additional recommendations and are associated with prolonged hospital stays and delayed surgery: a retrospective case control study".

This letter discusses the recent study by Vahabi et al., which examined the role of preoperative cardiology consultations in geriatric patients undergoing hip fracture surgery. While the study highlights the limited impact of these consultations on treatment modifications and the associated delays in surgical intervention, this letter suggests areas for further exploration.

Poisoned in their homes - Red blood cell abnormalities in lead-exposed residents of a Pakistani Industrial Zone.

The present study investigated the clinical and hematological effects of chronic lead exposure in the population residing in Shadi Pura, a small industrial zone in Lahore, Pakistan. A cross-sectional analysis of 149 participants recruited through health camps was conducted to explore the hematological manifestations of environmental lead exposure, focusing on various red blood cell (RBC) indices and morphology. Moreover, the study examined the differences in the impact of lead exposure on RBC indices and morphology between men, women, and children.

Modeling of historical and future changes in temperature and precipitation in the Panj River Basin in Central Asia under the CMIP5 RCP and CMIP6 SSP scenarios.

This study examines the complexities of climate modeling, specifically in the Panj River Basin (PRB) in Central Asia, to evaluate the transition from CMIP5 to CMIP6 models. The research aimed to identify differences in historical simulations and future predictions of rainfall and temperature, examining the accuracy of eight General Circulation Models (GCMs) used in both CMIP5 (RCP4.5 and 8.

Optimizing healthcare big data performance through regional computing.

The healthcare sector is experiencing a digital transformation propelled by the Internet of Medical Things (IOMT), real-time patient monitoring, robotic surgery, Electronic Health Records (EHR), medical imaging, and wearable technologies. This proliferation of digital tools generates vast quantities of healthcare data. Efficient and timely analysis of this data is critical for enhancing patient outcomes and optimizing care delivery.

Reinforcement learning based route optimization model to enhance energy efficiency in internet of vehicles.

The Internet of Vehicles (IoV) transforms the automobile industry through connected vehicles with communication infrastructure that improves traffic control, safety and information, and entertainment services. However, some issues remain, like data protection, privacy, compatibility with other protocols and systems, and the availability of stable and continuous connections. Specific problems are related to energy consumption for transmitting information, distributing energy loads across the vehicle's sensors and communication units, and designing energy-efficient approaches to processing received data and making decisions in the context of the IoV environment.

Influence of different priming treatments on germination potential and seedling establishment of four important hemp (Cannabis sativa L.) cultivars.

Medicinal hemp (Cannabis sativa L.) is gaining popularity due to its natural products with potential therapeutic properties, and its cultivation has recently been initiated in developing countries such as Turkey, Iran, India, and Pakistan. The crop is primarily grown using feminized seeds or popular varieties to achieve higher cannabidiol (CBD) yields, with seeds costing approximately $5-10 each.

Advancing neutron imaging techniques to highest resolution with fluorescent nuclear track detectors.

Neutron imaging is a nondestructive and noninvasive inspection technique with a wide range of potential applications. However, the fundamentals of this technique still need to be improved, one of which involves achieving micrometer scale or even better resolution, which is a challenging task. Recently, a high-resolution neutron imaging device based on fine-grained nuclear emulsions was developed.

Breather, lump and other wave profiles for the nonlinear Rosenau equation arising in physical systems.

This work explores the mathematical technique known as the Hirota bilinear transformation to investigate different wave behaviors of the nonlinear Rosenau equation, which is fundamental in the study of wave occurrences in a variety of physical systems such as fluid dynamics, plasma physics, and materials science, where nonlinear dynamics and dispersion offer significant functions. This equation was suggested to describe the dynamic behaviour of dense discrete systems. We use Mathematica to investigate these wave patterns and obtained variety of wave behaviors, such as M-shaped waves, mixed waves, multiple wave forms, periodic lumps, periodic cross kinks, bright and dark breathers, and kinks and anti-kinks.

A higher infection rate of Toxoplasma gondii in soft ticks infesting domestic hens: A novel report from Pakistan.

Ticks are the second most important hematophagous ectoparasites after mosquitoes and serve as vectors for various pathogens, transmitting them to wild and domestic animals, as well as humans. Argas persicus are the soft ticks that are known to parasitize domestic poultry. Hard ticks are known to be the reservoir of Toxoplasma (T.

Taxonomic identification and prevalence of hard ticks on different breeds of sheep from district Quetta in Balochistan, Pakistan.

Ticks, being ectoparasites, are vectors for the transmission of various pathogens that can infect animals and can also pose a significant threat to human health. Due to hot and humid climatic conditions across different agro-ecological regions of Pakistan, ticks are widespread and infest a diverse range of animal species. This study aimed for taxonomic identification and prevalence determination of ticks in sheep collected from four different marketplaces in the Quetta district of Balochistan.

Degradation of fenamates.

Fenamates are the most crucial non-steroidal anti-inflammatory drugs (NSAIDs) used to treat pain-related diseases. The clinically prescribed drugs of the fenamate group include mefenamic acid, tolfenamic acid, meclofenamic acid, flufenamic acid, and niflumic acid. Due to their widespread use, all these drugs are considered as the most common water and sewerage pollutants.

Cyclodextrins and their applications in pharmaceutical and related fields.

This chapter presents an overall account of cyclodextrins (CDs) with a brief description of the history, classification, and properties of these macromolecules. CDs act as complexing agents for drugs to form CD-drug inclusion complexes by various techniques. These complexes lead to the modification of the physicochemical properties of drugs to make them more soluble, chemically, and photochemically stable, and less toxic.

Characteristics of children and adolescents with multidrug-resistant and rifampicin-resistant tuberculosis and their association with treatment outcomes: a systematic review and individual participant data meta-analysis.

Background: There are few data on the treatment of children and adolescents with multidrug-resistant (MDR) or rifampicin-resistant (RR) tuberculosis, especially with more recently available drugs and regimens. We aimed to describe the clinical and treatment characteristics and their associations with treatment outcomes in this susceptible population.

Methods: We conducted a systematic review and individual participant data meta-analysis.

Effect of one prophylactic dose of Azithromycin on Bifidobacterium infantis colonization in infants from the Mumta Trial.

Objectives: The effects of antibiotics on the microbiome remain incompletely understood. Azithromycin (AZ) has been shown to improve child survival and infant growth outcomes. This study aimed to assess the impact of AZ on B.

Exploring Serotonin-1A receptor function in the effects of buspirone on cognition by molecular receptor expression and EEG analytical studies.

Buspirone, a commonly prescribed medication for generalized anxiety disorder (GAD), is gaining attention for its narrow window of side effects such as lack of physical dependence, non-sedative properties as compared to other anxiolytic drugs. Its dose-specific therapeutic effects beyond anxiety highlights its clinical significance. Pharmacologically, buspirone activates serotonin-1A pre-synaptic autoreceptors and post-synaptic heteroreceptors which modulate serotonergic neurotransmission induced behavioral changes such as anxiolytic and nootropic effects.